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The map label for this gene is nuoD [H]

Identifier: 138896930

GI number: 138896930

Start: 3408540

End: 3409640

Strand: Reverse

Name: nuoD [H]

Synonym: GTNG_3299

Alternate gene names: 138896930

Gene position: 3409640-3408540 (Counterclockwise)

Preceding gene: 138896931

Following gene: 138896929

Centisome position: 96.04

GC content: 53.41

Gene sequence:

>1101_bases
ATGCTGCGCACAGAAGAAATGATCTTAAACGTCGGCCCCCAGCACCCAAGTACGCACGGGGTATTTCGCCTCATTTTAAA
AATTGACGGTGAAATCATCCAAGAAGCGACGCCGGTCATCGGCTACTTGCACCGCGGGACGGAGAAAATCGCTGAAGGGC
TGCAATATACACAAATCATCCCGTATACCGACCGGATGGACTATTTGTCGGCGATGACGAACAACTATGTGCTTTGCCAT
GCGGTTGAAACCATGATGGGCATTGAAGTGCCGGAGCGGGCCGAGTATTTGCGCGTTCTCGCGATGGAGCTTGGGCGAAT
TGCCAGCCATCTCGTCTGGTGGGGGACGTATTTGCTTGACCTCGGCGCGACGAGCCCGTTTTTGTATGCATTCCGCGAGC
GCGAAATGATTATTAATCTATTAAATGAGCTGTCCGGGGCGCGGTTGACGTTTAACTATATGCGCATTGGCGGCGTCAAA
TGGGACGCGCCGGACGGCTGGATCGACAAAGTGAAACAGTTTGTTCCATACATGCGGGAAAAACTAGCCGGCTACCATGA
CCTTGTCACCGGCAACGAGATTTTCCGTGAACGCGTCACCGGCGTCGGGAGGTATACGAAAGAAGAAGCGATCAGTTATT
CATTAAGCGGGGTCAACTTGCGGTCGACCGGCGTCAAATGGGACTTGCGCAAAGATGAGCCATATTCAGTCTATGACCGG
TTTGATTTTGATGTTCCGGTGCGCGAGGGCGGCGACTGCCTTGCCCGCTATGAATGCCGGATGGCAGAAATTGAACAGTC
GCTTCGTATTATTGAACAGGCATGTGAGCAGTTTCCGGCCGACGGGCCGATTATGGGCAAATTGCCGCGCATCATTAAGG
CGCCACCGGGCGAGACGTTTGTCCGCATCGAAGCGCCGCGCGGCGAGATCGGTTGCTATATTGCGAGCGACGGCAAAAAA
GAGCCGTACCGTCTCAAATTCCGGCGCCCGTCGTTTTACAACTTGCAAATACTCCCGAAGCTGCTTAAAGGAGAAAATTT
GGCCAACGTCATCGCCATTCTCGGATCGATTGACATTGTGCTCGGGGAGGTCGACGGATAA

Upstream 100 bases:

>100_bases
CCGCGGCCACCCGAACTTAATCCGCATCTTCCTAGGGGAGCAATGGGTCGGGCATCCGCTGCGCAAAGATTACGAGCCGT
ATGATGCGGAGGTGTGAACG

Downstream 100 bases:

>100_bases
TGGAACAATGGCTCGAATCGGCGCCAGGCTGGACGAATGTCGCCGTCTTCTTCGGGCTTGGGGCGCTTTTGCTGCTAGTC
GTGCTCGGGTTCGTCACATA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MLRTEEMILNVGPQHPSTHGVFRLILKIDGEIIQEATPVIGYLHRGTEKIAEGLQYTQIIPYTDRMDYLSAMTNNYVLCH
AVETMMGIEVPERAEYLRVLAMELGRIASHLVWWGTYLLDLGATSPFLYAFREREMIINLLNELSGARLTFNYMRIGGVK
WDAPDGWIDKVKQFVPYMREKLAGYHDLVTGNEIFRERVTGVGRYTKEEAISYSLSGVNLRSTGVKWDLRKDEPYSVYDR
FDFDVPVREGGDCLARYECRMAEIEQSLRIIEQACEQFPADGPIMGKLPRIIKAPPGETFVRIEAPRGEIGCYIASDGKK
EPYRLKFRRPSFYNLQILPKLLKGENLANVIAILGSIDIVLGEVDG

Sequences:

>Translated_366_residues
MLRTEEMILNVGPQHPSTHGVFRLILKIDGEIIQEATPVIGYLHRGTEKIAEGLQYTQIIPYTDRMDYLSAMTNNYVLCH
AVETMMGIEVPERAEYLRVLAMELGRIASHLVWWGTYLLDLGATSPFLYAFREREMIINLLNELSGARLTFNYMRIGGVK
WDAPDGWIDKVKQFVPYMREKLAGYHDLVTGNEIFRERVTGVGRYTKEEAISYSLSGVNLRSTGVKWDLRKDEPYSVYDR
FDFDVPVREGGDCLARYECRMAEIEQSLRIIEQACEQFPADGPIMGKLPRIIKAPPGETFVRIEAPRGEIGCYIASDGKK
EPYRLKFRRPSFYNLQILPKLLKGENLANVIAILGSIDIVLGEVDG
>Mature_366_residues
MLRTEEMILNVGPQHPSTHGVFRLILKIDGEIIQEATPVIGYLHRGTEKIAEGLQYTQIIPYTDRMDYLSAMTNNYVLCH
AVETMMGIEVPERAEYLRVLAMELGRIASHLVWWGTYLLDLGATSPFLYAFREREMIINLLNELSGARLTFNYMRIGGVK
WDAPDGWIDKVKQFVPYMREKLAGYHDLVTGNEIFRERVTGVGRYTKEEAISYSLSGVNLRSTGVKWDLRKDEPYSVYDR
FDFDVPVREGGDCLARYECRMAEIEQSLRIIEQACEQFPADGPIMGKLPRIIKAPPGETFVRIEAPRGEIGCYIASDGKK
EPYRLKFRRPSFYNLQILPKLLKGENLANVIAILGSIDIVLGEVDG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=386, Percent_Identity=43.0051813471503, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI260898743, Length=381, Percent_Identity=42.257217847769, Blast_Score=309, Evalue=3e-84,
Organism=Escherichia coli, GI145693162, Length=384, Percent_Identity=39.5833333333333, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI1789076, Length=354, Percent_Identity=29.3785310734463, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1788832, Length=358, Percent_Identity=27.3743016759777, Blast_Score=131, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17568379, Length=386, Percent_Identity=41.1917098445596, Blast_Score=320, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17555284, Length=386, Percent_Identity=40.6735751295337, Blast_Score=318, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24638644, Length=383, Percent_Identity=44.1253263707572, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI221459469, Length=382, Percent_Identity=41.3612565445026, Blast_Score=315, Evalue=4e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 41698; Mature: 41698

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRTEEMILNVGPQHPSTHGVFRLILKIDGEIIQEATPVIGYLHRGTEKIAEGLQYTQII
CCCCHHHHEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEC
PYTDRMDYLSAMTNNYVLCHAVETMMGIEVPERAEYLRVLAMELGRIASHLVWWGTYLLD
CCCCHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGATSPFLYAFREREMIINLLNELSGARLTFNYMRIGGVKWDAPDGWIDKVKQFVPYMRE
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCEEECCCCHHHHHHHHHHHHHHH
KLAGYHDLVTGNEIFRERVTGVGRYTKEEAISYSLSGVNLRSTGVKWDLRKDEPYSVYDR
HHCCHHHCCCHHHHHHHHHHHCCCCCHHHHHEEEECCCEEECCCCEEEECCCCCCCHHHC
FDFDVPVREGGDCLARYECRMAEIEQSLRIIEQACEQFPADGPIMGKLPRIIKAPPGETF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCEE
VRIEAPRGEIGCYIASDGKKEPYRLKFRRPSFYNLQILPKLLKGENLANVIAILGSIDIV
EEEECCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHCCEEE
LGEVDG
EEECCC
>Mature Secondary Structure
MLRTEEMILNVGPQHPSTHGVFRLILKIDGEIIQEATPVIGYLHRGTEKIAEGLQYTQII
CCCCHHHHEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEC
PYTDRMDYLSAMTNNYVLCHAVETMMGIEVPERAEYLRVLAMELGRIASHLVWWGTYLLD
CCCCHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGATSPFLYAFREREMIINLLNELSGARLTFNYMRIGGVKWDAPDGWIDKVKQFVPYMRE
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCEEECCCCHHHHHHHHHHHHHHH
KLAGYHDLVTGNEIFRERVTGVGRYTKEEAISYSLSGVNLRSTGVKWDLRKDEPYSVYDR
HHCCHHHCCCHHHHHHHHHHHCCCCCHHHHHEEEECCCEEECCCCEEEECCCCCCCHHHC
FDFDVPVREGGDCLARYECRMAEIEQSLRIIEQACEQFPADGPIMGKLPRIIKAPPGETF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCEE
VRIEAPRGEIGCYIASDGKKEPYRLKFRRPSFYNLQILPKLLKGENLANVIAILGSIDIV
EEEECCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHCCEEE
LGEVDG
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA