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The map label for this gene is htpX

Identifier: 148660332

GI number: 148660332

Start: 655189

End: 656049

Strand: Direct

Name: htpX

Synonym: MRA_0570

Alternate gene names: 148660332

Gene position: 655189-656049 (Clockwise)

Preceding gene: 148660331

Following gene: 148660336

Centisome position: 14.82

GC content: 66.2

Gene sequence:

>861_bases
ATGACTTGGCATCCGCATGCCAACCGGCTGAAGACGTTCCTGCTGTTGGTCGGTATGTCCGCGTTGATCGTGGCCGTCGG
CGCGTTGTTTGGCAGGACGGCGCTGATGCTGGCGGCGCTGTTCGCCGTCGGAATGAACGTCTACGTCTACTTCAATAGCG
ACAAGCTGGCGCTGCGGGCGATGCATGCGCAACCGGTTTCCGAACTGCAGGCGCCGGCGATGTACCGGATCGTTCGAGAG
CTGGCGACCAGCGCTCACCAGCCGATGCCCCGGCTGTACATCAGCGACACCGCCGCACCCAACGCGTTCGCCACCGGCCG
CAACCCGCGCAATGCCGCGGTGTGTTGCACGACTGGCATCCTGCGTATCCTCAATGAGCGTGAGCTGCGTGCCGTGCTGG
GCCACGAGCTGTCTCACGTCTACAACCGCGACATCCTGATCTCTTGTGTGGCAGGTGCGCTGGCAGCGGTGATTACCGCG
CTGGCCAACATGGCCATGTGGGCCGGCATGTTCGGCGGCAACCGAGACAACGCCAATCCCTTTGCACTGCTTCTGGTTGC
GCTGCTGGGCCCGATCGCGGCAACCGTGATACGGATGGCCGTGTCGCGATCGCGGGAGTACCAGGCCGACGAGTCGGGTG
CCGTCCTGACCGGGGACCCGCTGGCGTTGGCGTCGGCATTGCGCAAGATCTCCGGCGGCGTCCAGGCGGCGCCGCTGCCG
CCGGAGCCGCAGCTGGCCAGCCAGGCGCACCTGATGATCGCCAACCCGTTCCGGGCGGGTGAGCGGATCGGATCGCTGTT
TTCGACTCACCCACCGATCGAGGACCGCATTCGCCGGCTGGAGGCGATGGCGCGCGGCTGA

Upstream 100 bases:

>100_bases
GTTGCCCGGCCAGGCTCGATTGCGGAACCAGCGGATACCCCTCAGGCGTTGAACCAGCAGTAATCTCCCAAGTTGAGGTG
TTCTAGGAGGACACGCACTG

Downstream 100 bases:

>100_bases
TAACTGTGGGTATCGAGATGCCATCGGTGATGAGTCAGGCGCCGCTATCGAGGAGGCGGTCGATCAGTTCGTGGCTGGCA
TGCCGGCGTGCGGCGAGGAC

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTWHPHANRLKTFLLLVGMSALIVAVGALFGRTALMLAALFAVGMNVYVYFNSDKLALRAMHAQPVSELQAPAMYRIVRE
LATSAHQPMPRLYISDTAAPNAFATGRNPRNAAVCCTTGILRILNERELRAVLGHELSHVYNRDILISCVAGALAAVITA
LANMAMWAGMFGGNRDNANPFALLLVALLGPIAATVIRMAVSRSREYQADESGAVLTGDPLALASALRKISGGVQAAPLP
PEPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDRIRRLEAMARG

Sequences:

>Translated_286_residues
MTWHPHANRLKTFLLLVGMSALIVAVGALFGRTALMLAALFAVGMNVYVYFNSDKLALRAMHAQPVSELQAPAMYRIVRE
LATSAHQPMPRLYISDTAAPNAFATGRNPRNAAVCCTTGILRILNERELRAVLGHELSHVYNRDILISCVAGALAAVITA
LANMAMWAGMFGGNRDNANPFALLLVALLGPIAATVIRMAVSRSREYQADESGAVLTGDPLALASALRKISGGVQAAPLP
PEPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDRIRRLEAMARG
>Mature_285_residues
TWHPHANRLKTFLLLVGMSALIVAVGALFGRTALMLAALFAVGMNVYVYFNSDKLALRAMHAQPVSELQAPAMYRIVREL
ATSAHQPMPRLYISDTAAPNAFATGRNPRNAAVCCTTGILRILNERELRAVLGHELSHVYNRDILISCVAGALAAVITAL
ANMAMWAGMFGGNRDNANPFALLLVALLGPIAATVIRMAVSRSREYQADESGAVLTGDPLALASALRKISGGVQAAPLPP
EPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDRIRRLEAMARG

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=263, Percent_Identity=31.9391634980989, Blast_Score=101, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_MYCBO (P65816)

Other databases:

- EMBL:   BX248335
- RefSeq:   NP_854238.1
- ProteinModelPortal:   P65816
- EnsemblBacteria:   EBMYCT00000015627
- GeneID:   1091660
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0578
- GeneTree:   EBGT00050000016372
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- ProtClustDB:   PRK03072
- BioCyc:   MBOV233413:MB0578-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 30682; Mature: 30551

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 136-136

Signals:

None

Transmembrane regions:

HASH(0x1b443050)-; HASH(0x1c94ee88)-; HASH(0x1c94231c)-; HASH(0x1ca5b82c)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWHPHANRLKTFLLLVGMSALIVAVGALFGRTALMLAALFAVGMNVYVYFNSDKLALRA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHH
MHAQPVSELQAPAMYRIVRELATSAHQPMPRLYISDTAAPNAFATGRNPRNAAVCCTTGI
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHH
LRILNERELRAVLGHELSHVYNRDILISCVAGALAAVITALANMAMWAGMFGGNRDNANP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
FALLLVALLGPIAATVIRMAVSRSREYQADESGAVLTGDPLALASALRKISGGVQAAPLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCC
PEPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDRIRRLEAMARG
CCCCHHCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCH
>Mature Secondary Structure 
TWHPHANRLKTFLLLVGMSALIVAVGALFGRTALMLAALFAVGMNVYVYFNSDKLALRA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHH
MHAQPVSELQAPAMYRIVRELATSAHQPMPRLYISDTAAPNAFATGRNPRNAAVCCTTGI
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHH
LRILNERELRAVLGHELSHVYNRDILISCVAGALAAVITALANMAMWAGMFGGNRDNANP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
FALLLVALLGPIAATVIRMAVSRSREYQADESGAVLTGDPLALASALRKISGGVQAAPLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCC
PEPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDRIRRLEAMARG
CCCCHHCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972