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The map label for this gene is mepA [H]

Identifier: 145300040

GI number: 145300040

Start: 3395093

End: 3396433

Strand: Direct

Name: mepA [H]

Synonym: ASA_3139

Alternate gene names: 145300040

Gene position: 3395093-3396433 (Clockwise)

Preceding gene: 145300039

Following gene: 145300062

Centisome position: 72.2

GC content: 61.3

Gene sequence:

>1341_bases
ATGTCTGCCTACTTCACATTGCGCCAGCGGGCGATGACCCGCCGTTTCTGGGGCTATGCCCTCCCCTCCATCATGGCCAT
GCTGGTTTCCGGTGCCTACTACCTGGTCGATGGCATCTTCGTCGGTCACTACGTGGGCGCGGCGACCGCCATCTCCTTCC
AGCAAGGGGCCAAGAACCTCAAGCTCGCCCGCCAGGCACTGGTCAATGCGCTCTGGCTGCTGGCCTTGCTCGGCACTCTG
GCCCCCCTGCTGCTGCACCACTGGCACATCGATATCCTGCTGGCATTGGGAATCAAGCAAGGCACAGAGACCTGGAAACA
GGCCAGTGACTACCTCTACTGGATTGGTGGCGGTACCCTGCTGCTGGCCAGCAACCTGGCGGTGCCCTATCTGCTGCGCA
ACGACGGCAAACCCAGGCTGGCCATGATCCTGGTCAGCGGGGGCGCAGTGCTGAACATCATTCTCAACTACATCATGGTC
GGTCGGCTGGGGTTGGGACTGGTGGGCTCTGCCCAGGCGACACTCATGTCCGAGGGGGTCGTCAGCCTGCTGGGCCTGGG
TTACTTCTTTACTTCCCATGCCAAACTGAATTTATCATGGCGCCATCTGGTGCCCAATTTTCCGGCCATGCCCAACCTGC
TCTTTACCGGCCTGCCGAGCCTGATCGCCCAGTTCAACCTGGGACTGCTGCTGCTGCTGCACAACAGCCAGCTGATGGCG
TATGGTACCATCAAGGATCTGGCCGGTTACACGGTAGCAGGCTACACGGAGGCAATATTCATCGTCATCCTGCAGGGACT
GGCATTTGGCATCCAGCCTCTCGTCAGTCAGGCGGCGGGGGCCAAGCGCTACCGTGATCTGAAATTCCTGATGGAGATGG
GGCTCAAGATCACGCTGGTCTATGGCATGGCAGTCTGGTTGCTGATCCAGCTGTTGCCGCGCCAGGTGGCCATGCTCTAC
ACCGGCGGTCAGGATGCCGAGTTGCTTGCCGCCGCCGTCAGCAGCCTGACTCTCAACCTCAGCGCCATTCCGCTGGAAGG
GATCATCATCTTTGGCATAGTGCTGCTGCAATCCATGGCTCGCACCAAGCAGGCACTGATCATATCGGCGGCCAAGACAC
TGCTGCTGCTGCCACTGATCTTCTTGCTGCCGATGCAGTGGGGACGCGAAGGTGTACTGCTCGCCCAGCCCACGACTGTG
CTGCTGTTGACACTGCCGCTGTGCTGGCTGCTGTGGCGAGAGTGGCGTCGCCTCAAGCTGGCGTGCGCTCCTCAGGGCCT
GCACCAGGCCACAGGGCTAACCGCTCGTCAGGCTCTGCGGCTGGCACGTCGCCCGAGCTAG

Upstream 100 bases:

>100_bases
AATTTTACTCATCAATTCATCAATCTTAAGGCGGATTATCAACAAAAATGTATTAATTTAGACTGTCGGCTCGATAATCG
AACTCCCCAAGAGAACAGAT

Downstream 100 bases:

>100_bases
ACACAAGTAGCACGACTACGTGCTAAAGCCGGGTAGCCTGCTCACGCACCTGTGGCAACACCATCACCTGCTGGGCTGCC
ACCAATTGCAGCTCATAGGC

Product: cation (Na+-coupled) multidrug resistance efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSAYFTLRQRAMTRRFWGYALPSIMAMLVSGAYYLVDGIFVGHYVGAATAISFQQGAKNLKLARQALVNALWLLALLGTL
APLLLHHWHIDILLALGIKQGTETWKQASDYLYWIGGGTLLLASNLAVPYLLRNDGKPRLAMILVSGGAVLNIILNYIMV
GRLGLGLVGSAQATLMSEGVVSLLGLGYFFTSHAKLNLSWRHLVPNFPAMPNLLFTGLPSLIAQFNLGLLLLLHNSQLMA
YGTIKDLAGYTVAGYTEAIFIVILQGLAFGIQPLVSQAAGAKRYRDLKFLMEMGLKITLVYGMAVWLLIQLLPRQVAMLY
TGGQDAELLAAAVSSLTLNLSAIPLEGIIIFGIVLLQSMARTKQALIISAAKTLLLLPLIFLLPMQWGREGVLLAQPTTV
LLLTLPLCWLLWREWRRLKLACAPQGLHQATGLTARQALRLARRPS

Sequences:

>Translated_446_residues
MSAYFTLRQRAMTRRFWGYALPSIMAMLVSGAYYLVDGIFVGHYVGAATAISFQQGAKNLKLARQALVNALWLLALLGTL
APLLLHHWHIDILLALGIKQGTETWKQASDYLYWIGGGTLLLASNLAVPYLLRNDGKPRLAMILVSGGAVLNIILNYIMV
GRLGLGLVGSAQATLMSEGVVSLLGLGYFFTSHAKLNLSWRHLVPNFPAMPNLLFTGLPSLIAQFNLGLLLLLHNSQLMA
YGTIKDLAGYTVAGYTEAIFIVILQGLAFGIQPLVSQAAGAKRYRDLKFLMEMGLKITLVYGMAVWLLIQLLPRQVAMLY
TGGQDAELLAAAVSSLTLNLSAIPLEGIIIFGIVLLQSMARTKQALIISAAKTLLLLPLIFLLPMQWGREGVLLAQPTTV
LLLTLPLCWLLWREWRRLKLACAPQGLHQATGLTARQALRLARRPS
>Mature_445_residues
SAYFTLRQRAMTRRFWGYALPSIMAMLVSGAYYLVDGIFVGHYVGAATAISFQQGAKNLKLARQALVNALWLLALLGTLA
PLLLHHWHIDILLALGIKQGTETWKQASDYLYWIGGGTLLLASNLAVPYLLRNDGKPRLAMILVSGGAVLNIILNYIMVG
RLGLGLVGSAQATLMSEGVVSLLGLGYFFTSHAKLNLSWRHLVPNFPAMPNLLFTGLPSLIAQFNLGLLLLLHNSQLMAY
GTIKDLAGYTVAGYTEAIFIVILQGLAFGIQPLVSQAAGAKRYRDLKFLMEMGLKITLVYGMAVWLLIQLLPRQVAMLYT
GGQDAELLAAAVSSLTLNLSAIPLEGIIIFGIVLLQSMARTKQALIISAAKTLLLLPLIFLLPMQWGREGVLLAQPTTVL
LLTLPLCWLLWREWRRLKLACAPQGLHQATGLTARQALRLARRPS

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48780; Mature: 48649

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAYFTLRQRAMTRRFWGYALPSIMAMLVSGAYYLVDGIFVGHYVGAATAISFQQGAKNL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
KLARQALVNALWLLALLGTLAPLLLHHWHIDILLALGIKQGTETWKQASDYLYWIGGGTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEECCCCE
LLASNLAVPYLLRNDGKPRLAMILVSGGAVLNIILNYIMVGRLGLGLVGSAQATLMSEGV
EEECCCCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VSLLGLGYFFTSHAKLNLSWRHLVPNFPAMPNLLFTGLPSLIAQFNLGLLLLLHNSQLMA
HHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEE
YGTIKDLAGYTVAGYTEAIFIVILQGLAFGIQPLVSQAAGAKRYRDLKFLMEMGLKITLV
EECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
YGMAVWLLIQLLPRQVAMLYTGGQDAELLAAAVSSLTLNLSAIPLEGIIIFGIVLLQSMA
HHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHH
RTKQALIISAAKTLLLLPLIFLLPMQWGREGVLLAQPTTVLLLTLPLCWLLWREWRRLKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
ACAPQGLHQATGLTARQALRLARRPS
CCCCCCHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAYFTLRQRAMTRRFWGYALPSIMAMLVSGAYYLVDGIFVGHYVGAATAISFQQGAKNL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
KLARQALVNALWLLALLGTLAPLLLHHWHIDILLALGIKQGTETWKQASDYLYWIGGGTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEECCCCE
LLASNLAVPYLLRNDGKPRLAMILVSGGAVLNIILNYIMVGRLGLGLVGSAQATLMSEGV
EEECCCCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VSLLGLGYFFTSHAKLNLSWRHLVPNFPAMPNLLFTGLPSLIAQFNLGLLLLLHNSQLMA
HHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEE
YGTIKDLAGYTVAGYTEAIFIVILQGLAFGIQPLVSQAAGAKRYRDLKFLMEMGLKITLV
EECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
YGMAVWLLIQLLPRQVAMLYTGGQDAELLAAAVSSLTLNLSAIPLEGIIIFGIVLLQSMA
HHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHH
RTKQALIISAAKTLLLLPLIFLLPMQWGREGVLLAQPTTVLLLTLPLCWLLWREWRRLKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
ACAPQGLHQATGLTARQALRLARRPS
CCCCCCHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA