Definition Vibrio cholerae O395 chromosome 2, complete sequence.
Accession NC_009457
Length 3,024,069

Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 147673667

GI number: 147673667

Start: 2070829

End: 2072109

Strand: Reverse

Name: thrC [H]

Synonym: VC0395_A1941

Alternate gene names: 147673667

Gene position: 2072109-2070829 (Counterclockwise)

Preceding gene: 147673067

Following gene: 147674847

Centisome position: 68.52

GC content: 49.57

Gene sequence:

>1281_bases
ATGAAGCTGTACAACATAAAAGAAAATGATGAACAAGTCTCTTTTGGTCAAGCCGTTCGCCAAGGGTTAGGCCGCAATCA
AGGCCTATTTTTTCCGGCACAATTGCCGAAGTTTGACGATATTGATGCGCTATTAGCCGAAGATTTCGTCTCTCGTAGCA
GCAAGATTTTATCGGCGTTGATTGGCGATGAACTGCCTGCGGATAAAATTCGCGCTATGGTGGATTCCGCCTTTCAATTC
GCCGCACCGATTGCCAAAGTGAAAGAGGGCGTTTACGCGCTCGAATTGTTCCACGGGCCAACGCTCGCGTTTAAAGATTT
TGGTGGTCGCTTTATGGCCCAGTCTCTGGCGGCGGTCTCGAACGGCGGAAAAATCACGATTTTGACGGCGACATCCGGTG
ATACCGGCGCTGCTGTTGCGCACGCATTTTATGGCATGCCAGATATTAATGTTGTGATCCTTTATCCGAAAGGAAAAATC
AGTCCGCTGCAAGAAAAGCTGTTCTGCACATTAGGTAAAAACATTCACACCGTGGCGATCAATGGTGATTTTGATGCTTG
CCAAGCGCTAGTGAAACAAGCTTTTGATGACGCAGAGCTGCGTCAACAGATCGGTTTGAACTCCGCCAACTCGATCAACA
TCAGCCGTTTGATGGCGCAAATCTGTTACTACTTTGAAGCCGCTGCGCAGATGAGCAAAGCTGAGCGTGAAAATCTGGTG
ATTTCAGTGCCTAGTGGCAACTTTGGTAACTTAACCGCAGGGCTGTTAGCCAAAGCACTGGGTTTATCGGTGAAGCGCTT
TATTGCGGCAACCAATGCCAACGATACAGTGCCACGTTACTTGGAAACGGGACGTTGGGAACCCAAACCCACGGTAGCAA
CAACGTCAAATGCGATGGATGTCAGCCAACCGAACAACTGGCCGCGTATCGAAGAGCTCTGCCAACGTATGGGATGGGGC
TTAGAAACGCTGGGCAAAGGCGCGGTTTCTGACGAGGAAAGTGCGCAAGCCGTACAAGAACTTTACGATCTAGGCTACTT
GTGTGAACCGCATGGTTCGATTGCTTACCGTGTATTGGAAGAGCAGCGCCAGCTGCAAGAAACGGGGCTGTTCTTATGTA
CCGCGCATCCCGCCAAATTCAAAGAAGTGGTGGACGATATTTTAGGTACCGACATTGCTCTACCAGCGCCATTGGCAAAA
CATGCGGCGATGGAATTGCTCTCACAAGAGCTGAATGCCGATTTCGCAGCGCTGCGTACGTTACTGGTGAATGTGAAATA
A

Upstream 100 bases:

>100_bases
TGGCACGTTGGCTTGAGCAAAACTATGTGCAAAATGAAGAAGGATTCGTCCACATTTGTCGTCTAGACAAGCAAGGTTCG
AAAGTAACAGGAAGTGAGCT

Downstream 100 bases:

>100_bases
TCCGCGGATTTGAGAAAGCGAAGATAATAAAAAACGGTGCTCATTGAGCACCGTTTTAGTATGGATTCTTTACTGACGAT
TACAGAGATTCAGTGAAAGT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPAQLPKFDDIDALLAEDFVSRSSKILSALIGDELPADKIRAMVDSAFQF
AAPIAKVKEGVYALELFHGPTLAFKDFGGRFMAQSLAAVSNGGKITILTATSGDTGAAVAHAFYGMPDINVVILYPKGKI
SPLQEKLFCTLGKNIHTVAINGDFDACQALVKQAFDDAELRQQIGLNSANSINISRLMAQICYYFEAAAQMSKAERENLV
ISVPSGNFGNLTAGLLAKALGLSVKRFIAATNANDTVPRYLETGRWEPKPTVATTSNAMDVSQPNNWPRIEELCQRMGWG
LETLGKGAVSDEESAQAVQELYDLGYLCEPHGSIAYRVLEEQRQLQETGLFLCTAHPAKFKEVVDDILGTDIALPAPLAK
HAAMELLSQELNADFAALRTLLVNVK

Sequences:

>Translated_426_residues
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPAQLPKFDDIDALLAEDFVSRSSKILSALIGDELPADKIRAMVDSAFQF
AAPIAKVKEGVYALELFHGPTLAFKDFGGRFMAQSLAAVSNGGKITILTATSGDTGAAVAHAFYGMPDINVVILYPKGKI
SPLQEKLFCTLGKNIHTVAINGDFDACQALVKQAFDDAELRQQIGLNSANSINISRLMAQICYYFEAAAQMSKAERENLV
ISVPSGNFGNLTAGLLAKALGLSVKRFIAATNANDTVPRYLETGRWEPKPTVATTSNAMDVSQPNNWPRIEELCQRMGWG
LETLGKGAVSDEESAQAVQELYDLGYLCEPHGSIAYRVLEEQRQLQETGLFLCTAHPAKFKEVVDDILGTDIALPAPLAK
HAAMELLSQELNADFAALRTLLVNVK
>Mature_426_residues
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPAQLPKFDDIDALLAEDFVSRSSKILSALIGDELPADKIRAMVDSAFQF
AAPIAKVKEGVYALELFHGPTLAFKDFGGRFMAQSLAAVSNGGKITILTATSGDTGAAVAHAFYGMPDINVVILYPKGKI
SPLQEKLFCTLGKNIHTVAINGDFDACQALVKQAFDDAELRQQIGLNSANSINISRLMAQICYYFEAAAQMSKAERENLV
ISVPSGNFGNLTAGLLAKALGLSVKRFIAATNANDTVPRYLETGRWEPKPTVATTSNAMDVSQPNNWPRIEELCQRMGWG
LETLGKGAVSDEESAQAVQELYDLGYLCEPHGSIAYRVLEEQRQLQETGLFLCTAHPAKFKEVVDDILGTDIALPAPLAK
HAAMELLSQELNADFAALRTLLVNVK

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=421, Percent_Identity=29.4536817102138, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI149193323, Length=421, Percent_Identity=27.790973871734, Blast_Score=155, Evalue=5e-38,
Organism=Escherichia coli, GI1786185, Length=426, Percent_Identity=67.6056338028169, Blast_Score=573, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319901, Length=448, Percent_Identity=32.3660714285714, Blast_Score=212, Evalue=7e-56,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46265; Mature: 46265

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPAQLPKFDDIDALLAEDFVSRSSKILSAL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IGDELPADKIRAMVDSAFQFAAPIAKVKEGVYALELFHGPTLAFKDFGGRFMAQSLAAVS
HCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEHHHCCCHHHHHHHHHHC
NGGKITILTATSGDTGAAVAHAFYGMPDINVVILYPKGKISPLQEKLFCTLGKNIHTVAI
CCCEEEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEE
NGDFDACQALVKQAFDDAELRQQIGLNSANSINISRLMAQICYYFEAAAQMSKAERENLV
CCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEE
ISVPSGNFGNLTAGLLAKALGLSVKRFIAATNANDTVPRYLETGRWEPKPTVATTSNAMD
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEECCCCCC
VSQPNNWPRIEELCQRMGWGLETLGKGAVSDEESAQAVQELYDLGYLCEPHGSIAYRVLE
CCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHCCCEECCCCHHHHHHHH
EQRQLQETGLFLCTAHPAKFKEVVDDILGTDIALPAPLAKHAAMELLSQELNADFAALRT
HHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
LLVNVK
HHHCCC
>Mature Secondary Structure
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPAQLPKFDDIDALLAEDFVSRSSKILSAL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IGDELPADKIRAMVDSAFQFAAPIAKVKEGVYALELFHGPTLAFKDFGGRFMAQSLAAVS
HCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEHHHCCCHHHHHHHHHHC
NGGKITILTATSGDTGAAVAHAFYGMPDINVVILYPKGKISPLQEKLFCTLGKNIHTVAI
CCCEEEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEE
NGDFDACQALVKQAFDDAELRQQIGLNSANSINISRLMAQICYYFEAAAQMSKAERENLV
CCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEE
ISVPSGNFGNLTAGLLAKALGLSVKRFIAATNANDTVPRYLETGRWEPKPTVATTSNAMD
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEECCCCCC
VSQPNNWPRIEELCQRMGWGLETLGKGAVSDEESAQAVQELYDLGYLCEPHGSIAYRVLE
CCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHCCCEECCCCHHHHHHHH
EQRQLQETGLFLCTAHPAKFKEVVDDILGTDIALPAPLAKHAAMELLSQELNADFAALRT
HHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
LLVNVK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]