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The map label for this gene is fabB [H]

Identifier: 146337236

GI number: 146337236

Start: 72036

End: 73259

Strand: Reverse

Name: fabB [H]

Synonym: BRADO0062

Alternate gene names: 146337236

Gene position: 73259-72036 (Counterclockwise)

Preceding gene: 146337237

Following gene: 146337235

Centisome position: 0.98

GC content: 64.71

Gene sequence:

>1224_bases
ATGAGGCGGGTCGTCATCACGGGCATGGGCATCGTCTCGTCGATCGGCAACAACACCCAGGAGGTGCTTGCGAGCCTGTA
CGAGGCGAAGTCCGGCATCTCCCGTGCTGAGAAATATGCCGAGCTTGGTTTCCGTTCGCAGGTGCAAGGTGCGCCGACGC
TGAATCCGGCCGAGGTGGTCGACCGTCGCGCGATGCGTTTCCTCGGCGAGGGCGCGGCGTGGAATCACGTCGCGATGGAG
CAGGCAATCCTCGATTCCGGTCTGGAGCCGACCGATGTCTCCAACGTCCGCACCGGCATCATCATGGGCTCGGGCGGGCC
GTCGACGCGCACCCTGGTCGAGGCCGCCGACATCACCCGCACCAAGGGCCCGAAGCGCGTCGGACCTTTCGCAGTGCCGA
AGGCGATGTCGTCGACGGCCTCGGCGACGCTCGCGACCTGGTTCAAGATCAAGGGCGTCAACTACTCGATCTCCTCGGCC
TGCGCGACCTCCAATCATTGCATCGGCAATGCCTATGAAATGATCCAGTATGGCAAGCAGGATGTGATGTTCGCCGGCGG
CTGCGAGGAGCTCGACTGGACGCTCTCGGTGCTGTTCGACGCGATGGGCGCGATGTCGTCCAAGCATAACGAGACGCCCG
CAACCGCCTCACGTCCGTATGATGTGAGCCGCGACGGCTTCGTGATCGCCGGCGGTGCTGGTGTGCTGGTGCTTGAAGAG
CTCGAGCGCGCCAAGGCGCGCGGCGCCAAGATCTATGGCGAGATCGTCGGCTATGGCGCGACCTCGGACGGCTACGACAT
GGTCGCGCCGTCGGGCGAGGGCGCGGAACGCTGCATGCAGATGGCACTGTCGACGGTGAAGACCAGGATCGATTACATCA
ATCCGCATGCGACCTCGACGCCGGCCGGCGATCCGCCGGAGATCGAGGCGATCCGCAAGGTGTTCGGATCGGGCGAGAAG
TGCCCGCCGATCGCGGCCACCAAGGCGCTGACCGGCCACTCGCTCGGCGCCACCGGCGTGCAGGAGGCGATCTACTCGCT
GCTCATGATGAAGAACGGCTTCATCTGCGAGAGCGCCAACATCACCGAGCTCGATCCGGTGTTCGCGGACATGCCGATCG
TGCGCAGGCGCATCGACAATGCCAAGCTCGGCACCGTGCTGTCGAACTCGTTTGGCTTCGGCGGCACCAACGCGACGCTG
GTCTTCAAGCACCTCGACGCCTAA

Upstream 100 bases:

>100_bases
AAGCAGGGCGCCGCGCCGTCTTGAACCGGCGGACCGCGACCACAGACAGTGCAGCGAGCACCACTGCAACAGAACACATG
AGCAAGGCGAGGCGGACATC

Downstream 100 bases:

>100_bases
GGTTTCGAACAACACGGGTTCCTCTCACGAGCCGGACAACAGCGCGACGCGTTTCGCACCGCTGTCCGGCTATCGACGTC
CGGGGAACCTGACGATCATC

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MRRVVITGMGIVSSIGNNTQEVLASLYEAKSGISRAEKYAELGFRSQVQGAPTLNPAEVVDRRAMRFLGEGAAWNHVAME
QAILDSGLEPTDVSNVRTGIIMGSGGPSTRTLVEAADITRTKGPKRVGPFAVPKAMSSTASATLATWFKIKGVNYSISSA
CATSNHCIGNAYEMIQYGKQDVMFAGGCEELDWTLSVLFDAMGAMSSKHNETPATASRPYDVSRDGFVIAGGAGVLVLEE
LERAKARGAKIYGEIVGYGATSDGYDMVAPSGEGAERCMQMALSTVKTRIDYINPHATSTPAGDPPEIEAIRKVFGSGEK
CPPIAATKALTGHSLGATGVQEAIYSLLMMKNGFICESANITELDPVFADMPIVRRRIDNAKLGTVLSNSFGFGGTNATL
VFKHLDA

Sequences:

>Translated_407_residues
MRRVVITGMGIVSSIGNNTQEVLASLYEAKSGISRAEKYAELGFRSQVQGAPTLNPAEVVDRRAMRFLGEGAAWNHVAME
QAILDSGLEPTDVSNVRTGIIMGSGGPSTRTLVEAADITRTKGPKRVGPFAVPKAMSSTASATLATWFKIKGVNYSISSA
CATSNHCIGNAYEMIQYGKQDVMFAGGCEELDWTLSVLFDAMGAMSSKHNETPATASRPYDVSRDGFVIAGGAGVLVLEE
LERAKARGAKIYGEIVGYGATSDGYDMVAPSGEGAERCMQMALSTVKTRIDYINPHATSTPAGDPPEIEAIRKVFGSGEK
CPPIAATKALTGHSLGATGVQEAIYSLLMMKNGFICESANITELDPVFADMPIVRRRIDNAKLGTVLSNSFGFGGTNATL
VFKHLDA
>Mature_407_residues
MRRVVITGMGIVSSIGNNTQEVLASLYEAKSGISRAEKYAELGFRSQVQGAPTLNPAEVVDRRAMRFLGEGAAWNHVAME
QAILDSGLEPTDVSNVRTGIIMGSGGPSTRTLVEAADITRTKGPKRVGPFAVPKAMSSTASATLATWFKIKGVNYSISSA
CATSNHCIGNAYEMIQYGKQDVMFAGGCEELDWTLSVLFDAMGAMSSKHNETPATASRPYDVSRDGFVIAGGAGVLVLEE
LERAKARGAKIYGEIVGYGATSDGYDMVAPSGEGAERCMQMALSTVKTRIDYINPHATSTPAGDPPEIEAIRKVFGSGEK
CPPIAATKALTGHSLGATGVQEAIYSLLMMKNGFICESANITELDPVFADMPIVRRRIDNAKLGTVLSNSFGFGGTNATL
VFKHLDA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=36.6666666666667, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI41872631, Length=335, Percent_Identity=23.8805970149254, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI223972627, Length=165, Percent_Identity=38.1818181818182, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1788663, Length=407, Percent_Identity=61.6707616707617, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=36.8038740920097, Blast_Score=248, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=35.1415094339623, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI71983535, Length=270, Percent_Identity=38.5185185185185, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI212642053, Length=354, Percent_Identity=25.1412429378531, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=278, Percent_Identity=27.3381294964029, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=32.2222222222222, Blast_Score=195, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=36.6430260047281, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI19920632, Length=337, Percent_Identity=26.7062314540059, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI221330659, Length=337, Percent_Identity=26.7062314540059, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24581345, Length=389, Percent_Identity=23.3933161953728, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43098; Mature: 43098

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGMGIVSSIGNNTQEVLASLYEAKSGISRAEKYAELGFRSQVQGAPTLNPAEVV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHH
DRRAMRFLGEGAAWNHVAMEQAILDSGLEPTDVSNVRTGIIMGSGGPSTRTLVEAADITR
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
TKGPKRVGPFAVPKAMSSTASATLATWFKIKGVNYSISSACATSNHCIGNAYEMIQYGKQ
CCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCEEHHHHHCCCCCCCHHHHHHHHCCCC
DVMFAGGCEELDWTLSVLFDAMGAMSSKHNETPATASRPYDVSRDGFVIAGGAGVLVLEE
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHH
LERAKARGAKIYGEIVGYGATSDGYDMVAPSGEGAERCMQMALSTVKTRIDYINPHATST
HHHHHHCCCEEEEHHEECCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
PAGDPPEIEAIRKVFGSGEKCPPIAATKALTGHSLGATGVQEAIYSLLMMKNGFICESAN
CCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEECCCC
ITELDPVFADMPIVRRRIDNAKLGTVLSNSFGFGGTNATLVFKHLDA
CCCCCHHHHCCHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MRRVVITGMGIVSSIGNNTQEVLASLYEAKSGISRAEKYAELGFRSQVQGAPTLNPAEVV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHH
DRRAMRFLGEGAAWNHVAMEQAILDSGLEPTDVSNVRTGIIMGSGGPSTRTLVEAADITR
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
TKGPKRVGPFAVPKAMSSTASATLATWFKIKGVNYSISSACATSNHCIGNAYEMIQYGKQ
CCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCEEHHHHHCCCCCCCHHHHHHHHCCCC
DVMFAGGCEELDWTLSVLFDAMGAMSSKHNETPATASRPYDVSRDGFVIAGGAGVLVLEE
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHH
LERAKARGAKIYGEIVGYGATSDGYDMVAPSGEGAERCMQMALSTVKTRIDYINPHATST
HHHHHHCCCEEEEHHEECCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
PAGDPPEIEAIRKVFGSGEKCPPIAATKALTGHSLGATGVQEAIYSLLMMKNGFICESAN
CCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEECCCC
ITELDPVFADMPIVRRRIDNAKLGTVLSNSFGFGGTNATLVFKHLDA
CCCCCHHHHCCHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]