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The map label for this gene is guaA [H]

Identifier: 148651832

GI number: 148651832

Start: 20646

End: 22244

Strand: Direct

Name: guaA [H]

Synonym: PsycPRwf_0015

Alternate gene names: 148651832

Gene position: 20646-22244 (Clockwise)

Preceding gene: 148651830

Following gene: 148651836

Centisome position: 0.69

GC content: 49.91

Gene sequence:

>1599_bases
ATGAGTATAGCCGCACCCACCATCAAAGAAGACCGCATTTTAATTATCGATTATGGCTCACAGTACAGCCAGCTGATTGC
CCGCCGTGTTCGTGAAGCGGGCGTATTCTGCGAAATGTACCCTTATGATATCGATACCAGTCGTATCGAAGCATTCGGTG
CCAAAGGGGTGATCTTATCAGGTGGCCCTGAAAGTGTGCACGACGAAAACAGCCCAAGAATCAATCAAGCTTTGTTTGAT
TTAAATGTGCCGATCTTAGGCATCTGCTACGGCATGCAGGCCATGGCCGATCACTTCGGTGGTAAGGTTCAGGCAAGTGA
TGTGCATGAATTTGGCGCGGCTACCATTGATGTGACGGGCCATAGTGCTTTACTTGATGGCATTGAAGATGAGCACAAAG
ACAACAGCCGCTTGCATGTGTGGATGAGCCACGGTGACAAAGTAGTTGAAGCCCCTAAAGGCTTTGATATCGTCGCCAGT
ACGCCAAGCTGCCCCATCGCCGTGATGGTCAATGAAGACAAAAAATACTATGGCCTACAATTCCATCCAGAGGTGACGCA
CACCTTACAAGGCGACGTGTTATTGTCTCGCTTTGTGCATCAAGTGTGTGGCTGCGCCGGTGACTGGACGCCAGATAACA
TCATCGATATGCGGGTTGAGCAATTAAAAGAGCAAATCGGTGATAAGCAAGTTCTACTTGGCCTATCAGGTGGTGTGGAC
AGCTCAGTTGTGGCGGCCTTATTACACAAAGCCATTGGCGATCAGCTGACTTGTGTGTTCGTGGATAATGGTCTACTGCG
TCTGCACGAAGGCGACCAAGTGATGCAAGTATTCGCCGAAAATATGGGCGTAAAAGTGGTGCGTGTCGATGCTGAAGATC
GCTTCTTAAGCGCATTAGCGGGTGAGAGTGAGCCGGAAGCTAAGCGTAAAATCATCGGCAAAACCTTTATCGATGTATTC
GCCGATGCCGCCCGTGATATCAGCCAAGGCAGCGACGGTAAGCCGGTTGAGTTCTTAGCGCAAGGTACCATTTACCCAGA
CGTGATTGAATCTGCCAAATCACACCAAGGTAAAGCGCACGTCATTAAGAGCCATCACAACGTAGGCGGCTTGCCCGATG
ATTTACAGTTTGAATTGGTTGAGCCATTACGTGATCTGTTCAAAGATGAAGTACGCAAACTGGGTATCGCCTTAGGCTTA
CCACACAAAATGATTTATCGTCATCCATTCCCAGGCCCAGGTCTAGGCGTACGCATCTTAGGCGAAGTCAAAAAAGAATA
CGCCGACATCCTGCGTCAAGCGGATGCTATCTTCATGCAAGAGCTTGAGCGCTCAGGCTGGTATGAGAAAACCGCGCAGG
CCTTTGCAGTATTTACCCCAGTGAAATCTGTCGGCGTGGTGGGTGATGGCCGCCGTTATGCGTGGGTTATCGCCCTACGT
GCGGTTGAAACCATCGACTTTATGACCGCCCGCTTTGCGCACTTGCCATACGAGCTGATCGAGACGGTGAGTAACCGCAT
CATGAACGAAATCAAAGATGTGTCTCGTGTGACTTATGATGTGTCGAGCAAGCCGCCGGCGACTATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
TAATTCTCTGTCATACAATCCCCATCATAACGCATAAACTTGTTAAAATAGGCGCTAAAATTTTTGCTAGTTATTCTTTA
TTCAAAGACTGGAAGACATT

Downstream 100 bases:

>100_bases
CCGACAGGCGCATCAAACTAAAAACCTGATTAGCGTTGTCAAACTCGTTCAGCCTACTTGATGTAGCGCTGTCACTCGTT
TTCCTCGCTACTCAAATTTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSIAAPTIKEDRILIIDYGSQYSQLIARRVREAGVFCEMYPYDIDTSRIEAFGAKGVILSGGPESVHDENSPRINQALFD
LNVPILGICYGMQAMADHFGGKVQASDVHEFGAATIDVTGHSALLDGIEDEHKDNSRLHVWMSHGDKVVEAPKGFDIVAS
TPSCPIAVMVNEDKKYYGLQFHPEVTHTLQGDVLLSRFVHQVCGCAGDWTPDNIIDMRVEQLKEQIGDKQVLLGLSGGVD
SSVVAALLHKAIGDQLTCVFVDNGLLRLHEGDQVMQVFAENMGVKVVRVDAEDRFLSALAGESEPEAKRKIIGKTFIDVF
ADAARDISQGSDGKPVEFLAQGTIYPDVIESAKSHQGKAHVIKSHHNVGGLPDDLQFELVEPLRDLFKDEVRKLGIALGL
PHKMIYRHPFPGPGLGVRILGEVKKEYADILRQADAIFMQELERSGWYEKTAQAFAVFTPVKSVGVVGDGRRYAWVIALR
AVETIDFMTARFAHLPYELIETVSNRIMNEIKDVSRVTYDVSSKPPATIEWE

Sequences:

>Translated_532_residues
MSIAAPTIKEDRILIIDYGSQYSQLIARRVREAGVFCEMYPYDIDTSRIEAFGAKGVILSGGPESVHDENSPRINQALFD
LNVPILGICYGMQAMADHFGGKVQASDVHEFGAATIDVTGHSALLDGIEDEHKDNSRLHVWMSHGDKVVEAPKGFDIVAS
TPSCPIAVMVNEDKKYYGLQFHPEVTHTLQGDVLLSRFVHQVCGCAGDWTPDNIIDMRVEQLKEQIGDKQVLLGLSGGVD
SSVVAALLHKAIGDQLTCVFVDNGLLRLHEGDQVMQVFAENMGVKVVRVDAEDRFLSALAGESEPEAKRKIIGKTFIDVF
ADAARDISQGSDGKPVEFLAQGTIYPDVIESAKSHQGKAHVIKSHHNVGGLPDDLQFELVEPLRDLFKDEVRKLGIALGL
PHKMIYRHPFPGPGLGVRILGEVKKEYADILRQADAIFMQELERSGWYEKTAQAFAVFTPVKSVGVVGDGRRYAWVIALR
AVETIDFMTARFAHLPYELIETVSNRIMNEIKDVSRVTYDVSSKPPATIEWE
>Mature_531_residues
SIAAPTIKEDRILIIDYGSQYSQLIARRVREAGVFCEMYPYDIDTSRIEAFGAKGVILSGGPESVHDENSPRINQALFDL
NVPILGICYGMQAMADHFGGKVQASDVHEFGAATIDVTGHSALLDGIEDEHKDNSRLHVWMSHGDKVVEAPKGFDIVAST
PSCPIAVMVNEDKKYYGLQFHPEVTHTLQGDVLLSRFVHQVCGCAGDWTPDNIIDMRVEQLKEQIGDKQVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDNGLLRLHEGDQVMQVFAENMGVKVVRVDAEDRFLSALAGESEPEAKRKIIGKTFIDVFA
DAARDISQGSDGKPVEFLAQGTIYPDVIESAKSHQGKAHVIKSHHNVGGLPDDLQFELVEPLRDLFKDEVRKLGIALGLP
HKMIYRHPFPGPGLGVRILGEVKKEYADILRQADAIFMQELERSGWYEKTAQAFAVFTPVKSVGVVGDGRRYAWVIALRA
VETIDFMTARFAHLPYELIETVSNRIMNEIKDVSRVTYDVSSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=533, Percent_Identity=36.0225140712946, Blast_Score=310, Evalue=2e-84,
Organism=Escherichia coli, GI1788854, Length=528, Percent_Identity=61.9318181818182, Blast_Score=694, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=577, Percent_Identity=36.7417677642981, Blast_Score=313, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71992710, Length=577, Percent_Identity=36.7417677642981, Blast_Score=313, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI133901714, Length=577, Percent_Identity=36.7417677642981, Blast_Score=312, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=526, Percent_Identity=49.8098859315589, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI281365319, Length=559, Percent_Identity=33.8103756708408, Blast_Score=291, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58721; Mature: 58589

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAAPTIKEDRILIIDYGSQYSQLIARRVREAGVFCEMYPYDIDTSRIEAFGAKGVILS
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCCEEEEC
GGPESVHDENSPRINQALFDLNVPILGICYGMQAMADHFGGKVQASDVHEFGAATIDVTG
CCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCHHHCCCEEEEECC
HSALLDGIEDEHKDNSRLHVWMSHGDKVVEAPKGFDIVASTPSCPIAVMVNEDKKYYGLQ
CHHHHHCCCCCCCCCCEEEEEECCCCEEEECCCCCEEEECCCCCCEEEEECCCCCEECEE
FHPEVTHTLQGDVLLSRFVHQVCGCAGDWTPDNIIDMRVEQLKEQIGDKQVLLGLSGGVD
ECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCC
SSVVAALLHKAIGDQLTCVFVDNGLLRLHEGDQVMQVFAENMGVKVVRVDAEDRFLSALA
HHHHHHHHHHHHCCCEEEEEEECCEEEECCCHHHHHHHHHCCCEEEEEECCHHHHHHHHC
GESEPEAKRKIIGKTFIDVFADAARDISQGSDGKPVEFLAQGTIYPDVIESAKSHQGKAH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCHHHHHHHHCCCCCEE
VIKSHHNVGGLPDDLQFELVEPLRDLFKDEVRKLGIALGLPHKMIYRHPFPGPGLGVRIL
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHH
GEVKKEYADILRQADAIFMQELERSGWYEKTAQAFAVFTPVKSVGVVGDGRRYAWVIALR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEECCHHHCCEECCCCEEEEEEEHH
AVETIDFMTARFAHLPYELIETVSNRIMNEIKDVSRVTYDVSSKPPATIEWE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEECC
>Mature Secondary Structure 
SIAAPTIKEDRILIIDYGSQYSQLIARRVREAGVFCEMYPYDIDTSRIEAFGAKGVILS
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCCEEEEC
GGPESVHDENSPRINQALFDLNVPILGICYGMQAMADHFGGKVQASDVHEFGAATIDVTG
CCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCHHHCCCEEEEECC
HSALLDGIEDEHKDNSRLHVWMSHGDKVVEAPKGFDIVASTPSCPIAVMVNEDKKYYGLQ
CHHHHHCCCCCCCCCCEEEEEECCCCEEEECCCCCEEEECCCCCCEEEEECCCCCEECEE
FHPEVTHTLQGDVLLSRFVHQVCGCAGDWTPDNIIDMRVEQLKEQIGDKQVLLGLSGGVD
ECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCC
SSVVAALLHKAIGDQLTCVFVDNGLLRLHEGDQVMQVFAENMGVKVVRVDAEDRFLSALA
HHHHHHHHHHHHCCCEEEEEEECCEEEECCCHHHHHHHHHCCCEEEEEECCHHHHHHHHC
GESEPEAKRKIIGKTFIDVFADAARDISQGSDGKPVEFLAQGTIYPDVIESAKSHQGKAH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCHHHHHHHHCCCCCEE
VIKSHHNVGGLPDDLQFELVEPLRDLFKDEVRKLGIALGLPHKMIYRHPFPGPGLGVRIL
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHH
GEVKKEYADILRQADAIFMQELERSGWYEKTAQAFAVFTPVKSVGVVGDGRRYAWVIALR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEECCHHHCCEECCCCEEEEEEEHH
AVETIDFMTARFAHLPYELIETVSNRIMNEIKDVSRVTYDVSSKPPATIEWE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA