Click here to switch to the map view.

The map label for this gene is gltP [H]

Identifier: 146337809

GI number: 146337809

Start: 722158

End: 723453

Strand: Direct

Name: gltP [H]

Synonym: BRADO0688

Alternate gene names: 146337809

Gene position: 722158-723453 (Clockwise)

Preceding gene: 146337806

Following gene: 146337810

Centisome position: 9.68

GC content: 61.11

Gene sequence:

>1296_bases
ATGTCGAACAGGTTCACGCAATACATTCTGATTGCGATGGTGCTTGGCATCGTGATGGGAACGCTGATCTTCAACCTGCT
GCCTGACAGCCGCATCGAACTCGCCGCCGACATCAACCTCGTTGCGATGCTTTTCCTGCGCCTCATCAAGATGATCATCG
CGCCGCTGGTGTTCGCGACCCTGGTCGGTGGCATCGCCCATATGGGGTCCGGCGCAAAGCTCGGACGCATCTTCGCCAAG
ACCATGGGATGGTTCCTCAGCGCGTCCTTCGTCTCGCTGCTGCTTGGCCTCGTCATGGTGAACCTGCTGCAGCCAGGTGC
GAACTTCCCGGGAACGCTGCCGGACAAGGGCCAGTCGACCAGCCTGCCGGTCTCGGCCTTCTCGATCGAAAAGTTTCTGA
CTCACTTGATCCCGACATCCATCGCCGATGCGATGGCGCAGAACGAGATTCTGCAGATCGTGATCTTCGCCGTATTCTTC
TCGATCGCGATGGGAGCGCTGCCGGAACGGTCCAAGGCGCTGTTGCAGCTGATCGATGACGTCGGCCACATCATGCTGAA
GGTCACGAGCTACTTCATGCTGTTCGCGCCGCTGGCGGTGTGGGCCGCGATCACGGCGACCGTCGCCAAGAACGGCCTCG
GGGTGCTCTGGAAGCTCGTGGTTTTCATGGGCGGCTTCTATCTCTCGCTGCTGCTGTTGTGGGCGATCCTCGTGGTGGTA
GGCTTCGTCGTCATCGGTCCGCGCTACAGTCATCTGTTGAAGCTGATCCGTGAGCCGTTGATGATCGCCTTCTCGACGGC
GAGCTCCGAGGCGGCCTATCCGAAAACGCTCGAGGGCCTGAACAGGTTCGGCGCCTCGAAGCGCATTTCAAGCTTCGTGC
TGCCTCTCGGCTATTCGTTCAACCTCGACGGCACGATGATGTATTGCACGTTCGCCAGCATCTTCATCGCCCAGACCTAC
AAGATCGAAATGCCGCTGGGCACGCAACTGGCCATGCTCGCCACCCTGATGATCACCTCGAAGGGTGTCGCCGGGGTGCC
GCGCGCTTCGCTGGTCGTCATTGCCTCGACATTGTCGCAGTTCGGCATACCTGAGGCGGGCCTGCTGATGATCATGGGCA
TCGACACCTTCCTCGACATGGGACGGAGCGCGACCAACGTGATCGGCAACACGCTTGCAACCTCGGTGGTGGCGAAGTGG
GAAGGTGAGCTCGGGCCGGAGCATGCGCTCGGCCCGTCGGATGTCGTGCCGCCCGACATGATCCCCGGCGAGGTTCCGGC
CATGGCCGGGCAGTGA

Upstream 100 bases:

>100_bases
ACGTCGGAAATCCAGCATCCGGAGTCGCTGCGGCATATTGCGCCCTTGCCAAAATCTGCCAAACTCAACCCGACCGGGAG
TTCTGCTTTGGGGGTGGTGA

Downstream 100 bases:

>100_bases
CGGAGGCCCGGCATGCGCGGTTGCGTCGTCGTCGCAAGTCTCACGGTCGCAGCACTGCTCGCGTGCGCCGGCGCGCAACC
GGGTATCGCGCAAAGCGGCG

Product: putative sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSNRFTQYILIAMVLGIVMGTLIFNLLPDSRIELAADINLVAMLFLRLIKMIIAPLVFATLVGGIAHMGSGAKLGRIFAK
TMGWFLSASFVSLLLGLVMVNLLQPGANFPGTLPDKGQSTSLPVSAFSIEKFLTHLIPTSIADAMAQNEILQIVIFAVFF
SIAMGALPERSKALLQLIDDVGHIMLKVTSYFMLFAPLAVWAAITATVAKNGLGVLWKLVVFMGGFYLSLLLLWAILVVV
GFVVIGPRYSHLLKLIREPLMIAFSTASSEAAYPKTLEGLNRFGASKRISSFVLPLGYSFNLDGTMMYCTFASIFIAQTY
KIEMPLGTQLAMLATLMITSKGVAGVPRASLVVIASTLSQFGIPEAGLLMIMGIDTFLDMGRSATNVIGNTLATSVVAKW
EGELGPEHALGPSDVVPPDMIPGEVPAMAGQ

Sequences:

>Translated_431_residues
MSNRFTQYILIAMVLGIVMGTLIFNLLPDSRIELAADINLVAMLFLRLIKMIIAPLVFATLVGGIAHMGSGAKLGRIFAK
TMGWFLSASFVSLLLGLVMVNLLQPGANFPGTLPDKGQSTSLPVSAFSIEKFLTHLIPTSIADAMAQNEILQIVIFAVFF
SIAMGALPERSKALLQLIDDVGHIMLKVTSYFMLFAPLAVWAAITATVAKNGLGVLWKLVVFMGGFYLSLLLLWAILVVV
GFVVIGPRYSHLLKLIREPLMIAFSTASSEAAYPKTLEGLNRFGASKRISSFVLPLGYSFNLDGTMMYCTFASIFIAQTY
KIEMPLGTQLAMLATLMITSKGVAGVPRASLVVIASTLSQFGIPEAGLLMIMGIDTFLDMGRSATNVIGNTLATSVVAKW
EGELGPEHALGPSDVVPPDMIPGEVPAMAGQ
>Mature_430_residues
SNRFTQYILIAMVLGIVMGTLIFNLLPDSRIELAADINLVAMLFLRLIKMIIAPLVFATLVGGIAHMGSGAKLGRIFAKT
MGWFLSASFVSLLLGLVMVNLLQPGANFPGTLPDKGQSTSLPVSAFSIEKFLTHLIPTSIADAMAQNEILQIVIFAVFFS
IAMGALPERSKALLQLIDDVGHIMLKVTSYFMLFAPLAVWAAITATVAKNGLGVLWKLVVFMGGFYLSLLLLWAILVVVG
FVVIGPRYSHLLKLIREPLMIAFSTASSEAAYPKTLEGLNRFGASKRISSFVLPLGYSFNLDGTMMYCTFASIFIAQTYK
IEMPLGTQLAMLATLMITSKGVAGVPRASLVVIASTLSQFGIPEAGLLMIMGIDTFLDMGRSATNVIGNTLATSVVAKWE
GELGPEHALGPSDVVPPDMIPGEVPAMAGQ

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=433, Percent_Identity=24.4803695150115, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI4827012, Length=255, Percent_Identity=29.8039215686275, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI40254478, Length=467, Percent_Identity=23.982869379015, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI21314632, Length=406, Percent_Identity=26.1083743842365, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI66773030, Length=464, Percent_Identity=23.9224137931034, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI5032093, Length=387, Percent_Identity=25.5813953488372, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI194239697, Length=148, Percent_Identity=36.4864864864865, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI223468564, Length=261, Percent_Identity=26.8199233716475, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI223468566, Length=261, Percent_Identity=26.8199233716475, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI301601644, Length=172, Percent_Identity=31.3953488372093, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI262359914, Length=365, Percent_Identity=22.7397260273973, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1790514, Length=420, Percent_Identity=41.4285714285714, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1789947, Length=403, Percent_Identity=36.2282878411911, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1788024, Length=386, Percent_Identity=26.1658031088083, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789473, Length=389, Percent_Identity=22.6221079691517, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=440, Percent_Identity=27.2727272727273, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71996953, Length=425, Percent_Identity=25.6470588235294, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI193206505, Length=435, Percent_Identity=27.1264367816092, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193206654, Length=482, Percent_Identity=23.4439834024896, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71983099, Length=409, Percent_Identity=21.2713936430318, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71983106, Length=409, Percent_Identity=21.2713936430318, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17541374, Length=399, Percent_Identity=20.8020050125313, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583025, Length=431, Percent_Identity=26.2180974477958, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI17137668, Length=431, Percent_Identity=26.2180974477958, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24583023, Length=431, Percent_Identity=26.2180974477958, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281360483, Length=417, Percent_Identity=26.1390887290168, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17137666, Length=417, Percent_Identity=26.1390887290168, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281360481, Length=417, Percent_Identity=26.1390887290168, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46173; Mature: 46042

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCC
>Mature Secondary Structure 
SNRFTQYILIAMVLGIVMGTLIFNLLPDSRIELAADINLVAMLFLRLIKMIIAPLVFAT
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGGIAHMGSGAKLGRIFAKTMGWFLSASFVSLLLGLVMVNLLQPGANFPGTLPDKGQST
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SLPVSAFSIEKFLTHLIPTSIADAMAQNEILQIVIFAVFFSIAMGALPERSKALLQLIDD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VGHIMLKVTSYFMLFAPLAVWAAITATVAKNGLGVLWKLVVFMGGFYLSLLLLWAILVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFVVIGPRYSHLLKLIREPLMIAFSTASSEAAYPKTLEGLNRFGASKRISSFVLPLGYSF
HHHHHCCCHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCCCEE
NLDGTMMYCTFASIFIAQTYKIEMPLGTQLAMLATLMITSKGVAGVPRASLVVIASTLSQ
CCCCHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
FGIPEAGLLMIMGIDTFLDMGRSATNVIGNTLATSVVAKWEGELGPEHALGPSDVVPPDM
HCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
IPGEVPAMAGQ
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]