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The map label for this gene is purC [H]

Identifier: 148359212

GI number: 148359212

Start: 1933513

End: 1934493

Strand: Reverse

Name: purC [H]

Synonym: LPC_1106

Alternate gene names: 148359212

Gene position: 1934493-1933513 (Counterclockwise)

Preceding gene: 148359213

Following gene: 148359211

Centisome position: 54.09

GC content: 39.55

Gene sequence:

>981_bases
ATGAATACCAATGTCCCTAGTCAAGAGGATCTTCTTGCTGCGTTGCCTTTTTGCTTAACCGAAACCTCTTTACCTTTCGG
CAAAAAGTATAAAGGGAAAGTAAGGGATACCTATGATCTCGGCGATCAATTGATTTTGGTAACTACAGATAGACAAAGTG
CCTTTGATCGATGCCTTGCTGCTGTACCTTATAAAGGACAAGTATTGAATTTGACTTCAGCATGGTGGTTTAAAAACACG
CAATCGATTGTGCCTAACCATTTAATTGCCGTACCTGATCCCAATGTGGCGATAGCCAAAAAATGCAAAATATTCCCTAT
TGAATTTGTTGTTCGTGGGTATATTTCGGGGAGTACAAGTACGTCTTTATGGACGCAATACCAAAAAGGAGTTCGTGAGT
ACTGTGGTATAACGTTTCCTGATGGATTAAGAAAAAATCAAAAACTTGAGAGCCCAGTGATAACCCCCACTACTAAAGAG
ACGCTCCATGACAGGCCGATTAGCCCACACGAAATCGTCGCAGAAGGCTGGATGACCCAAGAAGATTGGGATGAAACCAG
CAGTTATGCTTTAAAGTTATTTCAACATGGAATGGAAGTAGCACAGCAACATGGTTTGATTTTGGTGGATACCAAATATG
AATTTGGCCGTGATGCGGAAGGAAGAATTGTATTAGTGGATGAAATTCATACTCCAGATTCCAGTCGTTATTGGTTATTT
AACGGTTATCAAGAGCGATTTGATGCCGGTAAGGAGCCTGAGAATATAGATAAAGAATTTTTGCGCTTGTGGTTTGTTGA
TCACTGCGATCCTTATAAGGATGAAGTATTACCTCAAGCACCACAGGAGTTAATTGTTACTTTAGCATCAAGATATATCC
AATTATATGAAATGATTACAGGTGAATCGTTTGTGTATGACAGTAATCCTGGGCCAGTAAATGATAGGATTTTGCATAAT
ATACAACGTTGGTTAGGTTAA

Upstream 100 bases:

>100_bases
GTTTTGTGGATGTTTAGCAGTGAAAATGTTAAAATACAAGAATTGGCAGAATCCATTTTAGCTACTAATATTATCTTTAA
CCCTAATGCTCATATCTGCT

Downstream 100 bases:

>100_bases
TTTTTAGCCGGGGGAAAGGCTTATGTGTGGCATTGTAGGAATTTACAGTCATGAACCCGTTGCTGCTGAGCTTTATGATA
GCTTGATTCATTTACAGCAC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MNTNVPSQEDLLAALPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLAAVPYKGQVLNLTSAWWFKNT
QSIVPNHLIAVPDPNVAIAKKCKIFPIEFVVRGYISGSTSTSLWTQYQKGVREYCGITFPDGLRKNQKLESPVITPTTKE
TLHDRPISPHEIVAEGWMTQEDWDETSSYALKLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLF
NGYQERFDAGKEPENIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMITGESFVYDSNPGPVNDRILHN
IQRWLG

Sequences:

>Translated_326_residues
MNTNVPSQEDLLAALPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLAAVPYKGQVLNLTSAWWFKNT
QSIVPNHLIAVPDPNVAIAKKCKIFPIEFVVRGYISGSTSTSLWTQYQKGVREYCGITFPDGLRKNQKLESPVITPTTKE
TLHDRPISPHEIVAEGWMTQEDWDETSSYALKLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLF
NGYQERFDAGKEPENIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMITGESFVYDSNPGPVNDRILHN
IQRWLG
>Mature_326_residues
MNTNVPSQEDLLAALPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLAAVPYKGQVLNLTSAWWFKNT
QSIVPNHLIAVPDPNVAIAKKCKIFPIEFVVRGYISGSTSTSLWTQYQKGVREYCGITFPDGLRKNQKLESPVITPTTKE
TLHDRPISPHEIVAEGWMTQEDWDETSSYALKLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLF
NGYQERFDAGKEPENIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMITGESFVYDSNPGPVNDRILHN
IQRWLG

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=299, Percent_Identity=34.1137123745819, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 37355; Mature: 37355

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNVPSQEDLLAALPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLA
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
AVPYKGQVLNLTSAWWFKNTQSIVPNHLIAVPDPNVAIAKKCKIFPIEFVVRGYISGSTS
CCCCCCEEEEECHHHHHCCCHHHCCCCEEECCCCCCHHHHCCEEEEHHHHHHHHHCCCCC
TSLWTQYQKGVREYCGITFPDGLRKNQKLESPVITPTTKETLHDRPISPHEIVAEGWMTQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHCCCCC
EDWDETSSYALKLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLF
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEE
NGYQERFDAGKEPENIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMIT
CCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GESFVYDSNPGPVNDRILHNIQRWLG
CCEEEECCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNTNVPSQEDLLAALPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLA
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
AVPYKGQVLNLTSAWWFKNTQSIVPNHLIAVPDPNVAIAKKCKIFPIEFVVRGYISGSTS
CCCCCCEEEEECHHHHHCCCHHHCCCCEEECCCCCCHHHHCCEEEEHHHHHHHHHCCCCC
TSLWTQYQKGVREYCGITFPDGLRKNQKLESPVITPTTKETLHDRPISPHEIVAEGWMTQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHCCCCC
EDWDETSSYALKLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLF
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEE
NGYQERFDAGKEPENIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMIT
CCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GESFVYDSNPGPVNDRILHNIQRWLG
CCEEEECCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA