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The map label for this gene is fgd2 [H]

Identifier: 148659896

GI number: 148659896

Start: 161059

End: 162141

Strand: Reverse

Name: fgd2 [H]

Synonym: MRA_0139

Alternate gene names: 148659896

Gene position: 162141-161059 (Counterclockwise)

Preceding gene: 148659899

Following gene: 148659895

Centisome position: 3.67

GC content: 67.87

Gene sequence:

>1083_bases
ATGACCGGCATCTCACGGCGGACGTTCGGTCTGGCCGCCGGGTTCGGCGCGATCGGCGCCGGTGGGCTAGGCGGCGGTTG
CAGCACGCGCAGCGGTCCGACGCCGACCCCAGAGCCGGCAAGCCGCGGGGTGGGTGTCGTCTTATCCCACGAACAATTCC
GCACCGATCGGCTGGTGGCGCACGCCCAAGCCGCCGAGCAAGCTGGCTTCCGGTATGTGTGGGCCAGCGACCACCTACAG
CCATGGCAAGACAACGAGGGCCATTCGATGTTTCCCTGGCTGACCCTGGCGTTGGTGGGCAACAGCACCAGCAGCATCTT
GTTCGGCACCGGGGTGACCTGTCCCATATACCGCTACCATCCGGCCACCGTCGCTCAGGCGTTTGCCTCGCTGGCGATCC
TGAACCCCGGACGGGTGTTTCTGGGGCTGGGCACCGGCGAGCGGCTCAACGAACAAGCCGCCACCGACACGTTCGGCAAC
TACCGCGAGCGCCACGACCGGCTGATCGAGGCCATCGTACTGATCCGCCAGCTGTGGAGCGGTGAGCGGATCTCGTTCAC
GGGCCACTATTTTCGGACCGACGAGCTCAAGCTCTACGACACGCCGGCGATGCCGCCGCCGATCTTTGTCGCCGCGAGCG
GCCCCCAGAGCGCCACCCTGGCCGGCCGATACGGTGATGGTTGGATCGCCCAAGCCCGCGACATCAACGACGCCAAGCTG
CTCGCCGCGTTCGCCGCGGGCGCTCAAGCGGCCGGACGAGATCCCACCACCCTGGGTAAGCGGGCCGAACTGTTCGCCGT
CGTCGGCGACGACAAGGCGGCCGCCCGCGCCGCCGACTTGTGGCGATTCACCGCCGGGGCCGTCGACCAGCCCAATCCGG
TCGAGATCCAGCGTGCCGCCGAGTCGAACCCGATCGAGAAAGTGCTGGCCAATTGGGCGGTCGGTACCGATCCCGGCGTC
CACATCGGTGCGGTGCAAGCGGTTCTCGACGCCGGCGCCGTCCCCTTCCTGCATTTCCCCCAGGACGACCCGATCACCGC
CATCGACTTCTACCGCACCAACGTCCTGCCCGAACTGCGCTGA

Upstream 100 bases:

>100_bases
GCCTGCGGGGTCATCTCGCCAGGCTAACCGGTGGCGCCGACGGTGAGTCAGGATGCACTCTCGAAGGTGTGCTGCAGCGC
GACGCGGGTAGTGCAGCCCG

Downstream 100 bases:

>100_bases
AGCCGCTAGACCGCACCTACGATGGTCTTGCTCTATCAACGATGCCGGTGCGACGCCGCGCCGGGGAACGGTTGCCGACG
GTGTGGGACTTCGAAACCGA

Product: putative f420-dependent glucose-6-phosphate dehydrogenase Fgd2

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQ
PWQDNEGHSMFPWLTLALVGNSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGN
YRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQARDINDAKL
LAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAARAADLWRFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGV
HIGAVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLPELR

Sequences:

>Translated_360_residues
MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQ
PWQDNEGHSMFPWLTLALVGNSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGN
YRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQARDINDAKL
LAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAARAADLWRFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGV
HIGAVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLPELR
>Mature_359_residues
TGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQP
WQDNEGHSMFPWLTLALVGNSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGNY
RERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQARDINDAKLL
AAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAARAADLWRFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGVH
IGAVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLPELR

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 38446; Mature: 38314

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSHEQFRTDRLVA
CCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEECHHHHHHHHHH
HAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVGNSTSSILFGTGVTCPIYRYH
HHHHHHHCCEEEEEECCCCCCCCCCCCCEEHHEEEEEEECCCCCCEEEECCCCCEEEEEC
PATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGNYRERHDRLIEAIVLIRQLWS
HHHHHHHHHHHEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQARDINDAKL
CCEEEEEECEEECCCEEEEECCCCCCCEEEEECCCCCCEEEECCCCCCEEECCCCCHHHH
LAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAARAADLWRFTAGAVDQPNPVEIQRAA
HHHHHHCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCEECCC
ESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLPELR
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEEHHHCCCCCCC
>Mature Secondary Structure 
TGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSHEQFRTDRLVA
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEECHHHHHHHHHH
HAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVGNSTSSILFGTGVTCPIYRYH
HHHHHHHCCEEEEEECCCCCCCCCCCCCEEHHEEEEEEECCCCCCEEEECCCCCEEEEEC
PATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGNYRERHDRLIEAIVLIRQLWS
HHHHHHHHHHHEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQARDINDAKL
CCEEEEEECEEECCCEEEEECCCCCCCEEEEECCCCCCEEEECCCCCCEEECCCCCHHHH
LAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAARAADLWRFTAGAVDQPNPVEIQRAA
HHHHHHCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCEECCC
ESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLPELR
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEEHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]