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The map label for this gene is lpd [H]

Identifier: 148550590

GI number: 148550590

Start: 43355

End: 44752

Strand: Reverse

Name: lpd [H]

Synonym: Swit_5151

Alternate gene names: 148550590

Gene position: 44752-43355 (Counterclockwise)

Preceding gene: 148550591

Following gene: 148550588

Centisome position: 14.43

GC content: 58.44

Gene sequence:

>1398_bases
ATGGCTGATAGTTACGACGTGATTGTCCTTGGCTCAGGCCCCGGCGGCTATGTCGCCGCGATCCGCGCCGCTCAGCTCAA
GTTGAACACGGCGATTGTCGAGCGCGAGAATCTAGGCGGTGTCTGCCTCAACTGGGGTTGCATACCCACCAAGGCGTTGC
TGCGCTCGGCGGAGGTTTTTCGCTACATGCGGCATGCCAAGGATTATGGCCTGGTCGCGGAGAAGATAACCGCCGATCTG
GATGCAGTGGTGAAGCGCTCACGCGGCGTTGCCAGGCAGCTTAATCAGGGTGTCTCGCACCTGATGAAGAAGAACGGGAT
CGCCGTTTATATGGGTGAGGGGAAGCTCACCGGCAAAGGGAGGCTTTCTGTCACAGCGCCGGATGGTAAGACCAGTGAGT
TGACCGCGAAGAATATTATCATCGCCACGGGCGCGCGTGCTCGCGATCTGCCGTTCCCGAAAGCCGATGGAAAGCGCGTC
TGGACCTATCGCCACGCGATGAACCCGCCGGAAATGCCGAACAAGCTGCTTGTTATCGGCTCGGGCGCGATCGGCATCGA
GTTCGCCAGCTTTTACAACGACATGGGCGCGGAAGTGACAGTCGTCGAGATGCTGGACAGGATCGTTCCGGTCGAGGATG
CAGATGTCTCGACCTTCCTGGAAAAAGCGTTGGTGAAGCAGGGCATGAAGATCTTGACGGGTGCAGGTGTCCAAAAGCTC
GATATCGGTGCCACCGGCGTAACAGTCGCGATCAAAGCCCGGGATGGCAAACTTGTTTCGGACGAATACAGCCATGTCAT
CGTGGCAATCGGGATCGTCCCAAACACCGAAACCGTTGGGCTTGAGGCACTGGGTGTGAAAACGGAGCGTGGCCACATTG
TTACCGATGGCGCATGCCGCACCAATGTCGAGGGAATCTGGGCGATCGGAGACGCCACGGCGCCGCCTTGGCTAGCGCAC
AAGGCCAGCCATGAAGGTGTTATCGCGGCAGAAACCATAGCGGGTCAGCATCCGCACGCAATGGACCCCAGGAACATTCC
CGGCTGCACCTATTGCCACCCGCAGATCGCTAGTGTCGGCCTCACCGAAACAAATGCGAGGGAAGCAGGTCACGAAGTGA
GGATTGGCACCTTTCCCTTCATCGGCAATGGCAAGGCTATCGCGCTCGGCGAGCCAGAAGGCTTCGTCAAGACGGTATTT
GATGCCCAAACTGGCGAGCTGCTGGGCGCACACATGGTCGGCCCGGAGGTGACCGAAATGATCCACGGCTTCACCATCGG
TCGTACACTGGAAACAACCGAGGCGGAGCTGATGGAAACGGTTTTTCCGCATCCGACCATTTCCGAAACGATGCATGAAA
GCGTGCTTGCTGCCTTCGGGCGCGCAGTCCATATTTAG

Upstream 100 bases:

>100_bases
CGATCGATGGGGCGGACGGTGCGCAACTGATGGCCGCTTTCAAGCGCATCGTTGAGAAGCCGCTGACACTGTTGGCCTGA
ATCTCAAGGAATTTCCGAAC

Downstream 100 bases:

>100_bases
GCTATCTTCCATATTTGGGAGAGATCATGCCTCCTTCTGCTGCCGAACCACGAGCGGCGAGGCGTCAAGGTCAGCTACGT
ACTCTTGAAAGAACCCGTGC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MADSYDVIVLGSGPGGYVAAIRAAQLKLNTAIVERENLGGVCLNWGCIPTKALLRSAEVFRYMRHAKDYGLVAEKITADL
DAVVKRSRGVARQLNQGVSHLMKKNGIAVYMGEGKLTGKGRLSVTAPDGKTSELTAKNIIIATGARARDLPFPKADGKRV
WTYRHAMNPPEMPNKLLVIGSGAIGIEFASFYNDMGAEVTVVEMLDRIVPVEDADVSTFLEKALVKQGMKILTGAGVQKL
DIGATGVTVAIKARDGKLVSDEYSHVIVAIGIVPNTETVGLEALGVKTERGHIVTDGACRTNVEGIWAIGDATAPPWLAH
KASHEGVIAAETIAGQHPHAMDPRNIPGCTYCHPQIASVGLTETNAREAGHEVRIGTFPFIGNGKAIALGEPEGFVKTVF
DAQTGELLGAHMVGPEVTEMIHGFTIGRTLETTEAELMETVFPHPTISETMHESVLAAFGRAVHI

Sequences:

>Translated_465_residues
MADSYDVIVLGSGPGGYVAAIRAAQLKLNTAIVERENLGGVCLNWGCIPTKALLRSAEVFRYMRHAKDYGLVAEKITADL
DAVVKRSRGVARQLNQGVSHLMKKNGIAVYMGEGKLTGKGRLSVTAPDGKTSELTAKNIIIATGARARDLPFPKADGKRV
WTYRHAMNPPEMPNKLLVIGSGAIGIEFASFYNDMGAEVTVVEMLDRIVPVEDADVSTFLEKALVKQGMKILTGAGVQKL
DIGATGVTVAIKARDGKLVSDEYSHVIVAIGIVPNTETVGLEALGVKTERGHIVTDGACRTNVEGIWAIGDATAPPWLAH
KASHEGVIAAETIAGQHPHAMDPRNIPGCTYCHPQIASVGLTETNAREAGHEVRIGTFPFIGNGKAIALGEPEGFVKTVF
DAQTGELLGAHMVGPEVTEMIHGFTIGRTLETTEAELMETVFPHPTISETMHESVLAAFGRAVHI
>Mature_464_residues
ADSYDVIVLGSGPGGYVAAIRAAQLKLNTAIVERENLGGVCLNWGCIPTKALLRSAEVFRYMRHAKDYGLVAEKITADLD
AVVKRSRGVARQLNQGVSHLMKKNGIAVYMGEGKLTGKGRLSVTAPDGKTSELTAKNIIIATGARARDLPFPKADGKRVW
TYRHAMNPPEMPNKLLVIGSGAIGIEFASFYNDMGAEVTVVEMLDRIVPVEDADVSTFLEKALVKQGMKILTGAGVQKLD
IGATGVTVAIKARDGKLVSDEYSHVIVAIGIVPNTETVGLEALGVKTERGHIVTDGACRTNVEGIWAIGDATAPPWLAHK
ASHEGVIAAETIAGQHPHAMDPRNIPGCTYCHPQIASVGLTETNAREAGHEVRIGTFPFIGNGKAIALGEPEGFVKTVFD
AQTGELLGAHMVGPEVTEMIHGFTIGRTLETTEAELMETVFPHPTISETMHESVLAAFGRAVHI

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=479, Percent_Identity=37.3695198329854, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=28.1659388646288, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI22035672, Length=457, Percent_Identity=28.0087527352298, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI148277065, Length=443, Percent_Identity=26.1851015801354, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI33519430, Length=443, Percent_Identity=26.1851015801354, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI33519428, Length=443, Percent_Identity=26.1851015801354, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI33519426, Length=443, Percent_Identity=26.1851015801354, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI148277071, Length=443, Percent_Identity=26.1851015801354, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI291045266, Length=429, Percent_Identity=26.3403263403263, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI291045268, Length=423, Percent_Identity=25.7683215130024, Blast_Score=103, Evalue=5e-22,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=37.9157427937916, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI87082354, Length=471, Percent_Identity=27.6008492569002, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=27.7899343544858, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=28.5057471264368, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87081763, Length=190, Percent_Identity=31.0526315789474, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=36.0515021459227, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=26.5263157894737, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71983429, Length=447, Percent_Identity=25.0559284116331, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71983419, Length=447, Percent_Identity=25.0559284116331, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=24.4258872651357, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17559934, Length=210, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=474, Percent_Identity=36.4978902953587, Blast_Score=269, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=26.8343815513627, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6325166, Length=469, Percent_Identity=25.7995735607676, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=36.965811965812, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=26.4830508474576, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=26.5957446808511, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=26.5392781316348, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17737741, Length=482, Percent_Identity=25.3112033195021, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49507; Mature: 49375

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSYDVIVLGSGPGGYVAAIRAAQLKLNTAIVERENLGGVCLNWGCIPTKALLRSAEVF
CCCCEEEEEEECCCCCCEEEEEHHHEEEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
RYMRHAKDYGLVAEKITADLDAVVKRSRGVARQLNQGVSHLMKKNGIAVYMGEGKLTGKG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEECCCC
RLSVTAPDGKTSELTAKNIIIATGARARDLPFPKADGKRVWTYRHAMNPPEMPNKLLVIG
EEEEECCCCCCCCEEECEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEE
SGAIGIEFASFYNDMGAEVTVVEMLDRIVPVEDADVSTFLEKALVKQGMKILTGAGVQKL
CCCCCEEHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHEECCCCCEEE
DIGATGVTVAIKARDGKLVSDEYSHVIVAIGIVPNTETVGLEALGVKTERGHIVTDGACR
ECCCCCEEEEEEECCCCEECCCCCEEEEEEEECCCCCCCCEEEEEEEECCCEEEECCCCC
TNVEGIWAIGDATAPPWLAHKASHEGVIAAETIAGQHPHAMDPRNIPGCTYCHPQIASVG
CCCCEEEEECCCCCCCHHHHCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCHHHCC
LTETNAREAGHEVRIGTFPFIGNGKAIALGEPEGFVKTVFDAQTGELLGAHMVGPEVTEM
CCCCCHHHCCCEEEEECCEEECCCCEEEECCCCCHHHHHHCCCCCHHHHHHCCCHHHHHH
IHGFTIGRTLETTEAELMETVFPHPTISETMHESVLAAFGRAVHI
HHCEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADSYDVIVLGSGPGGYVAAIRAAQLKLNTAIVERENLGGVCLNWGCIPTKALLRSAEVF
CCCEEEEEEECCCCCCEEEEEHHHEEEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
RYMRHAKDYGLVAEKITADLDAVVKRSRGVARQLNQGVSHLMKKNGIAVYMGEGKLTGKG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEECCCC
RLSVTAPDGKTSELTAKNIIIATGARARDLPFPKADGKRVWTYRHAMNPPEMPNKLLVIG
EEEEECCCCCCCCEEECEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEE
SGAIGIEFASFYNDMGAEVTVVEMLDRIVPVEDADVSTFLEKALVKQGMKILTGAGVQKL
CCCCCEEHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHEECCCCCEEE
DIGATGVTVAIKARDGKLVSDEYSHVIVAIGIVPNTETVGLEALGVKTERGHIVTDGACR
ECCCCCEEEEEEECCCCEECCCCCEEEEEEEECCCCCCCCEEEEEEEECCCEEEECCCCC
TNVEGIWAIGDATAPPWLAHKASHEGVIAAETIAGQHPHAMDPRNIPGCTYCHPQIASVG
CCCCEEEEECCCCCCCHHHHCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCHHHCC
LTETNAREAGHEVRIGTFPFIGNGKAIALGEPEGFVKTVFDAQTGELLGAHMVGPEVTEM
CCCCCHHHCCCEEEEECCEEECCCCEEEECCCCCHHHHHHCCCCCHHHHHHCCCHHHHHH
IHGFTIGRTLETTEAELMETVFPHPTISETMHESVLAAFGRAVHI
HHCEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]