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The map label for this gene is coxE [H]

Identifier: 146343475

GI number: 146343475

Start: 6963081

End: 6964019

Strand: Reverse

Name: coxE [H]

Synonym: BRADO6705

Alternate gene names: 146343475

Gene position: 6964019-6963081 (Counterclockwise)

Preceding gene: 146343476

Following gene: 146343474

Centisome position: 93.39

GC content: 67.31

Gene sequence:

>939_bases
GTGTCGGTCATTGATCAGAACGCCATCGCCGTCGGCCCGCGGATTTCCGAGGCCGATGTCGGCGATTACATCGCGCTGCT
GAAGCCGCGGGTGATGTCGCTCGTGATCTTCACGGCGCTGATCGGCCTCCTGATTGCCCCTGGGCACTTCCATCCCGTGC
TCGCGATCACGTCGCTGTTGTGCATCGCCGTCGGCGCCGGCGCCTCCGGCGCCCTGAACATGGCGCTGGAAGGGGACATC
GACTCGCTGATGTCGCGCACCGCGAACCGTCCGATCCCGCGCGGCCGCGTCACCCGCCAGGAGGCGCTGGCCTTCGGCAT
CACGCTGTCGTTCTTCTCGGTGCTGACGCTCGGCATCCTCGTCAACTGGTTTGCCGGCGCGCTGCTCGCCTTCACCATCT
TCTTCTACGTCGTGATCTACACGCTGTGGCTGAAGCGCTGGACCGCGCAGAACATCGTCATCGGCGGCGCCGCCGGCGCG
CTGCCGCCGGTCGTGGCCTGGGCCGCGGTCACCGGATCGATCGCTCCTGAGCCGGTCTGGCTGTTCCTGATCATCTTCTT
CTGGACCCCGCCGCATTTCTGGGCGCTGGCGCTGTTCCGCACCGACGATTACGCCCGCGCCGGCGTGCCGATGCTTCCCG
TGGTCGCCGGCCCCGACGCGACGCGGCTGCAGATCCTGCTGTATACGATCGTGCTGGTGGCGATCGCCGCCGCGCCCTGG
CCGCTCGGCTATTTCGACGCCGTCTATGGCGTCGTCTCGCTGGCGCTCGGCGCCGGCATGCTGTGGTTGGCCATCGAGGT
GTTCCGCAAGCGCGATCGCATCCCCTCGCTGCGCGCCAACCGCAAGCTGTTCGGCTTCTCGATCCTGTATCTGTTCGCGC
TGTTTGCGACGCTCGGGCTCGAGGCGATCGCGCGCATGATCGCGCCGCTGATCTGGTAA

Upstream 100 bases:

>100_bases
TGCCATCTGCCGGCCGGTGCGCCCGCGCGCCGGCTGGATCTCTGAAGCGACGTGCTGACCTGTTTCGTTCAGCGCCTTTG
AATTGAAGTCTGGATTCGTC

Downstream 100 bases:

>100_bases
GGGGGCCGCGGGGCAGGAAAGCATGGCAACCGCAATGGTCGATCCGAATGAGCCCGAGGGCGTCGTCCTCACCGAGGCGC
AGCTGCGCAGCCGCCGCCGG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSVIDQNAIAVGPRISEADVGDYIALLKPRVMSLVIFTALIGLLIAPGHFHPVLAITSLLCIAVGAGASGALNMALEGDI
DSLMSRTANRPIPRGRVTRQEALAFGITLSFFSVLTLGILVNWFAGALLAFTIFFYVVIYTLWLKRWTAQNIVIGGAAGA
LPPVVAWAAVTGSIAPEPVWLFLIIFFWTPPHFWALALFRTDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPW
PLGYFDAVYGVVSLALGAGMLWLAIEVFRKRDRIPSLRANRKLFGFSILYLFALFATLGLEAIARMIAPLIW

Sequences:

>Translated_312_residues
MSVIDQNAIAVGPRISEADVGDYIALLKPRVMSLVIFTALIGLLIAPGHFHPVLAITSLLCIAVGAGASGALNMALEGDI
DSLMSRTANRPIPRGRVTRQEALAFGITLSFFSVLTLGILVNWFAGALLAFTIFFYVVIYTLWLKRWTAQNIVIGGAAGA
LPPVVAWAAVTGSIAPEPVWLFLIIFFWTPPHFWALALFRTDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPW
PLGYFDAVYGVVSLALGAGMLWLAIEVFRKRDRIPSLRANRKLFGFSILYLFALFATLGLEAIARMIAPLIW
>Mature_311_residues
SVIDQNAIAVGPRISEADVGDYIALLKPRVMSLVIFTALIGLLIAPGHFHPVLAITSLLCIAVGAGASGALNMALEGDID
SLMSRTANRPIPRGRVTRQEALAFGITLSFFSVLTLGILVNWFAGALLAFTIFFYVVIYTLWLKRWTAQNIVIGGAAGAL
PPVVAWAAVTGSIAPEPVWLFLIIFFWTPPHFWALALFRTDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPWP
LGYFDAVYGVVSLALGAGMLWLAIEVFRKRDRIPSLRANRKLFGFSILYLFALFATLGLEAIARMIAPLIW

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=260, Percent_Identity=33.0769230769231, Blast_Score=108, Evalue=4e-24,
Organism=Escherichia coli, GI1786631, Length=283, Percent_Identity=31.4487632508834, Blast_Score=114, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71998235, Length=289, Percent_Identity=29.757785467128, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325085, Length=218, Percent_Identity=31.1926605504587, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921064, Length=275, Percent_Identity=32.3636363636364, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33824; Mature: 33693

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIDQNAIAVGPRISEADVGDYIALLKPRVMSLVIFTALIGLLIAPGHFHPVLAITSLL
CCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CIAVGAGASGALNMALEGDIDSLMSRTANRPIPRGRVTRQEALAFGITLSFFSVLTLGIL
HHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VNWFAGALLAFTIFFYVVIYTLWLKRWTAQNIVIGGAAGALPPVVAWAAVTGSIAPEPVW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCCCCHHH
LFLIIFFWTPPHFWALALFRTDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPW
HHHHHHHHCCHHHHHHHHHCCCCHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCC
PLGYFDAVYGVVSLALGAGMLWLAIEVFRKRDRIPSLRANRKLFGFSILYLFALFATLGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EAIARMIAPLIW
HHHHHHHHHHCC
>Mature Secondary Structure 
SVIDQNAIAVGPRISEADVGDYIALLKPRVMSLVIFTALIGLLIAPGHFHPVLAITSLL
CCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CIAVGAGASGALNMALEGDIDSLMSRTANRPIPRGRVTRQEALAFGITLSFFSVLTLGIL
HHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VNWFAGALLAFTIFFYVVIYTLWLKRWTAQNIVIGGAAGALPPVVAWAAVTGSIAPEPVW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCCCCHHH
LFLIIFFWTPPHFWALALFRTDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPW
HHHHHHHHCCHHHHHHHHHCCCCHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCC
PLGYFDAVYGVVSLALGAGMLWLAIEVFRKRDRIPSLRANRKLFGFSILYLFALFATLGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EAIARMIAPLIW
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA