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The map label for this gene is pth [H]

Identifier: 146342828

GI number: 146342828

Start: 6234360

End: 6234965

Strand: Direct

Name: pth [H]

Synonym: BRADO6007

Alternate gene names: 146342828

Gene position: 6234360-6234965 (Clockwise)

Preceding gene: 146342827

Following gene: 146342829

Centisome position: 83.61

GC content: 65.84

Gene sequence:

>606_bases
ATGCTGCTGTTCGTCGGTCTCGGCAATCCCGGCGCGAAATATTCGCGCAACCGGCACAATATCGGCTTCATGGCCGTGGA
CGAGATTTCTCGACGCCACCGCTTCTCGCCGTGGCGCCGCAGGTTTCAGGGCGAGACCTCGGAAGGCACGCTCGACAGCG
AGCGCGTCATTCTGCTGAAGCCCACGACCTATATGAACGAATCCGGCCGTGCCGTGCAGGAAGCGGCTAGCTTCTTCAAG
CTCGGCGTCGGCGACGTCACCGTGTTTCAGGACGAGCTCGAGCTTGCCCCGGGCAAGCTGCGCGTGAAGGTCGGCGGCGG
CATCGCGGGCCACAACGGGCTGCGTTCGATCTCGGCGCATCTCGGCAACGACTACCGCCGCGTCCGCCTCGGCATCGGCC
ATCCCGGCGTCAAGGAGCTGGTGCACGGCCACGTGCTGTCGGACTTCGCCAAGAGCGAGATGCCCTGGGTCGAGGCGCTG
TGCGAGGCGGTGGCCGACAACGCGGAATTGCTGACCGGCAAGCGCGACTCCACCTTCGCCAACAAGGTGCATCTGGCGCT
GCAGGCCAAGGGTTTTCTGGACAAGGGCGACGCCGGCGCCGCGTGA

Upstream 100 bases:

>100_bases
GGCCAAGGCCCCCGAGAAGAAGAAGTAAGCCGATCCACTGTCGGAGCGCGCGGGCAGTCCCCGTGCGCTCCGCAGCGACG
GCAGGTCCCGGTCCCGCGCC

Downstream 100 bases:

>100_bases
GGCGCGCGCGACGTCGCCGTGAGAGGATGCGAGACGGGTCATGGGATTCAAATGCGGGATCGTCGGTCTGCCCAACGTCG
GCAAGTCGACGCTGTTCAAC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MLLFVGLGNPGAKYSRNRHNIGFMAVDEISRRHRFSPWRRRFQGETSEGTLDSERVILLKPTTYMNESGRAVQEAASFFK
LGVGDVTVFQDELELAPGKLRVKVGGGIAGHNGLRSISAHLGNDYRRVRLGIGHPGVKELVHGHVLSDFAKSEMPWVEAL
CEAVADNAELLTGKRDSTFANKVHLALQAKGFLDKGDAGAA

Sequences:

>Translated_201_residues
MLLFVGLGNPGAKYSRNRHNIGFMAVDEISRRHRFSPWRRRFQGETSEGTLDSERVILLKPTTYMNESGRAVQEAASFFK
LGVGDVTVFQDELELAPGKLRVKVGGGIAGHNGLRSISAHLGNDYRRVRLGIGHPGVKELVHGHVLSDFAKSEMPWVEAL
CEAVADNAELLTGKRDSTFANKVHLALQAKGFLDKGDAGAA
>Mature_201_residues
MLLFVGLGNPGAKYSRNRHNIGFMAVDEISRRHRFSPWRRRFQGETSEGTLDSERVILLKPTTYMNESGRAVQEAASFFK
LGVGDVTVFQDELELAPGKLRVKVGGGIAGHNGLRSISAHLGNDYRRVRLGIGHPGVKELVHGHVLSDFAKSEMPWVEAL
CEAVADNAELLTGKRDSTFANKVHLALQAKGFLDKGDAGAA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=35.1190476190476, Blast_Score=94, Evalue=8e-20,
Organism=Escherichia coli, GI1787455, Length=186, Percent_Identity=43.5483870967742, Blast_Score=118, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21937; Mature: 21937

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLFVGLGNPGAKYSRNRHNIGFMAVDEISRRHRFSPWRRRFQGETSEGTLDSERVILLK
CEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCEEEEC
PTTYMNESGRAVQEAASFFKLGVGDVTVFQDELELAPGKLRVKVGGGIAGHNGLRSISAH
CCCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHCCCCEEEEEECCCCCCCCHHHHHHHH
LGNDYRRVRLGIGHPGVKELVHGHVLSDFAKSEMPWVEALCEAVADNAELLTGKRDSTFA
HCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEECCCCCCCHH
NKVHLALQAKGFLDKGDAGAA
HHEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MLLFVGLGNPGAKYSRNRHNIGFMAVDEISRRHRFSPWRRRFQGETSEGTLDSERVILLK
CEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCEEEEC
PTTYMNESGRAVQEAASFFKLGVGDVTVFQDELELAPGKLRVKVGGGIAGHNGLRSISAH
CCCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHCCCCEEEEEECCCCCCCCHHHHHHHH
LGNDYRRVRLGIGHPGVKELVHGHVLSDFAKSEMPWVEALCEAVADNAELLTGKRDSTFA
HCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEECCCCCCCHH
NKVHLALQAKGFLDKGDAGAA
HHEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA