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The map label for this gene is aroA [H]

Identifier: 148379444

GI number: 148379444

Start: 1603556

End: 1604356

Strand: Direct

Name: aroA [H]

Synonym: CBO1472

Alternate gene names: 148379444

Gene position: 1603556-1604356 (Clockwise)

Preceding gene: 148379443

Following gene: 148379445

Centisome position: 41.26

GC content: 30.84

Gene sequence:

>801_bases
ATGGAAAAATTATTAATAGATAAGAAAAATGGTGAAAACATTAGAGTGAAGGTAGGAGATATAGTTATAGGTGGAGAAGA
AAAGATAATTATATCAGGACCCTGCGCTGTAGAAGATGAGAAAACAGTTGTGGCTATAGCAGAAAACCTTAAAAAATTAG
GCGTTCATATGTTAAGAGGAGGAGCCTTCAAACCAAGAACTTCTCCTTATTCTTTCCAAGGTTTAAAATTTGAGGGACTT
AAAATTTTAAAAGAATGTGGAAAGAAATTTAATATGCCTATAGTAAGCGAAGTAATGGATGCTAGGGATTTAAAAGAAGC
TTATGATTATATTGATATGATACAAATAGGTTCAAGAAATATGTATAACTACACTCTATTAAGAGAAGTAGGAAAGACAA
AAAAACCTATTCTTTTAAAAAGAGGCATGAGTGCTACTCTTAATGAATGGATTTATGCAGCAGAGTATATAATGAGTGAA
GGTAATATGAATGTAGTATTATGTGAAAGAGGTATAAGAACCTTTGAAAGTTATACAAGAAACACACTAGATTTAAATAC
TGTAGCCGTAATAAAGGATAAATATAGAGTTCCTATAATAGTAGATCCAAGTCATGCTACAGGCTTTAGGGAATATGTAA
AACCAATGTCTTTAGCTTCTATAGCGGGAGGAGCGGATGGACTTATAATAGAAAGTCATATAAATCCTGATAATGCTATA
TCTGATGCTAGACAGACTATAAATGTTAAAGAGATGAAAGAAATAATTGATAAAGTAAAACAAATGGATAAAATATTATA
G

Upstream 100 bases:

>100_bases
TTTAAAAGTTTAAAATAATATATAAAATACTTTAATAGTATATAAAAACATTAGTCTAAAGAAGAGAGAAAAGAAAGAAA
TTTTCGTAGGTGATATTTTA

Downstream 100 bases:

>100_bases
TGTAATTTTTTATACTTTTAGTTGCTAGGATACTTGATAAGTTATTGTAAAATTTTATAAATAAAAATATTTTTATGGAA
ATTTGGGTTAATAGGTTAAA

Product: 3-deoxy-7-phosphoheptulonate synthase

Products: NA

Alternate protein names: Phospho-2-dehydro-3-deoxyheptonate aldolase; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase; Chorismate mutase [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MEKLLIDKKNGENIRVKVGDIVIGGEEKIIISGPCAVEDEKTVVAIAENLKKLGVHMLRGGAFKPRTSPYSFQGLKFEGL
KILKECGKKFNMPIVSEVMDARDLKEAYDYIDMIQIGSRNMYNYTLLREVGKTKKPILLKRGMSATLNEWIYAAEYIMSE
GNMNVVLCERGIRTFESYTRNTLDLNTVAVIKDKYRVPIIVDPSHATGFREYVKPMSLASIAGGADGLIIESHINPDNAI
SDARQTINVKEMKEIIDKVKQMDKIL

Sequences:

>Translated_266_residues
MEKLLIDKKNGENIRVKVGDIVIGGEEKIIISGPCAVEDEKTVVAIAENLKKLGVHMLRGGAFKPRTSPYSFQGLKFEGL
KILKECGKKFNMPIVSEVMDARDLKEAYDYIDMIQIGSRNMYNYTLLREVGKTKKPILLKRGMSATLNEWIYAAEYIMSE
GNMNVVLCERGIRTFESYTRNTLDLNTVAVIKDKYRVPIIVDPSHATGFREYVKPMSLASIAGGADGLIIESHINPDNAI
SDARQTINVKEMKEIIDKVKQMDKIL
>Mature_266_residues
MEKLLIDKKNGENIRVKVGDIVIGGEEKIIISGPCAVEDEKTVVAIAENLKKLGVHMLRGGAFKPRTSPYSFQGLKFEGL
KILKECGKKFNMPIVSEVMDARDLKEAYDYIDMIQIGSRNMYNYTLLREVGKTKKPILLKRGMSATLNEWIYAAEYIMSE
GNMNVVLCERGIRTFESYTRNTLDLNTVAVIKDKYRVPIIVDPSHATGFREYVKPMSLASIAGGADGLIIESHINPDNAI
SDARQTINVKEMKEIIDKVKQMDKIL

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2876

COG function: function code E; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 chorismate mutase domain [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=271, Percent_Identity=23.9852398523985, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR002701
- InterPro:   IPR010954
- InterPro:   IPR020822
- InterPro:   IPR006218
- InterPro:   IPR006268 [H]

Pfam domain/function: PF01817 CM_2; PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.54; =5.4.99.5 [H]

Molecular weight: Translated: 29878; Mature: 29878

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLLIDKKNGENIRVKVGDIVIGGEEKIIISGPCAVEDEKTVVAIAENLKKLGVHMLRG
CCCCEEECCCCCEEEEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCC
GAFKPRTSPYSFQGLKFEGLKILKECGKKFNMPIVSEVMDARDLKEAYDYIDMIQIGSRN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
MYNYTLLREVGKTKKPILLKRGMSATLNEWIYAAEYIMSEGNMNVVLCERGIRTFESYTR
CHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCC
NTLDLNTVAVIKDKYRVPIIVDPSHATGFREYVKPMSLASIAGGADGLIIESHINPDNAI
CCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
SDARQTINVKEMKEIIDKVKQMDKIL
HHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKLLIDKKNGENIRVKVGDIVIGGEEKIIISGPCAVEDEKTVVAIAENLKKLGVHMLRG
CCCCEEECCCCCEEEEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCC
GAFKPRTSPYSFQGLKFEGLKILKECGKKFNMPIVSEVMDARDLKEAYDYIDMIQIGSRN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
MYNYTLLREVGKTKKPILLKRGMSATLNEWIYAAEYIMSEGNMNVVLCERGIRTFESYTR
CHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCC
NTLDLNTVAVIKDKYRVPIIVDPSHATGFREYVKPMSLASIAGGADGLIIESHINPDNAI
CCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
SDARQTINVKEMKEIIDKVKQMDKIL
HHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7496534; 9387221; 9384377 [H]