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The map label for this gene is hemE

Identifier: 145294554

GI number: 145294554

Start: 565309

End: 566385

Strand: Direct

Name: hemE

Synonym: cgR_0505

Alternate gene names: 145294554

Gene position: 565309-566385 (Clockwise)

Preceding gene: 145294553

Following gene: 145294555

Centisome position: 17.06

GC content: 52.46

Gene sequence:

>1077_bases
ATGTCTGCTCTTACTATTCCAGCTGCGCGTCGCACGCTAAATAACGCGCCCATTATTGATGCCGCTAATGGCAAGACCCC
GACTCGCACTCCGGTGTGGTTTATGCGCCAGGCGGGTAGGTCGTTGCCTGAGTACAAGAAGGTCCGTGAGGGAATCAGCA
TGTTGGATTCCTGTTTCATGCCGGAGTTGTTGGCGGAGATTACTTTGCAGCCGGTTCGTCGTCATGATGTGGATGCTGCG
ATTTTGTTCTCTGACATTGTGGTGCCGTTGCGTGCTGCGGGTGTTGGTGTGGAAATCGTGGCGGGTCGTGGACCTGTGTT
GGATGCGCCGGTGCGGAGCCGTGAGGATGTGTTGAATCTTCCTATTTTGGAGGGCAACGTTCCGGAGGTGGAGCAGGGTA
TTGGCATCATTTTGGATGAGTTGTCTGATTCTCAGGCGTTGATTGGTTTTGCTGGTGCGCCGTTTACGTTGGCGAGTTAC
TTGGTTGAGGGTGGTCCTTCCAAGAATCATGAGAAGACCAAAGCAATGATGCATGGTGATCCTGAGACGTGGCATGCGTT
GATGGCTCGTTTGGTGCCGACGATTGTGAATTCTTTGAAGTCGCAGATCGACGCAGGCATTGATGCGATGCAGTTGTTTG
ATTCGTGGGCTGGGTTCCTCACTGAGCGTGATTACACCGAGTTCGTGTTGCCGTATTCCACTGAGATTTTGGAGGAAGTG
GGTAAGTACCAGCTGCCTCGTATTCACTTTGGTGTGGGTACTGGTGAGTTGCTTGGTGCGATGAGCAAGGCTGGCTCAGA
GGTCATGGGTGTGGATTGGCGGGTGCCGTTGGATAAGGCTGCGGAGCGTATTGCTGCGGTATCAGGTCCTAAGGTGTTGC
AGGGTAACCTCGATCCTGCGTTATTGTTTGCGGGTCGCGCACCTTTGACTAAGGAAATTGAGCGCATCAAGGCAGAGGCT
CAGACTGCTATTGATGCAGGTCATGCAACGGGCCATATCTTTAACCTTGGTCATGGTGTGCTTCCTAATACGGTGGCGGA
AGATATTACTGAAGCCGTCTCCATCATTCATTCTTAA

Upstream 100 bases:

>100_bases
CCCAAAATCCCTCCCATATCGTTCTTTTTACTGATGCATTGTCCTCAATTAGGTGTGGCTTCTTTTCCTAAATTGGGATA
AATGGGGCAAGATTGAGCGC

Downstream 100 bases:

>100_bases
ACTAAGAGGAGTTTCATGCGTTTTGCCATCATCGGTGCAGGCCTTGCGGGTCTGACTGCTGCATATGAGATCCATAAAGC
TGATCCCACTGCCCAAATCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSALTIPAARRTLNNAPIIDAANGKTPTRTPVWFMRQAGRSLPEYKKVREGISMLDSCFMPELLAEITLQPVRRHDVDAA
ILFSDIVVPLRAAGVGVEIVAGRGPVLDAPVRSREDVLNLPILEGNVPEVEQGIGIILDELSDSQALIGFAGAPFTLASY
LVEGGPSKNHEKTKAMMHGDPETWHALMARLVPTIVNSLKSQIDAGIDAMQLFDSWAGFLTERDYTEFVLPYSTEILEEV
GKYQLPRIHFGVGTGELLGAMSKAGSEVMGVDWRVPLDKAAERIAAVSGPKVLQGNLDPALLFAGRAPLTKEIERIKAEA
QTAIDAGHATGHIFNLGHGVLPNTVAEDITEAVSIIHS

Sequences:

>Translated_358_residues
MSALTIPAARRTLNNAPIIDAANGKTPTRTPVWFMRQAGRSLPEYKKVREGISMLDSCFMPELLAEITLQPVRRHDVDAA
ILFSDIVVPLRAAGVGVEIVAGRGPVLDAPVRSREDVLNLPILEGNVPEVEQGIGIILDELSDSQALIGFAGAPFTLASY
LVEGGPSKNHEKTKAMMHGDPETWHALMARLVPTIVNSLKSQIDAGIDAMQLFDSWAGFLTERDYTEFVLPYSTEILEEV
GKYQLPRIHFGVGTGELLGAMSKAGSEVMGVDWRVPLDKAAERIAAVSGPKVLQGNLDPALLFAGRAPLTKEIERIKAEA
QTAIDAGHATGHIFNLGHGVLPNTVAEDITEAVSIIHS
>Mature_357_residues
SALTIPAARRTLNNAPIIDAANGKTPTRTPVWFMRQAGRSLPEYKKVREGISMLDSCFMPELLAEITLQPVRRHDVDAAI
LFSDIVVPLRAAGVGVEIVAGRGPVLDAPVRSREDVLNLPILEGNVPEVEQGIGIILDELSDSQALIGFAGAPFTLASYL
VEGGPSKNHEKTKAMMHGDPETWHALMARLVPTIVNSLKSQIDAGIDAMQLFDSWAGFLTERDYTEFVLPYSTEILEEVG
KYQLPRIHFGVGTGELLGAMSKAGSEVMGVDWRVPLDKAAERIAAVSGPKVLQGNLDPALLFAGRAPLTKEIERIKAEAQ
TAIDAGHATGHIFNLGHGVLPNTVAEDITEAVSIIHS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=356, Percent_Identity=37.0786516853933, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI2367337, Length=341, Percent_Identity=41.3489736070381, Blast_Score=242, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6320252, Length=347, Percent_Identity=34.5821325648415, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI19921920, Length=358, Percent_Identity=36.0335195530726, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI221330099, Length=358, Percent_Identity=36.0335195530726, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_CORGB (A4QB76)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001137375.1
- ProteinModelPortal:   A4QB76
- SMR:   A4QB76
- STRING:   A4QB76
- GeneID:   4994297
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_0505
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38532; Mature: 38401

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 85-85 BINDING 160-160 BINDING 215-215 BINDING 338-338

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALTIPAARRTLNNAPIIDAANGKTPTRTPVWFMRQAGRSLPEYKKVREGISMLDSCFM
CCCCCCCHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
PELLAEITLQPVRRHDVDAAILFSDIVVPLRAAGVGVEIVAGRGPVLDAPVRSREDVLNL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCCHHHHCC
PILEGNVPEVEQGIGIILDELSDSQALIGFAGAPFTLASYLVEGGPSKNHEKTKAMMHGD
CEECCCCCHHHHCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHCCC
PETWHALMARLVPTIVNSLKSQIDAGIDAMQLFDSWAGFLTERDYTEFVLPYSTEILEEV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHEECCCCHHHHHHH
GKYQLPRIHFGVGTGELLGAMSKAGSEVMGVDWRVPLDKAAERIAAVSGPKVLQGNLDPA
HHCCCCEEEECCCHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHCCCCCEEECCCCCE
LLFAGRAPLTKEIERIKAEAQTAIDAGHATGHIFNLGHGVLPNTVAEDITEAVSIIHS
EEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SALTIPAARRTLNNAPIIDAANGKTPTRTPVWFMRQAGRSLPEYKKVREGISMLDSCFM
CCCCCCHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
PELLAEITLQPVRRHDVDAAILFSDIVVPLRAAGVGVEIVAGRGPVLDAPVRSREDVLNL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCCHHHHCC
PILEGNVPEVEQGIGIILDELSDSQALIGFAGAPFTLASYLVEGGPSKNHEKTKAMMHGD
CEECCCCCHHHHCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHCCC
PETWHALMARLVPTIVNSLKSQIDAGIDAMQLFDSWAGFLTERDYTEFVLPYSTEILEEV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHEECCCCHHHHHHH
GKYQLPRIHFGVGTGELLGAMSKAGSEVMGVDWRVPLDKAAERIAAVSGPKVLQGNLDPA
HHCCCCEEEECCCHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHCCCCCEEECCCCCE
LLFAGRAPLTKEIERIKAEAQTAIDAGHATGHIFNLGHGVLPNTVAEDITEAVSIIHS
EEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA