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The map label for this gene is ycsA [H]

Identifier: 138897008

GI number: 138897008

Start: 3485810

End: 3486877

Strand: Reverse

Name: ycsA [H]

Synonym: GTNG_3379

Alternate gene names: 138897008

Gene position: 3486877-3485810 (Counterclockwise)

Preceding gene: 138897013

Following gene: 138897007

Centisome position: 98.21

GC content: 53.93

Gene sequence:

>1068_bases
ATGGTTGTGAAAAAGTGGGAAATCGCTGTTATTCCCGGCGACGGCATCGGTAAGGAAGTCGTGCCAGCAGCGTTGGATGT
GCTGCGGGCCGTCGCCGATGTCCATGGGGGGATGACGTTTTCGTTCACCGAATTTCCGTGGAGCTGTGACTACTATGTTG
AACACGGCAAAATGATGCCGGATGACGGGTTATCGATTTTGCGAAATTTTGATGCCATTTTTCTTGGAGCGGTCGGCAAT
CCAGCGCTTGTTCCCGATCATATTTCATTATGGGGCTTGCTCTTGAAAATCCGCCGCGAATTTGAACAAGTGATCAATAT
CCGTCCGGCGAAATATTTCCGCGGCTTGTCCTCCCCGCTTGCGGAGCCGCACGAATTTGATTTCATCGTCGTCCGTGAAA
ACAGCGAAGGTGAATATAGCGAAGTCGGTGGGCGCATTCATCGCGGTGAAGATGAAATCGCCATCCAAAACGCCGTATTT
ACCCGCAAAGGAACGGAGCGGGCGATGCGCTACGCGTTCGAGCTGGCCCAAAAGCGGAAAAGGCATGTGACGAGCGCAAC
GAAATCAAACGGTATTTTCCATACGATGCCGTTTTGGGACGAAGTGTTCGCCGACGTCAAGCGCGACTATCCGGATGTCG
CGACCGCGTCGTACCATATCGACGCGTTGGCGGCCTTTTTTGTCACACGGCCACACATGTTTGACGTTGTTGTCGCAAGC
AACTTGTTCGGCGACATTTTGACTGACCTCGGCGGCGCCATTATGGGAAGCATCGGCATCGCTCCGGCGGCGAACATAAA
CGTCAACGGCAAGTACCCGTCAATGTTTGAGCCCGTGCACGGTTCAGCGCCCGACATTTACGGCAAAGGCATTGCCAATC
CGATCGGGCAAATTTGGACGGCCAAATTAATGCTTGACCATTTCGGTGAAGAAGAACTCGGCGCTCTGTTGTTAAACGTA
GTCGAGGAGGTTACGGCCGACGGCGTCAAAACGCCGGATATCGGCGGCACGGCGACGACGAAGGAAGTAGCCGCGGAAAT
TTGCCGACGCTTGCGCGAGCATGCTTGA

Upstream 100 bases:

>100_bases
TTTTACCATAAATGAGGATTGTTCATGCATTCTACAAAGAAAGAGGAGTGAGTGCACTTTTTGTTGAATGAATGGCAAAG
AGAGAGTGGACAAGGAGGAG

Downstream 100 bases:

>100_bases
CCCGTCAGAGCAGCAAGCGGCGCGGTTTGCAGTTTCCTTCCATTCGGGTATACTTGTTGTCGGAAGAACTGACAAAGAAA
GGATGACATACGTTGTTCAA

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MVVKKWEIAVIPGDGIGKEVVPAALDVLRAVADVHGGMTFSFTEFPWSCDYYVEHGKMMPDDGLSILRNFDAIFLGAVGN
PALVPDHISLWGLLLKIRREFEQVINIRPAKYFRGLSSPLAEPHEFDFIVVRENSEGEYSEVGGRIHRGEDEIAIQNAVF
TRKGTERAMRYAFELAQKRKRHVTSATKSNGIFHTMPFWDEVFADVKRDYPDVATASYHIDALAAFFVTRPHMFDVVVAS
NLFGDILTDLGGAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIYGKGIANPIGQIWTAKLMLDHFGEEELGALLLNV
VEEVTADGVKTPDIGGTATTKEVAAEICRRLREHA

Sequences:

>Translated_355_residues
MVVKKWEIAVIPGDGIGKEVVPAALDVLRAVADVHGGMTFSFTEFPWSCDYYVEHGKMMPDDGLSILRNFDAIFLGAVGN
PALVPDHISLWGLLLKIRREFEQVINIRPAKYFRGLSSPLAEPHEFDFIVVRENSEGEYSEVGGRIHRGEDEIAIQNAVF
TRKGTERAMRYAFELAQKRKRHVTSATKSNGIFHTMPFWDEVFADVKRDYPDVATASYHIDALAAFFVTRPHMFDVVVAS
NLFGDILTDLGGAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIYGKGIANPIGQIWTAKLMLDHFGEEELGALLLNV
VEEVTADGVKTPDIGGTATTKEVAAEICRRLREHA
>Mature_355_residues
MVVKKWEIAVIPGDGIGKEVVPAALDVLRAVADVHGGMTFSFTEFPWSCDYYVEHGKMMPDDGLSILRNFDAIFLGAVGN
PALVPDHISLWGLLLKIRREFEQVINIRPAKYFRGLSSPLAEPHEFDFIVVRENSEGEYSEVGGRIHRGEDEIAIQNAVF
TRKGTERAMRYAFELAQKRKRHVTSATKSNGIFHTMPFWDEVFADVKRDYPDVATASYHIDALAAFFVTRPHMFDVVVAS
NLFGDILTDLGGAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIYGKGIANPIGQIWTAKLMLDHFGEEELGALLLNV
VEEVTADGVKTPDIGGTATTKEVAAEICRRLREHA

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=348, Percent_Identity=29.8850574712644, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4758582, Length=355, Percent_Identity=27.887323943662, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI28178838, Length=310, Percent_Identity=28.0645161290323, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI28178821, Length=351, Percent_Identity=24.2165242165242, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI28178816, Length=343, Percent_Identity=24.4897959183673, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI28178819, Length=186, Percent_Identity=26.3440860215054, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788101, Length=358, Percent_Identity=56.145251396648, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI87081683, Length=359, Percent_Identity=35.933147632312, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787381, Length=364, Percent_Identity=28.5714285714286, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71986051, Length=356, Percent_Identity=30.0561797752809, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17550882, Length=356, Percent_Identity=29.7752808988764, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25144293, Length=355, Percent_Identity=25.6338028169014, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17505779, Length=347, Percent_Identity=25.3602305475504, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322097, Length=366, Percent_Identity=33.0601092896175, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6319830, Length=360, Percent_Identity=30.2777777777778, Blast_Score=152, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6324709, Length=361, Percent_Identity=33.2409972299169, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324291, Length=361, Percent_Identity=29.6398891966759, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24643268, Length=351, Percent_Identity=29.9145299145299, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24643270, Length=351, Percent_Identity=29.3447293447293, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI161078635, Length=358, Percent_Identity=28.4916201117318, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI161078637, Length=358, Percent_Identity=28.4916201117318, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI161078633, Length=358, Percent_Identity=28.4916201117318, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24650122, Length=358, Percent_Identity=28.4916201117318, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI161078639, Length=353, Percent_Identity=28.8951841359773, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24661184, Length=356, Percent_Identity=28.0898876404494, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI20130355, Length=352, Percent_Identity=26.9886363636364, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281362242, Length=358, Percent_Identity=25.6983240223464, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24648872, Length=358, Percent_Identity=25.6983240223464, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 39102; Mature: 39102

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKKWEIAVIPGDGIGKEVVPAALDVLRAVADVHGGMTFSFTEFPWSCDYYVEHGKMMP
CCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHEECCCCCC
DDGLSILRNFDAIFLGAVGNPALVPDHISLWGLLLKIRREFEQVINIRPAKYFRGLSSPL
CHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
AEPHEFDFIVVRENSEGEYSEVGGRIHRGEDEIAIQNAVFTRKGTERAMRYAFELAQKRK
CCCCCCCEEEEEECCCCCHHHHCCEEECCCCHHEEHHHHHHCCCHHHHHHHHHHHHHHHH
RHVTSATKSNGIFHTMPFWDEVFADVKRDYPDVATASYHIDALAAFFVTRPHMFDVVVAS
HHHHHHHHCCCCEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
NLFGDILTDLGGAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIYGKGIANPIGQIWT
HHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
AKLMLDHFGEEELGALLLNVVEEVTADGVKTPDIGGTATTKEVAAEICRRLREHA
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVKKWEIAVIPGDGIGKEVVPAALDVLRAVADVHGGMTFSFTEFPWSCDYYVEHGKMMP
CCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHEECCCCCC
DDGLSILRNFDAIFLGAVGNPALVPDHISLWGLLLKIRREFEQVINIRPAKYFRGLSSPL
CHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
AEPHEFDFIVVRENSEGEYSEVGGRIHRGEDEIAIQNAVFTRKGTERAMRYAFELAQKRK
CCCCCCCEEEEEECCCCCHHHHCCEEECCCCHHEEHHHHHHCCCHHHHHHHHHHHHHHHH
RHVTSATKSNGIFHTMPFWDEVFADVKRDYPDVATASYHIDALAAFFVTRPHMFDVVVAS
HHHHHHHHCCCCEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
NLFGDILTDLGGAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIYGKGIANPIGQIWT
HHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
AKLMLDHFGEEELGALLLNVVEEVTADGVKTPDIGGTATTKEVAAEICRRLREHA
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]