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The map label for this gene is coxB [H]

Identifier: 146343477

GI number: 146343477

Start: 6965845

End: 6966684

Strand: Reverse

Name: coxB [H]

Synonym: BRADO6707

Alternate gene names: 146343477

Gene position: 6966684-6965845 (Counterclockwise)

Preceding gene: 146343479

Following gene: 146343476

Centisome position: 93.43

GC content: 62.98

Gene sequence:

>840_bases
ATGAAGATGTCGAAAGGCCAATTGGGCGCCTGCTTGCTGAAGTTGGCTGTGACGGGCGTGACGCTCGTGTCGGGTGGATC
GGCGTTTGCTGAAATGGGGCAGCCCGCCCCGTGGGAATACAAGCTGCAGGAAGCCGCGACGCCGGTGATGGAGAACATCA
CCTGGTTCCACGGGCTGCTGCTGACGATCATCACGCTGATCACGCTGTTCGTGCTGGCGCTGCTGGTCGCGGTGGTCGTC
AAGTTCAATGCGCGCGCCAATCCGGTGCCGTCGCGCACCACGCATAACACGCTGCTCGAAGTGGCGTGGACGCTGATCCC
GGTGCTGATCCTCGTCACCATCGCGGTGCCGTCGTTCCGCCTGCTGTTCCTCGAGCTCGACGTGCCGAAGGCCGATCTGA
CGATCAAGGCGACCGGCAAGCAGTGGTACTGGAGCTACGCCTATCCCGATAACGGCAAGTTCGAGTTCGACTCGCTGATG
GCGCAGGACAAGAAGCCGCGCCTGCTCGCCGTCGACAACGAGATGGTCGTTCCGGTCAACAAGGTGATCCGCGTCCAGAC
CACCGGGGCCGACGTCATCCACGCGTTCGCGGTGCCGTCCTTCGGCATCAAGATCGACGCCATTCCCGGCCGTCTCAACG
AGACCTGGTTCAAGGCGACCAAGGTCGGCATGTATTACGGCCAGTGCTCCGAGCTCTGCGGCAAGGACCACGCCTACATG
CCGATCGCGGTGCGCGTCGTGAGCGACCAGGAATTCACCGCCTGGATCGAGGACGCCAAGAAGAAATACGCCAGCGCGCC
CACCAGCACCTACGCGTCGGCTGCAGGCGTCTCGCAGTAA

Upstream 100 bases:

>100_bases
CGTCCGCCCGAAGGCCAATTGTCAGGAGAGCGGATCGACGGCGCGGCGCGTGACGAGCGCGGTGCGCCGAGGGGGAAAGT
TCTGAAGGGAGCGCGACGAC

Downstream 100 bases:

>100_bases
CGCACGAGGCGATGCTTAGGAATTGAGGGCCGCCTCTGGCGGTCCACCGGGGACATTGAGGATTGGACAATGGCGACGAA
CGTAGCGACCCAAACCGGCC

Product: cytochrome c oxidase subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MKMSKGQLGACLLKLAVTGVTLVSGGSAFAEMGQPAPWEYKLQEAATPVMENITWFHGLLLTIITLITLFVLALLVAVVV
KFNARANPVPSRTTHNTLLEVAWTLIPVLILVTIAVPSFRLLFLELDVPKADLTIKATGKQWYWSYAYPDNGKFEFDSLM
AQDKKPRLLAVDNEMVVPVNKVIRVQTTGADVIHAFAVPSFGIKIDAIPGRLNETWFKATKVGMYYGQCSELCGKDHAYM
PIAVRVVSDQEFTAWIEDAKKKYASAPTSTYASAAGVSQ

Sequences:

>Translated_279_residues
MKMSKGQLGACLLKLAVTGVTLVSGGSAFAEMGQPAPWEYKLQEAATPVMENITWFHGLLLTIITLITLFVLALLVAVVV
KFNARANPVPSRTTHNTLLEVAWTLIPVLILVTIAVPSFRLLFLELDVPKADLTIKATGKQWYWSYAYPDNGKFEFDSLM
AQDKKPRLLAVDNEMVVPVNKVIRVQTTGADVIHAFAVPSFGIKIDAIPGRLNETWFKATKVGMYYGQCSELCGKDHAYM
PIAVRVVSDQEFTAWIEDAKKKYASAPTSTYASAAGVSQ
>Mature_279_residues
MKMSKGQLGACLLKLAVTGVTLVSGGSAFAEMGQPAPWEYKLQEAATPVMENITWFHGLLLTIITLITLFVLALLVAVVV
KFNARANPVPSRTTHNTLLEVAWTLIPVLILVTIAVPSFRLLFLELDVPKADLTIKATGKQWYWSYAYPDNGKFEFDSLM
AQDKKPRLLAVDNEMVVPVNKVIRVQTTGADVIHAFAVPSFGIKIDAIPGRLNETWFKATKVGMYYGQCSELCGKDHAYM
PIAVRVVSDQEFTAWIEDAKKKYASAPTSTYASAAGVSQ

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=216, Percent_Identity=41.6666666666667, Blast_Score=180, Evalue=1e-45,
Organism=Escherichia coli, GI1786635, Length=215, Percent_Identity=26.046511627907, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6226540, Length=235, Percent_Identity=41.7021276595745, Blast_Score=174, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 30615; Mature: 30615

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMSKGQLGACLLKLAVTGVTLVSGGSAFAEMGQPAPWEYKLQEAATPVMENITWFHGLL
CCCCCCHHHHHHHHHHHHHEEEECCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
LTIITLITLFVLALLVAVVVKFNARANPVPSRTTHNTLLEVAWTLIPVLILVTIAVPSFR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLFLELDVPKADLTIKATGKQWYWSYAYPDNGKFEFDSLMAQDKKPRLLAVDNEMVVPVN
EEEEEECCCCCCEEEEECCCEEEEEEECCCCCCEEHHHHHHCCCCCCEEEECCCEEEECC
KVIRVQTTGADVIHAFAVPSFGIKIDAIPGRLNETWFKATKVGMYYGQCSELCGKDHAYM
CEEEEEECCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PIAVRVVSDQEFTAWIEDAKKKYASAPTSTYASAAGVSQ
EEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MKMSKGQLGACLLKLAVTGVTLVSGGSAFAEMGQPAPWEYKLQEAATPVMENITWFHGLL
CCCCCCHHHHHHHHHHHHHEEEECCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
LTIITLITLFVLALLVAVVVKFNARANPVPSRTTHNTLLEVAWTLIPVLILVTIAVPSFR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLFLELDVPKADLTIKATGKQWYWSYAYPDNGKFEFDSLMAQDKKPRLLAVDNEMVVPVN
EEEEEECCCCCCEEEEECCCEEEEEEECCCCCCEEHHHHHHCCCCCCEEEECCCEEEECC
KVIRVQTTGADVIHAFAVPSFGIKIDAIPGRLNETWFKATKVGMYYGQCSELCGKDHAYM
CEEEEEECCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PIAVRVVSDQEFTAWIEDAKKKYASAPTSTYASAAGVSQ
EEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA