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The map label for this gene is gabT

Identifier: 148823784

GI number: 148823784

Start: 2929677

End: 2931026

Strand: Direct

Name: gabT

Synonym: TBFG_12609

Alternate gene names: 148823784

Gene position: 2929677-2931026 (Clockwise)

Preceding gene: 148823776

Following gene: 148823785

Centisome position: 66.22

GC content: 66.96

Gene sequence:

>1350_bases
GTGGCCAGCCTGCAGCAGAGTCGGCGCCTGGTCACCGAAATCCCCGGTCCCGCATCGCAGGCACTGACTCACCGCCGGGC
GGCGGCGGTGTCCAGCGGTGTTGGGGTCACCCTGCCGGTGTTCGTAGCCCGCGCCGGCGGCGGCATCGTGGAAGACGTGG
ACGGTAACCGGCTCATCGACCTGGGTTCGGGCATCGCAGTGACGACGATCGGCAACTCGTCGCCACGCGTGGTGGATGCG
GTGCGCACGCAGGTGGCCGAATTTACCCACACCTGCTTCATGGTGACGCCATACGAGGGGTACGTGGCCGTCGCCGAGCA
ACTCAACCGGATTACCCCAGGTTCGGGCCCCAAGCGCTCGGTGTTGTTCAATTCCGGCGCCGAGGCAGTCGAGAACGCCG
TCAAGATCGCACGCTCCTACACCGGCAAGCCCGCGGTGGTGGCGTTCGACCACGCCTACCACGGTCGCACCAACCTAACG
ATGGCGCTGACCGCCAAGTCGATGCCCTACAAGAGCGGCTTCGGTCCGTTCGCGCCGGAGATCTACCGAGCGCCATTGTC
TTACCCCTATCGGGACGGCCTCCTCGATAAGCAACTGGCTACCAATGGTGAGCTAGCCGCGGCCCGAGCCATCGGCGTCA
TCGACAAGCAGGTAGGCGCGAACAACCTGGCCGCCCTCGTCATCGAACCGATCCAGGGCGAAGGCGGTTTCATCGTTCCG
GCCGAAGGGTTCCTACCTGCCCTCCTCGATTGGTGCCGCAAGAACCATGTGGTGTTCATCGCCGACGAGGTGCAAACCGG
CTTTGCCCGTACCGGGGCGATGTTCGCCTGCGAGCACGAGGGCCCCGACGGTCTAGAGCCCGACCTGATCTGCACGGCCA
AAGGCATCGCCGATGGATTGCCGCTGTCGGCGGTCACCGGCCGCGCCGAGATCATGAACGCCCCGCACGTGGGCGGCCTG
GGCGGCACGTTCGGCGGCAACCCGGTGGCCTGTGCGGCCGCGCTGGCCACCATCGCAACCATCGAAAGCGACGGGCTGAT
CGAGCGGGCCCGCCAGATCGAACGCCTGGTGACCGACCGGTTGACGACGCTGCAGGCCGTCGACGACCGGATCGGCGACG
TGCGTGGTCGCGGCGCCATGATCGCCGTAGAGCTGGTCAAATCCGGAACCACCGAGCCCGACGCCGGGCTGACCGAGCGG
CTGGCGACCGCGGCCCACGCCGCCGGCGTCATCATTTTGACCTGCGGCATGTTCGGCAACATCATCCGGCTACTGCCGCC
GCTGACCATCGGCGACGAGCTGCTGAGTGAGGGGCTGGACATCGTGTGCGCGATCTTGGCCGACCTCTGA

Upstream 100 bases:

>100_bases
AACAGTCCAGTGTGCCCGTCCAGTCTGGCAGGCCGGAAACATCGGTCAGCAGATAGGCTTTACCAGCGATGTGAACCGGC
GAGCCGGGTGAGGAGGATCT

Downstream 100 bases:

>100_bases
CGGCCTGCCGGCCCCGACTGCGTCATCCCGTGCCGCATCTCACAGCCGATCAGCAGCAGGCTTGCATTGTGTAATATATT
TACTTTAGCTAACGTTCTAT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MASLQQSRRLVTEIPGPASQALTHRRAAAVSSGVGVTLPVFVARAGGGIVEDVDGNRLIDLGSGIAVTTIGNSSPRVVDA
VRTQVAEFTHTCFMVTPYEGYVAVAEQLNRITPGSGPKRSVLFNSGAEAVENAVKIARSYTGKPAVVAFDHAYHGRTNLT
MALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLDKQLATNGELAAARAIGVIDKQVGANNLAALVIEPIQGEGGFIVP
AEGFLPALLDWCRKNHVVFIADEVQTGFARTGAMFACEHEGPDGLEPDLICTAKGIADGLPLSAVTGRAEIMNAPHVGGL
GGTFGGNPVACAAALATIATIESDGLIERARQIERLVTDRLTTLQAVDDRIGDVRGRGAMIAVELVKSGTTEPDAGLTER
LATAAHAAGVIILTCGMFGNIIRLLPPLTIGDELLSEGLDIVCAILADL

Sequences:

>Translated_449_residues
MASLQQSRRLVTEIPGPASQALTHRRAAAVSSGVGVTLPVFVARAGGGIVEDVDGNRLIDLGSGIAVTTIGNSSPRVVDA
VRTQVAEFTHTCFMVTPYEGYVAVAEQLNRITPGSGPKRSVLFNSGAEAVENAVKIARSYTGKPAVVAFDHAYHGRTNLT
MALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLDKQLATNGELAAARAIGVIDKQVGANNLAALVIEPIQGEGGFIVP
AEGFLPALLDWCRKNHVVFIADEVQTGFARTGAMFACEHEGPDGLEPDLICTAKGIADGLPLSAVTGRAEIMNAPHVGGL
GGTFGGNPVACAAALATIATIESDGLIERARQIERLVTDRLTTLQAVDDRIGDVRGRGAMIAVELVKSGTTEPDAGLTER
LATAAHAAGVIILTCGMFGNIIRLLPPLTIGDELLSEGLDIVCAILADL
>Mature_448_residues
ASLQQSRRLVTEIPGPASQALTHRRAAAVSSGVGVTLPVFVARAGGGIVEDVDGNRLIDLGSGIAVTTIGNSSPRVVDAV
RTQVAEFTHTCFMVTPYEGYVAVAEQLNRITPGSGPKRSVLFNSGAEAVENAVKIARSYTGKPAVVAFDHAYHGRTNLTM
ALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLDKQLATNGELAAARAIGVIDKQVGANNLAALVIEPIQGEGGFIVPA
EGFLPALLDWCRKNHVVFIADEVQTGFARTGAMFACEHEGPDGLEPDLICTAKGIADGLPLSAVTGRAEIMNAPHVGGLG
GTFGGNPVACAAALATIATIESDGLIERARQIERLVTDRLTTLQAVDDRIGDVRGRGAMIAVELVKSGTTEPDAGLTERL
ATAAHAAGVIILTCGMFGNIIRLLPPLTIGDELLSEGLDIVCAILADL

Specific function: Unknown

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI4557809, Length=419, Percent_Identity=30.0715990453461, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI37574042, Length=422, Percent_Identity=28.436018957346, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI13994255, Length=416, Percent_Identity=29.3269230769231, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI24119277, Length=427, Percent_Identity=29.7423887587822, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=28.1990521327014, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI226442709, Length=391, Percent_Identity=28.9002557544757, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI284507298, Length=329, Percent_Identity=31.6109422492401, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI188536080, Length=473, Percent_Identity=27.061310782241, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI38679950, Length=473, Percent_Identity=27.061310782241, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI38679946, Length=473, Percent_Identity=27.061310782241, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1787560, Length=431, Percent_Identity=43.3874709976798, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1789016, Length=426, Percent_Identity=42.018779342723, Blast_Score=332, Evalue=2e-92,
Organism=Escherichia coli, GI1789759, Length=418, Percent_Identity=31.8181818181818, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1788044, Length=415, Percent_Identity=31.8072289156626, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI145693181, Length=390, Percent_Identity=33.3333333333333, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=30.6791569086651, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786349, Length=328, Percent_Identity=29.5731707317073, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=460, Percent_Identity=31.0869565217391, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25144271, Length=465, Percent_Identity=28.3870967741935, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI32564660, Length=414, Percent_Identity=31.1594202898551, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25144274, Length=308, Percent_Identity=30.5194805194805, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=482, Percent_Identity=26.9709543568465, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324432, Length=403, Percent_Identity=31.2655086848635, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6323470, Length=423, Percent_Identity=30.2600472813239, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6324386, Length=445, Percent_Identity=24.4943820224719, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357415, Length=422, Percent_Identity=29.1469194312796, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21356575, Length=414, Percent_Identity=32.1256038647343, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI28574759, Length=401, Percent_Identity=33.4164588528678, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI161085790, Length=413, Percent_Identity=32.6876513317191, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI281366494, Length=412, Percent_Identity=25.2427184466019, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667139, Length=412, Percent_Identity=25.2427184466019, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667143, Length=412, Percent_Identity=25.2427184466019, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GABT_MYCBO (P63505)

Other databases:

- EMBL:   BX248343
- RefSeq:   NP_856266.1
- ProteinModelPortal:   P63505
- SMR:   P63505
- EnsemblBacteria:   EBMYCT00000018036
- GeneID:   1092014
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2620
- GeneTree:   EBGT00050000015339
- HOGENOM:   HBG725944
- OMA:   AEIWDKE
- ProtClustDB:   PRK06058
- BioCyc:   MBOV233413:MB2620-MONOMER
- BRENDA:   2.6.1.19
- BRENDA:   2.6.1.22
- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00700

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.19; =2.6.1.22

Molecular weight: Translated: 46813; Mature: 46682

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLQQSRRLVTEIPGPASQALTHRRAAAVSSGVGVTLPVFVARAGGGIVEDVDGNRLID
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEECCCCEEEE
LGSGIAVTTIGNSSPRVVDAVRTQVAEFTHTCFMVTPYEGYVAVAEQLNRITPGSGPKRS
ECCCEEEEEECCCCCHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHCCCCCCCCCE
VLFNSGAEAVENAVKIARSYTGKPAVVAFDHAYHGRTNLTMALTAKSMPYKSGFGPFAPE
EEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCHH
IYRAPLSYPYRDGLLDKQLATNGELAAARAIGVIDKQVGANNLAALVIEPIQGEGGFIVP
HHHCCCCCCHHCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEE
AEGFLPALLDWCRKNHVVFIADEVQTGFARTGAMFACEHEGPDGLEPDLICTAKGIADGL
CCCCHHHHHHHHCCCCEEEEECCCCCCHHHCCCEEEECCCCCCCCCCCEEEEECCCCCCC
PLSAVTGRAEIMNAPHVGGLGGTFGGNPVACAAALATIATIESDGLIERARQIERLVTDR
CCHHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LTTLQAVDDRIGDVRGRGAMIAVELVKSGTTEPDAGLTERLATAAHAAGVIILTCGMFGN
HHHHHHHHHHHHCCCCCCCEEEEEEHHCCCCCCCCCHHHHHHHHHHHCCEEEEECHHHHH
IIRLLPPLTIGDELLSEGLDIVCAILADL
HHHHCCCCCCCHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
ASLQQSRRLVTEIPGPASQALTHRRAAAVSSGVGVTLPVFVARAGGGIVEDVDGNRLID
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEECCCCEEEE
LGSGIAVTTIGNSSPRVVDAVRTQVAEFTHTCFMVTPYEGYVAVAEQLNRITPGSGPKRS
ECCCEEEEEECCCCCHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHCCCCCCCCCE
VLFNSGAEAVENAVKIARSYTGKPAVVAFDHAYHGRTNLTMALTAKSMPYKSGFGPFAPE
EEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCHH
IYRAPLSYPYRDGLLDKQLATNGELAAARAIGVIDKQVGANNLAALVIEPIQGEGGFIVP
HHHCCCCCCHHCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEE
AEGFLPALLDWCRKNHVVFIADEVQTGFARTGAMFACEHEGPDGLEPDLICTAKGIADGL
CCCCHHHHHHHHCCCCEEEEECCCCCCHHHCCCEEEECCCCCCCCCCCEEEEECCCCCCC
PLSAVTGRAEIMNAPHVGGLGGTFGGNPVACAAALATIATIESDGLIERARQIERLVTDR
CCHHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LTTLQAVDDRIGDVRGRGAMIAVELVKSGTTEPDAGLTERLATAAHAAGVIILTCGMFGN
HHHHHHHHHHHHCCCCCCCEEEEEEHHCCCCCCCCCHHHHHHHHHHHCCEEEEECHHHHH
IIRLLPPLTIGDELLSEGLDIVCAILADL
HHHHCCCCCCCHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972