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The map label for this gene is coxA [H]

Identifier: 146343476

GI number: 146343476

Start: 6964162

End: 6965775

Strand: Reverse

Name: coxA [H]

Synonym: BRADO6706

Alternate gene names: 146343476

Gene position: 6965775-6964162 (Counterclockwise)

Preceding gene: 146343477

Following gene: 146343475

Centisome position: 93.42

GC content: 63.63

Gene sequence:

>1614_bases
ATGGCGACGAACGTAGCGACCCAAACCGGCCATGACGATCACGCGCACGACCATCCGACCGGATGGCGGCGCTGGGTCTA
TTCGACCAACCACAAAGACATCGGCACGATGTACCTGATCTTCGCGGTGTGCGCCGGCATCATCGGCGCCGCCATGTCGG
TCGCGATCCGCATCGAGCTGATGTATCCGGGCGTGCAGCTCTTCCACGAGAGCCACACCTACAACGTGTTCGTGACCTCG
CACGGCCTGATCATGATCTTCTTCATGGTCATGCCGGCGATGATCGGCGGCTTCGGCAACTGGATGGTGCCGCTGATGAT
CGGCGCGCCGGACATGGCGTTCCCGCGCATGAACAACATCTCGTTCTGGCTGCTGCCGGCCTCCTTCGCGCTGCTCCTGA
CCTCGACCTTCGTCGAGGGCGAGCCGGGTGCCAACGGCGTCGGCGCCGGCTGGACGATGTATGTGCCGCTGTCGACCTCG
GGCCATCCGGGACCGGCTGTAGACTTCGCGATCCTGTCGCTGCATCTCGCCGGTGCGTCATCGATCCTGGGCTCGATCAA
CTTCATCACCACGATCTTCAACATGCGCGCGCCGGGCATGACCCTGCACAAGATGCCGCTGTTCGTGTGGTCGATCCTGG
TGACCGTGTTCCTGCTGCTGCTGTCTTTGCCGGTGCTCGCCGGCGCCATCACGATGATGCTGACCGACCGCAATTTCGGC
ACCACCTTCTTCGCTCCCGAAGGCGGCGGCGACCCGCTGCTGTTCCAGCATCTGTTCTGGTTCTTCGGCCACCCCGAAGT
GTACATCCTGATCCTGCCCGGCTTCGGCATGATCAGCCAGATCGTCTCGACCTTCTCGCGCAAGCCCGTGTTCGGCTATC
TCGGCATGGCCTACGCCATGGTCGCGATCGGCGGCATCGGCTTCGTGGTCTGGGCGCATCACATGTACACGGTCGGCATG
TCCTCGGCGACGCAGGCCTATTTCGTCGCCGCCACGATGGTGATCGCGGTGCCGACCGGCGTGAAAATCTTTTCCTGGAT
CGCCACGATGTGGGGCGGCTCGATCGAGTTCCGCGCGCCGATGCTGTGGGCCGTGGGCTTCATCTTCCTGTTCACGGTCG
GCGGCGTCACCGGCGTCGTGCTGGCGAACGCCGGCGTCGACCGCGTGCTGCAGGACACCTACTACGTCGTCGCGCACTTC
CACTACGTGCTGTCTCTCGGCGCCGTGTTCGCGATCTTCGCCGGCTGGTACTACTGGTTCCCGAAGATGTTCGGCTACAT
GTACAACGAGGGCATCGCCAAGGCGCACTTCTGGGTCACCTTCATCGGCGTGAACCTGGTGTTCTTCCCGCAGCACTTCC
TCGGCCTCTCCGGCATGCCGCGCCGATACATCGACTATCCCGACGCGTTCGCCGGCTGGAACCTGGTGTCGTCGATCGGC
TCCTACATCTCGGCGTTCGGCGTCCTGATCTTCATCTATGGCGTCGTCGAGGCCTTCATGCGCAAGCAGCAGGCCGCGGC
CAATCCGTGGGGACCGGGCGCGACCACCCTGGAATGGACCCTTTCGTCGCCGCCGCCGTTCCACCAGTTCGAAGTCCTGC
CGAAGGTGCAGTAG

Upstream 100 bases:

