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The map label for this gene is ytcI [H]

Identifier: 146340126

GI number: 146340126

Start: 3339539

End: 3341266

Strand: Direct

Name: ytcI [H]

Synonym: BRADO3141

Alternate gene names: 146340126

Gene position: 3339539-3341266 (Clockwise)

Preceding gene: 146340125

Following gene: 146340127

Centisome position: 44.79

GC content: 66.67

Gene sequence:

>1728_bases
ATGACGACATTCAAGGACGCACGCGCGTTTCTTTTGGCGCATCGCACCGACTACGATGCCGCCGTAAAGGGCTTTCGCTG
GCCCGATCCGGTGCCGTTCAACTGGGCGCTCGACTGGTTCGATGCCGAGCTCGCCTCCGATCCCGAGAGCCGCGAGCGTA
CGGCGCTGTGGATCTTCGATGCCGCGCAGGACCGCCAGACGAAACTGTCTTTCGCCGCGCTGTCGCGCCGCTCCAATCAG
GTCGCCAACTTCCTGCGTGGCCAGGGGCTGAAGCGCGGCGATCATCTGCTGCTTCTACTCGGCAATGTCGTGCCGCTGTG
GGAGACGATGCTGGCGGCGATGAAGCTCGGCGTCGTCGTGATCCCCGCGACCACGCTGCTGACCACCGACGAACTGCGCG
ACCGGCTGGAGCGCGGCCGCGCCAAGGCCGTGGTCGCCGCGCAGGATCAGGTCGCCAAGTTCGCCGATCTCGGCGCGGAC
GATCTCGTCCGCATTGTCGTGGGGACGACGACGTCCACTGGTTGGCTTCCGTTCGACAAGGCGGCCGATGCCGCCGAGCC
GTTCACGCCCGACGGACCGACGCAGCCCGATGATCCGATGCTGCTGTACTTCACGTCCGGCACGACGGCCAAGCCGAAGC
TGGTGCGGCACAGCCACCGCAGCTATCCGGTCGGCCATCTCTCGACGATGTACTGGCTCGGCCTGCAGCCGGGCGACGTC
CATCTCAACATCTCCTCGCCGGGCTGGGCCAAGCATGCCTGGAGCTGCTTCTTCTCGCCGTGGAATGCCGGCGCGACCGT
GTTCGTCGTCAACCAGCCGCGCTTCGACGCCAAGGGACTGCTCGCGATCATCAAGCGCTGCGGCGTGACGACGCTGTGCG
CGCCGCCGACGGTGTGGCGGCTGTTCATCCAGGAGCATCTCGCCGACTTCAAGGTGTCCTTGCGCGAAGCCTGCGGCGCC
GGCGAGCCGCTCAACCCGGAAGTGATCGATCAGGTCCGCGCCGCCTGGGGACTGACGATCCGCGATGGCTACGGCCAGAC
CGAGACCGCGGCGATCTGCGGCAACTCGCCGGGGCAGAAGCTCAAGATCGGCTCGATGGGGCGGCCGCTGCCGGGCTATC
GTGTCGAGGTTGCCGACATTGATGGCAATTTGGCGAGCGAGGGCGAGATCACCCTGGCGCTCACAGGCGAGCGCCCGGCC
GGCCTGATGCAAGGTTATCAGGGAGACGATGGTAAGCTCTCCGGCGCCGATGGCCCGCGCTATCGCGCCGGCGACGTCGT
GTTCCAGGACGAGGAGGGCTATCTCACTTTCGTTGGCCGCTCCGACGACGTGTTCAAATCGTCCGACTACCGTATCTCGC
CGTTCGAGCTCGAGAGCGTGCTGCTGGAGCACGAGGCGGTGGCCGAGGCGGCGGTGGTGCCGAGCCCCGATCCGATCCGA
CTGGCGATTCCCAAGGCCTATGTGCTGCTGACATCCGGCGCCCCGCGCTCGCGCGCGACCGCGCTGTCGATCTTCGAGCA
TCTGCAGCAGCGGCTGGCACCGTTCAAGCGCATCCGCCGGCTCGAGCTGGTCAGCGAGCTGCCGAAGACGATCTCCGGGA
AAATCCGGCGCGTGCAGCTGCGCCGGCTCGAGCACGAGGATAACCGCACGGATCATCTGCGCGGCACGGAGTTCAGGGAA
GAGGATTTCCCGGAATTGAAGACACGGCCATCCGGGCACGAGGTGTAG

