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The map label for this gene is purM [H]

Identifier: 148359214

GI number: 148359214

Start: 1935733

End: 1936776

Strand: Reverse

Name: purM [H]

Synonym: LPC_1108

Alternate gene names: 148359214

Gene position: 1936776-1935733 (Counterclockwise)

Preceding gene: 148359215

Following gene: 148359213

Centisome position: 54.15

GC content: 40.04

Gene sequence:

>1044_bases
ATGTCTACTATCAATTACAAATCAGCGGGTGTCGATATCGAGGCGGGAAATGAAGCTGTCGCACGCATTAAACGTAATGT
TGAAAAAACATTTTCGCCTCAAGTCCTGACAGGAATCGGTAGTTTTGGCGCAATGTATGATTTGAAGCCTTTTATGGAAA
AATTCAAACACCCCGTCATGGTTCAAAGCATTGATGGCGTAGGCACGAAGACAATAGTTGCTCGGATGATGCAAAAATTT
GATACAATCGGAATTGATTTGGTCAGTGCGACCACCAACGATATTATTGTGTTGGGTGCAAGGCCATTAACACTTTTGGA
CTATATAGCAACTGATCGATTGAAACCTGAATATATTGAAGAAATTATTATTGGCATGACGCAAGCTTGCCTCGAAAATA
ATATTTCCCTGGTCGGTGGTGAGACGGCTGAAATGCCTGATACCTATCTGAAGGGAGAGCATGATTTGGTAGGTATTATC
ACTGGTGTAGTGGAAAAGGATGAAGCCATACTAGGAAAAGATATAACTCCAGGCGATTCAGTCTTGGCATTTCCTTCCAG
TGGCTTACATACCAATGGATATTCACTTGCCAGAAAACTTTTGTTTGAACTAGGTGGATATACTGTAGAATCCCAACTTG
ACGAGTTGGATGCTACAGTTGGTGAGGCTTTACTGGTACCTCATATCAATTATACAAATCCTGTTCTACACCTGTTGAAT
AACAAAATCCCTATCAAGGGAATGGCTCATATTACTGGCGGAGGTGTACTGGAAAACATTCCGCGAGTATTACCTAATCA
TTGTTCCGTTGAAATCAATAAGAATTCATGTCCGGTGTTGCCGATCTTTAATGTGCTAAAAGCATTGGGGAAACTGGATG
ATCAGGAAATGTATCGTACTTTTAATATGGGAATAGGATTAGTAATGATAGCTTCCCCTGGTGTTGTTTCTGAAATTTAT
ACAGCGCTAAAAGAATTCCCTAATTTCCCTGTTTATGAAGTAGGAAAAGTCGTATCAGGAAAACCAGAAGTGAGATTATT
GTGA

Upstream 100 bases:

>100_bases
CTACAGAGCAGCCAGTTTTACAGATGAATTCGGTTATCAACTTGCCTGTCGAAGAAGCGAGGCAGGCTTGGGAAAATGGC
TTAAGAGAGAGGCTATTATA

Downstream 100 bases:

>100_bases
TGAAGATTGCAGTTGTTCAGTTTCCAGGCTCCAATTGCGAACGTGAGACAATGCTTGCGGTGCAACGAGCAGGTATGACT
CCAGTTGAGTTTCTGTGGAA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSTINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVMVQSIDGVGTKTIVARMMQKF
DTIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIEEIIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGII
TGVVEKDEAILGKDITPGDSVLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDATVGEALLVPHINYTNPVLHLLN
NKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRTFNMGIGLVMIASPGVVSEIY
TALKEFPNFPVYEVGKVVSGKPEVRLL

Sequences:

>Translated_347_residues
MSTINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVMVQSIDGVGTKTIVARMMQKF
DTIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIEEIIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGII
TGVVEKDEAILGKDITPGDSVLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDATVGEALLVPHINYTNPVLHLLN
NKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRTFNMGIGLVMIASPGVVSEIY
TALKEFPNFPVYEVGKVVSGKPEVRLL
>Mature_346_residues
STINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVMVQSIDGVGTKTIVARMMQKFD
TIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIEEIIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGIIT
GVVEKDEAILGKDITPGDSVLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDATVGEALLVPHINYTNPVLHLLNN
KIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRTFNMGIGLVMIASPGVVSEIYT
ALKEFPNFPVYEVGKVVSGKPEVRLL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=349, Percent_Identity=38.3954154727794, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI209869995, Length=349, Percent_Identity=38.3954154727794, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI209869993, Length=349, Percent_Identity=38.3954154727794, Blast_Score=238, Evalue=7e-63,
Organism=Escherichia coli, GI1788845, Length=347, Percent_Identity=42.9394812680115, Blast_Score=265, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17567511, Length=345, Percent_Identity=39.4202898550725, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=35.5029585798817, Blast_Score=206, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24582400, Length=289, Percent_Identity=34.9480968858132, Blast_Score=174, Evalue=8e-44,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37689; Mature: 37558

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVM
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
VQSIDGVGTKTIVARMMQKFDTIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIE
EEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCHHHHHHHHHHCCCCHHHHH
EIIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGIITGVVEKDEAILGKDITPGDS
HHHHHHHHHHHHCCCEEECCCCCCCCHHHHCCCCCHHHHHHHHHHCCCHHHCCCCCCCCC
VLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDATVGEALLVPHINYTNPVLHLLN
EEEECCCCCCCCHHHHHHHHHHHHCCEEHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHC
NKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRT
CCCCCCEEEEECCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHH
FNMGIGLVMIASPGVVSEIYTALKEFPNFPVYEVGKVVSGKPEVRLL
HHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEC
>Mature Secondary Structure 
STINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVM
CCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
VQSIDGVGTKTIVARMMQKFDTIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIE
EEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCHHHHHHHHHHCCCCHHHHH
EIIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGIITGVVEKDEAILGKDITPGDS
HHHHHHHHHHHHCCCEEECCCCCCCCHHHHCCCCCHHHHHHHHHHCCCHHHCCCCCCCCC
VLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDATVGEALLVPHINYTNPVLHLLN
EEEECCCCCCCCHHHHHHHHHHHHCCEEHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHC
NKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRT
CCCCCCEEEEECCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHH
FNMGIGLVMIASPGVVSEIYTALKEFPNFPVYEVGKVVSGKPEVRLL
HHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA