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The map label for this gene is hemC [H]

Identifier: 146338934

GI number: 146338934

Start: 2000266

End: 2001243

Strand: Direct

Name: hemC [H]

Synonym: BRADO1874

Alternate gene names: 146338934

Gene position: 2000266-2001243 (Clockwise)

Preceding gene: 146338933

Following gene: 146338936

Centisome position: 26.83

GC content: 70.04

Gene sequence:

>978_bases
GTGACACGTTTCCGGATCGGCACCCGCAAGAGCACGATGGCGCTGGCGCAGACGGAGGAGATCGCGCGCCGTCTGCAGGC
CGCGATCCCGTCGCTCGACATCGAGATCGTCAAGTTCGAGACCACGGGCGATTCCGACCAGACCAGCAAGCTCCTCACCC
ATGGCGGCAAGGGAGGGGCGTTCGTCGCCGAGATCCGGCGCGCCATGCTGGACGGCAAGCTGCATGCGGCGATGCATTCG
CTGAAGGACATGCCGGGCAATGAGGAGACGCCTGGCCTCGTCATTGCGGCGCTGCTGTCGCGCGATCCGCCGGGTGATGT
GCTGGTGTTGCGCAAGGGGCTGGCGCTGGAGGACTTCCGCAAGGATGGCGGCCGCGGCTTCAAGATCGGCACCAATGCGG
TGCGCCGCGCGGCCTATGCGCGGCGGCTGTTTCCGCACGCGGAGCTGATTCATTTCCGCGGCGCCGCCGACACCCGCATC
CGCAAGCTCGACAATGGTGAGCTGCAGCGGATGCCGGATGGCGGTGCGGTCGGCCCGGCGGATGCGCTGATCATGGCGCG
GTCCGGGCTGGAGCGGGTCGGCCTGTCCGACCGCGCGTCCCATGAATTCCCGGTCGCGGACATGCTGCCGGCGGTCGGGC
AGGGCATCGTCGCGGTCGAGTGCCCCGCATCGGATTTCGAGACGCGGCGCATTCTCGCGACCGTCGACGACGCGGCGGCT
CGGACCTGCGCGGATGCCGAGCGCGAGGTGCTGTGGGTGCTCAACGGCCACTGCAACTCGCCGATTGCGGGCTTCTCGAC
CATTGACGGCGCGCAGATGACCTTGACCGCCTCGGTGCTCGACGAGGACGGCGGCCGCTTCATCGAGGCCCAGCGGACCG
GCCCCGCCGATCGTCCGCGCGAGCTCGGCCGGGCGGTCGGGCTCGAATTGCTCGCCAGCGGCGCGGCCGCGCTGATCGAG
CGCAGCCGGCCGCGTTAG

Upstream 100 bases:

>100_bases
GGACCTGGTTTCGGGCAACACCAATGCGCCGGTCATCATGATCGCGGAGAAGGCCTCCGACATGATCTTGCAGGACGCGC
GCTGACGCAGGAATGACCTC

Downstream 100 bases:

>100_bases
GTCATCATCCTTTGTAGGCCCGTACACGCGCCAGCATCTGCTCGACATGGGCGATCGGGGTTTCTGGCGTGATGCCGTGG
CCGAGATTGAAGATGTGCCG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTRFRIGTRKSTMALAQTEEIARRLQAAIPSLDIEIVKFETTGDSDQTSKLLTHGGKGGAFVAEIRRAMLDGKLHAAMHS
LKDMPGNEETPGLVIAALLSRDPPGDVLVLRKGLALEDFRKDGGRGFKIGTNAVRRAAYARRLFPHAELIHFRGAADTRI
RKLDNGELQRMPDGGAVGPADALIMARSGLERVGLSDRASHEFPVADMLPAVGQGIVAVECPASDFETRRILATVDDAAA
RTCADAEREVLWVLNGHCNSPIAGFSTIDGAQMTLTASVLDEDGGRFIEAQRTGPADRPRELGRAVGLELLASGAAALIE
RSRPR

Sequences:

>Translated_325_residues
MTRFRIGTRKSTMALAQTEEIARRLQAAIPSLDIEIVKFETTGDSDQTSKLLTHGGKGGAFVAEIRRAMLDGKLHAAMHS
LKDMPGNEETPGLVIAALLSRDPPGDVLVLRKGLALEDFRKDGGRGFKIGTNAVRRAAYARRLFPHAELIHFRGAADTRI
RKLDNGELQRMPDGGAVGPADALIMARSGLERVGLSDRASHEFPVADMLPAVGQGIVAVECPASDFETRRILATVDDAAA
RTCADAEREVLWVLNGHCNSPIAGFSTIDGAQMTLTASVLDEDGGRFIEAQRTGPADRPRELGRAVGLELLASGAAALIE
RSRPR
>Mature_324_residues
TRFRIGTRKSTMALAQTEEIARRLQAAIPSLDIEIVKFETTGDSDQTSKLLTHGGKGGAFVAEIRRAMLDGKLHAAMHSL
KDMPGNEETPGLVIAALLSRDPPGDVLVLRKGLALEDFRKDGGRGFKIGTNAVRRAAYARRLFPHAELIHFRGAADTRIR
KLDNGELQRMPDGGAVGPADALIMARSGLERVGLSDRASHEFPVADMLPAVGQGIVAVECPASDFETRRILATVDDAAAR
TCADAEREVLWVLNGHCNSPIAGFSTIDGAQMTLTASVLDEDGGRFIEAQRTGPADRPRELGRAVGLELLASGAAALIER
SRPR

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=317, Percent_Identity=32.1766561514196, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI66933009, Length=317, Percent_Identity=32.1766561514196, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI48994974, Length=312, Percent_Identity=33.6538461538462, Blast_Score=145, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319996, Length=329, Percent_Identity=29.1793313069909, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI20130425, Length=293, Percent_Identity=34.4709897610922, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34862; Mature: 34731

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRFRIGTRKSTMALAQTEEIARRLQAAIPSLDIEIVKFETTGDSDQTSKLLTHGGKGGA
CCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCH
FVAEIRRAMLDGKLHAAMHSLKDMPGNEETPGLVIAALLSRDPPGDVLVLRKGLALEDFR
HHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHH
KDGGRGFKIGTNAVRRAAYARRLFPHAELIHFRGAADTRIRKLDNGELQRMPDGGAVGPA
HCCCCCEEECHHHHHHHHHHHHHCCCHHHEEECCCCCHHHHCCCCCCEEECCCCCCCCHH
DALIMARSGLERVGLSDRASHEFPVADMLPAVGQGIVAVECPASDFETRRILATVDDAAA
HHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCEEEEEHHHHHH
RTCADAEREVLWVLNGHCNSPIAGFSTIDGAQMTLTASVLDEDGGRFIEAQRTGPADRPR
HHHHCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEHHCCCCEEEEECCCCCCCCHH
ELGRAVGLELLASGAAALIERSRPR
HHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TRFRIGTRKSTMALAQTEEIARRLQAAIPSLDIEIVKFETTGDSDQTSKLLTHGGKGGA
CCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCH
FVAEIRRAMLDGKLHAAMHSLKDMPGNEETPGLVIAALLSRDPPGDVLVLRKGLALEDFR
HHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHH
KDGGRGFKIGTNAVRRAAYARRLFPHAELIHFRGAADTRIRKLDNGELQRMPDGGAVGPA
HCCCCCEEECHHHHHHHHHHHHHCCCHHHEEECCCCCHHHHCCCCCCEEECCCCCCCCHH
DALIMARSGLERVGLSDRASHEFPVADMLPAVGQGIVAVECPASDFETRRILATVDDAAA
HHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCEEEEEHHHHHH
RTCADAEREVLWVLNGHCNSPIAGFSTIDGAQMTLTASVLDEDGGRFIEAQRTGPADRPR
HHHHCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEHHCCCCEEEEECCCCCCCCHH
ELGRAVGLELLASGAAALIERSRPR
HHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA