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The map label for this gene is fabG [C]

Identifier: 148360523

GI number: 148360523

Start: 1017273

End: 1018121

Strand: Reverse

Name: fabG [C]

Synonym: LPC_2464

Alternate gene names: 148360523

Gene position: 1018121-1017273 (Counterclockwise)

Preceding gene: 148360521

Following gene: 148360529

Centisome position: 28.47

GC content: 37.1

Gene sequence:

>849_bases
ATGAATGTAGTAATTATCACTGGTGCAGCAAGTGGCATTGGACATGCCGTAAGTCAAGTTTGTCTTGGAAGTGGAAAAAC
TATAGTCATGGTTGATAAGAATCAGGACAAATTACATACAGAAGCCCAATCATTCATGACTAAATTCTCTCCTGAACATG
TTATTTGTTTTGCCTGCGATGTAACCCAACCATCAGAAGTAGAACGACTTGCAGAATATTCCTGTAAACAACTAGGCCAG
GTAGACTGGATATTTAATAATGCTGGGATCATTGGCAATTTACTTCCTGCCTGGGAACTGCAAGAAAATGATATTAATCA
GGTAATGCAAGTAAATTTGCATGGGATGCTTAATATAATTCGCTCATTCATGCCTTATTTATTCAAACAGAATTTCCGTT
CTCATATTATCAACATGGCAAGCCTGTATGCCTTATGTACAGGCTCACAAATGGCCGCCTATTCCATGTCAAAACATGCC
GTATTAGCCTTATCCGAGTCATTATATTTTGATTTAAATCGCCTTAAAAAACCTGTAGATGTTTCTGTAGTATTTCCTTC
TTTTACAGATACCTCGTTATTAGCGAGTAGTGGGAAATTAAACCATTCTCCAATCCACAATCAATTAAATAACTTGTTAG
CACATTCTCGACCCGCCATTGAAGTTGCAGAACATATAGTAAGGGAAGTTGAACAAAAAAGATTTTATATATTGCCTGAT
AAAGAAGTTAAAGGGTATTGTGAAGACAGAACCAAAGCCATCCTGTTGCAGGAAAATCCTCATCGTAACAGCGTCGAACA
ATTAATGTGTTCTTTATTAAAGCGCCAATCATCAGAAGCCAATCTGTAA

Upstream 100 bases:

>100_bases
TAAACTAAATGACCGAATTAAAAACTTTTTTTAACGAAGAGATTGGGGTTTTTCGTAAGTCCTGAAGAAGAGGGCATTAA
ACTTTTGTAAGGTATTTTAT

Downstream 100 bases:

>100_bases
ATTGTTTGTGATTTTCAAAACAGAATAAGTGTAACCCGGCTTATAACTGATGTGAGCATCCATGCTTTAACATTCATGTA
CTCATAACGAATCTAGGGAT

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MNVVIITGAASGIGHAVSQVCLGSGKTIVMVDKNQDKLHTEAQSFMTKFSPEHVICFACDVTQPSEVERLAEYSCKQLGQ
VDWIFNNAGIIGNLLPAWELQENDINQVMQVNLHGMLNIIRSFMPYLFKQNFRSHIINMASLYALCTGSQMAAYSMSKHA
VLALSESLYFDLNRLKKPVDVSVVFPSFTDTSLLASSGKLNHSPIHNQLNNLLAHSRPAIEVAEHIVREVEQKRFYILPD
KEVKGYCEDRTKAILLQENPHRNSVEQLMCSLLKRQSSEANL

Sequences:

>Translated_282_residues
MNVVIITGAASGIGHAVSQVCLGSGKTIVMVDKNQDKLHTEAQSFMTKFSPEHVICFACDVTQPSEVERLAEYSCKQLGQ
VDWIFNNAGIIGNLLPAWELQENDINQVMQVNLHGMLNIIRSFMPYLFKQNFRSHIINMASLYALCTGSQMAAYSMSKHA
VLALSESLYFDLNRLKKPVDVSVVFPSFTDTSLLASSGKLNHSPIHNQLNNLLAHSRPAIEVAEHIVREVEQKRFYILPD
KEVKGYCEDRTKAILLQENPHRNSVEQLMCSLLKRQSSEANL
>Mature_282_residues
MNVVIITGAASGIGHAVSQVCLGSGKTIVMVDKNQDKLHTEAQSFMTKFSPEHVICFACDVTQPSEVERLAEYSCKQLGQ
VDWIFNNAGIIGNLLPAWELQENDINQVMQVNLHGMLNIIRSFMPYLFKQNFRSHIINMASLYALCTGSQMAAYSMSKHA
VLALSESLYFDLNRLKKPVDVSVVFPSFTDTSLLASSGKLNHSPIHNQLNNLLAHSRPAIEVAEHIVREVEQKRFYILPD
KEVKGYCEDRTKAILLQENPHRNSVEQLMCSLLKRQSSEANL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI31542939, Length=196, Percent_Identity=28.0612244897959, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI20149619, Length=241, Percent_Identity=24.4813278008299, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI40254992, Length=191, Percent_Identity=28.2722513089005, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4503817, Length=242, Percent_Identity=27.6859504132231, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI310128830, Length=200, Percent_Identity=26, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI310115468, Length=200, Percent_Identity=26, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI224922801, Length=167, Percent_Identity=28.7425149700599, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI40807363, Length=239, Percent_Identity=26.7782426778243, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1787335, Length=192, Percent_Identity=23.9583333333333, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=202, Percent_Identity=26.2376237623762, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193203117, Length=194, Percent_Identity=28.3505154639175, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=194, Percent_Identity=28.3505154639175, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=193, Percent_Identity=25.3886010362694, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=231, Percent_Identity=25.1082251082251, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=250, Percent_Identity=24, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=194, Percent_Identity=29.8969072164948, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=233, Percent_Identity=23.175965665236, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=197, Percent_Identity=25.8883248730964, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=248, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24663911, Length=202, Percent_Identity=27.7227722772277, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281364892, Length=194, Percent_Identity=28.8659793814433, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641232, Length=204, Percent_Identity=26.9607843137255, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI23397609, Length=192, Percent_Identity=27.6041666666667, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI116007236, Length=201, Percent_Identity=25.8706467661692, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28571387, Length=208, Percent_Identity=26.4423076923077, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357041, Length=196, Percent_Identity=27.0408163265306, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24581726, Length=170, Percent_Identity=24.1176470588235, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI116007234, Length=205, Percent_Identity=27.8048780487805, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639444, Length=197, Percent_Identity=25.8883248730964, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI116007238, Length=190, Percent_Identity=25.7894736842105, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644339, Length=197, Percent_Identity=28.4263959390863, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24643142, Length=194, Percent_Identity=27.8350515463918, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665243, Length=194, Percent_Identity=25.7731958762887, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221331218, Length=194, Percent_Identity=25.7731958762887, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571526, Length=197, Percent_Identity=26.9035532994924, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21358495, Length=197, Percent_Identity=27.9187817258883, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31607; Mature: 31607

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVVIITGAASGIGHAVSQVCLGSGKTIVMVDKNQDKLHTEAQSFMTKFSPEHVICFACD
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEC
VTQPSEVERLAEYSCKQLGQVDWIFNNAGIIGNLLPAWELQENDINQVMQVNLHGMLNII
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RSFMPYLFKQNFRSHIINMASLYALCTGSQMAAYSMSKHAVLALSESLYFDLNRLKKPVD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHEEEHHHHHHHHHHCCCCCE
VSVVFPSFTDTSLLASSGKLNHSPIHNQLNNLLAHSRPAIEVAEHIVREVEQKRFYILPD
EEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEECCC
KEVKGYCEDRTKAILLQENPHRNSVEQLMCSLLKRQSSEANL
HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNVVIITGAASGIGHAVSQVCLGSGKTIVMVDKNQDKLHTEAQSFMTKFSPEHVICFACD
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEC
VTQPSEVERLAEYSCKQLGQVDWIFNNAGIIGNLLPAWELQENDINQVMQVNLHGMLNII
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RSFMPYLFKQNFRSHIINMASLYALCTGSQMAAYSMSKHAVLALSESLYFDLNRLKKPVD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHEEEHHHHHHHHHHCCCCCE
VSVVFPSFTDTSLLASSGKLNHSPIHNQLNNLLAHSRPAIEVAEHIVREVEQKRFYILPD
EEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEECCC
KEVKGYCEDRTKAILLQENPHRNSVEQLMCSLLKRQSSEANL
HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]