>100_bases
CTACGCGTCGGCTGCAGGCGTCTCGCAGTAACGCACGAGGCGATGCTTAGGAATTGAGGGCCGCCTCTGGCGGTCCACCG
GGGACATTGAGGATTGGACA

Downstream 100 bases:

>100_bases
GCACTCTCGGCCTCCGATGCGGCGCCGCGCTCGGCGCCGCATTGCCATCTGCCGGCCGGTGCGCCCGCGCGCCGGCTGGA
TCTCTGAAGCGACGTGCTGA

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MATNVATQTGHDDHAHDHPTGWRRWVYSTNHKDIGTMYLIFAVCAGIIGAAMSVAIRIELMYPGVQLFHESHTYNVFVTS
HGLIMIFFMVMPAMIGGFGNWMVPLMIGAPDMAFPRMNNISFWLLPASFALLLTSTFVEGEPGANGVGAGWTMYVPLSTS
GHPGPAVDFAILSLHLAGASSILGSINFITTIFNMRAPGMTLHKMPLFVWSILVTVFLLLLSLPVLAGAITMMLTDRNFG
TTFFAPEGGGDPLLFQHLFWFFGHPEVYILILPGFGMISQIVSTFSRKPVFGYLGMAYAMVAIGGIGFVVWAHHMYTVGM
SSATQAYFVAATMVIAVPTGVKIFSWIATMWGGSIEFRAPMLWAVGFIFLFTVGGVTGVVLANAGVDRVLQDTYYVVAHF
HYVLSLGAVFAIFAGWYYWFPKMFGYMYNEGIAKAHFWVTFIGVNLVFFPQHFLGLSGMPRRYIDYPDAFAGWNLVSSIG
SYISAFGVLIFIYGVVEAFMRKQQAAANPWGPGATTLEWTLSSPPPFHQFEVLPKVQ

Sequences:

>Translated_537_residues
MATNVATQTGHDDHAHDHPTGWRRWVYSTNHKDIGTMYLIFAVCAGIIGAAMSVAIRIELMYPGVQLFHESHTYNVFVTS
HGLIMIFFMVMPAMIGGFGNWMVPLMIGAPDMAFPRMNNISFWLLPASFALLLTSTFVEGEPGANGVGAGWTMYVPLSTS
GHPGPAVDFAILSLHLAGASSILGSINFITTIFNMRAPGMTLHKMPLFVWSILVTVFLLLLSLPVLAGAITMMLTDRNFG
TTFFAPEGGGDPLLFQHLFWFFGHPEVYILILPGFGMISQIVSTFSRKPVFGYLGMAYAMVAIGGIGFVVWAHHMYTVGM
SSATQAYFVAATMVIAVPTGVKIFSWIATMWGGSIEFRAPMLWAVGFIFLFTVGGVTGVVLANAGVDRVLQDTYYVVAHF
HYVLSLGAVFAIFAGWYYWFPKMFGYMYNEGIAKAHFWVTFIGVNLVFFPQHFLGLSGMPRRYIDYPDAFAGWNLVSSIG
SYISAFGVLIFIYGVVEAFMRKQQAAANPWGPGATTLEWTLSSPPPFHQFEVLPKVQ
>Mature_536_residues
ATNVATQTGHDDHAHDHPTGWRRWVYSTNHKDIGTMYLIFAVCAGIIGAAMSVAIRIELMYPGVQLFHESHTYNVFVTSH
GLIMIFFMVMPAMIGGFGNWMVPLMIGAPDMAFPRMNNISFWLLPASFALLLTSTFVEGEPGANGVGAGWTMYVPLSTSG
HPGPAVDFAILSLHLAGASSILGSINFITTIFNMRAPGMTLHKMPLFVWSILVTVFLLLLSLPVLAGAITMMLTDRNFGT
TFFAPEGGGDPLLFQHLFWFFGHPEVYILILPGFGMISQIVSTFSRKPVFGYLGMAYAMVAIGGIGFVVWAHHMYTVGMS
SATQAYFVAATMVIAVPTGVKIFSWIATMWGGSIEFRAPMLWAVGFIFLFTVGGVTGVVLANAGVDRVLQDTYYVVAHFH
YVLSLGAVFAIFAGWYYWFPKMFGYMYNEGIAKAHFWVTFIGVNLVFFPQHFLGLSGMPRRYIDYPDAFAGWNLVSSIGS
YISAFGVLIFIYGVVEAFMRKQQAAANPWGPGATTLEWTLSSPPPFHQFEVLPKVQ

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=513, Percent_Identity=63.5477582846004, Blast_Score=612, Evalue=1e-175,
Organism=Escherichia coli, GI1786634, Length=523, Percent_Identity=43.2122370936902, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6226519, Length=537, Percent_Identity=56.2383612662942, Blast_Score=607, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6226524, Length=327, Percent_Identity=61.4678899082569, Blast_Score=408, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6226523, Length=252, Percent_Identity=55.952380952381, Blast_Score=266, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6226522, Length=79, Percent_Identity=46.8354430379747, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6226521, Length=66, Percent_Identity=48.4848484848485, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59096; Mature: 58965

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNVATQTGHDDHAHDHPTGWRRWVYSTNHKDIGTMYLIFAVCAGIIGAAMSVAIRIEL
CCCCCCCCCCCCCCCCCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEE
MYPGVQLFHESHTYNVFVTSHGLIMIFFMVMPAMIGGFGNWMVPLMIGAPDMAFPRMNNI
ECCCHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
SFWLLPASFALLLTSTFVEGEPGANGVGAGWTMYVPLSTSGHPGPAVDFAILSLHLAGAS
EEEEHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCHH
SILGSINFITTIFNMRAPGMTLHKMPLFVWSILVTVFLLLLSLPVLAGAITMMLTDRNFG
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
TTFFAPEGGGDPLLFQHLFWFFGHPEVYILILPGFGMISQIVSTFSRKPVFGYLGMAYAM
CEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHH
VAIGGIGFVVWAHHMYTVGMSSATQAYFVAATMVIAVPTGVKIFSWIATMWGGSIEFRAP
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHCCCEEECCH
MLWAVGFIFLFTVGGVTGVVLANAGVDRVLQDTYYVVAHFHYVLSLGAVFAIFAGWYYWF
HHHHHHHHHHHHHHCHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PKMFGYMYNEGIAKAHFWVTFIGVNLVFFPQHFLGLSGMPRRYIDYPDAFAGWNLVSSIG
HHHHHHHHHCCCHHHHHEEEEEHHHHEEECHHHHCCCCCCHHHCCCCCHHHHHHHHHHHH
SYISAFGVLIFIYGVVEAFMRKQQAAANPWGPGATTLEWTLSSPPPFHQFEVLPKVQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATNVATQTGHDDHAHDHPTGWRRWVYSTNHKDIGTMYLIFAVCAGIIGAAMSVAIRIEL
CCCCCCCCCCCCCCCCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEE
MYPGVQLFHESHTYNVFVTSHGLIMIFFMVMPAMIGGFGNWMVPLMIGAPDMAFPRMNNI
ECCCHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
SFWLLPASFALLLTSTFVEGEPGANGVGAGWTMYVPLSTSGHPGPAVDFAILSLHLAGAS
EEEEHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCHH
SILGSINFITTIFNMRAPGMTLHKMPLFVWSILVTVFLLLLSLPVLAGAITMMLTDRNFG
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
TTFFAPEGGGDPLLFQHLFWFFGHPEVYILILPGFGMISQIVSTFSRKPVFGYLGMAYAM
CEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHH
VAIGGIGFVVWAHHMYTVGMSSATQAYFVAATMVIAVPTGVKIFSWIATMWGGSIEFRAP
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHCCCEEECCH
MLWAVGFIFLFTVGGVTGVVLANAGVDRVLQDTYYVVAHFHYVLSLGAVFAIFAGWYYWF
HHHHHHHHHHHHHHCHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PKMFGYMYNEGIAKAHFWVTFIGVNLVFFPQHFLGLSGMPRRYIDYPDAFAGWNLVSSIG
HHHHHHHHHCCCHHHHHEEEEEHHHHEEECHHHHCCCCCCHHHCCCCCHHHHHHHHHHHH
SYISAFGVLIFIYGVVEAFMRKQQAAANPWGPGATTLEWTLSSPPPFHQFEVLPKVQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]