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The map label for this gene is grdA

Identifier: 148379245

GI number: 148379245

Start: 1376386

End: 1376514

Strand: Direct

Name: grdA

Synonym: CBO1261

Alternate gene names: 148379245

Gene position: 1376386-1376514 (Clockwise)

Preceding gene: 148379244

Following gene: 148379246

Centisome position: 35.41

GC content: 35.66

Gene sequence:

>477_bases
ATGAGTCTATTTGAAGGGAAAAAAGTAATAATAATTGGAGATAGAGATGGAATACCAGGTCCAGCTATAGAAAAATGCAT
AGAAGGTACAGGCGCTGAAGTAGTTTTTTCATCCACAGAATGCTTTGTTTGAACTGCCGCCGGAGCAATGGATTTGGAAA
ATCAAAAAAGAGTAAAAACATTAACAGAAAAACATGGTGCTGAAAATATATTAGTAATTTTAGGTGCAGCAGAGGGAGAA
GCAGCAGGTCTTGCTGCGGAGACAGTTACTAATGGAGATCCAACTTTTGCAGGTCCATTGTCCAATGTCCAGTTAGGACT
AAGGGTTTATCATGCGGTAGAACCAGAATTTAAAGAAGAAGTGAATGAAGAAGTTTATGAGGAAGAAATAGGTATGATGG
AAATGGTTTTAGAGGTAGATGAAATTATAGAAGAGATGACAGATATAAGAACAGAGTTTTGTAAATTCCTTGATTAA

Upstream 100 bases:

>100_bases
AAACACACACTATAAAATTTTAAAGATTATTTAGTCATTTAAAGTGTGTATATAAATATCAAGGAATTTAAAATATAAAT
AAATTAAGGGAGGAATTTTA

Downstream 100 bases:

>100_bases
AACAGGGAAAGTAGATAAATAAAGAATTATAAAATTTAAGAGGCTGTACTATAGGTTTATAATCCAGCCTCCTAAATATT
AGGGGGGAAAAGCTATGAAT

Product: glycine/sarcosine/betaine reductase complex protein A

Products: NA

Alternate protein names: Selenoprotein PA; Thioredoxin reductase complex selenoprotein A

Number of amino acids: Translated: 43; Mature: 42

Protein sequence:

>157_residues
MSLFEGKKVIIIGDRDGIPGPAIEKCIEGTGAEVVFSSTECFVTAAGAMDLENQKRVKTLTEKHGAENILVILGAAEGEA
AGLAAETVTNGDPTFAGPLSNVQLGLRVYHAVEPEFKEEVNEEVYEEEIGMMEMVLEVDEIIEEMTDIRTEFCKFLD

Sequences:

>Translated_43_residues
MSLFEGKKVIIIGDRDGIPGPAIEKCIEGTGAEVVFSSTECFV
>Mature_42_residues
SLFEGKKVIIIGDRDGIPGPAIEKCIEGTGAEVVFSSTECFV

Specific function: In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a c

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the grdA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GRDA_CLOB1 (A7FTE0)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001383617.1
- STRING:   A7FTE0
- GeneID:   5394978
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_1290
- eggNOG:   NOG45844
- HOGENOM:   HBG305084
- ProtClustDB:   PRK13265
- BioCyc:   CBOT441770:CLB_1290-MONOMER
- HAMAP:   MF_00826
- InterPro:   IPR006812
- PIRSF:   PIRSF000181

Pfam domain/function: PF04723 GRDA

EC number: =1.21.4.2; =1.21.4.3; =1.21.4.4

Molecular weight: Translated: 4544; Mature: 4413

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: NA

Important sites: ACT_SITE 44-44

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFEGKKVIIIGDRDGIPGPAIEKCIEGTGAEVVFSSTECFV
CCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEEEECCEECC
>Mature Secondary Structure 
SLFEGKKVIIIGDRDGIPGPAIEKCIEGTGAEVVFSSTECFV
CCCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA