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The map label for this gene is patB [H]

Identifier: 148651830

GI number: 148651830

Start: 16859

End: 18010

Strand: Direct

Name: patB [H]

Synonym: PsycPRwf_0013

Alternate gene names: 148651830

Gene position: 16859-18010 (Clockwise)

Preceding gene: 148651829

Following gene: 148651832

Centisome position: 0.57

GC content: 44.01

Gene sequence:

>1152_bases
ATGCAGTACAATTTCGATGAAGTAATCGACAGAAACAACACCGGCTCGCTCAAATGGCATTATGAAGATGACACCATTCC
ATTGTGGGTGGCTGACATGGATTTTAAGGCCGCTCAGCCTATTTTAGACAGTCTACAGCAGATTATTACGCATGGCATTC
TTGGGTACACTAAACAAACCGATCGCTTATATCAAGCGATTATCAATTGGCACAGTAGCCGCTATGGTCTAGAGCTTGAG
GCCAGTAACATTCTGTTTTCGCCCGGCGTGGTTCCCAGTATTGCGTTACTGGTCAATTTGTTTACTGAGGTGGGCGATGC
AGTACTGATCAATGATCCGATTTATGCACCATTTGTGGCCAAGACCAAGCTAAATGGCTGTAAAGTTGTCAGCTCGGCAT
TACAAGAGGTCAACGGGCGTTATGAGTTTGATTTAGAAGACATCGAAGCCAAAATCAAGAAGCATAAAATTAAGCTGTTT
TTACTGTGTAATCCGCACAATCCGGGCGGGCGAGTATGGACCAAAGATGAGCTAAAAGCGGTGCTTGAGCTGTGTAAAAA
GTATCAAGTTGCCATTGTCAGTGATGAGATTCATCAAGATCTAACCCTAACTGGCCATACCTTTACCCCGTTTTTAAATT
TGGCATCAGGCTATGAGCACATGGTGGTCAGCCTAACCTCGATGACCAAAACCTTTAACATTGCGGGTATCAAAGGCTCG
ATGATATTTGCAAAAGACAAAGCTTTATTAAAACAAATCAGCAATCAGCAGCGCTTAAACGATGAATATGAGCTAAATAT
GTTTGCTTATAGCGCCATGCAAAGTGCTTATGAGCAGGGCGGTGAGTGGCTTGAGCAGGCGCTGGCTTATATTGAAAAAA
ATATTGAGTTAACGGTAGATTATCTGGCCAAACATTTGCCCGATATCAAGGTGATGCACCCTGAGGCCTCCTATCTAATT
TGGCTGGATTGCTCAGCTTATGCTGACGACAATCAGGCGCTATATGACAGCTTACGAGATGCTAAGGTCGAGCTCAATGC
CGGTATCAGCTATGGTAATGAAGGGCATCTAAAAATGCGTATTAATGTGGCTTGCCCAGAGTCGGTATTGCTTGAAGGCT
TGGCGCGGATCAAACAGGCACTAAATCATTAA

Upstream 100 bases:

>100_bases
ACTTATACTATCGTAATAAAGCAATTATTGAGCTTGAGCGGATAGATACTTAAAGCACTTAAACATAGACACAAGTGACA
TTAACTACGGGAACCCCACC

Downstream 100 bases:

>100_bases
AGCAGTTGCAACGTGAAATAAAAAGCGGCGGGATTCATTGATGAATCCCGCCGCTTTGGTTTTAGACGATTTACAAAGGT
ACTGTCTCTGGCTATCTGTC

Product: class I/II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MQYNFDEVIDRNNTGSLKWHYEDDTIPLWVADMDFKAAQPILDSLQQIITHGILGYTKQTDRLYQAIINWHSSRYGLELE
ASNILFSPGVVPSIALLVNLFTEVGDAVLINDPIYAPFVAKTKLNGCKVVSSALQEVNGRYEFDLEDIEAKIKKHKIKLF
LLCNPHNPGGRVWTKDELKAVLELCKKYQVAIVSDEIHQDLTLTGHTFTPFLNLASGYEHMVVSLTSMTKTFNIAGIKGS
MIFAKDKALLKQISNQQRLNDEYELNMFAYSAMQSAYEQGGEWLEQALAYIEKNIELTVDYLAKHLPDIKVMHPEASYLI
WLDCSAYADDNQALYDSLRDAKVELNAGISYGNEGHLKMRINVACPESVLLEGLARIKQALNH

Sequences:

>Translated_383_residues
MQYNFDEVIDRNNTGSLKWHYEDDTIPLWVADMDFKAAQPILDSLQQIITHGILGYTKQTDRLYQAIINWHSSRYGLELE
ASNILFSPGVVPSIALLVNLFTEVGDAVLINDPIYAPFVAKTKLNGCKVVSSALQEVNGRYEFDLEDIEAKIKKHKIKLF
LLCNPHNPGGRVWTKDELKAVLELCKKYQVAIVSDEIHQDLTLTGHTFTPFLNLASGYEHMVVSLTSMTKTFNIAGIKGS
MIFAKDKALLKQISNQQRLNDEYELNMFAYSAMQSAYEQGGEWLEQALAYIEKNIELTVDYLAKHLPDIKVMHPEASYLI
WLDCSAYADDNQALYDSLRDAKVELNAGISYGNEGHLKMRINVACPESVLLEGLARIKQALNH
>Mature_383_residues
MQYNFDEVIDRNNTGSLKWHYEDDTIPLWVADMDFKAAQPILDSLQQIITHGILGYTKQTDRLYQAIINWHSSRYGLELE
ASNILFSPGVVPSIALLVNLFTEVGDAVLINDPIYAPFVAKTKLNGCKVVSSALQEVNGRYEFDLEDIEAKIKKHKIKLF
LLCNPHNPGGRVWTKDELKAVLELCKKYQVAIVSDEIHQDLTLTGHTFTPFLNLASGYEHMVVSLTSMTKTFNIAGIKGS
MIFAKDKALLKQISNQQRLNDEYELNMFAYSAMQSAYEQGGEWLEQALAYIEKNIELTVDYLAKHLPDIKVMHPEASYLI
WLDCSAYADDNQALYDSLRDAKVELNAGISYGNEGHLKMRINVACPESVLLEGLARIKQALNH

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=324, Percent_Identity=21.2962962962963, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI169881279, Length=324, Percent_Identity=21.2962962962963, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI56713256, Length=255, Percent_Identity=24.3137254901961, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI56713254, Length=255, Percent_Identity=24.3137254901961, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI149944424, Length=303, Percent_Identity=22.4422442244224, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787909, Length=392, Percent_Identity=30.6122448979592, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1788722, Length=346, Percent_Identity=26.0115606936416, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788627, Length=301, Percent_Identity=22.9235880398671, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786816, Length=208, Percent_Identity=24.0384615384615, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=217, Percent_Identity=25.8064516129032, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994472, Length=217, Percent_Identity=25.8064516129032, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17567369, Length=240, Percent_Identity=24.1666666666667, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17567663, Length=352, Percent_Identity=21.0227272727273, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=203, Percent_Identity=28.0788177339901, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28573069, Length=329, Percent_Identity=26.1398176291793, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646114, Length=329, Percent_Identity=26.1398176291793, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573067, Length=329, Percent_Identity=26.1398176291793, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573065, Length=329, Percent_Identity=26.1398176291793, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43267; Mature: 43267

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYNFDEVIDRNNTGSLKWHYEDDTIPLWVADMDFKAAQPILDSLQQIITHGILGYTKQT
CCCCHHHHHCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHH
DRLYQAIINWHSSRYGLELEASNILFSPGVVPSIALLVNLFTEVGDAVLINDPIYAPFVA
HHHHHHHHHHCCCCCCEEEECCCEEECCCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEE
KTKLNGCKVVSSALQEVNGRYEFDLEDIEAKIKKHKIKLFLLCNPHNPGGRVWTKDELKA
ECCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHCEEEEEEEECCCCCCCCCCCHHHHHH
VLELCKKYQVAIVSDEIHQDLTLTGHTFTPFLNLASGYEHMVVSLTSMTKTFNIAGIKGS
HHHHHHHHEEEEEEHHHCCCEEECCCCHHHHHHHHCCHHHHHEEHHHHHHEEEEECCCCC
MIFAKDKALLKQISNQQRLNDEYELNMFAYSAMQSAYEQGGEWLEQALAYIEKNIELTVD
EEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHH
YLAKHLPDIKVMHPEASYLIWLDCSAYADDNQALYDSLRDAKVELNAGISYGNEGHLKMR
HHHHHCCCCEEECCCCCEEEEEEECCCCCCCHHHHHHHHCCEEEEECCCCCCCCCEEEEE
INVACPESVLLEGLARIKQALNH
EEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQYNFDEVIDRNNTGSLKWHYEDDTIPLWVADMDFKAAQPILDSLQQIITHGILGYTKQT
CCCCHHHHHCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHH
DRLYQAIINWHSSRYGLELEASNILFSPGVVPSIALLVNLFTEVGDAVLINDPIYAPFVA
HHHHHHHHHHCCCCCCEEEECCCEEECCCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEE
KTKLNGCKVVSSALQEVNGRYEFDLEDIEAKIKKHKIKLFLLCNPHNPGGRVWTKDELKA
ECCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHCEEEEEEEECCCCCCCCCCCHHHHHH
VLELCKKYQVAIVSDEIHQDLTLTGHTFTPFLNLASGYEHMVVSLTSMTKTFNIAGIKGS
HHHHHHHHEEEEEEHHHCCCEEECCCCHHHHHHHHCCHHHHHEEHHHHHHEEEEECCCCC
MIFAKDKALLKQISNQQRLNDEYELNMFAYSAMQSAYEQGGEWLEQALAYIEKNIELTVD
EEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHH
YLAKHLPDIKVMHPEASYLIWLDCSAYADDNQALYDSLRDAKVELNAGISYGNEGHLKMR
HHHHHCCCCEEECCCCCEEEEEEECCCCCCCHHHHHHHHCCEEEEECCCCCCCCCEEEEE
INVACPESVLLEGLARIKQALNH
EEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]