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The map label for this gene is ppiB

Identifier: 148823776

GI number: 148823776

Start: 2920131

End: 2921057

Strand: Direct

Name: ppiB

Synonym: TBFG_12602

Alternate gene names: 148823776

Gene position: 2920131-2921057 (Clockwise)

Preceding gene: 148823774

Following gene: 148823784

Centisome position: 66.0

GC content: 63.97

Gene sequence:

>927_bases
ATGGGCCACTTGACACCGGTCGCGGCGCCCCGATTAGCCTGTGCTTTCGTGCCGACCAATGCTCAGCGACGTGCCACAGC
CAAACGCAAACTCGAACGACAACTAGAGCGCCGCGCCAAGCAAGCCAAACGCCGTCGCATCTTGACTATCGTCGGTGGCT
CACTCGCAGCGGTGGCCGTGATCGTCGCGGTAGTCGTCACGGTGGTGGTCAACAAGGACGACCACCAGAGCACCACGTCA
GCAACCCCCACCGACTCGGCCTCGACCAGCCCCCCGCAGGCCGCGACCGCTCCCCCGCTGCCGCCGTTCAAGCCGTCGGC
CAACCTCGGCGCCAACTGCCAGTACCCGCCGTCGCCGGACAAGGCCGTCAAACCGGTCAAGTTGCCCCGGACCGGCAAGG
TACCCACCGACCCGGCCCAGGTCAGCGTGAGCATGGTGACCAACCAGGGCAACATCGGTCTAATGCTGGCCAACAACGAA
TCGCCGTGTACGGTCAATAGTTTCGTCAGCCTCGCGCAGCAGGGTTTCTTCAAGGGCACCACTTGTCACCGGCTGACCAC
CTCACCAATGTTGGCGGTTCTGCAATGCGGCGACCCTAAGGGCGACGGCACGGGCGGTCCGGGCTACCAGTTCGCCAACG
AATACCCCACCGACCAATACTCGGCGAACGACCCCAAGTTGAACGAGCCCGTCATCTATCCGCGCGGGACACTGGCCATG
GCCAACGCCGGCCCTAATACCAACAGCAGCCAGTTCTTCATGGTCTACCGGGACTCAAAGCTGCCACCCCAATACACCGT
GTTCGGCACGATCCAAGCCGACGGACTGACCACCCTGGACAAGATCGCCAAGGCCGGCGTCGCCGGTGGCGGCGAAGACG
GCAAGCCCGCCACCGAAGTCACCATCACGTCGGTGCTGCTGGATTAG

Upstream 100 bases:

>100_bases
ACATAACAGTTACACGCCAGCAACCCCGCAGGAAATCCGGTGATCAACACGGTTCCCAGTTTCCCATCCCCGGCGTCCGG
GGACGAGGCGGGCCGCGAAC

Downstream 100 bases:

>100_bases
CCCGACGCTCGCCGAGCAGACACAGAATCGCACGAAATCAGCCCGCCCAATGCGATTCTGCGTCTGCTCGGCGGAGAAAA
GCGCGCTACGCGGCCGAGGT

Product: peptidyl-prolyl-cis-trans-isomerase B ppiB

Products: NA

Alternate protein names: PPIase B; Rotamase B

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MGHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRRRILTIVGGSLAAVAVIVAVVVTVVVNKDDHQSTTS
ATPTDSASTSPPQAATAPPLPPFKPSANLGANCQYPPSPDKAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNE
SPCTVNSFVSLAQQGFFKGTTCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSANDPKLNEPVIYPRGTLAM
ANAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDKIAKAGVAGGGEDGKPATEVTITSVLLD

Sequences:

>Translated_308_residues
MGHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRRRILTIVGGSLAAVAVIVAVVVTVVVNKDDHQSTTS
ATPTDSASTSPPQAATAPPLPPFKPSANLGANCQYPPSPDKAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNE
SPCTVNSFVSLAQQGFFKGTTCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSANDPKLNEPVIYPRGTLAM
ANAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDKIAKAGVAGGGEDGKPATEVTITSVLLD
>Mature_307_residues
GHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRRRILTIVGGSLAAVAVIVAVVVTVVVNKDDHQSTTSA
TPTDSASTSPPQAATAPPLPPFKPSANLGANCQYPPSPDKAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNES
PCTVNSFVSLAQQGFFKGTTCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSANDPKLNEPVIYPRGTLAMA
NAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDKIAKAGVAGGGEDGKPATEVTITSVLLD

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain

Homologues:

Organism=Homo sapiens, GI19557636, Length=148, Percent_Identity=36.4864864864865, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI7706339, Length=156, Percent_Identity=33.974358974359, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI24308049, Length=174, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI64276486, Length=154, Percent_Identity=29.2207792207792, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI22547212, Length=169, Percent_Identity=28.9940828402367, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI7657473, Length=169, Percent_Identity=28.9940828402367, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI22547215, Length=169, Percent_Identity=28.9940828402367, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71997782, Length=172, Percent_Identity=31.9767441860465, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=146, Percent_Identity=35.6164383561644, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=164, Percent_Identity=34.1463414634146, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=166, Percent_Identity=33.7349397590361, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=31.5068493150685, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=31.5068493150685, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=165, Percent_Identity=35.1515151515151, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922376, Length=166, Percent_Identity=33.7349397590361, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21357249, Length=174, Percent_Identity=31.6091954022989, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17986117, Length=157, Percent_Identity=30.5732484076433, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): PPIB_MYCTU (Q50639)

Other databases:

- EMBL:   BX842580
- EMBL:   AE000516
- PIR:   E70725
- RefSeq:   NP_217098.1
- RefSeq:   NP_337158.1
- ProteinModelPortal:   Q50639
- SMR:   Q50639
- EnsemblBacteria:   EBMYCT00000002656
- EnsemblBacteria:   EBMYCT00000069345
- GeneID:   887691
- GeneID:   925654
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2659
- KEGG:   mtu:Rv2582
- TIGR:   MT2659
- TubercuList:   Rv2582
- GeneTree:   EBGT00050000015125
- HOGENOM:   HBG610621
- OMA:   GSQFFMV
- ProtClustDB:   CLSK791938
- BRENDA:   5.2.1.8
- GO:   GO:0040007
- InterPro:   IPR015891
- InterPro:   IPR002130
- Gene3D:   G3DSA:2.40.100.10
- PRINTS:   PR00153

Pfam domain/function: PF00160 Pro_isomerase; SSF50891 CSA_PPIase

EC number: =5.2.1.8

Molecular weight: Translated: 32371; Mature: 32240

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00170 CSA_PPIASE_1; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRRRILTIVGGSLAAVAV
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHH
IVAVVVTVVVNKDDHQSTTSATPTDSASTSPPQAATAPPLPPFKPSANLGANCQYPPSPD
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNESPCTVNSFVSLAQQGFFKGT
CCCCCEECCCCCCCCCCHHHEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCC
TCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSANDPKLNEPVIYPRGTLAM
CEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEE
ANAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDKIAKAGVAGGGEDGKPATEV
ECCCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHE
TITSVLLD
EEEEEECC
>Mature Secondary Structure 
GHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRRRILTIVGGSLAAVAV
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHH
IVAVVVTVVVNKDDHQSTTSATPTDSASTSPPQAATAPPLPPFKPSANLGANCQYPPSPD
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNESPCTVNSFVSLAQQGFFKGT
CCCCCEECCCCCCCCCCHHHEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCC
TCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSANDPKLNEPVIYPRGTLAM
CEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEE
ANAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDKIAKAGVAGGGEDGKPATEV
ECCCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHE
TITSVLLD
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036