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The map label for this gene is codB [H]

Identifier: 146342701

GI number: 146342701

Start: 6086598

End: 6087983

Strand: Reverse

Name: codB [H]

Synonym: BRADO5868

Alternate gene names: 146342701

Gene position: 6087983-6086598 (Counterclockwise)

Preceding gene: 146342702

Following gene: 146342700

Centisome position: 81.65

GC content: 62.12

Gene sequence:

>1386_bases
GTGCGTGAACGTCAACGACACATTCACAGGGGCACTGCAATGGATCACAGTTTGGCTAAGGCCGGTTCCGTCACCGGCAA
TCTTCATGATGCGGAGGATCAGGTCGATCATCTGCTCGGCAGCGAATACGAGCACGAGCCTGTGCCGATGAGCGCGCGGC
GCAGCGCCTTCTCGGTGACCATGGTGTGGCTCGGCTTCCCGATGATCATTACCGGAGCCATGACGGGCTCGCTGCTCGTG
CTGGGGATGGGCTTCTCCCGCGCGCTCGTCGCCATGATCGTGGGCAACCTGATCATGCTCGCCTATGTCGGACTGCTCGG
GCTGATCGGGACCAAGCGCGGCATGAACTTCGCGCTGATCGCCAGCATCGTGTTCGGGAAGAAAGGATATGTGTTCGCCT
CCGGCCTGCTCTCGACGCTGCTGCTCGGCTGGTACGCGGTACAGACCGGGATCACCGGAGCTCTTGTGAGTTCGACCTAC
GGGCTCAACTATGTCGCCATGACGATCCTGGCCGGTCTATTGTACATCGGCATCACGTTCGTCGGCGTGAAGGGACTGCA
CTATATCGGGCTGGTCTCGGTGCCGCTCTTCGTCGTTCTCGGCCTCTATGTCGCGATCGATGCGGCCGTGAGTCATTCGG
CGTCCGCCATCTTCGCCTACGCCGGCAATGGCGGCGTCGCGACGATGTCGATGGGCGTCGGGCTGACGGTCGTGATCGCG
CTGTTCATCGACGCCGGAACGGTGACGGCCGATTTCAACCGATGGGCCAAGACCCCGACCGCATCCCTGGTGGCGACCTT
CAGCGCATTTCCCTTCGCCAACCTGATCGCGATGCTTGTCGGCGGCGTGATGACGGCAGCGCTGGCGGTTCCGAACGCCA
ATCCGTTCGGTGCCGACAACATGTTCGGCTACATGAACGGCAAGCAGATGGCGTGGCTCAGTGTGCTTGCGTTCCTGTTC
CTCTACATCAACCTGGGGTCCGTCTGCTCGCACTGCCTCTACAATGCGGCGACCGGCTGGTCGCGGATCCTGGGAACGCA
TATGCGGCTGATGGCCGTCATTCTCGGCGCGATCGGCATTGCGGTCGCCGCGGGTAACGTCTGGGCGTTCTTCATTCAGT
GGCTGTCGTTGCTCGGTATCCTCGTTCCCCCGATCGGCGCGATCATTCTGATCGACCAGTATCTGTTCAGGCCGGAGTCG
AAGATCGATGCCGATTGGCGCCCGCAGGCGTTCGTGGCCTGGGCTGTCGGCTCGATCTGCGCCTTCGTCGTGGAGCAGTG
GATGCCGTATCTGTCGACAGCGCTGTCAGCGGCGATCGTGGCCGGCGTGGTCTATTTCGGCATCAGCCGGTCGACGAGCG
GTAGTGCCGTCCCTGCAAAATCGTGA

Upstream 100 bases:

>100_bases
TCCGCTTGGGGTAGGCAGGGCCGGACGCGGCAGGTCGAGGCGCAACCCGAAAAGATTGGCTTTGCTGGCGTCGTCGGAAC
TCGACGGCGAATGAGACATC

Downstream 100 bases:

>100_bases
AGCGCCATCTTCGGCGGCCACCGCGCGCGGTGACCGCCGAACCGTCATTGCAATTCCAGAACAGGAGCATCATCGTGAGT
CTCGATTACGACATCTACGA

Product: hypothetical protein

Products: Proton [Cytoplasm]; cytosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MRERQRHIHRGTAMDHSLAKAGSVTGNLHDAEDQVDHLLGSEYEHEPVPMSARRSAFSVTMVWLGFPMIITGAMTGSLLV
LGMGFSRALVAMIVGNLIMLAYVGLLGLIGTKRGMNFALIASIVFGKKGYVFASGLLSTLLLGWYAVQTGITGALVSSTY
GLNYVAMTILAGLLYIGITFVGVKGLHYIGLVSVPLFVVLGLYVAIDAAVSHSASAIFAYAGNGGVATMSMGVGLTVVIA
LFIDAGTVTADFNRWAKTPTASLVATFSAFPFANLIAMLVGGVMTAALAVPNANPFGADNMFGYMNGKQMAWLSVLAFLF
LYINLGSVCSHCLYNAATGWSRILGTHMRLMAVILGAIGIAVAAGNVWAFFIQWLSLLGILVPPIGAIILIDQYLFRPES
KIDADWRPQAFVAWAVGSICAFVVEQWMPYLSTALSAAIVAGVVYFGISRSTSGSAVPAKS

Sequences:

>Translated_461_residues
MRERQRHIHRGTAMDHSLAKAGSVTGNLHDAEDQVDHLLGSEYEHEPVPMSARRSAFSVTMVWLGFPMIITGAMTGSLLV
LGMGFSRALVAMIVGNLIMLAYVGLLGLIGTKRGMNFALIASIVFGKKGYVFASGLLSTLLLGWYAVQTGITGALVSSTY
GLNYVAMTILAGLLYIGITFVGVKGLHYIGLVSVPLFVVLGLYVAIDAAVSHSASAIFAYAGNGGVATMSMGVGLTVVIA
LFIDAGTVTADFNRWAKTPTASLVATFSAFPFANLIAMLVGGVMTAALAVPNANPFGADNMFGYMNGKQMAWLSVLAFLF
LYINLGSVCSHCLYNAATGWSRILGTHMRLMAVILGAIGIAVAAGNVWAFFIQWLSLLGILVPPIGAIILIDQYLFRPES
KIDADWRPQAFVAWAVGSICAFVVEQWMPYLSTALSAAIVAGVVYFGISRSTSGSAVPAKS
>Mature_461_residues
MRERQRHIHRGTAMDHSLAKAGSVTGNLHDAEDQVDHLLGSEYEHEPVPMSARRSAFSVTMVWLGFPMIITGAMTGSLLV
LGMGFSRALVAMIVGNLIMLAYVGLLGLIGTKRGMNFALIASIVFGKKGYVFASGLLSTLLLGWYAVQTGITGALVSSTY
GLNYVAMTILAGLLYIGITFVGVKGLHYIGLVSVPLFVVLGLYVAIDAAVSHSASAIFAYAGNGGVATMSMGVGLTVVIA
LFIDAGTVTADFNRWAKTPTASLVATFSAFPFANLIAMLVGGVMTAALAVPNANPFGADNMFGYMNGKQMAWLSVLAFLF
LYINLGSVCSHCLYNAATGWSRILGTHMRLMAVILGAIGIAVAAGNVWAFFIQWLSLLGILVPPIGAIILIDQYLFRPES
KIDADWRPQAFVAWAVGSICAFVVEQWMPYLSTALSAAIVAGVVYFGISRSTSGSAVPAKS

Specific function: Required for cytosine transport into the cell [H]

COG id: COG1457

COG function: function code F; Purine-cytosine permease and related proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine-cytosine permease family [H]

Homologues:

Organism=Escherichia coli, GI1786530, Length=378, Percent_Identity=28.042328042328, Blast_Score=114, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001248
- InterPro:   IPR012681 [H]

Pfam domain/function: PF02133 Transp_cyt_pur [H]

EC number: NA

Molecular weight: Translated: 48720; Mature: 48720

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRERQRHIHRGTAMDHSLAKAGSVTGNLHDAEDQVDHLLGSEYEHEPVPMSARRSAFSVT
CCCHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
MVWLGFPMIITGAMTGSLLVLGMGFSRALVAMIVGNLIMLAYVGLLGLIGTKRGMNFALI
HHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ASIVFGKKGYVFASGLLSTLLLGWYAVQTGITGALVSSTYGLNYVAMTILAGLLYIGITF
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VGVKGLHYIGLVSVPLFVVLGLYVAIDAAVSHSASAIFAYAGNGGVATMSMGVGLTVVIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHHHHHHHHHH
LFIDAGTVTADFNRWAKTPTASLVATFSAFPFANLIAMLVGGVMTAALAVPNANPFGADN
HHHCCCCEEECHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
MFGYMNGKQMAWLSVLAFLFLYINLGSVCSHCLYNAATGWSRILGTHMRLMAVILGAIGI
CCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
AVAAGNVWAFFIQWLSLLGILVPPIGAIILIDQYLFRPESKIDADWRPQAFVAWAVGSIC
HHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
AFVVEQWMPYLSTALSAAIVAGVVYFGISRSTSGSAVPAKS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRERQRHIHRGTAMDHSLAKAGSVTGNLHDAEDQVDHLLGSEYEHEPVPMSARRSAFSVT
CCCHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
MVWLGFPMIITGAMTGSLLVLGMGFSRALVAMIVGNLIMLAYVGLLGLIGTKRGMNFALI
HHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ASIVFGKKGYVFASGLLSTLLLGWYAVQTGITGALVSSTYGLNYVAMTILAGLLYIGITF
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VGVKGLHYIGLVSVPLFVVLGLYVAIDAAVSHSASAIFAYAGNGGVATMSMGVGLTVVIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHHHHHHHHHH
LFIDAGTVTADFNRWAKTPTASLVATFSAFPFANLIAMLVGGVMTAALAVPNANPFGADN
HHHCCCCEEECHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
MFGYMNGKQMAWLSVLAFLFLYINLGSVCSHCLYNAATGWSRILGTHMRLMAVILGAIGI
CCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
AVAAGNVWAFFIQWLSLLGILVPPIGAIILIDQYLFRPESKIDADWRPQAFVAWAVGSIC
HHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
AFVVEQWMPYLSTALSAAIVAGVVYFGISRSTSGSAVPAKS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; cytosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + cytosine [Periplasm] = Proton [Cytoplasm] + cytosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]