Click here to switch to the map view.

The map label for this gene is pdxA [H]

Identifier: 146340300

GI number: 146340300

Start: 3518553

End: 3519554

Strand: Reverse

Name: pdxA [H]

Synonym: BRADO3323

Alternate gene names: 146340300

Gene position: 3519554-3518553 (Counterclockwise)

Preceding gene: 146340301

Following gene: 146340299

Centisome position: 47.2

GC content: 69.36

Gene sequence:

>1002_bases
ATGACGATTCCCCTCGCGCTCACGCTGGGCGAGCCAGCAGGCATTGGACCGGACATCACCCTGCTGGCCTGGCTGCGTCG
CGCCGAGCTCGGTTTGCCCGCCTTCTATGTGCTCGGCGATCCCGCGTTCCTGGCGCAGCGCGCCAAGCTCCTGGACCTGC
AGATTCCGATCGCCGAGGCGCGGCCCGAAGAGGCCTCGCAAGCGTTCGCGAGCGCCCTCCCCGTCGTCTCCACGGGACAT
CGCATCACCGCCCCGCCCGGCCGGCCCGACGCGACCAGCGCCGAGGCGGCCATCGGTTCGATCCGCCAGGCCGTGGCCGA
CGTCAAGGCCGGGCGCGCAGGCGCCGTCGTGACCAACCCGATCGCGAAGGCCGTTCTCTACCGCGCCGGCTTTGCGCATC
CCGGCCACACCGAGTTTCTCGCCGAGCTGGCCGCCGATGGCGGCACCGTGCCGCAGCCCGTGATGATGCTGTGGTCGCCG
ATGCTGGCCGTCGTGCCCGTGACCATCCACGTCGCGTTGCGCGACGCGATCGAGCAGCTCACAAGCCCATTGATCACCTC
GACGACCCGCATCGTTGCCGCCAGCCTGCGCCGCTATTTCGGCGTGTCGCGGCCGCGCATCGCGATGTCCGGGCTCAATC
CGCATGCCGGCGAGGACGGCACGCTGGGCACCGAGGAAGACACCATCATTGCGCCTGCGATCGCAAATCTGCGCAACGCC
GGCATCGATGTGCAGGGGCCGCTGCCGGCCGACACGATGTTTCACCAGGCGGCGCGCAAGACCTATGATTGCGCCGTCTG
CATGTATCACGACCAGGCGCTGATCCCGATCAAGACGCTGGCCTTCGACGACGGCGTCAACGTCACGCTCGGCCTGCCCT
TCATCCGGACATCCCCCGACCACGGCACGGCGTTCGGGATCGCCGGCAAGGGCAGCGCCAATCCGGCGAGTCTGATCGCG
GCCCTGCAGCTCGCCGCGCGCATGGCCCGCCAATCGTCATGA

Upstream 100 bases:

>100_bases
CGCGCGAGATCAAGGAACAGATGTACGCCAAGAAATATGAGGCGACGTCGAAGGCCTATCTGCAGGAAGTCCGCAAGGCG
GCGATGATCGAATATCGCTG

Downstream 100 bases:

>100_bases
GCGCGATCGACGACCTCCCGCCGCTGCGCGAGGTCATCCGCGAGCACCAGCTGTCGGCGCGCAAGGCGCTCGGCCAGAAC
TTCCTGCTCGATCTCAACCT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase 2 [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MTIPLALTLGEPAGIGPDITLLAWLRRAELGLPAFYVLGDPAFLAQRAKLLDLQIPIAEARPEEASQAFASALPVVSTGH
RITAPPGRPDATSAEAAIGSIRQAVADVKAGRAGAVVTNPIAKAVLYRAGFAHPGHTEFLAELAADGGTVPQPVMMLWSP
MLAVVPVTIHVALRDAIEQLTSPLITSTTRIVAASLRRYFGVSRPRIAMSGLNPHAGEDGTLGTEEDTIIAPAIANLRNA
GIDVQGPLPADTMFHQAARKTYDCAVCMYHDQALIPIKTLAFDDGVNVTLGLPFIRTSPDHGTAFGIAGKGSANPASLIA
ALQLAARMARQSS

Sequences:

>Translated_333_residues
MTIPLALTLGEPAGIGPDITLLAWLRRAELGLPAFYVLGDPAFLAQRAKLLDLQIPIAEARPEEASQAFASALPVVSTGH
RITAPPGRPDATSAEAAIGSIRQAVADVKAGRAGAVVTNPIAKAVLYRAGFAHPGHTEFLAELAADGGTVPQPVMMLWSP
MLAVVPVTIHVALRDAIEQLTSPLITSTTRIVAASLRRYFGVSRPRIAMSGLNPHAGEDGTLGTEEDTIIAPAIANLRNA
GIDVQGPLPADTMFHQAARKTYDCAVCMYHDQALIPIKTLAFDDGVNVTLGLPFIRTSPDHGTAFGIAGKGSANPASLIA
ALQLAARMARQSS
>Mature_332_residues
TIPLALTLGEPAGIGPDITLLAWLRRAELGLPAFYVLGDPAFLAQRAKLLDLQIPIAEARPEEASQAFASALPVVSTGHR
ITAPPGRPDATSAEAAIGSIRQAVADVKAGRAGAVVTNPIAKAVLYRAGFAHPGHTEFLAELAADGGTVPQPVMMLWSPM
LAVVPVTIHVALRDAIEQLTSPLITSTTRIVAASLRRYFGVSRPRIAMSGLNPHAGEDGTLGTEEDTIIAPAIANLRNAG
IDVQGPLPADTMFHQAARKTYDCAVCMYHDQALIPIKTLAFDDGVNVTLGLPFIRTSPDHGTAFGIAGKGSANPASLIAA
LQLAARMARQSS

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=325, Percent_Identity=38.4615384615385, Blast_Score=204, Evalue=6e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 34775; Mature: 34643

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPLALTLGEPAGIGPDITLLAWLRRAELGLPAFYVLGDPAFLAQRAKLLDLQIPIAEA
CCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHEEECCHHHC
RPEEASQAFASALPVVSTGHRITAPPGRPDATSAEAAIGSIRQAVADVKAGRAGAVVTNP
CCHHHHHHHHHHCCCEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHH
IAKAVLYRAGFAHPGHTEFLAELAADGGTVPQPVMMLWSPMLAVVPVTIHVALRDAIEQL
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSPLITSTTRIVAASLRRYFGVSRPRIAMSGLNPHAGEDGTLGTEEDTIIAPAIANLRNA
HHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHHC
GIDVQGPLPADTMFHQAARKTYDCAVCMYHDQALIPIKTLAFDDGVNVTLGLPFIRTSPD
CCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCEEEEECCEEEECCC
HGTAFGIAGKGSANPASLIAALQLAARMARQSS
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIPLALTLGEPAGIGPDITLLAWLRRAELGLPAFYVLGDPAFLAQRAKLLDLQIPIAEA
CEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHEEECCHHHC
RPEEASQAFASALPVVSTGHRITAPPGRPDATSAEAAIGSIRQAVADVKAGRAGAVVTNP
CCHHHHHHHHHHCCCEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHH
IAKAVLYRAGFAHPGHTEFLAELAADGGTVPQPVMMLWSPMLAVVPVTIHVALRDAIEQL
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSPLITSTTRIVAASLRRYFGVSRPRIAMSGLNPHAGEDGTLGTEEDTIIAPAIANLRNA
HHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHHC
GIDVQGPLPADTMFHQAARKTYDCAVCMYHDQALIPIKTLAFDDGVNVTLGLPFIRTSPD
CCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCEEEEECCEEEECCC
HGTAFGIAGKGSANPASLIAALQLAARMARQSS
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]