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The map label for this gene is aceK [H]

Identifier: 145299950

GI number: 145299950

Start: 3278217

End: 3279944

Strand: Direct

Name: aceK [H]

Synonym: ASA_3042

Alternate gene names: 145299950

Gene position: 3278217-3279944 (Clockwise)

Preceding gene: 145299945

Following gene: 145299952

Centisome position: 69.71

GC content: 59.32

Gene sequence:

>1728_bases
ATGCAGCAGCCATTGGAACAGGCCGTCGCCGAGACGATCTTGCAACGCTTCGAGTCGTTTTACAGCCGGTTTCTCGAAAT
AACCCAGGGCAGCAAGAGCCGCTTCGAAAACAGTGACTGGCTGGGAGTACAGCTGGCCGGACGCGAGCGCATTCGCCTCT
ATGATCACCACGTCGGCGCCACCACGGCCCTGATCAAGCAGATGATGGGGGAGCATCACGCCACTCAGGAGCTGCTCAAA
CGGGTGAAAGGCGCCTTCAGTGATCTGCTGCCCCGTTGTGACAACTTCGAGGTGGCGGAGTCCTTCTTCAACTCCGTCTA
TCGCCGCATCTTCCGCCATCGCAACATTCGCGACGAGAACCTCTACATCCATCCCTTTCGCAGCCGGGGAGAGCATCCCG
ACTTGAGCGCCCTGCTGCGGGTCTATCGCACTGACCTCACCCATCTGCCCCAGACCCTGAGCCAGATGCTGGGGGATTAC
AGCTTCACCCTCCCCTATGAAGACAAGCAGCGCGACATTGTCGACATCCACCGCCATCTTGCCGAGAACGGCCCGCAGAT
CCTGCATGAAGAGCCCTTCGCCATCGAGCTGCTCAAAGAGGTGTTCTACCGCAACAAGGGCGCCTATCTGGTGGGACTTA
TTCGGGTGAAGGGGCAGGTGTTCCCCTTCATTCTGCCGCTGCTCAGCACAGGCCAGAGCATCTATGTGGATACCGTCATC
TTCGAGCCGGAGCTGGCCTCCATCGTGGTCGGCTTCGCCCGCGCCTACTTCATGGTCTACGCCCCTGTGCCGGCGCTGTT
TGTGGTGTTTTTGCGCCAGATCATGCCCCACAAGCCCGATTATGAGATCTACAACGCCATCGGCTGCCAGAAGCACGGCA
AGACTGAGCTCTATCGTCACTACCAGCAACACCTGGCCCAGAGCCGGGAACAATTTGTCATCGCCCCCGGCATCAAGGGA
ATGGTGATGAGCGTGTTCACCCTTCCCTCCTACGACGTTGTGTTCAAGGTGATAAAGGACGAGTTCACCCCGCCCAAGGA
TGTGAGTCACGAGCAGGTGCGGGCGAAATACCGGCTGGTAAAACAGCACGATCGGGTGGGCCGCATGGCCGATACCCAGG
AGTTCACCAACTTCGAGTTCCCCCTGGATCGCATCTCGCCCGAGCTCCTGGCAGAGCTCAAGACGGTGGCCCCCTCTGCG
CTCACCATCACCAGTGACAAGCTGGTGATCAAGCACCTCTACACAGAGCGCAAGATGATCCCGCTCAACCTCTATCTGGA
CAAGGCGGACGAGCAGCAGACCCGGCTCGCGCTGGAGGAGTACGGCAACGCCATCAAGCAGCTGGCGGCGGCCAACATCT
TCCCGGGAGACATGCTGTTCAAGAACTTCGGCGTCACCCGCCACGGCCGGGTGGTCTTCTACGACTACGACGAGATCTGC
TACATGACGGAGTGCAACTTCCGCCAGATCCCGCCACCCCGCTACCCGGAAGATGAATGGAGCGCCGAGCCCTGGTATTC
GGTGGCCCCCAACGACATCTTCCCCGAGGAGTTCGCCACCTTCCTGCTGCAAAAGCCCCAGGTGCGGGAGATCATGATGC
AGCTGCACAAGGAGATGTTCGACGCCAACTACTGGAAGATGCTGCAGAGCAACATCAAGGTGGGGGTGTTCGAGGATGTC
TATCCCTATCGACGCAAGAAGCGCTTCAAGTTCCAGCGAGGGGGATGA

