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The map label for this gene is cysM [H]

Identifier: 146300259

GI number: 146300259

Start: 2991222

End: 2992109

Strand: Reverse

Name: cysM [H]

Synonym: Fjoh_2504

Alternate gene names: 146300259

Gene position: 2992109-2991222 (Counterclockwise)

Preceding gene: 146300260

Following gene: 146300258

Centisome position: 49.08

GC content: 39.64

Gene sequence:

>888_bases
ATGGGTCCACAGAAACTGCTAAACCTAATTGGAAATACTCCATTAATGGAAACGGTCAATTTGGTTAAAAATAAAAACGT
TAAACTTTTACTGAAACTCGAAGGAAACAATCCGGGAGGAAGCGTAAAAGACAGAGCAGCATATAACATGATTGCAGCAG
CTCTTGAAAGAGGCGAAATTAAAAAAGGAGACAAATTAATTGAAGCAACAAGCGGTAATACAGGAATTGCCCTTGCTATG
ATTGCACAGTTGTTTGGAATAGAAATCGAATTGGTTTTACCGGAAGATTCAACAAAAGAAAGAACACAAACCATGCGTGC
TTATGGCGCTACGGTTATTTTAACGCCTGCTGAAGAAGGAATTATCGGTTCAAGAGATTATGCTGATAAAAAAGTAGCAC
AAGGCGGATATCTTATGCTGAATCAGTTTGCAAATGATGACAACTGGAAAGCACATTACAAAACAACCGGACCAGAAATA
TGGAATGATACAGAAGGAACTGTAACACATTTTGTTTCGGCAATGGGAACAACCGGAACTATTATTGGAACTTCGACTTA
TTTAAAAGAAAAAAATCCGGCCATTCAAATTATTGGCGCACAGCCAAGCGACGGATCGCAAATACCGGGAATCCGTAAAT
GGCCTCAGGAATATTTACCTAAAATTTTTGATGCTTCGAAAGTAGATACTGTTGTAGATGTCAGCGAAGAAGAAGCCCGA
GAAATGACCAAAAGACTAGCTCTTGAAGAAGGTGTTTTTGCCGGAATGAGCAGCGGCGGTTCTGTAGCTGTTGCCCTTAA
AATTGCTGAACAATTAGAATCTGGAGTTATAGTTGCCGTTATCTGCGACCGCGGCGACAGATATTTGTCATCGGATTTAT
TTGACTAA

Upstream 100 bases:

>100_bases
GTTATTGGAGGAAATTCATGGGTTACTAAATCTATTCCCGAAGATTCTATCGTATTAAACACCACTACAACAGAAGTCAA
AATAAAAGAAAAAAAATAAA

Downstream 100 bases:

>100_bases
AAAGGAACAAAGCGACAAAGGTTCAAAGGGACAAAGGCAGTCACAAACTACAACCCTTATACCCAAAAAAGACGCACTGC
TGTGCGCCTCTATAAAAAAC

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MGPQKLLNLIGNTPLMETVNLVKNKNVKLLLKLEGNNPGGSVKDRAAYNMIAAALERGEIKKGDKLIEATSGNTGIALAM
IAQLFGIEIELVLPEDSTKERTQTMRAYGATVILTPAEEGIIGSRDYADKKVAQGGYLMLNQFANDDNWKAHYKTTGPEI
WNDTEGTVTHFVSAMGTTGTIIGTSTYLKEKNPAIQIIGAQPSDGSQIPGIRKWPQEYLPKIFDASKVDTVVDVSEEEAR
EMTKRLALEEGVFAGMSSGGSVAVALKIAEQLESGVIVAVICDRGDRYLSSDLFD

Sequences:

>Translated_295_residues
MGPQKLLNLIGNTPLMETVNLVKNKNVKLLLKLEGNNPGGSVKDRAAYNMIAAALERGEIKKGDKLIEATSGNTGIALAM
IAQLFGIEIELVLPEDSTKERTQTMRAYGATVILTPAEEGIIGSRDYADKKVAQGGYLMLNQFANDDNWKAHYKTTGPEI
WNDTEGTVTHFVSAMGTTGTIIGTSTYLKEKNPAIQIIGAQPSDGSQIPGIRKWPQEYLPKIFDASKVDTVVDVSEEEAR
EMTKRLALEEGVFAGMSSGGSVAVALKIAEQLESGVIVAVICDRGDRYLSSDLFD
>Mature_294_residues
GPQKLLNLIGNTPLMETVNLVKNKNVKLLLKLEGNNPGGSVKDRAAYNMIAAALERGEIKKGDKLIEATSGNTGIALAMI
AQLFGIEIELVLPEDSTKERTQTMRAYGATVILTPAEEGIIGSRDYADKKVAQGGYLMLNQFANDDNWKAHYKTTGPEIW
NDTEGTVTHFVSAMGTTGTIIGTSTYLKEKNPAIQIIGAQPSDGSQIPGIRKWPQEYLPKIFDASKVDTVVDVSEEEARE
MTKRLALEEGVFAGMSSGGSVAVALKIAEQLESGVIVAVICDRGDRYLSSDLFD

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=34.7133757961783, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=34.7133757961783, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=34.7133757961783, Blast_Score=159, Evalue=3e-39,
Organism=Escherichia coli, GI2367138, Length=285, Percent_Identity=55.4385964912281, Blast_Score=327, Evalue=7e-91,
Organism=Escherichia coli, GI1788754, Length=304, Percent_Identity=40.1315789473684, Blast_Score=181, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=39.5973154362416, Blast_Score=198, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17562970, Length=298, Percent_Identity=37.5838926174497, Blast_Score=187, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI115535073, Length=297, Percent_Identity=38.7205387205387, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=38.2252559726962, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=36.5771812080537, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=34.5794392523364, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17534315, Length=315, Percent_Identity=30.4761904761905, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI25147552, Length=300, Percent_Identity=31.6666666666667, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71996324, Length=138, Percent_Identity=28.9855072463768, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=317, Percent_Identity=34.384858044164, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=33.1269349845201, Blast_Score=143, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24643623, Length=312, Percent_Identity=34.2948717948718, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI20129101, Length=312, Percent_Identity=34.2948717948718, Blast_Score=141, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31854; Mature: 31723

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPQKLLNLIGNTPLMETVNLVKNKNVKLLLKLEGNNPGGSVKDRAAYNMIAAALERGEI
CCHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
KKGDKLIEATSGNTGIALAMIAQLFGIEIELVLPEDSTKERTQTMRAYGATVILTPAEEG
CCCCEEEEECCCCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCEEEEECCCCC
IIGSRDYADKKVAQGGYLMLNQFANDDNWKAHYKTTGPEIWNDTEGTVTHFVSAMGTTGT
CCCCCCCCHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCE
IIGTSTYLKEKNPAIQIIGAQPSDGSQIPGIRKWPQEYLPKIFDASKVDTVVDVSEEEAR
EEECHHHHCCCCCEEEEEECCCCCCCCCCCHHCCHHHHHHHHHCCCCCCCEEECCHHHHH
EMTKRLALEEGVFAGMSSGGSVAVALKIAEQLESGVIVAVICDRGDRYLSSDLFD
HHHHHHHHHHCHHCCCCCCCCEEEEHEEHHHHHCCEEEEEEECCCCCHHHHCCCC
>Mature Secondary Structure 
GPQKLLNLIGNTPLMETVNLVKNKNVKLLLKLEGNNPGGSVKDRAAYNMIAAALERGEI
CHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
KKGDKLIEATSGNTGIALAMIAQLFGIEIELVLPEDSTKERTQTMRAYGATVILTPAEEG
CCCCEEEEECCCCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCEEEEECCCCC
IIGSRDYADKKVAQGGYLMLNQFANDDNWKAHYKTTGPEIWNDTEGTVTHFVSAMGTTGT
CCCCCCCCHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCE
IIGTSTYLKEKNPAIQIIGAQPSDGSQIPGIRKWPQEYLPKIFDASKVDTVVDVSEEEAR
EEECHHHHCCCCCEEEEEECCCCCCCCCCCHHCCHHHHHHHHHCCCCCCCEEECCHHHHH
EMTKRLALEEGVFAGMSSGGSVAVALKIAEQLESGVIVAVICDRGDRYLSSDLFD
HHHHHHHHHHCHHCCCCCCCCEEEEHEEHHHHHCCEEEEEEECCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]