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The map label for this gene is ctpB [H]

Identifier: 145294553

GI number: 145294553

Start: 562557

End: 565193

Strand: Direct

Name: ctpB [H]

Synonym: cgR_0504

Alternate gene names: 145294553

Gene position: 562557-565193 (Clockwise)

Preceding gene: 145294552

Following gene: 145294554

Centisome position: 16.97

GC content: 53.62

Gene sequence:

>2637_bases
GTGAGCACACCGGATTCTTCCTCGGTGGACAAGGCCGTAAACACTGCTATCTCTGACGCCAAAACAGCGGCGCTCAAGGC
AGGTGTTGGATTGAACCGAGCCACCGCCCCAGAAGAAGAGGAAGATTTAAGCTCAAGCATTAAGGTTTCTTTGGCCTTTG
AGCTCGAGGGATTAAGCAATGCGCCATCGCTGATGGCGGTTGAGAAAGCTCTAGAAAAGATCCCGGGTGTATCTGCGGAT
CTGATCTATCCTTCACAAACTGCTTGGATTACAGCAACTGATCGGGTGCATCCCGAAACCCTCATTGGGGTATTTGAGCA
GTTTGGCATCAAAGCGCAGCTTTCTAATTCTTCACTGCTGCGTAGGCATCAACAGCTCAGCGCGGAAGTAAATAGGGAAG
CCCGCATTGATCGTTATCGCTCCAGGATGGATGCGAAGCGGATTTCACCGCGGGTGCGTAGACACAACCGTCAAGAAATG
GTTCATGCGGTGCGTGCTCGCGAAAGTGGTTGGATTAAACGCATGAATCACACCACCTCGCAGCATGAAGACCCAATGTC
AGGTGATGTGCTGTTTACCGCCCGTGCCTTGATTACCCCCATGCGTTTATGGGTGTCACTGCCATTCGCTCTCATTGTGT
TGGCATTGTCATTGAATCCTTCGTGGCAGTTCGACTATTGGCAGTGGTTGTCCGCTGTGTTGGCTATTCCTGTGGTGGTG
TGGGGCGCGTGGCCGTTTCACCGAGCTGCAGCGGGCGGTATTCGTCGAGGAATTTCTGCCCTCGATGCGACAAGCTCAAT
CGCTATTGCTGCTGCGTACGCGTGGTCTATAGCCATGCTGTTGTTTGAAACCCCAGGAAATAAATCGTGGCGTTCTTATC
CGTCGTGGTTCGCTTTTAACCACGGCACGTTGACCCAAAACGAAATCTATTTTGATGTGGCCTGCGGAATCACCGTGTTG
CTTCTTGGCGGACGGCTGCTGACAAGGCGTCGAAGCCAATCTAGTTTGTTAGCGGAACTTGGTCGCCTCCAAATTGATCC
GCAGCGCATTGTGACTGTGGTGCGTAAACACCGATTGAAGCGCGTTGTCCAGGAACTGAATATTCCAGTGCAGGAAGTCC
GAGTTAATGACGATGTGAAAGTTCCACCAAATACCACGATTCCAGTAGATGGCACCGTCATCGGTGGTGGTTCGAGGATC
GCGGCCAGCATCATCATGGGACAAGACCAGCGTGATGTAAAAGTAAATGACAAAGTTTTCGCCGGCAGCCTCAACCTCGA
ATCAGAAATCAAGGTTCGTGTTATTCGCACTGGTCACCGCACCCGCATCGCCGCGGTACATAGGTGGGTTAAACAAGCGA
CGCTGCAGGAAAACCGACACAATAGGGCTGCGATCCGTTCGGCAGGCAACCTTGTGCCCATCACCTTCACCCTTGCTGTG
GTGGACTTCTGCCTGTGGGCGTTGATCTCTGGAAACATCAACGCTGCTTTTACTACCACCTTGGCAGTTCTTGCATGCGT
GGCTCCCGTGGCCTTGGCTCTGTCTGCTCCACTAGCTACGAGAAACTCCATCGAAGCTGCAGCACGACACGGTATTTTGG
TCCGGTCCGGTGAAATTTTCCGAGTTCTCGATGATGTGGATACCGCTGTATTCAACCGCGTGGGCACACTAACCGATGGC
GAAATGACAGTGGAAACCGTCACCGCAGACAAAGGTGAAGACCCAGAACTAGTGTTGCGTGTAGCCGGAGCTTTGGCCAT
GGAATCCCACCACGCGATTTCCAAAGCACTGGTGAAAGCATCTCGTGAAGCTCGTGATACCGGCGCCGGTGGTGAAGATG
TCCCACACTGGATTGAAGTAGGCAACGTGGAAATCACCGAAGCCGGCTCATTCCAAGCAACCATCGAGCTGCCACTGATC
AAACCATCTGGCGAAAAAATCATGCGCACCACAGAAGCACTCCTGTGGCGACCACGATCCATGACAGAAGTCCGTGAGCA
CTTAAGCCCCCGACTAGTGGCAGCAGCAACCTCAGGTGGCGCACCACTGATCGTGCGGTGGAAAGGCAAAGACCGCGGAG
TTATCACTCTAAGTGACCACGTGAGATCAGATTCCTCCGATGCGATTATTGCGATTGAAGAACAAGGCATCGAGACCATG
ATGCTTTCACGTGATACTTACCCGGTGGCACGTCGATACGCAGACAGCTTAGGCATCACCCACGTCTTGGCCGGCATCGC
GCCGGGCAAGAAAGCCCAGGTTGTCCGTGCAGTCCACACCCGCGGATCCACTGTCGCGATGATCGGCGATGAATCAGTAA
TGGACTGTTTGAAAGTCGCTGACGTGGGTGTACTGATGGGCGTCGATCGTCCCTCAGAGCTGCGTGATGATTCCGATGAC
CCGGCAGCTGACGTTGTGGTCATGCGCGAAGAGGTCATGAGCGTGCCGACGCTGTTTAAACTGGCTCGACGCTACGCCAA
GTTGGTCAATGGCAATATTGCTCTGGCCTGGATCTATAACGGTGTTGCCATGGTGGTTGCAGTGTCTGGCTTACTGCATC
CAATGGCTGCGACCGTGGCTATGCTGGCGTCTTCGCTGCTTATTGAATGGCGCTCGGGCAGGGCGCGCAAGTACTAA

Upstream 100 bases:

>100_bases
TACTTTTTCGCTACCGTGAGTCTTACCGTGAGCCTTATACTGTGAGGACATTAAAAGTGACACCTCTTTTTCTATCCTTT
ACAACCCAAGAAGGTTTATC

Downstream 100 bases:

>100_bases
CCAGCAATTCCCAAGCCCAAAATCCCTCCCATATCGTTCTTTTTACTGATGCATTGTCCTCAATTAGGTGTGGCTTCTTT
TCCTAAATTGGGATAAATGG

Product: hypothetical protein

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 878; Mature: 877

Protein sequence:

>878_residues
MSTPDSSSVDKAVNTAISDAKTAALKAGVGLNRATAPEEEEDLSSSIKVSLAFELEGLSNAPSLMAVEKALEKIPGVSAD
LIYPSQTAWITATDRVHPETLIGVFEQFGIKAQLSNSSLLRRHQQLSAEVNREARIDRYRSRMDAKRISPRVRRHNRQEM
VHAVRARESGWIKRMNHTTSQHEDPMSGDVLFTARALITPMRLWVSLPFALIVLALSLNPSWQFDYWQWLSAVLAIPVVV
WGAWPFHRAAAGGIRRGISALDATSSIAIAAAYAWSIAMLLFETPGNKSWRSYPSWFAFNHGTLTQNEIYFDVACGITVL
LLGGRLLTRRRSQSSLLAELGRLQIDPQRIVTVVRKHRLKRVVQELNIPVQEVRVNDDVKVPPNTTIPVDGTVIGGGSRI
AASIIMGQDQRDVKVNDKVFAGSLNLESEIKVRVIRTGHRTRIAAVHRWVKQATLQENRHNRAAIRSAGNLVPITFTLAV
VDFCLWALISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIFRVLDDVDTAVFNRVGTLTDG
EMTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKASREARDTGAGGEDVPHWIEVGNVEITEAGSFQATIELPLI
KPSGEKIMRTTEALLWRPRSMTEVREHLSPRLVAAATSGGAPLIVRWKGKDRGVITLSDHVRSDSSDAIIAIEEQGIETM
MLSRDTYPVARRYADSLGITHVLAGIAPGKKAQVVRAVHTRGSTVAMIGDESVMDCLKVADVGVLMGVDRPSELRDDSDD
PAADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYNGVAMVVAVSGLLHPMAATVAMLASSLLIEWRSGRARKY

Sequences:

>Translated_878_residues
MSTPDSSSVDKAVNTAISDAKTAALKAGVGLNRATAPEEEEDLSSSIKVSLAFELEGLSNAPSLMAVEKALEKIPGVSAD
LIYPSQTAWITATDRVHPETLIGVFEQFGIKAQLSNSSLLRRHQQLSAEVNREARIDRYRSRMDAKRISPRVRRHNRQEM
VHAVRARESGWIKRMNHTTSQHEDPMSGDVLFTARALITPMRLWVSLPFALIVLALSLNPSWQFDYWQWLSAVLAIPVVV
WGAWPFHRAAAGGIRRGISALDATSSIAIAAAYAWSIAMLLFETPGNKSWRSYPSWFAFNHGTLTQNEIYFDVACGITVL
LLGGRLLTRRRSQSSLLAELGRLQIDPQRIVTVVRKHRLKRVVQELNIPVQEVRVNDDVKVPPNTTIPVDGTVIGGGSRI
AASIIMGQDQRDVKVNDKVFAGSLNLESEIKVRVIRTGHRTRIAAVHRWVKQATLQENRHNRAAIRSAGNLVPITFTLAV
VDFCLWALISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIFRVLDDVDTAVFNRVGTLTDG
EMTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKASREARDTGAGGEDVPHWIEVGNVEITEAGSFQATIELPLI
KPSGEKIMRTTEALLWRPRSMTEVREHLSPRLVAAATSGGAPLIVRWKGKDRGVITLSDHVRSDSSDAIIAIEEQGIETM
MLSRDTYPVARRYADSLGITHVLAGIAPGKKAQVVRAVHTRGSTVAMIGDESVMDCLKVADVGVLMGVDRPSELRDDSDD
PAADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYNGVAMVVAVSGLLHPMAATVAMLASSLLIEWRSGRARKY
>Mature_877_residues
STPDSSSVDKAVNTAISDAKTAALKAGVGLNRATAPEEEEDLSSSIKVSLAFELEGLSNAPSLMAVEKALEKIPGVSADL
IYPSQTAWITATDRVHPETLIGVFEQFGIKAQLSNSSLLRRHQQLSAEVNREARIDRYRSRMDAKRISPRVRRHNRQEMV
HAVRARESGWIKRMNHTTSQHEDPMSGDVLFTARALITPMRLWVSLPFALIVLALSLNPSWQFDYWQWLSAVLAIPVVVW
GAWPFHRAAAGGIRRGISALDATSSIAIAAAYAWSIAMLLFETPGNKSWRSYPSWFAFNHGTLTQNEIYFDVACGITVLL
LGGRLLTRRRSQSSLLAELGRLQIDPQRIVTVVRKHRLKRVVQELNIPVQEVRVNDDVKVPPNTTIPVDGTVIGGGSRIA
ASIIMGQDQRDVKVNDKVFAGSLNLESEIKVRVIRTGHRTRIAAVHRWVKQATLQENRHNRAAIRSAGNLVPITFTLAVV
DFCLWALISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIFRVLDDVDTAVFNRVGTLTDGE
MTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKASREARDTGAGGEDVPHWIEVGNVEITEAGSFQATIELPLIK
PSGEKIMRTTEALLWRPRSMTEVREHLSPRLVAAATSGGAPLIVRWKGKDRGVITLSDHVRSDSSDAIIAIEEQGIETMM
LSRDTYPVARRYADSLGITHVLAGIAPGKKAQVVRAVHTRGSTVAMIGDESVMDCLKVADVGVLMGVDRPSELRDDSDDP
AADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYNGVAMVVAVSGLLHPMAATVAMLASSLLIEWRSGRARKY

Specific function: Involved In Copper Efflux. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=715, Percent_Identity=25.7342657342657, Blast_Score=176, Evalue=1e-43,
Organism=Homo sapiens, GI115529486, Length=696, Percent_Identity=24.2816091954023, Blast_Score=160, Evalue=5e-39,
Organism=Homo sapiens, GI55743073, Length=553, Percent_Identity=26.7631103074141, Blast_Score=152, Evalue=1e-36,
Organism=Escherichia coli, GI1786691, Length=666, Percent_Identity=24.6246246246246, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1789879, Length=532, Percent_Identity=23.3082706766917, Blast_Score=67, Evalue=7e-12,
Organism=Escherichia coli, GI1786914, Length=441, Percent_Identity=23.1292517006803, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17556548, Length=944, Percent_Identity=23.3050847457627, Blast_Score=146, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6320475, Length=679, Percent_Identity=24.8895434462445, Blast_Score=147, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6319772, Length=651, Percent_Identity=22.4270353302611, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI221329854, Length=404, Percent_Identity=25, Blast_Score=98, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR000579
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 95828; Mature: 95697

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPDSSSVDKAVNTAISDAKTAALKAGVGLNRATAPEEEEDLSSSIKVSLAFELEGLSN
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCEEEEEEEEECCCCC
APSLMAVEKALEKIPGVSADLIYPSQTAWITATDRVHPETLIGVFEQFGIKAQLSNSSLL
CCHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCEEEECCHHHH
RRHQQLSAEVNREARIDRYRSRMDAKRISPRVRRHNRQEMVHAVRARESGWIKRMNHTTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCHHHHHCCCCC
QHEDPMSGDVLFTARALITPMRLWVSLPFALIVLALSLNPSWQFDYWQWLSAVLAIPVVV
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
WGAWPFHRAAAGGIRRGISALDATSSIAIAAAYAWSIAMLLFETPGNKSWRSYPSWFAFN
HCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEC
HGTLTQNEIYFDVACGITVLLLGGRLLTRRRSQSSLLAELGRLQIDPQRIVTVVRKHRLK
CCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RVVQELNIPVQEVRVNDDVKVPPNTTIPVDGTVIGGGSRIAASIIMGQDQRDVKVNDKVF
HHHHHHCCCHHHEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHCCCCCCCCEECCEEE
AGSLNLESEIKVRVIRTGHRTRIAAVHRWVKQATLQENRHNRAAIRSAGNLVPITFTLAV
EECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEHHHHHHH
VDFCLWALISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEEECCCEE
RVLDDVDTAVFNRVGTLTDGEMTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKA
EHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SREARDTGAGGEDVPHWIEVGNVEITEAGSFQATIELPLIKPSGEKIMRTTEALLWRPRS
HHHHHCCCCCCCCCCCCEEECCEEEEECCCEEEEEEEEEECCCCHHHHHHHHHHHCCCCC
MTEVREHLSPRLVAAATSGGAPLIVRWKGKDRGVITLSDHVRSDSSDAIIAIEEQGIETM
HHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCCCEEE
MLSRDTYPVARRYADSLGITHVLAGIAPGKKAQVVRAVHTRGSTVAMIGDESVMDCLKVA
EECCCCCHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
DVGVLMGVDRPSELRDDSDDPAADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYN
HHHHEEECCCCHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEHHH
GVAMVVAVSGLLHPMAATVAMLASSLLIEWRSGRARKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STPDSSSVDKAVNTAISDAKTAALKAGVGLNRATAPEEEEDLSSSIKVSLAFELEGLSN
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCEEEEEEEEECCCCC
APSLMAVEKALEKIPGVSADLIYPSQTAWITATDRVHPETLIGVFEQFGIKAQLSNSSLL
CCHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCEEEECCHHHH
RRHQQLSAEVNREARIDRYRSRMDAKRISPRVRRHNRQEMVHAVRARESGWIKRMNHTTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCHHHHHCCCCC
QHEDPMSGDVLFTARALITPMRLWVSLPFALIVLALSLNPSWQFDYWQWLSAVLAIPVVV
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
WGAWPFHRAAAGGIRRGISALDATSSIAIAAAYAWSIAMLLFETPGNKSWRSYPSWFAFN
HCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEC
HGTLTQNEIYFDVACGITVLLLGGRLLTRRRSQSSLLAELGRLQIDPQRIVTVVRKHRLK
CCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RVVQELNIPVQEVRVNDDVKVPPNTTIPVDGTVIGGGSRIAASIIMGQDQRDVKVNDKVF
HHHHHHCCCHHHEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHCCCCCCCCEECCEEE
AGSLNLESEIKVRVIRTGHRTRIAAVHRWVKQATLQENRHNRAAIRSAGNLVPITFTLAV
EECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEHHHHHHH
VDFCLWALISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEEECCCEE
RVLDDVDTAVFNRVGTLTDGEMTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKA
EHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SREARDTGAGGEDVPHWIEVGNVEITEAGSFQATIELPLIKPSGEKIMRTTEALLWRPRS
HHHHHCCCCCCCCCCCCEEECCEEEEECCCEEEEEEEEEECCCCHHHHHHHHHHHCCCCC
MTEVREHLSPRLVAAATSGGAPLIVRWKGKDRGVITLSDHVRSDSSDAIIAIEEQGIETM
HHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCCCEEE
MLSRDTYPVARRYADSLGITHVLAGIAPGKKAQVVRAVHTRGSTVAMIGDESVMDCLKVA
EECCCCCHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
DVGVLMGVDRPSELRDDSDDPAADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYN
HHHHEEECCCCHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEHHH
GVAMVVAVSGLLHPMAATVAMLASSLLIEWRSGRARKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7476188; 11234002 [H]