Upstream 100 bases:

>100_bases
ATGCCGTGAGTGATTGAGCGCTTGCAGGGCAAGGACAGGACGACAGACCAGCCCCGGACTCAGCCGCCATACCAGCCGAC
ACATCACAAGGAAGAGAGAG

Downstream 100 bases:

>100_bases
AGAGGCGAGCCTCGCCTTGCTGCCAACTTGAGATGCAATGCATATTGCGACGGCAGAACCGGGAGTCTTGCCACAACGCT
ATGGCGCAGTATTGAAAAAA

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MQQPLEQAVAETILQRFESFYSRFLEITQGSKSRFENSDWLGVQLAGRERIRLYDHHVGATTALIKQMMGEHHATQELLK
RVKGAFSDLLPRCDNFEVAESFFNSVYRRIFRHRNIRDENLYIHPFRSRGEHPDLSALLRVYRTDLTHLPQTLSQMLGDY
SFTLPYEDKQRDIVDIHRHLAENGPQILHEEPFAIELLKEVFYRNKGAYLVGLIRVKGQVFPFILPLLSTGQSIYVDTVI
FEPELASIVVGFARAYFMVYAPVPALFVVFLRQIMPHKPDYEIYNAIGCQKHGKTELYRHYQQHLAQSREQFVIAPGIKG
MVMSVFTLPSYDVVFKVIKDEFTPPKDVSHEQVRAKYRLVKQHDRVGRMADTQEFTNFEFPLDRISPELLAELKTVAPSA
LTITSDKLVIKHLYTERKMIPLNLYLDKADEQQTRLALEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
YMTECNFRQIPPPRYPEDEWSAEPWYSVAPNDIFPEEFATFLLQKPQVREIMMQLHKEMFDANYWKMLQSNIKVGVFEDV
YPYRRKKRFKFQRGG

Sequences:

>Translated_575_residues
MQQPLEQAVAETILQRFESFYSRFLEITQGSKSRFENSDWLGVQLAGRERIRLYDHHVGATTALIKQMMGEHHATQELLK
RVKGAFSDLLPRCDNFEVAESFFNSVYRRIFRHRNIRDENLYIHPFRSRGEHPDLSALLRVYRTDLTHLPQTLSQMLGDY
SFTLPYEDKQRDIVDIHRHLAENGPQILHEEPFAIELLKEVFYRNKGAYLVGLIRVKGQVFPFILPLLSTGQSIYVDTVI
FEPELASIVVGFARAYFMVYAPVPALFVVFLRQIMPHKPDYEIYNAIGCQKHGKTELYRHYQQHLAQSREQFVIAPGIKG
MVMSVFTLPSYDVVFKVIKDEFTPPKDVSHEQVRAKYRLVKQHDRVGRMADTQEFTNFEFPLDRISPELLAELKTVAPSA
LTITSDKLVIKHLYTERKMIPLNLYLDKADEQQTRLALEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
YMTECNFRQIPPPRYPEDEWSAEPWYSVAPNDIFPEEFATFLLQKPQVREIMMQLHKEMFDANYWKMLQSNIKVGVFEDV
YPYRRKKRFKFQRGG
>Mature_575_residues
MQQPLEQAVAETILQRFESFYSRFLEITQGSKSRFENSDWLGVQLAGRERIRLYDHHVGATTALIKQMMGEHHATQELLK
RVKGAFSDLLPRCDNFEVAESFFNSVYRRIFRHRNIRDENLYIHPFRSRGEHPDLSALLRVYRTDLTHLPQTLSQMLGDY
SFTLPYEDKQRDIVDIHRHLAENGPQILHEEPFAIELLKEVFYRNKGAYLVGLIRVKGQVFPFILPLLSTGQSIYVDTVI
FEPELASIVVGFARAYFMVYAPVPALFVVFLRQIMPHKPDYEIYNAIGCQKHGKTELYRHYQQHLAQSREQFVIAPGIKG
MVMSVFTLPSYDVVFKVIKDEFTPPKDVSHEQVRAKYRLVKQHDRVGRMADTQEFTNFEFPLDRISPELLAELKTVAPSA
LTITSDKLVIKHLYTERKMIPLNLYLDKADEQQTRLALEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
YMTECNFRQIPPPRYPEDEWSAEPWYSVAPNDIFPEEFATFLLQKPQVREIMMQLHKEMFDANYWKMLQSNIKVGVFEDV
YPYRRKKRFKFQRGG

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=586, Percent_Identity=51.3651877133106, Blast_Score=577, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 67386; Mature: 67386

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQPLEQAVAETILQRFESFYSRFLEITQGSKSRFENSDWLGVQLAGRERIRLYDHHVGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEECCCCCEEEHHHHCCH
TTALIKQMMGEHHATQELLKRVKGAFSDLLPRCDNFEVAESFFNSVYRRIFRHRNIRDEN
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
LYIHPFRSRGEHPDLSALLRVYRTDLTHLPQTLSQMLGDYSFTLPYEDKQRDIVDIHRHL
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHH
AENGPQILHEEPFAIELLKEVFYRNKGAYLVGLIRVKGQVFPFILPLLSTGQSIYVDTVI
HHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEEEE
FEPELASIVVGFARAYFMVYAPVPALFVVFLRQIMPHKPDYEIYNAIGCQKHGKTELYRH
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHH
YQQHLAQSREQFVIAPGIKGMVMSVFTLPSYDVVFKVIKDEFTPPKDVSHEQVRAKYRLV
HHHHHHCCCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
KQHDRVGRMADTQEFTNFEFPLDRISPELLAELKTVAPSALTITSDKLVIKHLYTERKMI
HHHHHHCCCCCHHHHCCCCCCHHHCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCEE
PLNLYLDKADEQQTRLALEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCCEE
YMTECNFRQIPPPRYPEDEWSAEPWYSVAPNDIFPEEFATFLLQKPQVREIMMQLHKEMF
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
DANYWKMLQSNIKVGVFEDVYPYRRKKRFKFQRGG
CCHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQQPLEQAVAETILQRFESFYSRFLEITQGSKSRFENSDWLGVQLAGRERIRLYDHHVGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEECCCCCEEEHHHHCCH
TTALIKQMMGEHHATQELLKRVKGAFSDLLPRCDNFEVAESFFNSVYRRIFRHRNIRDEN
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
LYIHPFRSRGEHPDLSALLRVYRTDLTHLPQTLSQMLGDYSFTLPYEDKQRDIVDIHRHL
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHH
AENGPQILHEEPFAIELLKEVFYRNKGAYLVGLIRVKGQVFPFILPLLSTGQSIYVDTVI
HHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEEEE
FEPELASIVVGFARAYFMVYAPVPALFVVFLRQIMPHKPDYEIYNAIGCQKHGKTELYRH
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHH
YQQHLAQSREQFVIAPGIKGMVMSVFTLPSYDVVFKVIKDEFTPPKDVSHEQVRAKYRLV
HHHHHHCCCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
KQHDRVGRMADTQEFTNFEFPLDRISPELLAELKTVAPSALTITSDKLVIKHLYTERKMI
HHHHHHCCCCCHHHHCCCCCCHHHCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCEE
PLNLYLDKADEQQTRLALEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCCEE
YMTECNFRQIPPPRYPEDEWSAEPWYSVAPNDIFPEEFATFLLQKPQVREIMMQLHKEMF
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
DANYWKMLQSNIKVGVFEDVYPYRRKKRFKFQRGG
CCHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA