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The map label for this gene is apt

Identifier: 146300723

GI number: 146300723

Start: 3524563

End: 3525075

Strand: Reverse

Name: apt

Synonym: Fjoh_2974

Alternate gene names: 146300723

Gene position: 3525075-3524563 (Counterclockwise)

Preceding gene: 146300724

Following gene: 146300718

Centisome position: 57.82

GC content: 35.87

Gene sequence:

>513_bases
ATGAAGATTGAAAATTATATACGTGATATTCAGGGATTTCCAAAAGAAGGAATTTTATTTAAAGATATCACTCCGTTGTT
AAATAACGTCGAAGCCAGACAGGAATGCTTGTCAATTCTGGTAAATTCTCTAAAAGGGCAGAAAATCGATAAGGTAGTAG
GAGCAGAAAGCCGCGGCTTTTTCTTCGGAATGTTATTGGCACAAGAATTAAAAGCAGGATTTATTCCGGTTAGAAAACCT
AAAAAACTGCCTTTTGATATTATTTCAGCTTCATACGAATTAGAATACGGAACAGACAGTCTCGAAATGCATATAGATGC
CATAAAAAAAGGCGATCGTGTTTTAATTCATGACGATGTACTGGCAACCGGCGGAACAGCAAAAGCCGTTTGTGAATTGG
TTGAAAAACTAGGCGGAGAAATTGTACAATGTAATTTCCTGATGGAGTTAACTTTTCTAAACGGACGTAAAAAAATTAAA
GAATATCCTGTTTTTGCTGCGCTGACTTATTAA

Upstream 100 bases:

>100_bases
TAGCTATTTTTTTGTAGCTTTGTTGATTGCTTATTGCGGGTGCAAAGATAGACATAAATGTGACATATACAAACATAAAA
TAAGATAAAAATAAAAAAAA

Downstream 100 bases:

>100_bases
TTATACAAATACAATTTTGTGTTTAACGGCATACAGTACTAAACCTATTCTGGTTTTTATTTCTAATTTATCAAATAAAC
ATTCCCTGTAACCGTCGATG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MKIENYIRDIQGFPKEGILFKDITPLLNNVEARQECLSILVNSLKGQKIDKVVGAESRGFFFGMLLAQELKAGFIPVRKP
KKLPFDIISASYELEYGTDSLEMHIDAIKKGDRVLIHDDVLATGGTAKAVCELVEKLGGEIVQCNFLMELTFLNGRKKIK
EYPVFAALTY

Sequences:

>Translated_170_residues
MKIENYIRDIQGFPKEGILFKDITPLLNNVEARQECLSILVNSLKGQKIDKVVGAESRGFFFGMLLAQELKAGFIPVRKP
KKLPFDIISASYELEYGTDSLEMHIDAIKKGDRVLIHDDVLATGGTAKAVCELVEKLGGEIVQCNFLMELTFLNGRKKIK
EYPVFAALTY
>Mature_170_residues
MKIENYIRDIQGFPKEGILFKDITPLLNNVEARQECLSILVNSLKGQKIDKVVGAESRGFFFGMLLAQELKAGFIPVRKP
KKLPFDIISASYELEYGTDSLEMHIDAIKKGDRVLIHDDVLATGGTAKAVCELVEKLGGEIVQCNFLMELTFLNGRKKIK
EYPVFAALTY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=44.4444444444444, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=44, Blast_Score=107, Evalue=7e-24,
Organism=Escherichia coli, GI1786675, Length=159, Percent_Identity=49.685534591195, Blast_Score=165, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=42.6900584795322, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=180, Percent_Identity=43.8888888888889, Blast_Score=123, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=34.5029239766082, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136334, Length=159, Percent_Identity=41.5094339622642, Blast_Score=123, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_FLAJ1 (A5FFL9)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001195314.1
- ProteinModelPortal:   A5FFL9
- SMR:   A5FFL9
- STRING:   A5FFL9
- GeneID:   5091590
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_2974
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   FJOH376686:FJOH_2974-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19043; Mature: 19043

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIENYIRDIQGFPKEGILFKDITPLLNNVEARQECLSILVNSLKGQKIDKVVGAESRGF
CCHHHHHHHHHCCCCCCEEHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCH
FFGMLLAQELKAGFIPVRKPKKLPFDIISASYELEYGTDSLEMHIDAIKKGDRVLIHDDV
HHHHHHHHHHHCCCCCCCCCCCCCHHHHCCEEEEECCCCHHHHHHHHHCCCCEEEEECCE
LATGGTAKAVCELVEKLGGEIVQCNFLMELTFLNGRKKIKEYPVFAALTY
ECCCCCHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHCCEEEEECC
>Mature Secondary Structure
MKIENYIRDIQGFPKEGILFKDITPLLNNVEARQECLSILVNSLKGQKIDKVVGAESRGF
CCHHHHHHHHHCCCCCCEEHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCH
FFGMLLAQELKAGFIPVRKPKKLPFDIISASYELEYGTDSLEMHIDAIKKGDRVLIHDDV
HHHHHHHHHHHCCCCCCCCCCCCCHHHHCCEEEEECCCCHHHHHHHHHCCCCEEEEECCE
LATGGTAKAVCELVEKLGGEIVQCNFLMELTFLNGRKKIKEYPVFAALTY
ECCCCCHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA