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The map label for this gene is trpC [H]

Identifier: 148360521

GI number: 148360521

Start: 1018597

End: 1019373

Strand: Reverse

Name: trpC [H]

Synonym: LPC_2462

Alternate gene names: 148360521

Gene position: 1019373-1018597 (Counterclockwise)

Preceding gene: 148360520

Following gene: 148360523

Centisome position: 28.5

GC content: 35.78

Gene sequence:

>777_bases
ATGAATAGTATCCTGGAACGAATAGCCAAACATAAACTAGAAGAAGTTGCAGTTGCGAAAAAAAATAAGCCTTTACATGT
TCTGTCAAAACAACAACCGGGGGAAATACGTGACTTCATAACTGCTTTAAAATCCAATACCTCACCTGCAGTCATAGCCG
AGATAAAAAAGGCTTCTCCAAGCAAAGGTCTAATTCGAAAAGATTTTAATGTTGCAGAAATTGCCAAGATTTATACCCAA
AATGGCGCAAGATGCTTATCCGTTTTAACGGATATTGAGTTTTTTCAAGGTCATCCTGATTATTTGGCTTTAGCAAAATC
AAAAACTACTTTGCCCGTATTGCGTAAAGACTTTATTATTGATTCTTATCAAATCTATGAAAGCCTTGTCTTGGGTGCTG
ATTGCATTTTACTGATTGTCGCATTATTAGATGATGTTCAATTAATGGATTTTTGCCAACTGGCTCAAGAACTTAAAATG
TCTGTTTTGGTTGAAAGCCACACGCAAGATGAATTAGAAAGAGCATTACGCTTACCCACCCCTCTTATAGGCATTAATAA
CCGCAGCCTACACAACTTTAAAACAGACATTCAACTGAGTATCCAATTAAAACAATTTGTTCCTAAAGATAAAATTATTA
TTACTGAAAGCGGAATCAACACCCGTGAAGACATAAAATTAATGCAATCCCATGGCATTAATGCCTTTTTGATTGGAGAG
AGTTTAATGAGGGCAGATAACATCGGGAAAGCATTACAGAAACTAATGACTGACTAA

Upstream 100 bases:

>100_bases
TCCATAGAGGAAGCAAGAATTGCGATTGATAGTGGTAAAGCAAATCATTGTTTTAACAAACTCCGATTATTGACCCAAAC
TTTAAATAAAGAATCAAATC

Downstream 100 bases:

>100_bases
ATAAACTACTCAAAACCTGGCTCAGGAGTTTGACTTGGCTCAGGCTCAGGCAATTCGGGATAACCAGGCTCCAGAGGCTC
TGGATTATCAGGGTACTCCA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MNSILERIAKHKLEEVAVAKKNKPLHVLSKQQPGEIRDFITALKSNTSPAVIAEIKKASPSKGLIRKDFNVAEIAKIYTQ
NGARCLSVLTDIEFFQGHPDYLALAKSKTTLPVLRKDFIIDSYQIYESLVLGADCILLIVALLDDVQLMDFCQLAQELKM
SVLVESHTQDELERALRLPTPLIGINNRSLHNFKTDIQLSIQLKQFVPKDKIIITESGINTREDIKLMQSHGINAFLIGE
SLMRADNIGKALQKLMTD

Sequences:

>Translated_258_residues
MNSILERIAKHKLEEVAVAKKNKPLHVLSKQQPGEIRDFITALKSNTSPAVIAEIKKASPSKGLIRKDFNVAEIAKIYTQ
NGARCLSVLTDIEFFQGHPDYLALAKSKTTLPVLRKDFIIDSYQIYESLVLGADCILLIVALLDDVQLMDFCQLAQELKM
SVLVESHTQDELERALRLPTPLIGINNRSLHNFKTDIQLSIQLKQFVPKDKIIITESGINTREDIKLMQSHGINAFLIGE
SLMRADNIGKALQKLMTD
>Mature_258_residues
MNSILERIAKHKLEEVAVAKKNKPLHVLSKQQPGEIRDFITALKSNTSPAVIAEIKKASPSKGLIRKDFNVAEIAKIYTQ
NGARCLSVLTDIEFFQGHPDYLALAKSKTTLPVLRKDFIIDSYQIYESLVLGADCILLIVALLDDVQLMDFCQLAQELKM
SVLVESHTQDELERALRLPTPLIGINNRSLHNFKTDIQLSIQLKQFVPKDKIIITESGINTREDIKLMQSHGINAFLIGE
SLMRADNIGKALQKLMTD

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=256, Percent_Identity=38.671875, Blast_Score=169, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=229, Percent_Identity=38.8646288209607, Blast_Score=154, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28932; Mature: 28932

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSILERIAKHKLEEVAVAKKNKPLHVLSKQQPGEIRDFITALKSNTSPAVIAEIKKASP
CHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCC
SKGLIRKDFNVAEIAKIYTQNGARCLSVLTDIEFFQGHPDYLALAKSKTTLPVLRKDFII
CCCCHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHH
DSYQIYESLVLGADCILLIVALLDDVQLMDFCQLAQELKMSVLVESHTQDELERALRLPT
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
PLIGINNRSLHNFKTDIQLSIQLKQFVPKDKIIITESGINTREDIKLMQSHGINAFLIGE
CEEECCCCCCCCCCCCEEEEEEHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEHHH
SLMRADNIGKALQKLMTD
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSILERIAKHKLEEVAVAKKNKPLHVLSKQQPGEIRDFITALKSNTSPAVIAEIKKASP
CHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCC
SKGLIRKDFNVAEIAKIYTQNGARCLSVLTDIEFFQGHPDYLALAKSKTTLPVLRKDFII
CCCCHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHH
DSYQIYESLVLGADCILLIVALLDDVQLMDFCQLAQELKMSVLVESHTQDELERALRLPT
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
PLIGINNRSLHNFKTDIQLSIQLKQFVPKDKIIITESGINTREDIKLMQSHGINAFLIGE
CEEECCCCCCCCCCCCEEEEEEHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEHHH
SLMRADNIGKALQKLMTD
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA