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The map label for this gene is gmpk [H]

Identifier: 148284451

GI number: 148284451

Start: 766361

End: 767026

Strand: Direct

Name: gmpk [H]

Synonym: OTBS_0788

Alternate gene names: 148284451

Gene position: 766361-767026 (Clockwise)

Preceding gene: 148284450

Following gene: 148284452

Centisome position: 36.03

GC content: 31.83

Gene sequence:

>666_bases
ATGTTTATTAGTTTTCCAAAACCTGCTATAGCACTTATAATATCATCTCCATCTGGGGCTGGGAAATCAAGCTTAGCTCA
TGCGGTTATTCAAAATAATATCAATATTAAATTCTCTGTTTCAATGACAACTAGAGAAAAACGTAATAATGAAATAAATG
GCAAAGACTATATCTTTGTGACAAAAGAACAATTCGAACAGGAAATTAACAACAATACACTTCTTGAATTTTCTAAAGTA
TTCAACAACTACTATGGCATTCCAAAAGCTGGGGTGTTAGAAGATCTTAGTCAAGGTCAGAGCATTATTTTTGATATCGA
TTGGCAAGGCGCTAAAACAATACGAAAGGCTCTGAAATGTTATGTCGTTAGTGTATGCATACTTCCTCCATCAATGCAAG
AGCTAGAAAATAGATTAAAAAAACGTAATAAAGATTCTCCAGAAACTATTCGCTACCGTTTAGAACAAGCAAAAGAAGAT
ATTAAGCATTATAGCGAATATGATTATGTAATAGTAAATGACCGCTTTGATCAAGCATTACTTGCTTTGCAATCAATACT
GATAGCTGAACAGCATAAGTTAAAAAGACTGAGTTTTAAAAATGATACACTGTTAAATTATGAACAATTGTTACAAAGAG
ATGCATGCTTTAATTATAGACAATGA

Upstream 100 bases:

>100_bases
AATAGCTTTTATGCAAATAATTATAATATGATATGTTGTATTTTACTTTTAAAAATTAAGTTATTGAATAATAATACAAT
TTAGAATATATTGACTTACC

Downstream 100 bases:

>100_bases
AATATTGATCTTTTATTTTATTTTACATAAAATGAGGAAAATTGTATAAAAAATGTTTTAGAACTCAAATTAAATTGAGG
TACACTAAAATTATATTACA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MFISFPKPAIALIISSPSGAGKSSLAHAVIQNNINIKFSVSMTTREKRNNEINGKDYIFVTKEQFEQEINNNTLLEFSKV
FNNYYGIPKAGVLEDLSQGQSIIFDIDWQGAKTIRKALKCYVVSVCILPPSMQELENRLKKRNKDSPETIRYRLEQAKED
IKHYSEYDYVIVNDRFDQALLALQSILIAEQHKLKRLSFKNDTLLNYEQLLQRDACFNYRQ

Sequences:

>Translated_221_residues
MFISFPKPAIALIISSPSGAGKSSLAHAVIQNNINIKFSVSMTTREKRNNEINGKDYIFVTKEQFEQEINNNTLLEFSKV
FNNYYGIPKAGVLEDLSQGQSIIFDIDWQGAKTIRKALKCYVVSVCILPPSMQELENRLKKRNKDSPETIRYRLEQAKED
IKHYSEYDYVIVNDRFDQALLALQSILIAEQHKLKRLSFKNDTLLNYEQLLQRDACFNYRQ
>Mature_221_residues
MFISFPKPAIALIISSPSGAGKSSLAHAVIQNNINIKFSVSMTTREKRNNEINGKDYIFVTKEQFEQEINNNTLLEFSKV
FNNYYGIPKAGVLEDLSQGQSIIFDIDWQGAKTIRKALKCYVVSVCILPPSMQELENRLKKRNKDSPETIRYRLEQAKED
IKHYSEYDYVIVNDRFDQALLALQSILIAEQHKLKRLSFKNDTLLNYEQLLQRDACFNYRQ

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=198, Percent_Identity=37.3737373737374, Blast_Score=127, Evalue=8e-30,
Organism=Homo sapiens, GI226874833, Length=198, Percent_Identity=37.3737373737374, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI4504221, Length=198, Percent_Identity=37.3737373737374, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI38570142, Length=175, Percent_Identity=30.8571428571429, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI14780902, Length=188, Percent_Identity=29.2553191489362, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4505237, Length=176, Percent_Identity=31.25, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118259, Length=176, Percent_Identity=31.25, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118263, Length=176, Percent_Identity=31.25, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118255, Length=176, Percent_Identity=31.25, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=196, Percent_Identity=42.8571428571429, Blast_Score=173, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI193203132, Length=177, Percent_Identity=37.2881355932203, Blast_Score=113, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=177, Percent_Identity=37.2881355932203, Blast_Score=113, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71984092, Length=114, Percent_Identity=32.4561403508772, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=38.0434782608696, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356141, Length=181, Percent_Identity=32.0441988950276, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI45554481, Length=189, Percent_Identity=25.3968253968254, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI85724806, Length=189, Percent_Identity=25.3968253968254, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI116007136, Length=189, Percent_Identity=25.3968253968254, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25595; Mature: 25595

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFISFPKPAIALIISSPSGAGKSSLAHAVIQNNINIKFSVSMTTREKRNNEINGKDYIFV
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEEHHHHCCCCCCCCEEEEE
TKEQFEQEINNNTLLEFSKVFNNYYGIPKAGVLEDLSQGQSIIFDIDWQGAKTIRKALKC
EHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
YVVSVCILPPSMQELENRLKKRNKDSPETIRYRLEQAKEDIKHYSEYDYVIVNDRFDQAL
HHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHH
LALQSILIAEQHKLKRLSFKNDTLLNYEQLLQRDACFNYRQ
HHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFISFPKPAIALIISSPSGAGKSSLAHAVIQNNINIKFSVSMTTREKRNNEINGKDYIFV
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEEHHHHCCCCCCCCEEEEE
TKEQFEQEINNNTLLEFSKVFNNYYGIPKAGVLEDLSQGQSIIFDIDWQGAKTIRKALKC
EHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
YVVSVCILPPSMQELENRLKKRNKDSPETIRYRLEQAKEDIKHYSEYDYVIVNDRFDQAL
HHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHH
LALQSILIAEQHKLKRLSFKNDTLLNYEQLLQRDACFNYRQ
HHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]