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The map label for this gene is gmhA

Identifier: 148659876

GI number: 148659876

Start: 138678

End: 139268

Strand: Direct

Name: gmhA

Synonym: MRA_0119

Alternate gene names: 148659876

Gene position: 138678-139268 (Clockwise)

Preceding gene: 148659875

Following gene: 148659877

Centisome position: 3.14

GC content: 57.87

Gene sequence:

>591_bases
GTGTGCACCGCGAGAACTGCTGAGGAGATCTTTGTAGAGACAATCGCTGTCAAGACACGCATCCTCAATGACCGGGTCTT
GCTGGAAGCCGCTCGCGCAATTGGGGACCGCTTGATTGCCGGCTATCGTGCGGGAGCACGCGTCTTCATGTGTGGCAACG
GTGGTAGCGCTGCGGATGCGCAACATTTTGCCGCGGAGCTAACGGGTCACCTGATCTTTGATCGGCCACCGCTTGGCGCC
GAGGCACTCCACGCCAATTCGTCGCACCTAACAGCGGTGGCCAACGACTATGACTACGACACCGTTTTTGCCAGGGCCCT
CGAAGGATCTGCGCGTCCCGGCGACACGCTTTTTGCGATAAGTACCTCCGGCAATTCTATGAGTGTACTGCGGGCCGCGA
AAACCGCAAGGGAGTTGGGTGTGACGGTTGTTGCAATGACGGGCGAATCCGGCGGCCAGCTGGCAGAATTCGCAGATTTC
TTGATCAACGTCCCGTCACGCGACACCGGGCGAATCCAGGAATCTCACATCGTTTTTATTCATGCGATCTCCGAACATGT
CGAACACGCGCTTTTCGCGCCTCGCCAATAG

Upstream 100 bases:

>100_bases
AAATCCGAGTCCGCCCTGATGGTGTGACCGAATGTCTTTGTCCTGCCAACCTGAGGAGCAGATAAGATTGACCGTAACGG
ACTCTCAGTATCGACAAAAG

Downstream 100 bases:

>100_bases
GAAAGCCGATCCTTACGCGGCCATTCGAAAGATGGTCGCGGAACGTGCGGGACACCAATGGTGTCTCTTCCTCGATAGAG
ACGGGGTCATCAATCGACAA

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MCTARTAEEIFVETIAVKTRILNDRVLLEAARAIGDRLIAGYRAGARVFMCGNGGSAADAQHFAAELTGHLIFDRPPLGA
EALHANSSHLTAVANDYDYDTVFARALEGSARPGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADF
LINVPSRDTGRIQESHIVFIHAISEHVEHALFAPRQ

Sequences:

>Translated_196_residues
MCTARTAEEIFVETIAVKTRILNDRVLLEAARAIGDRLIAGYRAGARVFMCGNGGSAADAQHFAAELTGHLIFDRPPLGA
EALHANSSHLTAVANDYDYDTVFARALEGSARPGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADF
LINVPSRDTGRIQESHIVFIHAISEHVEHALFAPRQ
>Mature_196_residues
MCTARTAEEIFVETIAVKTRILNDRVLLEAARAIGDRLIAGYRAGARVFMCGNGGSAADAQHFAAELTGHLIFDRPPLGA
EALHANSSHLTAVANDYDYDTVFARALEGSARPGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADF
LINVPSRDTGRIQESHIVFIHAISEHVEHALFAPRQ

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1786416, Length=151, Percent_Identity=44.3708609271523, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789539, Length=189, Percent_Identity=37.5661375661376, Blast_Score=121, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_MYCBO (P0A605)

Other databases:

- EMBL:   BX248334
- RefSeq:   NP_853784.1
- ProteinModelPortal:   P0A605
- SMR:   P0A605
- EnsemblBacteria:   EBMYCT00000015072
- GeneID:   1090800
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0117
- GeneTree:   EBGT00050000016047
- HOGENOM:   HBG671955
- OMA:   QEMHILI
- ProtClustDB:   PRK13938
- BioCyc:   MBOV233413:MB0117-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR020620
- InterPro:   IPR001347

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 20923; Mature: 20923

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS51464 SIS

Important sites: BINDING 66-66 BINDING 126-126 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTARTAEEIFVETIAVKTRILNDRVLLEAARAIGDRLIAGYRAGARVFMCGNGGSAADA
CCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHH
QHFAAELTGHLIFDRPPLGAEALHANSSHLTAVANDYDYDTVFARALEGSARPGDTLFAI
HHHHHHHHCCEEECCCCCCHHHEECCCCEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEE
STSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADFLINVPSRDTGRIQESHIVFI
EECCCCHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHEECCCCCCCCEECCEEEEE
HAISEHVEHALFAPRQ
EEHHHHHHHHHCCCCC
>Mature Secondary Structure
MCTARTAEEIFVETIAVKTRILNDRVLLEAARAIGDRLIAGYRAGARVFMCGNGGSAADA
CCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHH
QHFAAELTGHLIFDRPPLGAEALHANSSHLTAVANDYDYDTVFARALEGSARPGDTLFAI
HHHHHHHHCCEEECCCCCCHHHEECCCCEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEE
STSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADFLINVPSRDTGRIQESHIVFI
EECCCCHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHEECCCCCCCCEECCEEEEE
HAISEHVEHALFAPRQ
EEHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972