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The map label for this gene is purQ [H]

Identifier: 148359213

GI number: 148359213

Start: 1934474

End: 1935733

Strand: Reverse

Name: purQ [H]

Synonym: LPC_1107

Alternate gene names: 148359213

Gene position: 1935733-1934474 (Counterclockwise)

Preceding gene: 148359214

Following gene: 148359212

Centisome position: 54.12

GC content: 37.78

Gene sequence:

>1260_bases
ATGAAGATTGCAGTTGTTCAGTTTCCAGGCTCCAATTGCGAACGTGAGACAATGCTTGCGGTGCAACGAGCAGGTATGAC
TCCAGTTGAGTTTCTGTGGAATGATTCATCACAAAAACTGCGAGAAATGGATGGTTATATTATTATTGGTGGTTTTTCAT
ATGAGGATAGATCAAGAGCAGGAATTATTGCAGCCCTTGATCCGGTAATGAAAGAAATAAAATTGCAGAGTGAATTGGGA
AAACCTGTTCTTGGTATTTGCAATGGAGCACAGATCCTTGTTGAAACAGGCCTCGTTCCTGGTTTAAAAAACTATCAAAT
TGGTATGGCTCTGACTGAGAATAAGCGAATTCAGGATGGAAAAATTTTAGGAACAGGATTTTATAACAGCTGGATTCATA
TGCGAACCGGTGACCGAGTGAGGCAAAATGCATTCACCCGCTATTTATCAAAGGATTCTGTATTATCAATTCCTGCTGCC
CATGCTGAAGGGCGTTTTGTGATGCCTGTTAAATTATTGCAAGAAATTGAAGAAGAAGGTTTAAATGCGTTTCAATATTG
TGATGCGCAGGGAAACAGAGATGATAATTTCCCCGTTAATCCTAATGGTTCTCTACGGAATATTGCCGCTATTATTAATA
AAGCGGGTAATGTCATGGCCATAATGCCTCACCCTGAACGTACATTTGCGGGAGATCCTATATTCCATTCAATGAAAGAA
TATATTAAGGAGAAAAAAACATTCAAGCAGCAAACATTATCTTATCAACCGGAGCCAGTTAAAATAATTCCTTATGACAA
AAAAGACAATGCCCATGAGTTGATTGTTAAATTGATTATTACCGATAATGCTGCTTTAACAGTACAAAATACGCTAAGAC
AGTTAGGTATACCAGTCACAGTTAATCGTATGATGTATTGGCATGTCGATACAAATTTTCCTGAAACAATCGAAAAAATA
AAGCAGACAGGGGTTTTATATAATGATCGGAAAGAGTATTTGGTAACGTCTGAGCATATATTTTCATCAGCAGCCAAGGC
TTTTTTGGTTAAATCAAAAGACGATATGATCGGGCAACAGAAGCTGCAAATGCTTCGGGATCATTTCTCAATTGATGGCG
TTGATGCCATACACCATGGTGTTTTGTGGATGTTTAGCAGTGAAAATGTTAAAATACAAGAATTGGCAGAATCCATTTTA
GCTACTAATATTATCTTTAACCCTAATGCTCATATCTGCTATGAATACCAATGTCCCTAG

Upstream 100 bases:

>100_bases
TTGTTTCTGAAATTTATACAGCGCTAAAAGAATTCCCTAATTTCCCTGTTTATGAAGTAGGAAAAGTCGTATCAGGAAAA
CCAGAAGTGAGATTATTGTG

Downstream 100 bases:

>100_bases
TCAAGAGGATCTTCTTGCTGCGTTGCCTTTTTGCTTAACCGAAACCTCTTTACCTTTCGGCAAAAAGTATAAAGGGAAAG
TAAGGGATACCTATGATCTC

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKIAVVQFPGSNCERETMLAVQRAGMTPVEFLWNDSSQKLREMDGYIIIGGFSYEDRSRAGIIAALDPVMKEIKLQSELG
KPVLGICNGAQILVETGLVPGLKNYQIGMALTENKRIQDGKILGTGFYNSWIHMRTGDRVRQNAFTRYLSKDSVLSIPAA
HAEGRFVMPVKLLQEIEEEGLNAFQYCDAQGNRDDNFPVNPNGSLRNIAAIINKAGNVMAIMPHPERTFAGDPIFHSMKE
YIKEKKTFKQQTLSYQPEPVKIIPYDKKDNAHELIVKLIITDNAALTVQNTLRQLGIPVTVNRMMYWHVDTNFPETIEKI
KQTGVLYNDRKEYLVTSEHIFSSAAKAFLVKSKDDMIGQQKLQMLRDHFSIDGVDAIHHGVLWMFSSENVKIQELAESIL
ATNIIFNPNAHICYEYQCP

Sequences:

>Translated_419_residues
MKIAVVQFPGSNCERETMLAVQRAGMTPVEFLWNDSSQKLREMDGYIIIGGFSYEDRSRAGIIAALDPVMKEIKLQSELG
KPVLGICNGAQILVETGLVPGLKNYQIGMALTENKRIQDGKILGTGFYNSWIHMRTGDRVRQNAFTRYLSKDSVLSIPAA
HAEGRFVMPVKLLQEIEEEGLNAFQYCDAQGNRDDNFPVNPNGSLRNIAAIINKAGNVMAIMPHPERTFAGDPIFHSMKE
YIKEKKTFKQQTLSYQPEPVKIIPYDKKDNAHELIVKLIITDNAALTVQNTLRQLGIPVTVNRMMYWHVDTNFPETIEKI
KQTGVLYNDRKEYLVTSEHIFSSAAKAFLVKSKDDMIGQQKLQMLRDHFSIDGVDAIHHGVLWMFSSENVKIQELAESIL
ATNIIFNPNAHICYEYQCP
>Mature_419_residues
MKIAVVQFPGSNCERETMLAVQRAGMTPVEFLWNDSSQKLREMDGYIIIGGFSYEDRSRAGIIAALDPVMKEIKLQSELG
KPVLGICNGAQILVETGLVPGLKNYQIGMALTENKRIQDGKILGTGFYNSWIHMRTGDRVRQNAFTRYLSKDSVLSIPAA
HAEGRFVMPVKLLQEIEEEGLNAFQYCDAQGNRDDNFPVNPNGSLRNIAAIINKAGNVMAIMPHPERTFAGDPIFHSMKE
YIKEKKTFKQQTLSYQPEPVKIIPYDKKDNAHELIVKLIITDNAALTVQNTLRQLGIPVTVNRMMYWHVDTNFPETIEKI
KQTGVLYNDRKEYLVTSEHIFSSAAKAFLVKSKDDMIGQQKLQMLRDHFSIDGVDAIHHGVLWMFSSENVKIQELAESIL
ATNIIFNPNAHICYEYQCP

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=247, Percent_Identity=31.5789473684211, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI48994899, Length=251, Percent_Identity=27.8884462151394, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17553022, Length=274, Percent_Identity=26.2773722627737, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321498, Length=244, Percent_Identity=29.9180327868852, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24582111, Length=244, Percent_Identity=31.9672131147541, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24582109, Length=244, Percent_Identity=31.9672131147541, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137292, Length=244, Percent_Identity=31.9672131147541, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010075 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 47343; Mature: 47343

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVVQFPGSNCERETMLAVQRAGMTPVEFLWNDSSQKLREMDGYIIIGGFSYEDRSRA
CEEEEEECCCCCCCHHHHHHHHHCCCCHHHEEECCCHHHHHHCCCEEEEEECCCCCCCCC
GIIAALDPVMKEIKLQSELGKPVLGICNGAQILVETGLVPGLKNYQIGMALTENKRIQDG
CEEEHHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCC
KILGTGFYNSWIHMRTGDRVRQNAFTRYLSKDSVLSIPAAHAEGRFVMPVKLLQEIEEEG
EEEEECCCCCEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCCCCEEEHHHHHHHHHHHC
LNAFQYCDAQGNRDDNFPVNPNGSLRNIAAIINKAGNVMAIMPHPERTFAGDPIFHSMKE
CCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHH
YIKEKKTFKQQTLSYQPEPVKIIPYDKKDNAHELIVKLIITDNAALTVQNTLRQLGIPVT
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHEEEEEEEECCCEEEHHHHHHHCCCCEE
VNRMMYWHVDTNFPETIEKIKQTGVLYNDRKEYLVTSEHIFSSAAKAFLVKSKDDMIGQQ
EEEEEEEEECCCCHHHHHHHHHCCCEEECCCCEEEEHHHHHHHHHHHEEEECCHHHHHHH
KLQMLRDHFSIDGVDAIHHGVLWMFSSENVKIQELAESILATNIIFNPNAHICYEYQCP
HHHHHHHHCCCCCHHHHHCCEEEEEECCCEEHHHHHHHHHHHEEEECCCCCEEEEECCC
>Mature Secondary Structure
MKIAVVQFPGSNCERETMLAVQRAGMTPVEFLWNDSSQKLREMDGYIIIGGFSYEDRSRA
CEEEEEECCCCCCCHHHHHHHHHCCCCHHHEEECCCHHHHHHCCCEEEEEECCCCCCCCC
GIIAALDPVMKEIKLQSELGKPVLGICNGAQILVETGLVPGLKNYQIGMALTENKRIQDG
CEEEHHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCC
KILGTGFYNSWIHMRTGDRVRQNAFTRYLSKDSVLSIPAAHAEGRFVMPVKLLQEIEEEG
EEEEECCCCCEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCCCCEEEHHHHHHHHHHHC
LNAFQYCDAQGNRDDNFPVNPNGSLRNIAAIINKAGNVMAIMPHPERTFAGDPIFHSMKE
CCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHH
YIKEKKTFKQQTLSYQPEPVKIIPYDKKDNAHELIVKLIITDNAALTVQNTLRQLGIPVT
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHEEEEEEEECCCEEEHHHHHHHCCCCEE
VNRMMYWHVDTNFPETIEKIKQTGVLYNDRKEYLVTSEHIFSSAAKAFLVKSKDDMIGQQ
EEEEEEEEECCCCHHHHHHHHHCCCEEECCCCEEEEHHHHHHHHHHHEEEECCHHHHHHH
KLQMLRDHFSIDGVDAIHHGVLWMFSSENVKIQELAESILATNIIFNPNAHICYEYQCP
HHHHHHHHCCCCCHHHHHCCEEEEEECCCEEHHHHHHHHHHHEEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA