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The map label for this gene is pepE [H]

Identifier: 148827800

GI number: 148827800

Start: 1154976

End: 1155680

Strand: Direct

Name: pepE [H]

Synonym: CGSHiGG_06345

Alternate gene names: 148827800

Gene position: 1154976-1155680 (Clockwise)

Preceding gene: 148827797

Following gene: 148827801

Centisome position: 61.2

GC content: 36.88

Gene sequence:

>705_bases
ATGAAAAATATGTTACTGCTCAGTAGCTCAAAATACAAGAACACGGGTTATCTTGAACACACCCTACCTTGGTTACAAAA
TTTCTTGGCGGATTATCGTGGTAAAACAATTGCTTTTGTGCCTTATGCTGGGGTACGCCGCACTTTTGATGAATACGAAA
AAACTGTGCAAAATGCACTTTCTTATTTAGAGATGAATATTGTTTCCGTTCATCATGGTAAACAGCATCGAGATATTATT
GAACAAGCAGATGTCATCGCTATTGGCGGCGGGAATACATTTTGTTTGTTAAAACAGCTTTATGAACACAATTTAATTGA
TATCATTCGTGAAAAAGTGAATAACAGTACGCCTTATTTTGGTTGGAGTGCTGGGGCAAATGTAGTGGGTGCATCCATTA
TGACAACGAATGATATGCCGATTACTTATCCTCCTTCATTTCAAGCATTACAGCTTTTTCCTCATCAAATTAATCCGCAC
TTTATTTCAGGTAAAATGCAAGGTCATAATGGCGAAAGCCGAGAAGAACGTTTGGCTGAATTTTTACTCGTTAATCCAAC
CGCACTTGTATATGCATTGCCTGAAGGTTCTGCACTTCATATACAAAATGAAATGGCAACTGTGTTGGGTGAAAATCCTA
TTTTGTGCTTCAGTGAAAATATGGAATGTGGCACATTTGATATCAATACAACTTTTTCTTATTAA

Upstream 100 bases:

>100_bases
TTTTTGATATTCGTCAAACAATTATAATTTTTCGTTGAAAATTAACCTTTTCTAAGCGTAATATTGGTATTGCTAAATGC
CTCTAAAAAGGATTATAAAT

Downstream 100 bases:

>100_bases
CTTAAAAGGAACATATAATGGAATTATTCAAATCCATCGTTGCAGTGATTGGCATTATTGCCACAATTTATTTTCTGATT
AAAAAAGCCGAAACCCGAAC

Product: peptidase E

Products: NA

Alternate protein names: Alpha-aspartyl dipeptidase; Asp-specific dipeptidase; Dipeptidase E [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKNMLLLSSSKYKNTGYLEHTLPWLQNFLADYRGKTIAFVPYAGVRRTFDEYEKTVQNALSYLEMNIVSVHHGKQHRDII
EQADVIAIGGGNTFCLLKQLYEHNLIDIIREKVNNSTPYFGWSAGANVVGASIMTTNDMPITYPPSFQALQLFPHQINPH
FISGKMQGHNGESREERLAEFLLVNPTALVYALPEGSALHIQNEMATVLGENPILCFSENMECGTFDINTTFSY

Sequences:

>Translated_234_residues
MKNMLLLSSSKYKNTGYLEHTLPWLQNFLADYRGKTIAFVPYAGVRRTFDEYEKTVQNALSYLEMNIVSVHHGKQHRDII
EQADVIAIGGGNTFCLLKQLYEHNLIDIIREKVNNSTPYFGWSAGANVVGASIMTTNDMPITYPPSFQALQLFPHQINPH
FISGKMQGHNGESREERLAEFLLVNPTALVYALPEGSALHIQNEMATVLGENPILCFSENMECGTFDINTTFSY
>Mature_234_residues
MKNMLLLSSSKYKNTGYLEHTLPWLQNFLADYRGKTIAFVPYAGVRRTFDEYEKTVQNALSYLEMNIVSVHHGKQHRDII
EQADVIAIGGGNTFCLLKQLYEHNLIDIIREKVNNSTPYFGWSAGANVVGASIMTTNDMPITYPPSFQALQLFPHQINPH
FISGKMQGHNGESREERLAEFLLVNPTALVYALPEGSALHIQNEMATVLGENPILCFSENMECGTFDINTTFSY

Specific function: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids [H]

COG id: COG3340

COG function: function code E; Peptidase E

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S51 family [H]

Homologues:

Organism=Escherichia coli, GI1790452, Length=220, Percent_Identity=40.9090909090909, Blast_Score=174, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24641669, Length=207, Percent_Identity=42.9951690821256, Blast_Score=160, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005320
- InterPro:   IPR023172 [H]

Pfam domain/function: PF03575 Peptidase_S51 [H]

EC number: =3.4.13.21 [H]

Molecular weight: Translated: 26384; Mature: 26384

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNMLLLSSSKYKNTGYLEHTLPWLQNFLADYRGKTIAFVPYAGVRRTFDEYEKTVQNAL
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHH
SYLEMNIVSVHHGKQHRDIIEQADVIAIGGGNTFCLLKQLYEHNLIDIIREKVNNSTPYF
HHHHHHEEEECCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCC
GWSAGANVVGASIMTTNDMPITYPPSFQALQLFPHQINPHFISGKMQGHNGESREERLAE
EECCCCCCEEEEEEEECCCCEECCCCCHHHEECCCCCCCEEEECEECCCCCCHHHHHHHH
FLLVNPTALVYALPEGSALHIQNEMATVLGENPILCFSENMECGTFDINTTFSY
HHEECCCEEEEECCCCCEEEEHHHHHHHHCCCCEEEEECCCCCCEEEECEEECC
>Mature Secondary Structure
MKNMLLLSSSKYKNTGYLEHTLPWLQNFLADYRGKTIAFVPYAGVRRTFDEYEKTVQNAL
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHH
SYLEMNIVSVHHGKQHRDIIEQADVIAIGGGNTFCLLKQLYEHNLIDIIREKVNNSTPYF
HHHHHHEEEECCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCC
GWSAGANVVGASIMTTNDMPITYPPSFQALQLFPHQINPHFISGKMQGHNGESREERLAE
EECCCCCCEEEEEEEECCCCEECCCCCHHHEECCCCCCCEEEECEECCCCCCHHHHHHHH
FLLVNPTALVYALPEGSALHIQNEMATVLGENPILCFSENMECGTFDINTTFSY
HHEECCCEEEEECCCCCEEEEHHHHHHHHCCCCEEEEECCCCCCEEEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA