Click here to switch to the map view.

The map label for this gene is menB [H]

Identifier: 146300534

GI number: 146300534

Start: 3317458

End: 3318291

Strand: Direct

Name: menB [H]

Synonym: Fjoh_2784

Alternate gene names: 146300534

Gene position: 3317458-3318291 (Clockwise)

Preceding gene: 146300533

Following gene: 146300535

Centisome position: 54.41

GC content: 39.21

Gene sequence:

>834_bases
ATGGATTGGATTACTGCCAGAGAATTTGAAGATATAACCTATAAAAAATGTAACGGAGTTGCCAGAATTGCTTTTAACAG
ACCAAATGTTAGAAATGCTTTCAGACCCAAAACAACTTCAGAATTATACCAGGCTTTTTACGATGCTCAAGAAGATACTT
CAATTGGAGTAGTTTTATTGTCTGCAGAAGGTCCATCGACAAAAGATGGTGTTTACTCATTTTGCAGCGGAGGTGACCAA
AACGCACGTGGTCATCAGGGATATGTTGGCGATGACGGACAGCATCGTTTAAATATTTTAGAAGTACAGCGATTAATACG
CTTTATGCCAAAAGTGGTTATTGCTGTTGTTCCGGGCTGGGCAGTTGGCGGCGGACATAGTTTACATGTAGTTTGCGATA
TGACTTTGGCAAGTAAAGAACACGCTATTTTTAAACAGACAGATGCTGATGTTACAAGTTTTGATGGCGGCTACGGATCG
GCTTATCTTGCTAAAATGGTGGGACAGAAAAAAGCACGTGAAATCTTCTTTTTAGGACGTAATTATTCTGCTCAGGAAGC
TTTTGAAATGGGAATGGTTAATGCTGTAATTCCGCATGATGAATTAGAAGCAACTGCTTATGAATGGGCACAGGAAATTC
TACAAAAGTCACCAACTTCTATAAAAATGCTGAAATTCGCCATGAATTTAACTGACGACGGAATGGTAGGACAGCAGGTT
TTTGCCGGCGAAGCGACTCGTTTGGCTTATATGACTGAAGAAGCAAAAGAAGGAAGAAATGCCTTTTTAGAAAAAAGAAA
ACCAAACTTTGGAGAAAATAAATGGTTACCATAA

Upstream 100 bases:

>100_bases
AAACCGTTATTAATGCTGACTAAAACGAAAATCAATAGGTTAAAATGTAAAAAATGCTTTATTTTTACACTATAATTTTT
TAAAATAAAAACAAATAGAA

Downstream 100 bases:

>100_bases
ATAGTTTGAATTTTAGATTGCAGCTTCTAGATTTTTTGAATTTAAAACTGACATCTAAACTTTAGATTAAAAAACAATAT
TATCATTTAGATTACAGATT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MDWITAREFEDITYKKCNGVARIAFNRPNVRNAFRPKTTSELYQAFYDAQEDTSIGVVLLSAEGPSTKDGVYSFCSGGDQ
NARGHQGYVGDDGQHRLNILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDMTLASKEHAIFKQTDADVTSFDGGYGS
AYLAKMVGQKKAREIFFLGRNYSAQEAFEMGMVNAVIPHDELEATAYEWAQEILQKSPTSIKMLKFAMNLTDDGMVGQQV
FAGEATRLAYMTEEAKEGRNAFLEKRKPNFGENKWLP

Sequences:

>Translated_277_residues
MDWITAREFEDITYKKCNGVARIAFNRPNVRNAFRPKTTSELYQAFYDAQEDTSIGVVLLSAEGPSTKDGVYSFCSGGDQ
NARGHQGYVGDDGQHRLNILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDMTLASKEHAIFKQTDADVTSFDGGYGS
AYLAKMVGQKKAREIFFLGRNYSAQEAFEMGMVNAVIPHDELEATAYEWAQEILQKSPTSIKMLKFAMNLTDDGMVGQQV
FAGEATRLAYMTEEAKEGRNAFLEKRKPNFGENKWLP
>Mature_277_residues
MDWITAREFEDITYKKCNGVARIAFNRPNVRNAFRPKTTSELYQAFYDAQEDTSIGVVLLSAEGPSTKDGVYSFCSGGDQ
NARGHQGYVGDDGQHRLNILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDMTLASKEHAIFKQTDADVTSFDGGYGS
AYLAKMVGQKKAREIFFLGRNYSAQEAFEMGMVNAVIPHDELEATAYEWAQEILQKSPTSIKMLKFAMNLTDDGMVGQQV
FAGEATRLAYMTEEAKEGRNAFLEKRKPNFGENKWLP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=265, Percent_Identity=31.3207547169811, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI31542718, Length=264, Percent_Identity=27.6515151515151, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI157694516, Length=217, Percent_Identity=27.1889400921659, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI213417737, Length=217, Percent_Identity=27.1889400921659, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1788597, Length=280, Percent_Identity=51.0714285714286, Blast_Score=284, Evalue=4e-78,
Organism=Escherichia coli, GI1787659, Length=265, Percent_Identity=27.1698113207547, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082183, Length=268, Percent_Identity=27.2388059701493, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787660, Length=258, Percent_Identity=28.2945736434109, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI221142681, Length=268, Percent_Identity=26.1194029850746, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=253, Percent_Identity=29.2490118577075, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25145438, Length=257, Percent_Identity=28.7937743190661, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=233, Percent_Identity=28.755364806867, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24653139, Length=262, Percent_Identity=27.4809160305344, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI20129971, Length=261, Percent_Identity=29.1187739463602, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24653477, Length=261, Percent_Identity=29.1187739463602, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30858; Mature: 30858

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWITAREFEDITYKKCNGVARIAFNRPNVRNAFRPKTTSELYQAFYDAQEDTSIGVVLL
CCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEE
SAEGPSTKDGVYSFCSGGDQNARGHQGYVGDDGQHRLNILEVQRLIRFMPKVVIAVVPGW
ECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
AVGGGHSLHVVCDMTLASKEHAIFKQTDADVTSFDGGYGSAYLAKMVGQKKAREIFFLGR
EECCCCEEEEEEEEECCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEECC
NYSAQEAFEMGMVNAVIPHDELEATAYEWAQEILQKSPTSIKMLKFAMNLTDDGMVGQQV
CCCHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHH
FAGEATRLAYMTEEAKEGRNAFLEKRKPNFGENKWLP
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MDWITAREFEDITYKKCNGVARIAFNRPNVRNAFRPKTTSELYQAFYDAQEDTSIGVVLL
CCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEE
SAEGPSTKDGVYSFCSGGDQNARGHQGYVGDDGQHRLNILEVQRLIRFMPKVVIAVVPGW
ECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
AVGGGHSLHVVCDMTLASKEHAIFKQTDADVTSFDGGYGSAYLAKMVGQKKAREIFFLGR
EECCCCEEEEEEEEECCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEECC
NYSAQEAFEMGMVNAVIPHDELEATAYEWAQEILQKSPTSIKMLKFAMNLTDDGMVGQQV
CCCHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHH
FAGEATRLAYMTEEAKEGRNAFLEKRKPNFGENKWLP
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]