Upstream 100 bases:

>100_bases
ATGCGCAGGAAATCTACAAGGCGTTCGACGCCGCCGGCCATGGTGGCGTCGATTTCTCAGGCATCATTCAGCACGTCCGC
AAGCTCGCCGGGACCACCTG

Downstream 100 bases:

>100_bases
GGAACGCATGAACAAGATCTGGAATAAGCCGCCGATTTCACTCGAAGCCTATCAGGCCATGGTTGGCCAGGAGATCGGGG
TCTCGTCATGGCACGTGCTC

Product: putative acetyl-CoA synthetase

Products: AMP; diphosphate; acetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MTTFKDARAFLLAHRTDYDAAVKGFRWPDPVPFNWALDWFDAELASDPESRERTALWIFDAAQDRQTKLSFAALSRRSNQ
VANFLRGQGLKRGDHLLLLLGNVVPLWETMLAAMKLGVVVIPATTLLTTDELRDRLERGRAKAVVAAQDQVAKFADLGAD
DLVRIVVGTTTSTGWLPFDKAADAAEPFTPDGPTQPDDPMLLYFTSGTTAKPKLVRHSHRSYPVGHLSTMYWLGLQPGDV
HLNISSPGWAKHAWSCFFSPWNAGATVFVVNQPRFDAKGLLAIIKRCGVTTLCAPPTVWRLFIQEHLADFKVSLREACGA
GEPLNPEVIDQVRAAWGLTIRDGYGQTETAAICGNSPGQKLKIGSMGRPLPGYRVEVADIDGNLASEGEITLALTGERPA
GLMQGYQGDDGKLSGADGPRYRAGDVVFQDEEGYLTFVGRSDDVFKSSDYRISPFELESVLLEHEAVAEAAVVPSPDPIR
LAIPKAYVLLTSGAPRSRATALSIFEHLQQRLAPFKRIRRLELVSELPKTISGKIRRVQLRRLEHEDNRTDHLRGTEFRE
EDFPELKTRPSGHEV

Sequences:

>Translated_575_residues
MTTFKDARAFLLAHRTDYDAAVKGFRWPDPVPFNWALDWFDAELASDPESRERTALWIFDAAQDRQTKLSFAALSRRSNQ
VANFLRGQGLKRGDHLLLLLGNVVPLWETMLAAMKLGVVVIPATTLLTTDELRDRLERGRAKAVVAAQDQVAKFADLGAD
DLVRIVVGTTTSTGWLPFDKAADAAEPFTPDGPTQPDDPMLLYFTSGTTAKPKLVRHSHRSYPVGHLSTMYWLGLQPGDV
HLNISSPGWAKHAWSCFFSPWNAGATVFVVNQPRFDAKGLLAIIKRCGVTTLCAPPTVWRLFIQEHLADFKVSLREACGA
GEPLNPEVIDQVRAAWGLTIRDGYGQTETAAICGNSPGQKLKIGSMGRPLPGYRVEVADIDGNLASEGEITLALTGERPA
GLMQGYQGDDGKLSGADGPRYRAGDVVFQDEEGYLTFVGRSDDVFKSSDYRISPFELESVLLEHEAVAEAAVVPSPDPIR
LAIPKAYVLLTSGAPRSRATALSIFEHLQQRLAPFKRIRRLELVSELPKTISGKIRRVQLRRLEHEDNRTDHLRGTEFRE
EDFPELKTRPSGHEV
>Mature_574_residues
TTFKDARAFLLAHRTDYDAAVKGFRWPDPVPFNWALDWFDAELASDPESRERTALWIFDAAQDRQTKLSFAALSRRSNQV
ANFLRGQGLKRGDHLLLLLGNVVPLWETMLAAMKLGVVVIPATTLLTTDELRDRLERGRAKAVVAAQDQVAKFADLGADD
LVRIVVGTTTSTGWLPFDKAADAAEPFTPDGPTQPDDPMLLYFTSGTTAKPKLVRHSHRSYPVGHLSTMYWLGLQPGDVH
LNISSPGWAKHAWSCFFSPWNAGATVFVVNQPRFDAKGLLAIIKRCGVTTLCAPPTVWRLFIQEHLADFKVSLREACGAG
EPLNPEVIDQVRAAWGLTIRDGYGQTETAAICGNSPGQKLKIGSMGRPLPGYRVEVADIDGNLASEGEITLALTGERPAG
LMQGYQGDDGKLSGADGPRYRAGDVVFQDEEGYLTFVGRSDDVFKSSDYRISPFELESVLLEHEAVAEAAVVPSPDPIRL
AIPKAYVLLTSGAPRSRATALSIFEHLQQRLAPFKRIRRLELVSELPKTISGKIRRVQLRRLEHEDNRTDHLRGTEFREE
DFPELKTRPSGHEV

