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The map label for this gene is folP [H]

Identifier: 147674024

GI number: 147674024

Start: 170913

End: 171749

Strand: Direct

Name: folP [H]

Synonym: VC0395_A0167

Alternate gene names: 147674024

Gene position: 170913-171749 (Clockwise)

Preceding gene: 147673292

Following gene: 147674754

Centisome position: 5.65

GC content: 45.88

Gene sequence:

>837_bases
ATGCTGAAAATCAGTCATGCCGATAAGCAGCTTGAGCTGCATTCACCCGTTGTGATGGGTATCTTAAATACTACGCCAGA
TTCCTTTTCCGATGGCGGCCGTTACGTTGACCTTGATGTCGCGTTGGCAAGAGCACAGCAAATGATCGACCTTGGCGTCG
CGATTATTGATATTGGCGGTGAGTCAACTCGACCAGGCGCTCCTGATGTTGCTTTAGAAGAGGAATTACAGCGCGTCATC
CCACTTATCAAAGCGATTCGAAAACAGAATGCTGAGGTATGGATTTCGATTGATACCAGCAAAGCGGAAGTGATGCGCCA
AGCATTAGCTGCGGGAGCCGATCTGATTAATGATGTGCGTGCTTTGCAAGAGCCGGGAGCTCTTGAAGTAGCAGCGCAGG
CTCAAGTCCCGGTTTGTATTATGCATATGCAAGGTCAGCCGCGGACGATGCAAGCTAACCCACACTACTACAATATTATT
GAAGAGGTTTGCCAGTTTTTAGCTGAGCGAATTGCACAATGCGAAGCTGCGGGTATTAAGCGTGAGAATATTATCTTAGA
TCCCGGTTTTGGTTTTGGAAAATCGGTGCAACACAATTATCATTTGCTCGCCCATTTAGAACAGTTTCATCGTTTTGGAT
TGCCAGTTTTAGCTGGAATGTCACGTAAATCAATGATTTTTAAAACACTGAATAAGCAACCAGCTGAATGTGTGGCAGGA
AGCGTTGCGTGTGCCACATTGGCTGCGCAAAAAGGCGCACAAATTATCCGTGTTCATGATGTAGAGCAGACCATTGATGC
ACTCAAAATGGTGCAGATGATGCATAACAATTTGTAA

Upstream 100 bases:

>100_bases
CGCGACAGCAAGCGAGAAAAAAGACGCTGAATAACATCACTTTTAACTTTAAACCCCGACTTGTTCGGGGTTTTGTGTTT
GCAGGGAATATATTTTTAGA

Downstream 100 bases:

>100_bases
AAACAATAATGTAAAGGAAACACAAATGTCTGATAAGAGACGTTATTTTGGCACTGATGGGGTTCGTGGCAAAGTTGGCC
AGTACCCAATTACTCCTGAT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MLKISHADKQLELHSPVVMGILNTTPDSFSDGGRYVDLDVALARAQQMIDLGVAIIDIGGESTRPGAPDVALEEELQRVI
PLIKAIRKQNAEVWISIDTSKAEVMRQALAAGADLINDVRALQEPGALEVAAQAQVPVCIMHMQGQPRTMQANPHYYNII
EEVCQFLAERIAQCEAAGIKRENIILDPGFGFGKSVQHNYHLLAHLEQFHRFGLPVLAGMSRKSMIFKTLNKQPAECVAG
SVACATLAAQKGAQIIRVHDVEQTIDALKMVQMMHNNL

Sequences:

>Translated_278_residues
MLKISHADKQLELHSPVVMGILNTTPDSFSDGGRYVDLDVALARAQQMIDLGVAIIDIGGESTRPGAPDVALEEELQRVI
PLIKAIRKQNAEVWISIDTSKAEVMRQALAAGADLINDVRALQEPGALEVAAQAQVPVCIMHMQGQPRTMQANPHYYNII
EEVCQFLAERIAQCEAAGIKRENIILDPGFGFGKSVQHNYHLLAHLEQFHRFGLPVLAGMSRKSMIFKTLNKQPAECVAG
SVACATLAAQKGAQIIRVHDVEQTIDALKMVQMMHNNL
>Mature_278_residues
MLKISHADKQLELHSPVVMGILNTTPDSFSDGGRYVDLDVALARAQQMIDLGVAIIDIGGESTRPGAPDVALEEELQRVI
PLIKAIRKQNAEVWISIDTSKAEVMRQALAAGADLINDVRALQEPGALEVAAQAQVPVCIMHMQGQPRTMQANPHYYNII
EEVCQFLAERIAQCEAAGIKRENIILDPGFGFGKSVQHNYHLLAHLEQFHRFGLPVLAGMSRKSMIFKTLNKQPAECVAG
SVACATLAAQKGAQIIRVHDVEQTIDALKMVQMMHNNL

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=271, Percent_Identity=57.1955719557196, Blast_Score=329, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=29.0625, Blast_Score=132, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30445; Mature: 30445

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKISHADKQLELHSPVVMGILNTTPDSFSDGGRYVDLDVALARAQQMIDLGVAIIDIGG
CCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHCEEEEEECC
ESTRPGAPDVALEEELQRVIPLIKAIRKQNAEVWISIDTSKAEVMRQALAAGADLINDVR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
ALQEPGALEVAAQAQVPVCIMHMQGQPRTMQANPHYYNIIEEVCQFLAERIAQCEAAGIK
HHCCCCCEEEEECCCCCEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
RENIILDPGFGFGKSVQHNYHLLAHLEQFHRFGLPVLAGMSRKSMIFKTLNKQPAECVAG
CCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCHHHHHHH
SVACATLAAQKGAQIIRVHDVEQTIDALKMVQMMHNNL
HHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKISHADKQLELHSPVVMGILNTTPDSFSDGGRYVDLDVALARAQQMIDLGVAIIDIGG
CCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHCEEEEEECC
ESTRPGAPDVALEEELQRVIPLIKAIRKQNAEVWISIDTSKAEVMRQALAAGADLINDVR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
ALQEPGALEVAAQAQVPVCIMHMQGQPRTMQANPHYYNIIEEVCQFLAERIAQCEAAGIK
HHCCCCCEEEEECCCCCEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
RENIILDPGFGFGKSVQHNYHLLAHLEQFHRFGLPVLAGMSRKSMIFKTLNKQPAECVAG
CCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCHHHHHHH
SVACATLAAQKGAQIIRVHDVEQTIDALKMVQMMHNNL
HHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]