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The map label for this gene is purL [H]

Identifier: 148359215

GI number: 148359215

Start: 1936776

End: 1939118

Strand: Reverse

Name: purL [H]

Synonym: LPC_1109

Alternate gene names: 148359215

Gene position: 1939118-1936776 (Counterclockwise)

Preceding gene: 148359216

Following gene: 148359214

Centisome position: 54.22

GC content: 42.17

Gene sequence:

>2343_bases
ATGCAAAATCTTACTGAAACCCTTGATTTTTCTTCTTTGAATCGTGGAGAAATTGAAAAATTACTGCGCGATTATAATTT
AAATCTTTCTGTAGATGAGGCGTTGACTATACAGAATGAATTCCTCAAAAGACCCCCGACTATTTCAGAGTGTGTACTTT
GGTCTATTCAAGGATCAGAACATTGTTCTTATAAAAGCAGCCGTATTCATTTAAAGCAATTCAATACCTCAGGCCCTCAC
GTGATACTGGGCGCCAAGGAGGATGCAGGTATAGTATCTGTAGCCCAAGATAAAAATGGTTATAGATATGGCGTTATTGT
CAGTCATGAATCACATAATCACCCATCTCAAATTGTTCCCTATGAAGGCGCAGCTACCGGAGTTGGTGGTAATGTCCGTG
ATGTCTGTTGTATGGGTGGGGAAGTTATAGCAGTAGCAGACAGTTTGCGTTTCGGAGATATCAAACGTGCACGTACTCAC
TGGATACAGGAAGGGGTGGTTTCAGGTATTGCCGGGTATGGCAATCCTTTGGGAATACCGAATATAGCTGGTGATGTGTA
CTATGATCCGGCCTACAATGAAAATTGTTTGGTTACTGTAGTCACTCTGGGGATAGTAAGAGAGGATCATATTATACATT
CTTATGCTCCGCCCGAAGCTGAGAACTATGTTTTTATTTTAGTAGGTAAGCCAACTGATAATAGTGGGTTTGGCGGCGCG
AGCTTTGCCTCAACAGTATTGGAAGAAGATTCACAAGAAAAGAATAAGGGAGCTGTTCAAGAGCCCAATGCTTTTTTACA
GAGACATCTCCTTAAAGCTAATTATTCATTATTTCAATTACTAAGAGAAAAGAATTTAATTGACAAGGTAGGCTTTAAAG
ATTTAGGAGCAGGTGGCGTGGCCTGCGCAAGTATCGAGTTGGCTGAAGCCGGCGGTTCTTATGGCGCCGAAATTGATCTG
GACAAGGTACCCACAGGAATGCCAGGATTAATGCCTTCAGTCATTCTATGCTCTGAAACTCAGGAGCGTTTTATGTGGGT
TGTTCCCCCTGATTTAGTAGATACTATCCTGAAACACTATAATGAAACCTTCGCGTTACCACAGGTTTCTGAAGGGGCAT
GCGCTGCAGTTATCGGCAAAATTCGTACCGATGGATTATACGTGGTGAATTACAAAGGGCGAGAACTTGTGAGAGCTAAA
GTCCCTGATGTCACGAAAGGCATTGTTTATAACAGGCCACATGCCTCTTCGCAGAAGCAAAACACAGAACCAGTTTTTCT
CCCACCAGATGATTATAATCAAATTTTGTTGCAGTTATTGGCCCATGAGAATATAGCGAGCAAGGAACCTATTTTTGAAA
TGTATGACAAGCAAGTGCAGGGTCGCACCCTCATACAAGCAGGATGGGCTGATGCTGGAGTATTACAACCATTTAATGAA
TCGAAGTATCCTGAGGAAATTCGTAAAACAGGTATTGCCTTGTCTTTAGATCAAAATCCCCGCTATAACAAAATTGATGC
CTATTGGGGAGCTGTTAACGCGGTTGTCGAATCGGTACGGAACATCACTGCAGTTGGAGCTACTCCAGTCGCAATAACAG
ATTGCTTGTGTTTTGGTAATCCGGAAAAGCCAGAACAAATGCGCGAATTTGTTGATTCTGTGCGAGGAATTAGTGATGCC
TGTGCCGCTGTTCATCTGAAAGATCATCCCCAATCAACTTTGCCTGTCATTGCCGGGAATGTCTCATTGTATAATGAATC
AGTGAAAGGGGCTATTCCTCCCAGCCCCATGATTAGTTGCCTGGGAACGCTTCCAGATATTGATTTTGCTATTACCTTTG
ATTTTAAGAAAAGTGATAGCCTATTGATATTGATTGGAGAGCGTAAAGACGAATGTGGTGGTAGCGTTTATTATCAACTC
CATAATGAATTGGGTTCTAATGTTCCAAAACCGGATTTAAGCTTGTTTAATAGAGAAATCCATGCTGTTTCATCGGCAAT
TCAGCATGGGTTGGTTAACGCTGCTCATGATGTCTCAGAGGGAGGGGTTGCTGTTGCTCTTGCTGAGATGAGTTTTAAGA
ACTCCCTGGGAGTTGCTGTACAGATTAATGGAGAGTTATCTGCGGACAAACTTTTATTTGGAGAGACAGGCGGTTTTATT
CTTGAAATCGATAAACAACATAAAGCCGCTTTTGACAAACTGGTTACTCAATATCAAGTCCCTTACATGGTTATCGGACA
TACTACAGAGCAGCCAGTTTTACAGATGAATTCGGTTATCAACTTGCCTGTCGAAGAAGCGAGGCAGGCTTGGGAAAATG
GCTTAAGAGAGAGGCTATTATAA

Upstream 100 bases:

>100_bases
GCTTATACCCCGTGTAAAAATATACAATATCTACTGCTTTGGGGAGAGATTAGTCCTTTACTGATCAATCAGAGATTAAT
TCTATCTGGTATAGAGATTC

Downstream 100 bases:

>100_bases
TGTCTACTATCAATTACAAATCAGCGGGTGTCGATATCGAGGCGGGAAATGAAGCTGTCGCACGCATTAAACGTAATGTT
GAAAAAACATTTTCGCCTCA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 780; Mature: 780

Protein sequence:

>780_residues
MQNLTETLDFSSLNRGEIEKLLRDYNLNLSVDEALTIQNEFLKRPPTISECVLWSIQGSEHCSYKSSRIHLKQFNTSGPH
VILGAKEDAGIVSVAQDKNGYRYGVIVSHESHNHPSQIVPYEGAATGVGGNVRDVCCMGGEVIAVADSLRFGDIKRARTH
WIQEGVVSGIAGYGNPLGIPNIAGDVYYDPAYNENCLVTVVTLGIVREDHIIHSYAPPEAENYVFILVGKPTDNSGFGGA
SFASTVLEEDSQEKNKGAVQEPNAFLQRHLLKANYSLFQLLREKNLIDKVGFKDLGAGGVACASIELAEAGGSYGAEIDL
DKVPTGMPGLMPSVILCSETQERFMWVVPPDLVDTILKHYNETFALPQVSEGACAAVIGKIRTDGLYVVNYKGRELVRAK
VPDVTKGIVYNRPHASSQKQNTEPVFLPPDDYNQILLQLLAHENIASKEPIFEMYDKQVQGRTLIQAGWADAGVLQPFNE
SKYPEEIRKTGIALSLDQNPRYNKIDAYWGAVNAVVESVRNITAVGATPVAITDCLCFGNPEKPEQMREFVDSVRGISDA
CAAVHLKDHPQSTLPVIAGNVSLYNESVKGAIPPSPMISCLGTLPDIDFAITFDFKKSDSLLILIGERKDECGGSVYYQL
HNELGSNVPKPDLSLFNREIHAVSSAIQHGLVNAAHDVSEGGVAVALAEMSFKNSLGVAVQINGELSADKLLFGETGGFI
LEIDKQHKAAFDKLVTQYQVPYMVIGHTTEQPVLQMNSVINLPVEEARQAWENGLRERLL

Sequences:

>Translated_780_residues
MQNLTETLDFSSLNRGEIEKLLRDYNLNLSVDEALTIQNEFLKRPPTISECVLWSIQGSEHCSYKSSRIHLKQFNTSGPH
VILGAKEDAGIVSVAQDKNGYRYGVIVSHESHNHPSQIVPYEGAATGVGGNVRDVCCMGGEVIAVADSLRFGDIKRARTH
WIQEGVVSGIAGYGNPLGIPNIAGDVYYDPAYNENCLVTVVTLGIVREDHIIHSYAPPEAENYVFILVGKPTDNSGFGGA
SFASTVLEEDSQEKNKGAVQEPNAFLQRHLLKANYSLFQLLREKNLIDKVGFKDLGAGGVACASIELAEAGGSYGAEIDL
DKVPTGMPGLMPSVILCSETQERFMWVVPPDLVDTILKHYNETFALPQVSEGACAAVIGKIRTDGLYVVNYKGRELVRAK
VPDVTKGIVYNRPHASSQKQNTEPVFLPPDDYNQILLQLLAHENIASKEPIFEMYDKQVQGRTLIQAGWADAGVLQPFNE
SKYPEEIRKTGIALSLDQNPRYNKIDAYWGAVNAVVESVRNITAVGATPVAITDCLCFGNPEKPEQMREFVDSVRGISDA
CAAVHLKDHPQSTLPVIAGNVSLYNESVKGAIPPSPMISCLGTLPDIDFAITFDFKKSDSLLILIGERKDECGGSVYYQL
HNELGSNVPKPDLSLFNREIHAVSSAIQHGLVNAAHDVSEGGVAVALAEMSFKNSLGVAVQINGELSADKLLFGETGGFI
LEIDKQHKAAFDKLVTQYQVPYMVIGHTTEQPVLQMNSVINLPVEEARQAWENGLRERLL
>Mature_780_residues
MQNLTETLDFSSLNRGEIEKLLRDYNLNLSVDEALTIQNEFLKRPPTISECVLWSIQGSEHCSYKSSRIHLKQFNTSGPH
VILGAKEDAGIVSVAQDKNGYRYGVIVSHESHNHPSQIVPYEGAATGVGGNVRDVCCMGGEVIAVADSLRFGDIKRARTH
WIQEGVVSGIAGYGNPLGIPNIAGDVYYDPAYNENCLVTVVTLGIVREDHIIHSYAPPEAENYVFILVGKPTDNSGFGGA
SFASTVLEEDSQEKNKGAVQEPNAFLQRHLLKANYSLFQLLREKNLIDKVGFKDLGAGGVACASIELAEAGGSYGAEIDL
DKVPTGMPGLMPSVILCSETQERFMWVVPPDLVDTILKHYNETFALPQVSEGACAAVIGKIRTDGLYVVNYKGRELVRAK
VPDVTKGIVYNRPHASSQKQNTEPVFLPPDDYNQILLQLLAHENIASKEPIFEMYDKQVQGRTLIQAGWADAGVLQPFNE
SKYPEEIRKTGIALSLDQNPRYNKIDAYWGAVNAVVESVRNITAVGATPVAITDCLCFGNPEKPEQMREFVDSVRGISDA
CAAVHLKDHPQSTLPVIAGNVSLYNESVKGAIPPSPMISCLGTLPDIDFAITFDFKKSDSLLILIGERKDECGGSVYYQL
HNELGSNVPKPDLSLFNREIHAVSSAIQHGLVNAAHDVSEGGVAVALAEMSFKNSLGVAVQINGELSADKLLFGETGGFI
LEIDKQHKAAFDKLVTQYQVPYMVIGHTTEQPVLQMNSVINLPVEEARQAWENGLRERLL

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=769, Percent_Identity=25.0975292587776, Blast_Score=115, Evalue=2e-25,
Organism=Escherichia coli, GI48994899, Length=830, Percent_Identity=24.0963855421687, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6321498, Length=831, Percent_Identity=23.2250300842359, Blast_Score=121, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 85160; Mature: 85160

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNLTETLDFSSLNRGEIEKLLRDYNLNLSVDEALTIQNEFLKRPPTISECVLWSIQGSE
CCCHHHHHCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHEEEEEECCCC
HCSYKSSRIHLKQFNTSGPHVILGAKEDAGIVSVAQDKNGYRYGVIVSHESHNHPSQIVP
CCCCCCCEEEEEEECCCCCEEEEECCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCEEC
YEGAATGVGGNVRDVCCMGGEVIAVADSLRFGDIKRARTHWIQEGVVSGIAGYGNPLGIP
CCCCCCCCCCCCHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
NIAGDVYYDPAYNENCLVTVVTLGIVREDHIIHSYAPPEAENYVFILVGKPTDNSGFGGA
CCCCCEEECCCCCCCCEEEEEEEHHHHCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCH
SFASTVLEEDSQEKNKGAVQEPNAFLQRHLLKANYSLFQLLREKNLIDKVGFKDLGAGGV
HHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCE
ACASIELAEAGGSYGAEIDLDKVPTGMPGLMPSVILCSETQERFMWVVPPDLVDTILKHY
EEEEEEEECCCCCCCCEEECCCCCCCCCCCCCHHEEECCCCCCEEEEECHHHHHHHHHHC
NETFALPQVSEGACAAVIGKIRTDGLYVVNYKGRELVRAKVPDVTKGIVYNRPHASSQKQ
CCEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCEECCCCCCCCCC
NTEPVFLPPDDYNQILLQLLAHENIASKEPIFEMYDKQVQGRTLIQAGWADAGVLQPFNE
CCCCEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
SKYPEEIRKTGIALSLDQNPRYNKIDAYWGAVNAVVESVRNITAVGATPVAITDCLCFGN
CCCHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHCCCC
PEKPEQMREFVDSVRGISDACAAVHLKDHPQSTLPVIAGNVSLYNESVKGAIPPSPMISC
CCCHHHHHHHHHHHCCHHHHHHEEEECCCCCCCCCEEECCEEEECCCCCCCCCCHHHHHH
LGTLPDIDFAITFDFKKSDSLLILIGERKDECGGSVYYQLHNELGSNVPKPDLSLFNREI
HHCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCEEHEEEHHHHCCCCCCCCHHHHHHHH
HAVSSAIQHGLVNAAHDVSEGGVAVALAEMSFKNSLGVAVQINGELSADKLLFGETGGFI
HHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCCCEEEEECCCCCCCEEEEECCCCEE
LEIDKQHKAAFDKLVTQYQVPYMVIGHTTEQPVLQMNSVINLPVEEARQAWENGLRERLL
EEECCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNLTETLDFSSLNRGEIEKLLRDYNLNLSVDEALTIQNEFLKRPPTISECVLWSIQGSE
CCCHHHHHCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHEEEEEECCCC
HCSYKSSRIHLKQFNTSGPHVILGAKEDAGIVSVAQDKNGYRYGVIVSHESHNHPSQIVP
CCCCCCCEEEEEEECCCCCEEEEECCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCEEC
YEGAATGVGGNVRDVCCMGGEVIAVADSLRFGDIKRARTHWIQEGVVSGIAGYGNPLGIP
CCCCCCCCCCCCHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
NIAGDVYYDPAYNENCLVTVVTLGIVREDHIIHSYAPPEAENYVFILVGKPTDNSGFGGA
CCCCCEEECCCCCCCCEEEEEEEHHHHCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCH
SFASTVLEEDSQEKNKGAVQEPNAFLQRHLLKANYSLFQLLREKNLIDKVGFKDLGAGGV
HHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCE
ACASIELAEAGGSYGAEIDLDKVPTGMPGLMPSVILCSETQERFMWVVPPDLVDTILKHY
EEEEEEEECCCCCCCCEEECCCCCCCCCCCCCHHEEECCCCCCEEEEECHHHHHHHHHHC
NETFALPQVSEGACAAVIGKIRTDGLYVVNYKGRELVRAKVPDVTKGIVYNRPHASSQKQ
CCEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCEECCCCCCCCCC
NTEPVFLPPDDYNQILLQLLAHENIASKEPIFEMYDKQVQGRTLIQAGWADAGVLQPFNE
CCCCEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
SKYPEEIRKTGIALSLDQNPRYNKIDAYWGAVNAVVESVRNITAVGATPVAITDCLCFGN
CCCHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHCCCC
PEKPEQMREFVDSVRGISDACAAVHLKDHPQSTLPVIAGNVSLYNESVKGAIPPSPMISC
CCCHHHHHHHHHHHCCHHHHHHEEEECCCCCCCCCEEECCEEEECCCCCCCCCCHHHHHH
LGTLPDIDFAITFDFKKSDSLLILIGERKDECGGSVYYQLHNELGSNVPKPDLSLFNREI
HHCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCEEHEEEHHHHCCCCCCCCHHHHHHHH
HAVSSAIQHGLVNAAHDVSEGGVAVALAEMSFKNSLGVAVQINGELSADKLLFGETGGFI
HHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCCCEEEEECCCCCCCEEEEECCCCEE
LEIDKQHKAAFDKLVTQYQVPYMVIGHTTEQPVLQMNSVINLPVEEARQAWENGLRERLL
EEECCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA