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The map label for this gene is fadE1 [H]

Identifier: 148659895

GI number: 148659895

Start: 159674

End: 161017

Strand: Reverse

Name: fadE1 [H]

Synonym: MRA_0138

Alternate gene names: 148659895

Gene position: 161017-159674 (Counterclockwise)

Preceding gene: 148659896

Following gene: 148659893

Centisome position: 3.64

GC content: 64.88

Gene sequence:

>1344_bases
ATGCCGGTGCGACGCCGCGCCGGGGAACGGTTGCCGACGGTGTGGGACTTCGAAACCGACCCGCAATACCAGTCCAAGCT
GGATTGGGTCGAAAAATTCATGGCCGAGGAACTCGAACCGCTCGATCTGGTCGCCCTCGATCCTTACGACAAAAAGAACG
CCGACACGATGGCGATCCTGCGGCCGCTGCAGCGGCAGGTGAAAGACCAGGGGTTGTGGGCCGCGCATTTGCGTCCCGAA
CTCGGCGGACAGGGCTTCGGTCAGGTCAAGCTGGCGCTGCTCAACGAGATCATCGGCCGCTCCCGGTGGGCGCCGTCGGC
GTTCGGCTGTCAGGCGCCGGACTCCGGCAACGCCGAGATCCTGGCGCTGTTCGGCACCGACGAGCAGAAAGCCCGCTATC
TACGACCGCTGCTCGACGGCGAGATCACCTCCTGCTATTCGATGACCGAGCCGCAGGGTGGTTCCGATCCCGGGCTGTTC
GTGACCGCGGCGACCCGCGATGCCGCGGGAAACGGGGACTGGATCATCAACGGCGAGAAGTGGTTTTCCACCAACGCCAA
GCATGCGTCGTTCTTTATCGTCATGGCCGTCACCAAGCCGGAAGCCCGTACGTACGAGAAGATGTCGCTGTTCATCGTCC
CGGCCGACACCCCGGGCATCGAGATCGTGCGCAACGTCGGTGTGGGAGCCGAGTCCACCCGGCACGCCAGCCACGGCTAC
ATCCGCTACCACGACGTCCGGGTGCCGGCCGATCATGTGCTCGGCGGCGAGGGCCAAGCGTTCATGATCGCGCAGACCCG
ATTGGGCGGCGGCCGAATACATCACGCGATGCGGACAATCGCGCTGGCGCGCAGAGCATTCGACATGATGTGCGAGCGTG
CCCTGTCGCGCCAGACTAGACACGGGCGGCTCGCCGATCTGCAGATGACCCAGGAGAAGATCGCCGATAGTTGGATCCAG
ATCGAGCAGTTCCGGCTGCTGGTACTGCGCACCGCGTGGCTTATCGACAAACACCACGACTATCAAAAGGTGCGCCGCGA
CATCGCGGCGGTCAAGGTGGCGATGCCCCAGGTGCTGCATGACGTCGTGCAGCGGGCCATGCACCTGCACGGCGCGCTCG
GGGTCTCCGACGAGATGCCGTTCGTCAAGATGATGCTGGCAGCCGAGTCACTGGGCATCGCCGACGGCGCCACTGAGCTG
CACAAGATGACCGTCGCCCGCCGTACGCTGCGCGAATACCAGCCGGTGACAACGCTTTTCCCGTCACAGCACATTCCGAC
CCGGCGCGCGCACGCCGAGGCCTGGCTGGCCCAACGCCTCGAGCACGCGATCGCCGAATTCTGA

Upstream 100 bases:

>100_bases
ACGACCCGATCACCGCCATCGACTTCTACCGCACCAACGTCCTGCCCGAACTGCGCTGAAGCCGCTAGACCGCACCTACG
ATGGTCTTGCTCTATCAACG

Downstream 100 bases:

>100_bases
CCGCGAGTTGCCTCAGGCGACGTAGCGCACGATGCTTTCGGCCACACACGCCGGCTTGGCCGATCCCTCGACCTCGACGG
TCGTCGACACCGTCGCCTGC

Product: acyl-CoA dehydrogenase FadE1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MPVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLVALDPYDKKNADTMAILRPLQRQVKDQGLWAAHLRPE
LGGQGFGQVKLALLNEIIGRSRWAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLF
VTAATRDAAGNGDWIINGEKWFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGY
IRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSRQTRHGRLADLQMTQEKIADSWIQ
IEQFRLLVLRTAWLIDKHHDYQKVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGATEL
HKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF

Sequences:

>Translated_447_residues
MPVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLVALDPYDKKNADTMAILRPLQRQVKDQGLWAAHLRPE
LGGQGFGQVKLALLNEIIGRSRWAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLF
VTAATRDAAGNGDWIINGEKWFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGY
IRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSRQTRHGRLADLQMTQEKIADSWIQ
IEQFRLLVLRTAWLIDKHHDYQKVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGATEL
HKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF
>Mature_446_residues
PVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLVALDPYDKKNADTMAILRPLQRQVKDQGLWAAHLRPEL
GGQGFGQVKLALLNEIIGRSRWAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLFV
TAATRDAAGNGDWIINGEKWFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGYI
RYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSRQTRHGRLADLQMTQEKIADSWIQI
EQFRLLVLRTAWLIDKHHDYQKVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGATELH
KMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI38505218, Length=399, Percent_Identity=36.0902255639098, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI211971008, Length=360, Percent_Identity=38.0555555555556, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI48976061, Length=360, Percent_Identity=38.0555555555556, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI4557233, Length=422, Percent_Identity=29.8578199052133, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI187960098, Length=414, Percent_Identity=29.2270531400966, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI4557231, Length=414, Percent_Identity=29.2270531400966, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI4501859, Length=388, Percent_Identity=27.319587628866, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI21361497, Length=383, Percent_Identity=27.154046997389, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI7656849, Length=410, Percent_Identity=23.6585365853659, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI226958412, Length=410, Percent_Identity=24.8780487804878, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4557235, Length=385, Percent_Identity=24.6753246753247, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI76496475, Length=385, Percent_Identity=24.6753246753247, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI226958414, Length=347, Percent_Identity=24.7838616714697, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4501857, Length=392, Percent_Identity=25.5102040816327, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4503943, Length=292, Percent_Identity=26.3698630136986, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI7669494, Length=276, Percent_Identity=26.8115942028986, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI87081958, Length=294, Percent_Identity=28.2312925170068, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786223, Length=352, Percent_Identity=25, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562446, Length=357, Percent_Identity=38.0952380952381, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17534899, Length=357, Percent_Identity=29.9719887955182, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17570075, Length=419, Percent_Identity=26.9689737470167, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17569725, Length=363, Percent_Identity=28.9256198347107, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17506239, Length=392, Percent_Identity=27.8061224489796, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=26.8096514745308, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17538396, Length=387, Percent_Identity=24.2894056847545, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71985184, Length=382, Percent_Identity=24.6073298429319, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17533517, Length=388, Percent_Identity=24.2268041237113, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71985192, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71990804, Length=295, Percent_Identity=28.4745762711864, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17505929, Length=353, Percent_Identity=23.5127478753541, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71982178, Length=286, Percent_Identity=27.2727272727273, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17551932, Length=346, Percent_Identity=23.4104046242775, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17534353, Length=294, Percent_Identity=27.2108843537415, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI32563615, Length=243, Percent_Identity=27.9835390946502, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21356377, Length=353, Percent_Identity=31.1614730878187, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24660351, Length=393, Percent_Identity=29.5165394402036, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646207, Length=353, Percent_Identity=30.028328611898, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24666513, Length=410, Percent_Identity=27.8048780487805, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21355753, Length=401, Percent_Identity=24.4389027431421, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281363737, Length=404, Percent_Identity=22.029702970297, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19920834, Length=391, Percent_Identity=25.8312020460358, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.21 [H]

Molecular weight: Translated: 50224; Mature: 50093

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLVALDPYDKKNADTMAIL
CCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHH
RPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIIGRSRWAPSAFGCQAPDSGNAEI
HHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
LALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLFVTAATRDAAGNGDWIINGEK
EEEECCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCC
WFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGY
EECCCCCCCEEEEEEEEECCCCCCEEEEEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCE
IRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSRQTR
EEEEEEECCHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRDIAAVKVAMPQVLH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
DVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGATELHKMTVARRTLREYQPVTTLF
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHCC
PSQHIPTRRAHAEAWLAQRLEHAIAEF
CCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLVALDPYDKKNADTMAIL
CCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHH
RPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIIGRSRWAPSAFGCQAPDSGNAEI
HHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
LALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLFVTAATRDAAGNGDWIINGEK
EEEECCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCC
WFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGY
EECCCCCCCEEEEEEEEECCCCCCEEEEEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCE
IRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSRQTR
EEEEEEECCHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRDIAAVKVAMPQVLH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
DVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGATELHKMTVARRTLREYQPVTTLF
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHCC
PSQHIPTRRAHAEAWLAQRLEHAIAEF
CCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10629170; 12420174 [H]