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The map label for this gene is ybiC [H]

Identifier: 146339605

GI number: 146339605

Start: 2781084

End: 2782169

Strand: Direct

Name: ybiC [H]

Synonym: BRADO2597

Alternate gene names: 146339605

Gene position: 2781084-2782169 (Clockwise)

Preceding gene: 146339604

Following gene: 146339606

Centisome position: 37.3

GC content: 64.73

Gene sequence:

>1086_bases
ATGGTTACAATCCAGGTTGAGCGCCTCATCGACTTCGTTGCCGACGTCTTCGAACATGCCCAGTCTTCTCCGGAGGAGGC
GCGCCGGATCGCAACCTATCTCACGACCGCCAACCTCACAGGGCACGACAGCCATGGCGTGATCCGGGTCCCCGTCTACA
TCCGCTGGCAGAAGATGGGTTCGATCGTCCCCAACCAGACGGCGGAGATCGTGGTCGATACGCCATCGCTGGTAGTGGTC
GACGGCAAGTTCGGATACGGCCAGACGGTCACGCCGCAGGCGGTCAAGATCGGCATCGAGCGCTGCAAGACGAGTGGCCT
GGCGGCGCTCGCGTTGCGCAATTCCGGCCATCTCGGCCGCGTCGGCGACTGGGCCGAAATGGCCGCCGCTGAAGGTCTCG
TCTCGATTCACTTCGTGACTGCCGCGGGTTCTTTGTTGGTTGCGCCCTATGGCGGAGTGGAGAAGCGGTTCTCGACGGCG
CCGTATTGCGTCGGCATTCCGCGTATGGGCCAGGATCCGATCGTGCTCGATTTTGCGACCTCGATCGTCGCCGAAGGCAA
GGTCCTGGTGGCGAGCCGTGGTGGCAAGAAGTTACCGAAGGGAGCGCTGATCGATGCCGACGGCACCCTGAGCGAGAATC
CTGCGGTGCTCTATGGTCCATATGAGGCCGAAGGCCCGCGCGACCACACCAAGGGCACGGGCGCGATCCGCGCCTTCGGC
GAGCACAAGGGCTCGGGTCTCGCCTTCATCTGCGAACTGCTTGGCGGTGCCTTGACGGGCACGGGCGCGACCTCGTCCGG
CCGGCGCTTTGCCAACGGCATGCTCGCGATCTACATCGACCCCAAGGTGGTCGATCCTGCCAACTTCTTCGATGGCGAGA
TCACCCGCTACACGGATTTCATCCGGGCGACGAAGCCGGTGGCCGGCGTCGATCACGTGCTGGTGCCCGGCGACGTCGAG
CGCAAGACGCGGGCCGATCGCACGGCCAATGGTGTGCCGCTGCCTGACGACACTTGGGCAGCGATCGTTGGGACGGCCCG
CGAGGTCGGCGTGAGCGAGGTGAGCATTCAGCGGGCGACGTCATGA

Upstream 100 bases:

>100_bases
GATAAGAAGCGATGCAGTCGAGCGGAGATGGCGTTGCGTCGCAGGCATGGCAATCCATGCTAACTCTGTTTTCGCATGCT
GATCGAACCCGCGAGTTGTC

Downstream 100 bases:

>100_bases
TCTCCAGAGATTGCCGGTGGCGCGGCGCGGCATGTGAGCGGGATTGCATCGCGCTCACGCATCGAAGAACGAGTTTGAAC
AACGTAGACTGAACAACCAG

Product: hypothetical protein

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MVTIQVERLIDFVADVFEHAQSSPEEARRIATYLTTANLTGHDSHGVIRVPVYIRWQKMGSIVPNQTAEIVVDTPSLVVV
DGKFGYGQTVTPQAVKIGIERCKTSGLAALALRNSGHLGRVGDWAEMAAAEGLVSIHFVTAAGSLLVAPYGGVEKRFSTA
PYCVGIPRMGQDPIVLDFATSIVAEGKVLVASRGGKKLPKGALIDADGTLSENPAVLYGPYEAEGPRDHTKGTGAIRAFG
EHKGSGLAFICELLGGALTGTGATSSGRRFANGMLAIYIDPKVVDPANFFDGEITRYTDFIRATKPVAGVDHVLVPGDVE
RKTRADRTANGVPLPDDTWAAIVGTAREVGVSEVSIQRATS

Sequences:

>Translated_361_residues
MVTIQVERLIDFVADVFEHAQSSPEEARRIATYLTTANLTGHDSHGVIRVPVYIRWQKMGSIVPNQTAEIVVDTPSLVVV
DGKFGYGQTVTPQAVKIGIERCKTSGLAALALRNSGHLGRVGDWAEMAAAEGLVSIHFVTAAGSLLVAPYGGVEKRFSTA
PYCVGIPRMGQDPIVLDFATSIVAEGKVLVASRGGKKLPKGALIDADGTLSENPAVLYGPYEAEGPRDHTKGTGAIRAFG
EHKGSGLAFICELLGGALTGTGATSSGRRFANGMLAIYIDPKVVDPANFFDGEITRYTDFIRATKPVAGVDHVLVPGDVE
RKTRADRTANGVPLPDDTWAAIVGTAREVGVSEVSIQRATS
>Mature_361_residues
MVTIQVERLIDFVADVFEHAQSSPEEARRIATYLTTANLTGHDSHGVIRVPVYIRWQKMGSIVPNQTAEIVVDTPSLVVV
DGKFGYGQTVTPQAVKIGIERCKTSGLAALALRNSGHLGRVGDWAEMAAAEGLVSIHFVTAAGSLLVAPYGGVEKRFSTA
PYCVGIPRMGQDPIVLDFATSIVAEGKVLVASRGGKKLPKGALIDADGTLSENPAVLYGPYEAEGPRDHTKGTGAIRAFG
EHKGSGLAFICELLGGALTGTGATSSGRRFANGMLAIYIDPKVVDPANFFDGEITRYTDFIRATKPVAGVDHVLVPGDVE
RKTRADRTANGVPLPDDTWAAIVGTAREVGVSEVSIQRATS

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=357, Percent_Identity=38.375350140056, Blast_Score=248, Evalue=3e-67,
Organism=Escherichia coli, GI1786727, Length=358, Percent_Identity=23.7430167597765, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790000, Length=326, Percent_Identity=23.9263803680982, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17507179, Length=329, Percent_Identity=28.8753799392097, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17536633, Length=358, Percent_Identity=22.9050279329609, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24667908, Length=331, Percent_Identity=27.7945619335347, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45553211, Length=331, Percent_Identity=27.7945619335347, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24667912, Length=331, Percent_Identity=27.7945619335347, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24667904, Length=331, Percent_Identity=27.7945619335347, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24648360, Length=333, Percent_Identity=25.5255255255255, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24658010, Length=319, Percent_Identity=24.1379310344828, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 38139; Mature: 38139

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTIQVERLIDFVADVFEHAQSSPEEARRIATYLTTANLTGHDSHGVIRVPVYIRWQKMG
CEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCEEEEEEEEEEEECC
SIVPNQTAEIVVDTPSLVVVDGKFGYGQTVTPQAVKIGIERCKTSGLAALALRNSGHLGR
CCCCCCCCEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCC
VGDWAEMAAAEGLVSIHFVTAAGSLLVAPYGGVEKRFSTAPYCVGIPRMGQDPIVLDFAT
CCCHHHHHHHCCEEEEEEEECCCCEEEECCCCHHHHCCCCCEEEECCCCCCCCEEEEEHH
SIVAEGKVLVASRGGKKLPKGALIDADGTLSENPAVLYGPYEAEGPRDHTKGTGAIRAFG
HHHHCCEEEEEECCCCCCCCCCEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEC
EHKGSGLAFICELLGGALTGTGATSSGRRFANGMLAIYIDPKVVDPANFFDGEITRYTDF
CCCCCCHHHHHHHHCCCEECCCCCCCCCHHHCCEEEEEECCEEECCCCCCCCCHHHHHHH
IRATKPVAGVDHVLVPGDVERKTRADRTANGVPLPDDTWAAIVGTAREVGVSEVSIQRAT
HHHCCCCCCCCEEECCCCCCHHHHCCCCCCCCCCCCCCHHHHHHCHHHCCCCCEEEEECC
S
C
>Mature Secondary Structure
MVTIQVERLIDFVADVFEHAQSSPEEARRIATYLTTANLTGHDSHGVIRVPVYIRWQKMG
CEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCEEEEEEEEEEEECC
SIVPNQTAEIVVDTPSLVVVDGKFGYGQTVTPQAVKIGIERCKTSGLAALALRNSGHLGR
CCCCCCCCEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCC
VGDWAEMAAAEGLVSIHFVTAAGSLLVAPYGGVEKRFSTAPYCVGIPRMGQDPIVLDFAT
CCCHHHHHHHCCEEEEEEEECCCCEEEECCCCHHHHCCCCCEEEECCCCCCCCEEEEEHH
SIVAEGKVLVASRGGKKLPKGALIDADGTLSENPAVLYGPYEAEGPRDHTKGTGAIRAFG
HHHHCCEEEEEECCCCCCCCCCEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEC
EHKGSGLAFICELLGGALTGTGATSSGRRFANGMLAIYIDPKVVDPANFFDGEITRYTDF
CCCCCCHHHHHHHHCCCEECCCCCCCCCHHHCCEEEEEECCEEECCCCCCCCCHHHHHHH
IRATKPVAGVDHVLVPGDVERKTRADRTANGVPLPDDTWAAIVGTAREVGVSEVSIQRAT
HHHCCCCCCCCEEECCCCCCHHHHCCCCCCCCCCCCCCHHHHHHCHHHCCCCCEEEEECC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]