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The map label for this gene is metC [H]

Identifier: 146340851

GI number: 146340851

Start: 4092676

End: 4093869

Strand: Direct

Name: metC [H]

Synonym: BRADO3914

Alternate gene names: 146340851

Gene position: 4092676-4093869 (Clockwise)

Preceding gene: 146340846

Following gene: 146340852

Centisome position: 54.89

GC content: 65.16

Gene sequence:

>1194_bases
ATGGCATCCTCGAACGACCCCGCTTCGGCGGTGCGACAAAACGTCGAAACACGGCTGGTCACGGTGGGACGGGACACCAA
GGCGCAGCACGGATTCGTGAATCCGCCGGTCGTGCATGGCTCGACCGTGCTGTATCCCACCGCGGAGGATCTGCATGCAC
ACCGCGGCGAATTCCAGTATGGCCGCCACGGCACACCGACGACGAAAGCGCTGCAGCAGGCCTTGATGGCCCTCGAAGGT
CCGCAATGCGCAGGCGTCGGAATCGCGCCGTCCGGTCTCGGAGCCATCTCCACGACCCTGCTGTCGGTGCTGAAGGCCGG
GGACCATGTTCTGGTCTGCGACAGCATTTATCGTCCCACCCGAAATTTCTGCAACGGTATGCTGGCGCGCTACGGCGTCG
AAACGACCTATTTCGATCCATTGATCGGCACAGGAATTGAGCAACTGCTCAAACCGAATACACGCGCGGTGGTTGTCGAG
GCGCCCGGCTCGCAGTCCTTCGAAATGCCGGACATTCCGGCGATTGCAGCGGTGGCGCATGCGCATGGCGCGCTGGTCAT
CGACGACAACACCTGGGCCACGCCGCTGTACCACCGCTCCCTCGACCAGGGCGTCGACATCAGCATGCAGGCGGCCACCA
AATATATCGGCGGCCACTCCGACATCATGTTCGGCACGATTTCGGCCAACGCGAAGGCGTGGCCGCTGATCTCCGAAGGC
ATCCGCCTGCTTGGCGTCTGCGCCGGCCCCGACGACGTGTTCCTCGCCCTGCGCGGCGTGCGGACGCTCGGCGTGCGGCT
CGCGCAGCATCATCGCTCGGGACTGGAGATGGCGCGTTGGCTCGCGGCGCGCCCCGAGGTGATCGAGGTGCTGCATCCCG
CGCTCGAGAGCCATCCGGGCCACGCGATCTGGAAGCGCGACTTCACCGGCGCCTCCGGTCTGTTCAGCATCGTGCTGCAA
CCAAAGCCGCAAGCCGCCGTCGACGCCATGCTCGACACGCTGACCTTGTTCGGCATGGGTTATTCCTGGGGCGGCTTCGA
GAGTCTCGCGATCCCGTTCGACTGCTCGAGCTATCGCACCGCAACCTCATGGGCGCCCGGCGGACCCACGCTGCGGCTGC
ACATCGGGCTGGAGAACACCGAGGATCTCAAGGCCGATCTCGACCGCGGCTTCGCGGCCTTCAACGCCGCGTAA

Upstream 100 bases:

>100_bases
TCAAGGGGTTGACGGCCCTGTTCTGCATTCTGTTATTAACGACCGTAGTCCTGCCCGATTTGCGCTATCCCGGCGGCAAT
ACAAGAGAAAAGACACACTG

Downstream 100 bases:

>100_bases
GTCGGCTTCGCCGGCGGCGAAACGCCCGGCGATCAGGCAGCCGGGGCCGACAAAATAGCGTTGATCCCCGGCGGATTGGG
CGTAGCCTTCGCGGCAGGGC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MASSNDPASAVRQNVETRLVTVGRDTKAQHGFVNPPVVHGSTVLYPTAEDLHAHRGEFQYGRHGTPTTKALQQALMALEG
PQCAGVGIAPSGLGAISTTLLSVLKAGDHVLVCDSIYRPTRNFCNGMLARYGVETTYFDPLIGTGIEQLLKPNTRAVVVE
APGSQSFEMPDIPAIAAVAHAHGALVIDDNTWATPLYHRSLDQGVDISMQAATKYIGGHSDIMFGTISANAKAWPLISEG
IRLLGVCAGPDDVFLALRGVRTLGVRLAQHHRSGLEMARWLAARPEVIEVLHPALESHPGHAIWKRDFTGASGLFSIVLQ
PKPQAAVDAMLDTLTLFGMGYSWGGFESLAIPFDCSSYRTATSWAPGGPTLRLHIGLENTEDLKADLDRGFAAFNAA

Sequences:

>Translated_397_residues
MASSNDPASAVRQNVETRLVTVGRDTKAQHGFVNPPVVHGSTVLYPTAEDLHAHRGEFQYGRHGTPTTKALQQALMALEG
PQCAGVGIAPSGLGAISTTLLSVLKAGDHVLVCDSIYRPTRNFCNGMLARYGVETTYFDPLIGTGIEQLLKPNTRAVVVE
APGSQSFEMPDIPAIAAVAHAHGALVIDDNTWATPLYHRSLDQGVDISMQAATKYIGGHSDIMFGTISANAKAWPLISEG
IRLLGVCAGPDDVFLALRGVRTLGVRLAQHHRSGLEMARWLAARPEVIEVLHPALESHPGHAIWKRDFTGASGLFSIVLQ
PKPQAAVDAMLDTLTLFGMGYSWGGFESLAIPFDCSSYRTATSWAPGGPTLRLHIGLENTEDLKADLDRGFAAFNAA
>Mature_396_residues
ASSNDPASAVRQNVETRLVTVGRDTKAQHGFVNPPVVHGSTVLYPTAEDLHAHRGEFQYGRHGTPTTKALQQALMALEGP
QCAGVGIAPSGLGAISTTLLSVLKAGDHVLVCDSIYRPTRNFCNGMLARYGVETTYFDPLIGTGIEQLLKPNTRAVVVEA
PGSQSFEMPDIPAIAAVAHAHGALVIDDNTWATPLYHRSLDQGVDISMQAATKYIGGHSDIMFGTISANAKAWPLISEGI
RLLGVCAGPDDVFLALRGVRTLGVRLAQHHRSGLEMARWLAARPEVIEVLHPALESHPGHAIWKRDFTGASGLFSIVLQP
KPQAAVDAMLDTLTLFGMGYSWGGFESLAIPFDCSSYRTATSWAPGGPTLRLHIGLENTEDLKADLDRGFAAFNAA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=344, Percent_Identity=33.4302325581395, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI299473759, Length=343, Percent_Identity=30.3206997084548, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI25453487, Length=343, Percent_Identity=29.7376093294461, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI1789383, Length=391, Percent_Identity=44.7570332480818, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1790375, Length=387, Percent_Identity=30.2325581395349, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=31.6076294277929, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=323, Percent_Identity=34.3653250773994, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17538055, Length=295, Percent_Identity=33.5593220338983, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6321170, Length=341, Percent_Identity=46.9208211143695, Blast_Score=326, Evalue=5e-90,
Organism=Saccharomyces cerevisiae, GI6319307, Length=358, Percent_Identity=31.0055865921788, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323333, Length=384, Percent_Identity=25.5208333333333, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6321904, Length=280, Percent_Identity=29.2857142857143, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321254, Length=414, Percent_Identity=26.0869565217391, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19922554, Length=350, Percent_Identity=33.7142857142857, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42419; Mature: 42288

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSNDPASAVRQNVETRLVTVGRDTKAQHGFVNPPVVHGSTVLYPTAEDLHAHRGEFQY
CCCCCCHHHHHHHCCHHEEEEECCCCCCCCCCCCCCEECCCEEEECCHHHHHHCCCCCCC
GRHGTPTTKALQQALMALEGPQCAGVGIAPSGLGAISTTLLSVLKAGDHVLVCDSIYRPT
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECHHHCCH
RNFCNGMLARYGVETTYFDPLIGTGIEQLLKPNTRAVVVEAPGSQSFEMPDIPAIAAVAH
HHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHH
AHGALVIDDNTWATPLYHRSLDQGVDISMQAATKYIGGHSDIMFGTISANAKAWPLISEG
HCCEEEECCCCCCCHHHHHHHCCCCCEEHHHHHHHHCCCCCEEEEEECCCCCCCCCHHCC
IRLLGVCAGPDDVFLALRGVRTLGVRLAQHHRSGLEMARWLAARPEVIEVLHPALESHPG
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
HAIWKRDFTGASGLFSIVLQPKPQAAVDAMLDTLTLFGMGYSWGGFESLAIPFDCSSYRT
CEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCC
ATSWAPGGPTLRLHIGLENTEDLKADLDRGFAAFNAA
CCCCCCCCCEEEEEECCCCCHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
ASSNDPASAVRQNVETRLVTVGRDTKAQHGFVNPPVVHGSTVLYPTAEDLHAHRGEFQY
CCCCCHHHHHHHCCHHEEEEECCCCCCCCCCCCCCEECCCEEEECCHHHHHHCCCCCCC
GRHGTPTTKALQQALMALEGPQCAGVGIAPSGLGAISTTLLSVLKAGDHVLVCDSIYRPT
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECHHHCCH
RNFCNGMLARYGVETTYFDPLIGTGIEQLLKPNTRAVVVEAPGSQSFEMPDIPAIAAVAH
HHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHH
AHGALVIDDNTWATPLYHRSLDQGVDISMQAATKYIGGHSDIMFGTISANAKAWPLISEG
HCCEEEECCCCCCCHHHHHHHCCCCCEEHHHHHHHHCCCCCEEEEEECCCCCCCCCHHCC
IRLLGVCAGPDDVFLALRGVRTLGVRLAQHHRSGLEMARWLAARPEVIEVLHPALESHPG
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
HAIWKRDFTGASGLFSIVLQPKPQAAVDAMLDTLTLFGMGYSWGGFESLAIPFDCSSYRT
CEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCC
ATSWAPGGPTLRLHIGLENTEDLKADLDRGFAAFNAA
CCCCCCCCCEEEEEECCCCCHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]