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The map label for this gene is gcvT [H]

Identifier: 146341852

GI number: 146341852

Start: 5178841

End: 5179998

Strand: Direct

Name: gcvT [H]

Synonym: BRADO4982

Alternate gene names: 146341852

Gene position: 5178841-5179998 (Clockwise)

Preceding gene: 146341849

Following gene: 146341853

Centisome position: 69.45

GC content: 70.12

Gene sequence:

>1158_bases
ATGGCTGAACCGGCTGCTGCAACCTCCTCTTCCTCTTTAATGCGAACGCCGCTGCATGCGCTGCATGTCAGCCTCGGCGG
CAAGATGGTGCCGTTTGCGGGCTATGAGATGCCCGTGCAATACGCGCCCGGCGTGCTCAAGGAGCACCTTCATACCCGCA
GCCACGCGGGTCTTTTCGACGTCTCCCACATGGGCCAGGTCGCCCTGCTGCCGAAGTTCGGCAAGGTCGCAGACGCCGCT
GCCGCGCTGGAGCGGCTGGTGCCGCAGGACATCGTCGGCATGTCAGCGGGCCGCCAGCGCTACGCCCAGTTCACCAATGC
CGACGGCGGCATTCTCGATGACCTGATGGTGGCGAACTTCGGCGAGCACCTGGTGCTGGTCGTGAACGCCGCCTGCAAGG
AGGCCGACATCCAGCTGCTGCGCGACGGCGTGTCCGACGTCTGCGAGGTGCAGCCGCTGGCCGACCGGGCGCTGCTGGCG
CTGCAGGGGCCGAAGGCGGCGTCGGTGCTGGCGAAATTCTGTGCAGAGGCCGAAGGCATGCGGTTCATGGATGCGGGGCC
GCGCGCGGTCGACGGCCTCGCCTGCTACGTCTCGCGCTCCGGTTACACCGGCGAGGACGGCTACGAGATCTCGGTTCCTG
CCGACCAGGCCGAGCAGCTCGCCGAAGCGCTGCTGTCCGACAAGGACGTGCTGCCGATCGGGCTCGGCGCCCGCGACAGC
CTGCGGCTCGAGGCCGGGCTCTGCCTCTATGGCCACGACATCGACACGACAACGACGCCGGTCGAGGCGGCGCTGGAATG
GTCGGTGCAGAAGGTCCGCCGCAGCGGCGGCGCCCGCGCCGGCGGCTTCCCGGGCGCGGCGAAGATCCTGGCGCAGTTCG
ACGGCGGCGCGGCGCGTCGCCGGGTCGGCCTGCGGCCGGAGGGCCGCGCGCCGGTGCGCGAAGGGGCCACGCTGTTTGCC
ACCTCCGACTCGACCGAGCCGGTCGGCAAAGTCACCTCCGGCGGCTTCGGGCCGACTCTGAATGCGCCGGTCGCGATGGG
CTACGTGCCGACCACCCTCGCCGCGCCGGACACCCAATTGTTCGCCGATGTGCGCGGGCAACGCCTGCCGCTGCGCGTCG
CCGCCACGCCTTTTGTCCCCAACACCTACAAGCGCTGA

Upstream 100 bases:

>100_bases
AGGCGTCCGCCGACGGGATAATACTCTCAGGCACAGCGACAGATGGGGCTTCGGTAGTGTTTTCCGGGACTGGTCCCGAG
GAACCGCGCGAGGACCCCTG

Downstream 100 bases:

>100_bases
AGGACGTCCATGACCACGCTGTACACCTCCGACCATGAATGGCTCAGCATCGAGGGCGATGTCGCCACCATCGGCATCAC
GGACTATGCGCAGGCGCAGC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MAEPAAATSSSSLMRTPLHALHVSLGGKMVPFAGYEMPVQYAPGVLKEHLHTRSHAGLFDVSHMGQVALLPKFGKVADAA
AALERLVPQDIVGMSAGRQRYAQFTNADGGILDDLMVANFGEHLVLVVNAACKEADIQLLRDGVSDVCEVQPLADRALLA
LQGPKAASVLAKFCAEAEGMRFMDAGPRAVDGLACYVSRSGYTGEDGYEISVPADQAEQLAEALLSDKDVLPIGLGARDS
LRLEAGLCLYGHDIDTTTTPVEAALEWSVQKVRRSGGARAGGFPGAAKILAQFDGGAARRRVGLRPEGRAPVREGATLFA
TSDSTEPVGKVTSGGFGPTLNAPVAMGYVPTTLAAPDTQLFADVRGQRLPLRVAATPFVPNTYKR

Sequences:

>Translated_385_residues
MAEPAAATSSSSLMRTPLHALHVSLGGKMVPFAGYEMPVQYAPGVLKEHLHTRSHAGLFDVSHMGQVALLPKFGKVADAA
AALERLVPQDIVGMSAGRQRYAQFTNADGGILDDLMVANFGEHLVLVVNAACKEADIQLLRDGVSDVCEVQPLADRALLA
LQGPKAASVLAKFCAEAEGMRFMDAGPRAVDGLACYVSRSGYTGEDGYEISVPADQAEQLAEALLSDKDVLPIGLGARDS
LRLEAGLCLYGHDIDTTTTPVEAALEWSVQKVRRSGGARAGGFPGAAKILAQFDGGAARRRVGLRPEGRAPVREGATLFA
TSDSTEPVGKVTSGGFGPTLNAPVAMGYVPTTLAAPDTQLFADVRGQRLPLRVAATPFVPNTYKR
>Mature_384_residues
AEPAAATSSSSLMRTPLHALHVSLGGKMVPFAGYEMPVQYAPGVLKEHLHTRSHAGLFDVSHMGQVALLPKFGKVADAAA
ALERLVPQDIVGMSAGRQRYAQFTNADGGILDDLMVANFGEHLVLVVNAACKEADIQLLRDGVSDVCEVQPLADRALLAL
QGPKAASVLAKFCAEAEGMRFMDAGPRAVDGLACYVSRSGYTGEDGYEISVPADQAEQLAEALLSDKDVLPIGLGARDSL
RLEAGLCLYGHDIDTTTTPVEAALEWSVQKVRRSGGARAGGFPGAAKILAQFDGGAARRRVGLRPEGRAPVREGATLFAT
SDSTEPVGKVTSGGFGPTLNAPVAMGYVPTTLAAPDTQLFADVRGQRLPLRVAATPFVPNTYKR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=379, Percent_Identity=46.4379947229551, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI257796258, Length=360, Percent_Identity=46.6666666666667, Blast_Score=274, Evalue=8e-74,
Organism=Homo sapiens, GI257796254, Length=373, Percent_Identity=41.2868632707775, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI257796256, Length=315, Percent_Identity=45.3968253968254, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI24797151, Length=381, Percent_Identity=23.6220472440945, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1789272, Length=382, Percent_Identity=32.4607329842932, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17560118, Length=391, Percent_Identity=41.4322250639386, Blast_Score=241, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6320222, Length=393, Percent_Identity=39.6946564885496, Blast_Score=260, Evalue=3e-70,
Organism=Drosophila melanogaster, GI20129441, Length=397, Percent_Identity=43.8287153652393, Blast_Score=273, Evalue=1e-73,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40449; Mature: 40317

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPAAATSSSSLMRTPLHALHVSLGGKMVPFAGYEMPVQYAPGVLKEHLHTRSHAGLFD
CCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCHHHCCHHHHHHHHHHCCCCEEE
VSHMGQVALLPKFGKVADAAAALERLVPQDIVGMSAGRQRYAQFTNADGGILDDLMVANF
HHHCCCEEECCCCCHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHCC
GEHLVLVVNAACKEADIQLLRDGVSDVCEVQPLADRALLALQGPKAASVLAKFCAEAEGM
CCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHEEEEECCCHHHHHHHHHHHHHCCC
RFMDAGPRAVDGLACYVSRSGYTGEDGYEISVPADQAEQLAEALLSDKDVLPIGLGARDS
EEECCCCCHHCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEECCCCCCC
LRLEAGLCLYGHDIDTTTTPVEAALEWSVQKVRRSGGARAGGFPGAAKILAQFDGGAARR
EEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHH
RVGLRPEGRAPVREGATLFATSDSTEPVGKVTSGGFGPTLNAPVAMGYVPTTLAAPDTQL
CCCCCCCCCCCHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHH
FADVRGQRLPLRVAATPFVPNTYKR
HHHCCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
AEPAAATSSSSLMRTPLHALHVSLGGKMVPFAGYEMPVQYAPGVLKEHLHTRSHAGLFD
CCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCHHHCCHHHHHHHHHHCCCCEEE
VSHMGQVALLPKFGKVADAAAALERLVPQDIVGMSAGRQRYAQFTNADGGILDDLMVANF
HHHCCCEEECCCCCHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHCC
GEHLVLVVNAACKEADIQLLRDGVSDVCEVQPLADRALLALQGPKAASVLAKFCAEAEGM
CCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHEEEEECCCHHHHHHHHHHHHHCCC
RFMDAGPRAVDGLACYVSRSGYTGEDGYEISVPADQAEQLAEALLSDKDVLPIGLGARDS
EEECCCCCHHCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEECCCCCCC
LRLEAGLCLYGHDIDTTTTPVEAALEWSVQKVRRSGGARAGGFPGAAKILAQFDGGAARR
EEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHH
RVGLRPEGRAPVREGATLFATSDSTEPVGKVTSGGFGPTLNAPVAMGYVPTTLAAPDTQL
CCCCCCCCCCCHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHH
FADVRGQRLPLRVAATPFVPNTYKR
HHHCCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA