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The map label for this gene is hisA [H]

Identifier: 146337382

GI number: 146337382

Start: 226985

End: 227719

Strand: Direct

Name: hisA [H]

Synonym: BRADO0215

Alternate gene names: 146337382

Gene position: 226985-227719 (Clockwise)

Preceding gene: 146337381

Following gene: 146337383

Centisome position: 3.04

GC content: 66.26

Gene sequence:

>735_bases
ATGATCCTGTTTCCCGCCATCGATCTGAAGAACGGCCAATGCGTGCGCCTGGAGCAGGGCGACATGGCGCGGGCCACGGT
GTTCAACCTCGACCCCGCAGCCCAGGCCAAGAGCTTCGCCGATCAGGGCTTCGAATATCTCCACGTCGTCGACCTCGACG
GCGCCTTCGCCGGCAAGCCGATGAACGCGCAGGCCGTCGAGGCGATGCTGAAAATCGTCAAGATGCCGGTGCAGCTCGGC
GGCGGCATCCGCGATCTCAAGACCGTCGAGGCCTGGCTCGGCAAGGGCATCACCCGCGTCATCATCGGCACCGCCGCGGT
GCGCGATCCCGAGCTGGTGAAGATGGCCGCGAAAGCCTTTCCCGGCCGCGTCGCCGTCGGCCTCGATGCGCGCGACGGCA
AGGTCGCGGTCGAGGGCTGGGCGGAAACGTCAGAAGTGACAGCGCTCGATATTGCCAAACGTTTCGAGGACGCCGGCGTC
GCGGCGATCATCTTCACCGACATCGCGCGCGACGGCTTGCTGAAGGGTTTAAATCTCGACGCCACAATCGCACTCGGTGA
CGCCATCTCGATCCCCGTCATCGCCTCCGGCGGTCTCGCCTCGATCGAAGACGTCAAGGCAATGCTGACGCCGCGGGCGA
GGAAGCTCGAAGGCGCCATCGCCGGCCGCGCGCTCTATGACGGGCGGCTGGATCCGGCGGAAGCGCTGGCGCTGATTCGC
GCGATCAGCGGGTAG

Upstream 100 bases:

>100_bases
GGTCTCGCCTTGATTTCCAACTTCCTGAAATGGAAGCCGTGAGCGCCGTCGTCCTGTTCGCCCCGGGGCGGGCAGGGCGC
GCTCTTGAGAGTCACCAGAT

Downstream 100 bases:

>100_bases
GGGAGAACAATATGTTCAAGGTCCGCGTCATTCCCTGCCTCGACGTCAAGGACGGCCGTGTCGTCAAGGGCGTCAACTTC
GTCAATCTGCGCGACGCCGG

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MILFPAIDLKNGQCVRLEQGDMARATVFNLDPAAQAKSFADQGFEYLHVVDLDGAFAGKPMNAQAVEAMLKIVKMPVQLG
GGIRDLKTVEAWLGKGITRVIIGTAAVRDPELVKMAAKAFPGRVAVGLDARDGKVAVEGWAETSEVTALDIAKRFEDAGV
AAIIFTDIARDGLLKGLNLDATIALGDAISIPVIASGGLASIEDVKAMLTPRARKLEGAIAGRALYDGRLDPAEALALIR
AISG

Sequences:

>Translated_244_residues
MILFPAIDLKNGQCVRLEQGDMARATVFNLDPAAQAKSFADQGFEYLHVVDLDGAFAGKPMNAQAVEAMLKIVKMPVQLG
GGIRDLKTVEAWLGKGITRVIIGTAAVRDPELVKMAAKAFPGRVAVGLDARDGKVAVEGWAETSEVTALDIAKRFEDAGV
AAIIFTDIARDGLLKGLNLDATIALGDAISIPVIASGGLASIEDVKAMLTPRARKLEGAIAGRALYDGRLDPAEALALIR
AISG
>Mature_244_residues
MILFPAIDLKNGQCVRLEQGDMARATVFNLDPAAQAKSFADQGFEYLHVVDLDGAFAGKPMNAQAVEAMLKIVKMPVQLG
GGIRDLKTVEAWLGKGITRVIIGTAAVRDPELVKMAAKAFPGRVAVGLDARDGKVAVEGWAETSEVTALDIAKRFEDAGV
AAIIFTDIARDGLLKGLNLDATIALGDAISIPVIASGGLASIEDVKAMLTPRARKLEGAIAGRALYDGRLDPAEALALIR
AISG

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=247, Percent_Identity=35.2226720647773, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1788336, Length=248, Percent_Identity=23.7903225806452, Blast_Score=70, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 25576; Mature: 25576

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILFPAIDLKNGQCVRLEQGDMARATVFNLDPAAQAKSFADQGFEYLHVVDLDGAFAGKP
CEEECEEECCCCCEEEECCCCCCEEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCCCC
MNAQAVEAMLKIVKMPVQLGGGIRDLKTVEAWLGKGITRVIIGTAAVRDPELVKMAAKAF
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEHHCCCCHHHHHHHHHHC
PGRVAVGLDARDGKVAVEGWAETSEVTALDIAKRFEDAGVAAIIFTDIARDGLLKGLNLD
CCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHCCCCCC
ATIALGDAISIPVIASGGLASIEDVKAMLTPRARKLEGAIAGRALYDGRLDPAEALALIR
EEEEECCCEECCEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCEEECCCCCHHHHHHHHH
AISG
HHCC
>Mature Secondary Structure
MILFPAIDLKNGQCVRLEQGDMARATVFNLDPAAQAKSFADQGFEYLHVVDLDGAFAGKP
CEEECEEECCCCCEEEECCCCCCEEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCCCC
MNAQAVEAMLKIVKMPVQLGGGIRDLKTVEAWLGKGITRVIIGTAAVRDPELVKMAAKAF
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEHHCCCCHHHHHHHHHHC
PGRVAVGLDARDGKVAVEGWAETSEVTALDIAKRFEDAGVAAIIFTDIARDGLLKGLNLD
CCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHCCCCCC
ATIALGDAISIPVIASGGLASIEDVKAMLTPRARKLEGAIAGRALYDGRLDPAEALALIR
EEEEECCCEECCEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCEEECCCCCHHHHHHHHH
AISG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA