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The map label for this gene is betA [H]

Identifier: 146338933

GI number: 146338933

Start: 1998625

End: 2000250

Strand: Direct

Name: betA [H]

Synonym: BRADO1873

Alternate gene names: 146338933

Gene position: 1998625-2000250 (Clockwise)

Preceding gene: 146338932

Following gene: 146338934

Centisome position: 26.8

GC content: 65.93

Gene sequence:

>1626_bases
ATGGAAGGCAGCGTAGCATTGCGTGATCAGGAGCTGGAGTTCGATTACGTCGTGGTCGGCGCCGGCTCCGCTGGTTGCGT
GCTCGCCAATCGGCTCAGCAGCGACGGCAGGCACACGGTGCTGCTGCTCGAAGCCGGCCCAAAGGACACCAACATCTGGA
TCCATGTCCCGCTCGGCTACGGCAAGCTCTTCAAGGAAAAGACCGTCAACTGGATGTACCAGACCGAGCCCGAACCGGGG
CTCGACGGCCGCTCGGTGTTCCAGCCGCGCGGCAAGGTGCTCGGCGGCTCCAGCTCGATCAACGGCCTGCTGTATGTCCG
CGGCCAGCACGAGGACTACGACCGCTGGCGCCAGCGCGGCAATGTCGGCTGGGGCTATGACGACGTGCTGCCCTATTTCA
AGCGGGCTGAAAACCAGTCGCGCGGCGCCGACGACTATCACGGCACAGGCGGTCCGCTGCCGGTGTCGGACTGGCGGCAC
GAGGATCCTCTGTCGGAGGCCTTCGTCAAGGCGGCGGTCGAGACCGGCCTGCCTTTCAACGGCGACTTCAACGGTGCGAG
CCAGGAGGGCGCAGGCTTCTTCCAGACCACGACCCGACGCGGGCGCCGCGCCAGCAGCGCGGTGTCCTATCTGCGACCGG
CGCTCGGCCGCAGCAATCTCCATGTCGAGACCGATGCGCTGGCACAGCGCATCCTGTTCGAAGGACGCCGTGCCTGCGGT
GTCACGTTCAGCCAGCGCGGCCGGCTCCGGACGGCGCGGGCCCGCAAGGAGGTCCTCGTCTCGAGCGGGGCCTACAATTC
GCCGCAGCTGCTGCAGCTGTCCGGCGTCGGTCCTGCCGATCTGCTGAAGCAGCATGGCATCGACGTCGTGCTCGATGCGC
CGGGCGTCGGCGCCGACCTGCAGGACCATCTCCAGGTTCGCATCGTGATGCGTTGCAGTCAGCGCATCACACTCAACGAC
ATCGTCAATCATCCGGTCCGAAAGGTGATGGCAGGGGCACGCTACGCCGCGTTCCGCAAGGGGCCGCTGACGATCGCCGC
CGGCACGGCGGGTGCCTTCTTCAAGACAGATCCGCGGCTCGCCAGCCCCGACATCCAGATCCACTTCATTCCGTTCTCCA
CCGACAAGATGGGTGAAAAGCTGCACACCTTCTCCGGCTTCACGGCATCGGTCTGCCAGCTCCGGCCCGAAAGCCGGGGA
TCGCTGCGGATCCGGAGCGCCGATCCCGCGGTACCGCCGGAAATCCGCATCAATTATCTCGCCAGCGAGACCGACCGCCG
CGCCAACATCGACGGTCTTCGCATCCTGCGGAAAATCCTGGCGGCTCCGGCCCTGAAGCCGTATGTCTCGGATGAAGCCT
ATCCGGGGGGAAAGGTCGTGAGCGACGACGACATCCTGGCCTATTGCCGGCAGACCGGCAGCACGATCTATCATCCGACC
TCGACCTGCCGGATGGGGACCGATGCGCTGGCCGTGGTCGATGAGCGCCTGCGCGTGCGTGGAATCGGCGGTCTGCGGGT
CGTCGACGCCTCGATCATGCCGGACCTGGTTTCGGGCAACACCAATGCGCCGGTCATCATGATCGCGGAGAAGGCCTCCG
ACATGATCTTGCAGGACGCGCGCTGA

Upstream 100 bases:

>100_bases
AAGGACCGGTGTGCCGGCCAGATCTTCCGATTTGCCGCTTGCATGTGCTGCCTTTTTGGTATCTCCAGGATGAAAGAACA
AATGACCGGGCAGGAACACG

Downstream 100 bases:

>100_bases
CGCAGGAATGACCTCGTGACACGTTTCCGGATCGGCACCCGCAAGAGCACGATGGCGCTGGCGCAGACGGAGGAGATCGC
GCGCCGTCTGCAGGCCGCGA

Product: choline dehydrogenase

Products: betaine aldehyde; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MEGSVALRDQELEFDYVVVGAGSAGCVLANRLSSDGRHTVLLLEAGPKDTNIWIHVPLGYGKLFKEKTVNWMYQTEPEPG
LDGRSVFQPRGKVLGGSSSINGLLYVRGQHEDYDRWRQRGNVGWGYDDVLPYFKRAENQSRGADDYHGTGGPLPVSDWRH
EDPLSEAFVKAAVETGLPFNGDFNGASQEGAGFFQTTTRRGRRASSAVSYLRPALGRSNLHVETDALAQRILFEGRRACG
VTFSQRGRLRTARARKEVLVSSGAYNSPQLLQLSGVGPADLLKQHGIDVVLDAPGVGADLQDHLQVRIVMRCSQRITLND
IVNHPVRKVMAGARYAAFRKGPLTIAAGTAGAFFKTDPRLASPDIQIHFIPFSTDKMGEKLHTFSGFTASVCQLRPESRG
SLRIRSADPAVPPEIRINYLASETDRRANIDGLRILRKILAAPALKPYVSDEAYPGGKVVSDDDILAYCRQTGSTIYHPT
STCRMGTDALAVVDERLRVRGIGGLRVVDASIMPDLVSGNTNAPVIMIAEKASDMILQDAR

Sequences:

>Translated_541_residues
MEGSVALRDQELEFDYVVVGAGSAGCVLANRLSSDGRHTVLLLEAGPKDTNIWIHVPLGYGKLFKEKTVNWMYQTEPEPG
LDGRSVFQPRGKVLGGSSSINGLLYVRGQHEDYDRWRQRGNVGWGYDDVLPYFKRAENQSRGADDYHGTGGPLPVSDWRH
EDPLSEAFVKAAVETGLPFNGDFNGASQEGAGFFQTTTRRGRRASSAVSYLRPALGRSNLHVETDALAQRILFEGRRACG
VTFSQRGRLRTARARKEVLVSSGAYNSPQLLQLSGVGPADLLKQHGIDVVLDAPGVGADLQDHLQVRIVMRCSQRITLND
IVNHPVRKVMAGARYAAFRKGPLTIAAGTAGAFFKTDPRLASPDIQIHFIPFSTDKMGEKLHTFSGFTASVCQLRPESRG
SLRIRSADPAVPPEIRINYLASETDRRANIDGLRILRKILAAPALKPYVSDEAYPGGKVVSDDDILAYCRQTGSTIYHPT
STCRMGTDALAVVDERLRVRGIGGLRVVDASIMPDLVSGNTNAPVIMIAEKASDMILQDAR
>Mature_541_residues
MEGSVALRDQELEFDYVVVGAGSAGCVLANRLSSDGRHTVLLLEAGPKDTNIWIHVPLGYGKLFKEKTVNWMYQTEPEPG
LDGRSVFQPRGKVLGGSSSINGLLYVRGQHEDYDRWRQRGNVGWGYDDVLPYFKRAENQSRGADDYHGTGGPLPVSDWRH
EDPLSEAFVKAAVETGLPFNGDFNGASQEGAGFFQTTTRRGRRASSAVSYLRPALGRSNLHVETDALAQRILFEGRRACG
VTFSQRGRLRTARARKEVLVSSGAYNSPQLLQLSGVGPADLLKQHGIDVVLDAPGVGADLQDHLQVRIVMRCSQRITLND
IVNHPVRKVMAGARYAAFRKGPLTIAAGTAGAFFKTDPRLASPDIQIHFIPFSTDKMGEKLHTFSGFTASVCQLRPESRG
SLRIRSADPAVPPEIRINYLASETDRRANIDGLRILRKILAAPALKPYVSDEAYPGGKVVSDDDILAYCRQTGSTIYHPT
STCRMGTDALAVVDERLRVRGIGGLRVVDASIMPDLVSGNTNAPVIMIAEKASDMILQDAR

Specific function: Converts aliphatic medium-chain-length alcohols into aldehydes. May be linked to the electron transfer chain [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=533, Percent_Identity=46.5290806754221, Blast_Score=458, Evalue=1e-129,
Organism=Escherichia coli, GI1786503, Length=535, Percent_Identity=42.0560747663551, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17532301, Length=556, Percent_Identity=37.589928057554, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24642059, Length=565, Percent_Identity=41.7699115044248, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24642042, Length=574, Percent_Identity=40.0696864111498, Blast_Score=358, Evalue=5e-99,
Organism=Drosophila melanogaster, GI45551458, Length=570, Percent_Identity=40.3508771929825, Blast_Score=357, Evalue=1e-98,
Organism=Drosophila melanogaster, GI45549471, Length=570, Percent_Identity=40.3508771929825, Blast_Score=357, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24642055, Length=586, Percent_Identity=37.542662116041, Blast_Score=344, Evalue=7e-95,
Organism=Drosophila melanogaster, GI24642048, Length=572, Percent_Identity=38.986013986014, Blast_Score=338, Evalue=5e-93,
Organism=Drosophila melanogaster, GI24642039, Length=573, Percent_Identity=38.9179755671902, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI17137792, Length=560, Percent_Identity=38.0357142857143, Blast_Score=319, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24650267, Length=568, Percent_Identity=37.5, Blast_Score=317, Evalue=2e-86,
Organism=Drosophila melanogaster, GI18859995, Length=569, Percent_Identity=36.9068541300527, Blast_Score=308, Evalue=7e-84,
Organism=Drosophila melanogaster, GI24642037, Length=569, Percent_Identity=35.8523725834798, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24642035, Length=577, Percent_Identity=35.8752166377816, Blast_Score=295, Evalue=8e-80,
Organism=Drosophila melanogaster, GI18859993, Length=571, Percent_Identity=35.3765323992995, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24642051, Length=569, Percent_Identity=33.9191564147627, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24642057, Length=585, Percent_Identity=29.9145299145299, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24645930, Length=577, Percent_Identity=27.7296360485269, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1

Molecular weight: Translated: 59071; Mature: 59071

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGSVALRDQELEFDYVVVGAGSAGCVLANRLSSDGRHTVLLLEAGPKDTNIWIHVPLGY
CCCCEEEECCCCCEEEEEEECCCCCCHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCC
GKLFKEKTVNWMYQTEPEPGLDGRSVFQPRGKVLGGSSSINGLLYVRGQHEDYDRWRQRG
HHHHHHHCCCEEEECCCCCCCCCCCEECCCCCEECCCCCCCEEEEEECCCCCHHHHHHCC
NVGWGYDDVLPYFKRAENQSRGADDYHGTGGPLPVSDWRHEDPLSEAFVKAAVETGLPFN
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
GDFNGASQEGAGFFQTTTRRGRRASSAVSYLRPALGRSNLHVETDALAQRILFEGRRACG
CCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCHHCC
VTFSQRGRLRTARARKEVLVSSGAYNSPQLLQLSGVGPADLLKQHGIDVVLDAPGVGADL
CCHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHCCCEEEEECCCCCCCH
QDHLQVRIVMRCSQRITLNDIVNHPVRKVMAGARYAAFRKGPLTIAAGTAGAFFKTDPRL
HHHHHEEEEEHHCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCEEEEECCCCCEEECCCCC
ASPDIQIHFIPFSTDKMGEKLHTFSGFTASVCQLRPESRGSLRIRSADPAVPPEIRINYL
CCCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHCCCCCCCCEEEECCCCCCCCCEEEEEE
ASETDRRANIDGLRILRKILAAPALKPYVSDEAYPGGKVVSDDDILAYCRQTGSTIYHPT
ECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCHHHHHHHHCCCEEECCC
STCRMGTDALAVVDERLRVRGIGGLRVVDASIMPDLVSGNTNAPVIMIAEKASDMILQDA
CCCCCCCHHHHHHHHHHHEECCCCEEEEEHHHCCHHHCCCCCCCEEEEECCCCCCHHCCC
R
C
>Mature Secondary Structure
MEGSVALRDQELEFDYVVVGAGSAGCVLANRLSSDGRHTVLLLEAGPKDTNIWIHVPLGY
CCCCEEEECCCCCEEEEEEECCCCCCHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCC
GKLFKEKTVNWMYQTEPEPGLDGRSVFQPRGKVLGGSSSINGLLYVRGQHEDYDRWRQRG
HHHHHHHCCCEEEECCCCCCCCCCCEECCCCCEECCCCCCCEEEEEECCCCCHHHHHHCC
NVGWGYDDVLPYFKRAENQSRGADDYHGTGGPLPVSDWRHEDPLSEAFVKAAVETGLPFN
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
GDFNGASQEGAGFFQTTTRRGRRASSAVSYLRPALGRSNLHVETDALAQRILFEGRRACG
CCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCHHCC
VTFSQRGRLRTARARKEVLVSSGAYNSPQLLQLSGVGPADLLKQHGIDVVLDAPGVGADL
CCHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHCCCEEEEECCCCCCCH
QDHLQVRIVMRCSQRITLNDIVNHPVRKVMAGARYAAFRKGPLTIAAGTAGAFFKTDPRL
HHHHHEEEEEHHCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCEEEEECCCCCEEECCCCC
ASPDIQIHFIPFSTDKMGEKLHTFSGFTASVCQLRPESRGSLRIRSADPAVPPEIRINYL
CCCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHCCCCCCCCEEEECCCCCCCCCEEEEEE
ASETDRRANIDGLRILRKILAAPALKPYVSDEAYPGGKVVSDDDILAYCRQTGSTIYHPT
ECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCHHHHHHHHCCCEEECCC
STCRMGTDALAVVDERLRVRGIGGLRVVDASIMPDLVSGNTNAPVIMIAEKASDMILQDA
CCCCCCCHHHHHHHHHHHEECCCCEEEEEHHHCCHHHCCCCCCCEEEEECCCCCCHHCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: choline; acceptor

Specific reaction: choline + acceptor = betaine aldehyde + reduced acceptor

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11390693 [H]