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The map label for this gene is 148823288

Identifier: 148823288

GI number: 148823288

Start: 2344826

End: 2345575

Strand: Reverse

Name: 148823288

Synonym: TBFG_12109

Alternate gene names: NA

Gene position: 2345575-2344826 (Counterclockwise)

Preceding gene: 148823290

Following gene: 148823287

Centisome position: 53.01

GC content: 70.93

Gene sequence:

>750_bases
GTGGACGACACGGGCGCTGCTCCGGTAGTAATTTTCGGCGGCCGCAGCCAGATCGGCGGCGAACTCGCGCGACGCCTGGC
TGCCGGGGCGACGATGGTGCTGGCCGCGCGGAACGCCGATCAACTCGCCGACCAGGCCGCCGCACTCCGCGCAGCTGGCG
CTATAGCGGTGCACACCCGGGAGTTCGACGCCGACGACCTGGCCGCACACGGCCCGTTGGTCGCTTCGCTCGTTGCCGAG
CACGGCCCCATCGGCACCGCGGTGCTGGCCTTCGGGATACTCGGCGACCAGGCCCGCGCCGAGACAGACGCGGCGCACGC
GGTGGCCATCGTGCACACCGACTACGTCGCCCAGGTCAGCCTGCTGACTCATCTGGCAGCGGCGATGCGCACCGCCGGAC
GGGGATCGCTGGTGGTGTTCTCCTCGGTCGCCGGGATTCGGGTGCGCCGCGCCAACTATGTCTACGGATCGGCCAAAGCC
GGCCTGGACGGCTTCGCCAGCGGCCTGGCCGATGCGTTGCACGGCACCGGGGTGCGGTTACTGATCGCGCGGCCGGGATT
CGTCATCGGGCGCATGACCGAGGGCATGACGCCCGCACCCCTGTCGGTCACCCCGGAGCGGGTGGCCGCCGCGACCGCGC
GTGCGCTGGTCAACGGTAAGCGCGTGGTGTGGATTCCGTGGGCGCTGCGGCCAATGTTTGTTGCGCTGCGGTTGCTTCCC
CGGTTCGTCTGGCGCAGGATGCCGCGATGA

Upstream 100 bases:

>100_bases
GCCAGATGGCGTTCGGAAAGAAACGCCAGCGCGTCGTCACTAAGCCGCGTAGTGGTGTTGACCATCGCCACTCACGCTAG
CGCAGGCAATAATCGCAGCC

Downstream 100 bases:

>100_bases
TCCGCGACGATGCAGAGCGCAGCGATGCGGTGGGGGTACCGCCCGCTTGCGGGGGAGAGCGGCGCCGATGATCATCGTTG
TCGGGATCGGCGCCGACGGC

Product: short-chain type dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MDDTGAAPVVIFGGRSQIGGELARRLAAGATMVLAARNADQLADQAAALRAAGAIAVHTREFDADDLAAHGPLVASLVAE
HGPIGTAVLAFGILGDQARAETDAAHAVAIVHTDYVAQVSLLTHLAAAMRTAGRGSLVVFSSVAGIRVRRANYVYGSAKA
GLDGFASGLADALHGTGVRLLIARPGFVIGRMTEGMTPAPLSVTPERVAAATARALVNGKRVVWIPWALRPMFVALRLLP
RFVWRRMPR

Sequences:

>Translated_249_residues
MDDTGAAPVVIFGGRSQIGGELARRLAAGATMVLAARNADQLADQAAALRAAGAIAVHTREFDADDLAAHGPLVASLVAE
HGPIGTAVLAFGILGDQARAETDAAHAVAIVHTDYVAQVSLLTHLAAAMRTAGRGSLVVFSSVAGIRVRRANYVYGSAKA
GLDGFASGLADALHGTGVRLLIARPGFVIGRMTEGMTPAPLSVTPERVAAATARALVNGKRVVWIPWALRPMFVALRLLP
RFVWRRMPR
>Mature_249_residues
MDDTGAAPVVIFGGRSQIGGELARRLAAGATMVLAARNADQLADQAAALRAAGAIAVHTREFDADDLAAHGPLVASLVAE
HGPIGTAVLAFGILGDQARAETDAAHAVAIVHTDYVAQVSLLTHLAAAMRTAGRGSLVVFSSVAGIRVRRANYVYGSAKA
GLDGFASGLADALHGTGVRLLIARPGFVIGRMTEGMTPAPLSVTPERVAAATARALVNGKRVVWIPWALRPMFVALRLLP
RFVWRRMPR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2073_MYCTU (Q10681)

Other databases:

- EMBL:   BX842578
- EMBL:   AE000516
- PIR:   D70765
- RefSeq:   NP_216589.1
- RefSeq:   NP_336599.1
- ProteinModelPortal:   Q10681
- SMR:   Q10681
- EnsemblBacteria:   EBMYCT00000002049
- EnsemblBacteria:   EBMYCT00000070401
- GeneID:   887267
- GeneID:   926388
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2133
- KEGG:   mtu:Rv2073c
- TIGR:   MT2133
- TubercuList:   Rv2073c
- GeneTree:   EBGT00050000015167
- HOGENOM:   HBG750976
- OMA:   VVHTDYV
- ProtClustDB:   CLSK872000
- GO:   GO:0005488
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR19410
- PRINTS:   PR00081

Pfam domain/function: PF00106 adh_short

EC number: NA

Molecular weight: Translated: 25922; Mature: 25922

Theoretical pI: Translated: 11.55; Mature: 11.55

Prosite motif: PS00061 ADH_SHORT

Important sites: ACT_SITE 155-155 BINDING 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDTGAAPVVIFGGRSQIGGELARRLAAGATMVLAARNADQLADQAAALRAAGAIAVHTR
CCCCCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEEC
EFDADDLAAHGPLVASLVAEHGPIGTAVLAFGILGDQARAETDAAHAVAIVHTDYVAQVS
CCCCHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCHHHEEEEEEHHHHHHHH
LLTHLAAAMRTAGRGSLVVFSSVAGIRVRRANYVYGSAKAGLDGFASGLADALHGTGVRL
HHHHHHHHHHHCCCCCEEEEECCCCEEEEECEEEECCCCCCHHHHHHHHHHHHCCCCEEE
LIARPGFVIGRMTEGMTPAPLSVTPERVAAATARALVNGKRVVWIPWALRPMFVALRLLP
EEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHH
RFVWRRMPR
HHHHHHCCC
>Mature Secondary Structure
MDDTGAAPVVIFGGRSQIGGELARRLAAGATMVLAARNADQLADQAAALRAAGAIAVHTR
CCCCCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEEC
EFDADDLAAHGPLVASLVAEHGPIGTAVLAFGILGDQARAETDAAHAVAIVHTDYVAQVS
CCCCHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCHHHEEEEEEHHHHHHHH
LLTHLAAAMRTAGRGSLVVFSSVAGIRVRRANYVYGSAKAGLDGFASGLADALHGTGVRL
HHHHHHHHHHHCCCCCEEEEECCCCEEEEECEEEECCCCCCHHHHHHHHHHHHCCCCEEE
LIARPGFVIGRMTEGMTPAPLSVTPERVAAATARALVNGKRVVWIPWALRPMFVALRLLP
EEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHH
RFVWRRMPR
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036