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The map label for this gene is mmsB [H]

Identifier: 146340125

GI number: 146340125

Start: 3338649

End: 3339539

Strand: Direct

Name: mmsB [H]

Synonym: BRADO3140

Alternate gene names: 146340125

Gene position: 3338649-3339539 (Clockwise)

Preceding gene: 146340124

Following gene: 146340126

Centisome position: 44.77

GC content: 67.79

Gene sequence:

>891_bases
ATGGCAACGATCGCATTCATCGGCCTCGGCAACATGGGCGGCCCGATGGCCGCCAATCTCGTCAAGGCCGGCCACCAGGT
GGTCGCGTTCGATCTGGTCGAGGCCTCGCGCGCGCAGGCCAAGGCCGATGGCGCCGCGATCGCCGAGAGCGCCGTCGTTG
CGGTGAAGGGCGCGGACGCGGTCGTCACCATGCTGCCGGCCGGCAAGCACGTGCTGGCGGTGTGGAACGAGGTTGTACCC
GCGATGAGCAAGGGCGCCCTGATCATCGACTCCTCGACCATCGACGTCGAGAGCGCGCGATCAGCGCATGCGCTCGCTGC
CAAGCATGGCATCGCCGCCGTCGACGCCCCGGTGTCCGGCGGCACAGGCGGCGCCAAAGCCGCCACGCTCACCTTCATGT
GCGGCGGCGAGGAGGGCGCTTTCGCTGCAGCGAAGCCGATCCTCGAGACAATGGGCAAGAAGATCGTCCATTGCGGCGGC
GCCGGCGCGGGGCAGGCGGCCAAGATCTGCAACAACATGATCCTGGGCATCTCGATGATCGCGGTCGGCGAGGCCTTTGC
GCTAGGCGAAAAGCTCGGGCTGTCGCACCAGGCGCTGTTCGACGTCGCCTCGACCTCCTCAGGGCAGTGCTGGTCGCTGA
CGTCGTATTGCCCCGTGCCCGGCCCGGTACCGGCTTCGCCGGCAAACAACGACTATAGACCGGGCTTCGCGACCGCGCTG
ATGCTCAAGGATCTCACGCTCTCGCAGGACGCGGCCAAGGCCGCCGGTGCGGCGACGCCGCTCGGCCAGCATGCGCAGGA
AATCTACAAGGCGTTCGACGCCGCCGGCCATGGTGGCGTCGATTTCTCAGGCATCATTCAGCACGTCCGCAAGCTCGCCG
GGACCACCTGA

Upstream 100 bases:

>100_bases
ACGCCGGAGATGTTGGCGCCGTATCTCGCCGAGAACGGCCCTGACGAGCTGACATTCCCGCAAGCGAGATAACAAGCAGG
TCGAGGGGAGACAACGAAGC

Downstream 100 bases:

>100_bases
TGACGACATTCAAGGACGCACGCGCGTTTCTTTTGGCGCATCGCACCGACTACGATGCCGCCGTAAAGGGCTTTCGCTGG
CCCGATCCGGTGCCGTTCAA

Product: putative 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MATIAFIGLGNMGGPMAANLVKAGHQVVAFDLVEASRAQAKADGAAIAESAVVAVKGADAVVTMLPAGKHVLAVWNEVVP
AMSKGALIIDSSTIDVESARSAHALAAKHGIAAVDAPVSGGTGGAKAATLTFMCGGEEGAFAAAKPILETMGKKIVHCGG
AGAGQAAKICNNMILGISMIAVGEAFALGEKLGLSHQALFDVASTSSGQCWSLTSYCPVPGPVPASPANNDYRPGFATAL
MLKDLTLSQDAAKAAGAATPLGQHAQEIYKAFDAAGHGGVDFSGIIQHVRKLAGTT

Sequences:

>Translated_296_residues
MATIAFIGLGNMGGPMAANLVKAGHQVVAFDLVEASRAQAKADGAAIAESAVVAVKGADAVVTMLPAGKHVLAVWNEVVP
AMSKGALIIDSSTIDVESARSAHALAAKHGIAAVDAPVSGGTGGAKAATLTFMCGGEEGAFAAAKPILETMGKKIVHCGG
AGAGQAAKICNNMILGISMIAVGEAFALGEKLGLSHQALFDVASTSSGQCWSLTSYCPVPGPVPASPANNDYRPGFATAL
MLKDLTLSQDAAKAAGAATPLGQHAQEIYKAFDAAGHGGVDFSGIIQHVRKLAGTT
>Mature_295_residues
ATIAFIGLGNMGGPMAANLVKAGHQVVAFDLVEASRAQAKADGAAIAESAVVAVKGADAVVTMLPAGKHVLAVWNEVVPA
MSKGALIIDSSTIDVESARSAHALAAKHGIAAVDAPVSGGTGGAKAATLTFMCGGEEGAFAAAKPILETMGKKIVHCGGA
GAGQAAKICNNMILGISMIAVGEAFALGEKLGLSHQALFDVASTSSGQCWSLTSYCPVPGPVPASPANNDYRPGFATALM
LKDLTLSQDAAKAAGAATPLGQHAQEIYKAFDAAGHGGVDFSGIIQHVRKLAGTT

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=42.9553264604811, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI40556376, Length=287, Percent_Identity=24.390243902439, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1790315, Length=301, Percent_Identity=35.8803986710963, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI145693186, Length=294, Percent_Identity=32.9931972789116, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786719, Length=305, Percent_Identity=33.7704918032787, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789092, Length=289, Percent_Identity=28.719723183391, Blast_Score=88, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17557316, Length=300, Percent_Identity=42, Blast_Score=225, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6321695, Length=209, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24655230, Length=290, Percent_Identity=43.7931034482759, Blast_Score=240, Evalue=7e-64,
Organism=Drosophila melanogaster, GI19922568, Length=290, Percent_Identity=43.7931034482759, Blast_Score=240, Evalue=7e-64,
Organism=Drosophila melanogaster, GI28574115, Length=294, Percent_Identity=23.1292517006803, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 29500; Mature: 29369

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIAFIGLGNMGGPMAANLVKAGHQVVAFDLVEASRAQAKADGAAIAESAVVAVKGADA
CCEEEEEEECCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCHHHHHCEEEEEECCCE
VVTMLPAGKHVLAVWNEVVPAMSKGALIIDSSTIDVESARSAHALAAKHGIAAVDAPVSG
EEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHCCHHHHHHHHCCCEEECCCCCC
GTGGAKAATLTFMCGGEEGAFAAAKPILETMGKKIVHCGGAGAGQAAKICNNMILGISMI
CCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHH
AVGEAFALGEKLGLSHQALFDVASTSSGQCWSLTSYCPVPGPVPASPANNDYRPGFATAL
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHH
MLKDLTLSQDAAKAAGAATPLGQHAQEIYKAFDAAGHGGVDFSGIIQHVRKLAGTT
HHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATIAFIGLGNMGGPMAANLVKAGHQVVAFDLVEASRAQAKADGAAIAESAVVAVKGADA
CEEEEEEECCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCHHHHHCEEEEEECCCE
VVTMLPAGKHVLAVWNEVVPAMSKGALIIDSSTIDVESARSAHALAAKHGIAAVDAPVSG
EEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHCCHHHHHHHHCCCEEECCCCCC
GTGGAKAATLTFMCGGEEGAFAAAKPILETMGKKIVHCGGAGAGQAAKICNNMILGISMI
CCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHH
AVGEAFALGEKLGLSHQALFDVASTSSGQCWSLTSYCPVPGPVPASPANNDYRPGFATAL
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHH
MLKDLTLSQDAAKAAGAATPLGQHAQEIYKAFDAAGHGGVDFSGIIQHVRKLAGTT
HHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]