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The map label for this gene is aroA [H]

Identifier: 148379445

GI number: 148379445

Start: 1604490

End: 1605818

Strand: Direct

Name: aroA [H]

Synonym: CBO1473

Alternate gene names: 148379445

Gene position: 1604490-1605818 (Clockwise)

Preceding gene: 148379444

Following gene: 148379446

Centisome position: 41.28

GC content: 28.14

Gene sequence:

>1329_bases
ATGGATTTATTCGTTAAAGGTTTAAAAAAAAGTTTAACAGGAGAATACGAAATAATAGGAGACAAATCTATAGGTCATAG
ATCTTTAATAATAGGAGCATTACCTAAAGGAGAATATAAAGTTTATAATTTCCCTAAAAACTTAGATTGTATGGCCACTT
TAGACTCTATAAAAAAGCTTGGAGTAGATATAAAGGTAGAAGGAAATGTCTTAGAGGTAAATTCTCCTGGTTATGAAAAT
TTTAATAAGAAACCGGAAGTATTACAGGGTAAGAATTCAGGAACCACGGTAAGACTTATGGCGGGTATTTTGAGTGGCAT
AAGGGCAGAAACAAGATTTATAGGCGATGAATCTTTAAGTTGTAGACCTATGAAAAGAATTATAGAACCCTTAGAAAAAA
TGGGAGCAGAAATAGAGAGCAAAGATAATAAGCTACCTCTTAAGTTTTTAAAGCATAGTGGATTAAATTCTATAAAATAT
AATATGGAAATAGCATCAGCCCAAGTAAAATCTTGTATATTATTAGCAGGTTTAATGTCAAAAGGAAAAACCACAATAGT
AGAGAATAAATCTACTAGAGATCATACAGAGAGAATGTTAAAATATTTAGATGCTTCTATAAATATAAGGAATATATATT
CTAAGGATAAAAAGAAAAGTAGTTCTAAAAAGGAAATAACTATAGAAAAGTCTAAATTAAATAGTAAAGATATATATGTA
CCGGGAGATATATCTTCGGCAGCCTTTTTAATTTCAGCGGCTTTACTTATACAAGGTTCTAATCTATGTATAAAAAATGT
ACTTTTAAATGAGGGCAGGATAGAATATATAAATGTTTTAAGGAATATGGGAGCAAATATAGAAATAGAAAAGGGAAAAT
TATTAAATGGTGAACCTGTAGGGAATATATATGTAAAAGAAAGCTATTTAAAGGGTATTACAGTAGAAAAACACATTACG
CCTAATATAATAGATGAAATACCAGTATTATCTGTAATAGCAGCCTTTAGTGAAGGAAAAACTATATTTAAATCTGTAGA
AGAACTAAAATTTAAAGAAAGTGATAGAGTAGAAGCTATTATAGAAAATTTGAAAAGAGCTGATGTAAAAGCCATATATA
AAAATGGAGATTTGATTATAGAAGGAAACAGATCTTACATAGATAAATCCTTAGAGATAGAAAGTTTCAAAGATCACAGA
ATAGCTTTAGCTTTTTTAGTTTTATCTCTAAAAAATAAAAAACATACTTTAATTAAGGATTACCAATGCACAGAAATATC
ATTCCCTAATTCTTTAAGTTTATTTAATCTAGATTACGAGTTAATTTAG

Upstream 100 bases:

>100_bases
TTGATAAGTTATTGTAAAATTTTATAAATAAAAATATTTTTATGGAAATTTGGGTTAATAGGTTAAAAATAGATTAATAT
TAAGAAATTGGTGAATAAAA

Downstream 100 bases:

>100_bases
ATAGGCTTAAATTTCTTATATATATAAAATTTTTACTATAATATATAAATTTAATTTAAAAAAGTAATAGTTATTATAAT
AAGGAGTTTGTTATTATATA

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MDLFVKGLKKSLTGEYEIIGDKSIGHRSLIIGALPKGEYKVYNFPKNLDCMATLDSIKKLGVDIKVEGNVLEVNSPGYEN
FNKKPEVLQGKNSGTTVRLMAGILSGIRAETRFIGDESLSCRPMKRIIEPLEKMGAEIESKDNKLPLKFLKHSGLNSIKY
NMEIASAQVKSCILLAGLMSKGKTTIVENKSTRDHTERMLKYLDASINIRNIYSKDKKKSSSKKEITIEKSKLNSKDIYV
PGDISSAAFLISAALLIQGSNLCIKNVLLNEGRIEYINVLRNMGANIEIEKGKLLNGEPVGNIYVKESYLKGITVEKHIT
PNIIDEIPVLSVIAAFSEGKTIFKSVEELKFKESDRVEAIIENLKRADVKAIYKNGDLIIEGNRSYIDKSLEIESFKDHR
IALAFLVLSLKNKKHTLIKDYQCTEISFPNSLSLFNLDYELI

Sequences:

>Translated_442_residues
MDLFVKGLKKSLTGEYEIIGDKSIGHRSLIIGALPKGEYKVYNFPKNLDCMATLDSIKKLGVDIKVEGNVLEVNSPGYEN
FNKKPEVLQGKNSGTTVRLMAGILSGIRAETRFIGDESLSCRPMKRIIEPLEKMGAEIESKDNKLPLKFLKHSGLNSIKY
NMEIASAQVKSCILLAGLMSKGKTTIVENKSTRDHTERMLKYLDASINIRNIYSKDKKKSSSKKEITIEKSKLNSKDIYV
PGDISSAAFLISAALLIQGSNLCIKNVLLNEGRIEYINVLRNMGANIEIEKGKLLNGEPVGNIYVKESYLKGITVEKHIT
PNIIDEIPVLSVIAAFSEGKTIFKSVEELKFKESDRVEAIIENLKRADVKAIYKNGDLIIEGNRSYIDKSLEIESFKDHR
IALAFLVLSLKNKKHTLIKDYQCTEISFPNSLSLFNLDYELI
>Mature_442_residues
MDLFVKGLKKSLTGEYEIIGDKSIGHRSLIIGALPKGEYKVYNFPKNLDCMATLDSIKKLGVDIKVEGNVLEVNSPGYEN
FNKKPEVLQGKNSGTTVRLMAGILSGIRAETRFIGDESLSCRPMKRIIEPLEKMGAEIESKDNKLPLKFLKHSGLNSIKY
NMEIASAQVKSCILLAGLMSKGKTTIVENKSTRDHTERMLKYLDASINIRNIYSKDKKKSSSKKEITIEKSKLNSKDIYV
PGDISSAAFLISAALLIQGSNLCIKNVLLNEGRIEYINVLRNMGANIEIEKGKLLNGEPVGNIYVKESYLKGITVEKHIT
PNIIDEIPVLSVIAAFSEGKTIFKSVEELKFKESDRVEAIIENLKRADVKAIYKNGDLIIEGNRSYIDKSLEIESFKDHR
IALAFLVLSLKNKKHTLIKDYQCTEISFPNSLSLFNLDYELI

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=438, Percent_Identity=22.6027397260274, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320332, Length=461, Percent_Identity=22.1258134490239, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 49431; Mature: 49431

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS00104 EPSP_SYNTHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLFVKGLKKSLTGEYEIIGDKSIGHRSLIIGALPKGEYKVYNFPKNLDCMATLDSIKKL
CCHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHC
GVDIKVEGNVLEVNSPGYENFNKKPEVLQGKNSGTTVRLMAGILSGIRAETRFIGDESLS
CCEEEECCCEEEECCCCCCCCCCCCHHEECCCCCCCHHHHHHHHHHHHHHHEECCCCCCC
CRPMKRIIEPLEKMGAEIESKDNKLPLKFLKHSGLNSIKYNMEIASAQVKSCILLAGLMS
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHC
KGKTTIVENKSTRDHTERMLKYLDASINIRNIYSKDKKKSSSKKEITIEKSKLNSKDIYV
CCCEEEEECCCCHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCEEEEECCCCCCCCEEE
PGDISSAAFLISAALLIQGSNLCIKNVLLNEGRIEYINVLRNMGANIEIEKGKLLNGEPV
CCCCCHHHHHHHHHHHHCCCCCEEEHHHHCCCCHHHHHHHHHCCCCEEEECCEEECCCCC
GNIYVKESYLKGITVEKHITPNIIDEIPVLSVIAAFSEGKTIFKSVEELKFKESDRVEAI
CEEEEEEHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHH
IENLKRADVKAIYKNGDLIIEGNRSYIDKSLEIESFKDHRIALAFLVLSLKNKKHTLIKD
HHHHHHHHHHEEEECCCEEEECCHHHHCCCCEECCCCCHHHHHHHHHHHHCCCCCCEEEC
YQCTEISFPNSLSLFNLDYELI
CEEEEECCCCCEEEEECCEEEC
>Mature Secondary Structure
MDLFVKGLKKSLTGEYEIIGDKSIGHRSLIIGALPKGEYKVYNFPKNLDCMATLDSIKKL
CCHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHC
GVDIKVEGNVLEVNSPGYENFNKKPEVLQGKNSGTTVRLMAGILSGIRAETRFIGDESLS
CCEEEECCCEEEECCCCCCCCCCCCHHEECCCCCCCHHHHHHHHHHHHHHHEECCCCCCC
CRPMKRIIEPLEKMGAEIESKDNKLPLKFLKHSGLNSIKYNMEIASAQVKSCILLAGLMS
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHC
KGKTTIVENKSTRDHTERMLKYLDASINIRNIYSKDKKKSSSKKEITIEKSKLNSKDIYV
CCCEEEEECCCCHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCEEEEECCCCCCCCEEE
PGDISSAAFLISAALLIQGSNLCIKNVLLNEGRIEYINVLRNMGANIEIEKGKLLNGEPV
CCCCCHHHHHHHHHHHHCCCCCEEEHHHHCCCCHHHHHHHHHCCCCEEEECCEEECCCCC
GNIYVKESYLKGITVEKHITPNIIDEIPVLSVIAAFSEGKTIFKSVEELKFKESDRVEAI
CEEEEEEHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHH
IENLKRADVKAIYKNGDLIIEGNRSYIDKSLEIESFKDHRIALAFLVLSLKNKKHTLIKD
HHHHHHHHHHEEEECCCEEEECCHHHHCCCCEECCCCCHHHHHHHHHHHHCCCCCCEEEC
YQCTEISFPNSLSLFNLDYELI
CEEEEECCCCCEEEEECCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]