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=557, Percent_Identity=37.5224416517056, Blast_Score=358, Evalue=1e-98,
Organism=Homo sapiens, GI38505220, Length=529, Percent_Identity=37.6181474480151, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI122937307, Length=555, Percent_Identity=38.7387387387387, Blast_Score=336, Evalue=4e-92,
Organism=Homo sapiens, GI58082049, Length=529, Percent_Identity=34.4045368620038, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI157311624, Length=529, Percent_Identity=34.4045368620038, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI157311622, Length=529, Percent_Identity=34.4045368620038, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI115511026, Length=540, Percent_Identity=34.8148148148148, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI42544134, Length=385, Percent_Identity=34.8051948051948, Blast_Score=227, Evalue=3e-59,
Organism=Homo sapiens, GI195947378, Length=435, Percent_Identity=31.0344827586207, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI13375727, Length=535, Percent_Identity=25.607476635514, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI8923896, Length=549, Percent_Identity=26.0473588342441, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI28416953, Length=565, Percent_Identity=23.716814159292, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI253970489, Length=390, Percent_Identity=28.2051282051282, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI156151445, Length=543, Percent_Identity=25.7826887661142, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI187761345, Length=389, Percent_Identity=25.9640102827763, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI187761343, Length=389, Percent_Identity=25.9640102827763, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1790505, Length=564, Percent_Identity=27.4822695035461, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI221142682, Length=507, Percent_Identity=26.0355029585799, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786810, Length=507, Percent_Identity=27.6134122287968, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786529, Length=553, Percent_Identity=24.4122965641953, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788107, Length=514, Percent_Identity=25.0972762645914, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI145693145, Length=529, Percent_Identity=24.1965973534972, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1786801, Length=455, Percent_Identity=25.9340659340659, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788595, Length=349, Percent_Identity=26.0744985673352, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531443, Length=530, Percent_Identity=25.6603773584906, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71983001, Length=541, Percent_Identity=26.6173752310536, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71982997, Length=541, Percent_Identity=26.6173752310536, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17559526, Length=539, Percent_Identity=23.9332096474954, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17557194, Length=543, Percent_Identity=24.4935543278085, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71985884, Length=386, Percent_Identity=24.8704663212435, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=498, Percent_Identity=23.2931726907631, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71996755, Length=499, Percent_Identity=23.8476953907816, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17538037, Length=543, Percent_Identity=25.414364640884, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994694, Length=524, Percent_Identity=22.5190839694656, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI32563687, Length=515, Percent_Identity=22.7184466019417, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71994703, Length=524, Percent_Identity=22.5190839694656, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71994690, Length=524, Percent_Identity=22.5190839694656, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560308, Length=381, Percent_Identity=26.7716535433071, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560140, Length=414, Percent_Identity=24.8792270531401, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323182, Length=539, Percent_Identity=27.6437847866419, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319264, Length=530, Percent_Identity=27.7358490566038, Blast_Score=134, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6319699, Length=351, Percent_Identity=23.9316239316239, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24667955, Length=547, Percent_Identity=25.4113345521024, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI62472339, Length=540, Percent_Identity=25.5555555555556, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24667959, Length=372, Percent_Identity=29.0322580645161, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21355181, Length=515, Percent_Identity=26.7961165048544, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355225, Length=525, Percent_Identity=24.7619047619048, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI18859661, Length=518, Percent_Identity=25.8687258687259, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922652, Length=487, Percent_Identity=24.6406570841889, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356947, Length=486, Percent_Identity=24.0740740740741, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24581924, Length=514, Percent_Identity=24.7081712062257, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648260, Length=511, Percent_Identity=25.0489236790607, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24648255, Length=506, Percent_Identity=22.9249011857708, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24653035, Length=209, Percent_Identity=28.7081339712919, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24648253, Length=422, Percent_Identity=23.2227488151659, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1

Molecular weight: Translated: 63574; Mature: 63443

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFKDARAFLLAHRTDYDAAVKGFRWPDPVPFNWALDWFDAELASDPESRERTALWIFD
CCCHHHHHEEEEEECCCHHHHHCCCCCCCCCCCCEEEHHHHHHHCCCCCCCCCEEEEEEE
AAQDRQTKLSFAALSRRSNQVANFLRGQGLKRGDHLLLLLGNVVPLWETMLAAMKLGVVV
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEE
IPATTLLTTDELRDRLERGRAKAVVAAQDQVAKFADLGADDLVRIVVGTTTSTGWLPFDK
ECCHHEEEHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCC
AADAAEPFTPDGPTQPDDPMLLYFTSGTTAKPKLVRHSHRSYPVGHLSTMYWLGLQPGDV
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCHHHCEEEEEECCCCCE
HLNISSPGWAKHAWSCFFSPWNAGATVFVVNQPRFDAKGLLAIIKRCGVTTLCAPPTVWR
EEEECCCCCHHHHHHEECCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEECCCHHHHH
LFIQEHLADFKVSLREACGAGEPLNPEVIDQVRAAWGLTIRDGYGQTETAAICGNSPGQK
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEECCCCCCCEEEEECCCCCCE
LKIGSMGRPLPGYRVEVADIDGNLASEGEITLALTGERPAGLMQGYQGDDGKLSGADGPR
EEECCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCEECCCCCCC
YRAGDVVFQDEEGYLTFVGRSDDVFKSSDYRISPFELESVLLEHEAVAEAAVVPSPDPIR
CCCCCEEEECCCCEEEEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCEE
LAIPKAYVLLTSGAPRSRATALSIFEHLQQRLAPFKRIRRLELVSELPKTISGKIRRVQL
EECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLEHEDNRTDHLRGTEFREEDFPELKTRPSGHEV
HHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCC
>Mature Secondary Structure 
TTFKDARAFLLAHRTDYDAAVKGFRWPDPVPFNWALDWFDAELASDPESRERTALWIFD
CCHHHHHEEEEEECCCHHHHHCCCCCCCCCCCCEEEHHHHHHHCCCCCCCCCEEEEEEE
AAQDRQTKLSFAALSRRSNQVANFLRGQGLKRGDHLLLLLGNVVPLWETMLAAMKLGVVV
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEE
IPATTLLTTDELRDRLERGRAKAVVAAQDQVAKFADLGADDLVRIVVGTTTSTGWLPFDK
ECCHHEEEHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCC
AADAAEPFTPDGPTQPDDPMLLYFTSGTTAKPKLVRHSHRSYPVGHLSTMYWLGLQPGDV
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCHHHCEEEEEECCCCCE
HLNISSPGWAKHAWSCFFSPWNAGATVFVVNQPRFDAKGLLAIIKRCGVTTLCAPPTVWR
EEEECCCCCHHHHHHEECCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEECCCHHHHH
LFIQEHLADFKVSLREACGAGEPLNPEVIDQVRAAWGLTIRDGYGQTETAAICGNSPGQK
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEECCCCCCCEEEEECCCCCCE
LKIGSMGRPLPGYRVEVADIDGNLASEGEITLALTGERPAGLMQGYQGDDGKLSGADGPR
EEECCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCEECCCCCCC
YRAGDVVFQDEEGYLTFVGRSDDVFKSSDYRISPFELESVLLEHEAVAEAAVVPSPDPIR
CCCCCEEEECCCCEEEEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCEE
LAIPKAYVLLTSGAPRSRATALSIFEHLQQRLAPFKRIRRLELVSELPKTISGKIRRVQL
EECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLEHEDNRTDHLRGTEFREEDFPELKTRPSGHEV
HHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetate; CoA

Specific reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

General reaction: Acid-thiol ligation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]