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The map label for this gene is hisG [H]

Identifier: 138896663

GI number: 138896663

Start: 3121723

End: 3122346

Strand: Reverse

Name: hisG [H]

Synonym: GTNG_3026

Alternate gene names: 138896663

Gene position: 3122346-3121723 (Counterclockwise)

Preceding gene: 138896664

Following gene: 138896662

Centisome position: 87.95

GC content: 54.01

Gene sequence:

>624_bases
ATGCTGACGATTGCGATGCCGAAAGGGCGCATTTTTGAAGAGGCGGTCGAGCTGCTGCGCCGGGCGGACTATATGCTGCC
GCCGGAATTTGAAGAATCGCGAAAACTCGTCATTGACGTCGCAGAGGAAAATATGCGCTTTATTTTGGCGAAACCGATGG
ATGTCGTGACGTATGTGGAGCATGGGGTGGCGGATTTAGGCATAGCGGGCAAAGATGTCTTGATGGAGGAAGAACGGAAC
GTCTATGAGCTGCTGGATTTGCAAATCAGCCGCTGCCATTTGGCGGTGGCGGGGCTGCCCGGCGTCAAAATGAATGGGAT
CGCGCCCCGGGTGGCGACAAAATATCCGAATGTCGCGTCAACGTATTTCCGCGAACAAGGCGAGCAAGTTGAAATCATCC
GCTTGAACGGATCGATTGAACTCGCTCCGCTTATCGGTTTGGCCGACCGGATTGTGGATATTGTTTCGACAGGAAGGACG
TTGAAAGAAAACGGGCTTGTTGAACTCGAACGGATCGCTGACGTGACGTCGCGTCTTATTGTCAATCCGGCAAGCTACCG
GTTGAATGGCGAGGTGATTGAGCGGTTGGTCGACCGATTAGCGGCGGTCATCCCACAACCGTAG

Upstream 100 bases:

>100_bases
AGAAAACGTGCACGCGGCGTGAATGGAATCCAACCCATTGCCGCAGGGATGGCTGCGCGGTTTATGGAGCTGACATGACA
AGGAGCAGGGAGGAAGAGCG

Downstream 100 bases:

>100_bases
GAAAAGGGGAACCGGGCGGTTTCCCATGAATGGATTGGTAGAGATTCGGGACTGGTGTTGCCGAATGGTGGAGCGGCGTT
GACAGCGCTGAAAAGGTTGC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MLTIAMPKGRIFEEAVELLRRADYMLPPEFEESRKLVIDVAEENMRFILAKPMDVVTYVEHGVADLGIAGKDVLMEEERN
VYELLDLQISRCHLAVAGLPGVKMNGIAPRVATKYPNVASTYFREQGEQVEIIRLNGSIELAPLIGLADRIVDIVSTGRT
LKENGLVELERIADVTSRLIVNPASYRLNGEVIERLVDRLAAVIPQP

Sequences:

>Translated_207_residues
MLTIAMPKGRIFEEAVELLRRADYMLPPEFEESRKLVIDVAEENMRFILAKPMDVVTYVEHGVADLGIAGKDVLMEEERN
VYELLDLQISRCHLAVAGLPGVKMNGIAPRVATKYPNVASTYFREQGEQVEIIRLNGSIELAPLIGLADRIVDIVSTGRT
LKENGLVELERIADVTSRLIVNPASYRLNGEVIERLVDRLAAVIPQP
>Mature_207_residues
MLTIAMPKGRIFEEAVELLRRADYMLPPEFEESRKLVIDVAEENMRFILAKPMDVVTYVEHGVADLGIAGKDVLMEEERN
VYELLDLQISRCHLAVAGLPGVKMNGIAPRVATKYPNVASTYFREQGEQVEIIRLNGSIELAPLIGLADRIVDIVSTGRT
LKENGLVELERIADVTSRLIVNPASYRLNGEVIERLVDRLAAVIPQP

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=220, Percent_Identity=33.1818181818182, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320896, Length=202, Percent_Identity=31.1881188118812, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23078; Mature: 23078

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIAMPKGRIFEEAVELLRRADYMLPPEFEESRKLVIDVAEENMRFILAKPMDVVTYVE
CEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEECCHHHHHHHH
HGVADLGIAGKDVLMEEERNVYELLDLQISRCHLAVAGLPGVKMNGIAPRVATKYPNVAS
HCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHEEEEECCCCCEECCCCCHHHHCCCCHHH
TYFREQGEQVEIIRLNGSIELAPLIGLADRIVDIVSTGRTLKENGLVELERIADVTSRLI
HHHHCCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHH
VNPASYRLNGEVIERLVDRLAAVIPQP
CCCCCEEECHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTIAMPKGRIFEEAVELLRRADYMLPPEFEESRKLVIDVAEENMRFILAKPMDVVTYVE
CEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEECCHHHHHHHH
HGVADLGIAGKDVLMEEERNVYELLDLQISRCHLAVAGLPGVKMNGIAPRVATKYPNVAS
HCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHEEEEECCCCCEECCCCCHHHHCCCCHHH
TYFREQGEQVEIIRLNGSIELAPLIGLADRIVDIVSTGRTLKENGLVELERIADVTSRLI
HHHHCCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHH
VNPASYRLNGEVIERLVDRLAAVIPQP
CCCCCEEECHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA