Click here to switch to the map view.

The map label for this gene is hisS [H]

Identifier: 138896141

GI number: 138896141

Start: 2607460

End: 2608740

Strand: Reverse

Name: hisS [H]

Synonym: GTNG_2504

Alternate gene names: 138896141

Gene position: 2608740-2607460 (Counterclockwise)

Preceding gene: 138896142

Following gene: 138896140

Centisome position: 73.48

GC content: 53.01

Gene sequence:

>1281_bases
ATGGCTTTTCAAATTCCAAGAGGGACACAAGATTTATTACCGGGTGAAACGGAAAAATGGCAATATGTCGAACAAGTGGC
CCGCGACCTGTGTAGACGGTACGGCTATGAAGAAATACGGACGCCGATTTTTGAACATACGGAGCTGTTTTTACGTGGCG
TTGGTGATACGACCGATATCGTCCAAAAAGAGATGTACACGTTTGAAGACAAAGGGGGGCGTGCGTTGACGCTCCGTCCG
GAAGGAACCGCACCGGTCGTGCGGGCGTTCGTCGAGCATAAGCTGTACGGCAGCCCGAATCAGCCGGTCAAGTTGTATTA
TGCGGGACCAATGTTCCGTTATGAGCGGCCGGAAGCCGGACGGTTCCGCCAATTCGTCCAGTTTGGTGTTGAGGCAATTG
GCAGCAGTGATCCGGCGATTGACGCCGAGGTGATGGCGTTAGCGATGCATATTTATAAGGCGCTTGGTTTAAAACACATC
CGGCTCGTAATCAACAGTTTAGGCGATGTAGACAGCCGCCGGGCGCATCGCGAAGCGCTTGTCCGCCATTTTTCTGACCG
CATTCATGAACTGTGCCCGGACTGTCAGGCGCGGCTTGAGACGAATCCGCTCCGCATTCTCGATTGTAAAAAGGACCGCG
ATCATGAACTGATGGCGTCAGCACCGTCGATTTTAGACTATTTGAATGACGAATCGAGCGCGTATTTTGAGAAGGTGAAG
CAATATTTAACGATGCTTGACATCCCGTTTGTCATTGACTCGCGGCTCGTGCGCGGCCTCGATTATTACAACCATACGAC
GTTTGAAATTATGAGCGAGGCTGAAGGATTCGGCGCAGCGGCGACTCTTTGCGGCGGCGGACGCTATAACGGGCTTGTGC
AAGAAATTGGCGGCCCGGAAACGCCTGGCATCGGCTTTGCGTTAAGCATTGAACGGCTGCTGGCGGCGCTTGAAGCGGAA
GGGATTGAACTGCCGATCCATCGAGGAATCGATTGCTATGTTGTCGCTGTCGGTGAGCGGGCAAAAGATGAAACTGTCCG
CCTCGTTTACGAATTGCGCCGTGCCGGCCTGCGTGTGGAGCAAGACTATTTAGGTCGAAAAATGAAGGCACAGCTGAAGG
CAGCTGACCGTCTTGGCGCATCATTCGTTGCCATCATCGGCGACGAGGAGCTGGAAAAACAGACAGCAGCTGTGAAACAC
ATGGCGAGCGGCGAGCAAACTGATGTGCCGCTTGGAGAGTTGGCGTCCTTTTTAATAGAACGAACAAAACGGGAGGAGTA
A

Upstream 100 bases:

>100_bases
GCTGTATGCTTCAATTAGGGTGGCACCGCGGGAATGACGCTCTCGTCCCTATCGATGATGGGGATAAGGGCGTTTTTATT
TTGGGCAAAGGAGGAAGAGT

Downstream 100 bases:

>100_bases
AAAGTGGAACGAACGTATTATTGTGGTGAAGTGCCGGAAACGGCCGTCGGCGAGCGTGTTGTGCTCAAAGGCTGGGTGCA
AAAGCGCCGTGATTTGGGTG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MAFQIPRGTQDLLPGETEKWQYVEQVARDLCRRYGYEEIRTPIFEHTELFLRGVGDTTDIVQKEMYTFEDKGGRALTLRP
EGTAPVVRAFVEHKLYGSPNQPVKLYYAGPMFRYERPEAGRFRQFVQFGVEAIGSSDPAIDAEVMALAMHIYKALGLKHI
RLVINSLGDVDSRRAHREALVRHFSDRIHELCPDCQARLETNPLRILDCKKDRDHELMASAPSILDYLNDESSAYFEKVK
QYLTMLDIPFVIDSRLVRGLDYYNHTTFEIMSEAEGFGAAATLCGGGRYNGLVQEIGGPETPGIGFALSIERLLAALEAE
GIELPIHRGIDCYVVAVGERAKDETVRLVYELRRAGLRVEQDYLGRKMKAQLKAADRLGASFVAIIGDEELEKQTAAVKH
MASGEQTDVPLGELASFLIERTKREE

Sequences:

>Translated_426_residues
MAFQIPRGTQDLLPGETEKWQYVEQVARDLCRRYGYEEIRTPIFEHTELFLRGVGDTTDIVQKEMYTFEDKGGRALTLRP
EGTAPVVRAFVEHKLYGSPNQPVKLYYAGPMFRYERPEAGRFRQFVQFGVEAIGSSDPAIDAEVMALAMHIYKALGLKHI
RLVINSLGDVDSRRAHREALVRHFSDRIHELCPDCQARLETNPLRILDCKKDRDHELMASAPSILDYLNDESSAYFEKVK
QYLTMLDIPFVIDSRLVRGLDYYNHTTFEIMSEAEGFGAAATLCGGGRYNGLVQEIGGPETPGIGFALSIERLLAALEAE
GIELPIHRGIDCYVVAVGERAKDETVRLVYELRRAGLRVEQDYLGRKMKAQLKAADRLGASFVAIIGDEELEKQTAAVKH
MASGEQTDVPLGELASFLIERTKREE
>Mature_425_residues
AFQIPRGTQDLLPGETEKWQYVEQVARDLCRRYGYEEIRTPIFEHTELFLRGVGDTTDIVQKEMYTFEDKGGRALTLRPE
GTAPVVRAFVEHKLYGSPNQPVKLYYAGPMFRYERPEAGRFRQFVQFGVEAIGSSDPAIDAEVMALAMHIYKALGLKHIR
LVINSLGDVDSRRAHREALVRHFSDRIHELCPDCQARLETNPLRILDCKKDRDHELMASAPSILDYLNDESSAYFEKVKQ
YLTMLDIPFVIDSRLVRGLDYYNHTTFEIMSEAEGFGAAATLCGGGRYNGLVQEIGGPETPGIGFALSIERLLAALEAEG
IELPIHRGIDCYVVAVGERAKDETVRLVYELRRAGLRVEQDYLGRKMKAQLKAADRLGASFVAIIGDEELEKQTAAVKHM
ASGEQTDVPLGELASFLIERTKREE

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=477, Percent_Identity=25.9958071278826, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI15029520, Length=477, Percent_Identity=24.9475890985325, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1788861, Length=419, Percent_Identity=43.1980906921241, Blast_Score=350, Evalue=9e-98,
Organism=Saccharomyces cerevisiae, GI6325290, Length=488, Percent_Identity=22.7459016393443, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24643061, Length=478, Percent_Identity=25.1046025104602, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24643059, Length=504, Percent_Identity=24.0079365079365, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 48009; Mature: 47878

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFQIPRGTQDLLPGETEKWQYVEQVARDLCRRYGYEEIRTPIFEHTELFLRGVGDTTDI
CCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCHHHH
VQKEMYTFEDKGGRALTLRPEGTAPVVRAFVEHKLYGSPNQPVKLYYAGPMFRYERPEAG
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCEEECCCCCHH
RFRQFVQFGVEAIGSSDPAIDAEVMALAMHIYKALGLKHIRLVINSLGDVDSRRAHREAL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VRHFSDRIHELCPDCQARLETNPLRILDCKKDRDHELMASAPSILDYLNDESSAYFEKVK
HHHHHHHHHHHCCHHHHHCCCCCEEEEECCCCCCCHHHHCCHHHHHHHCCCHHHHHHHHH
QYLTMLDIPFVIDSRLVRGLDYYNHTTFEIMSEAEGFGAAATLCGGGRYNGLVQEIGGPE
HHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHCCCCC
TPGIGFALSIERLLAALEAEGIELPIHRGIDCYVVAVGERAKDETVRLVYELRRAGLRVE
CCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCC
QDYLGRKMKAQLKAADRLGASFVAIIGDEELEKQTAAVKHMASGEQTDVPLGELASFLIE
HHHHCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
RTKREE
HHHCCC
>Mature Secondary Structure 
AFQIPRGTQDLLPGETEKWQYVEQVARDLCRRYGYEEIRTPIFEHTELFLRGVGDTTDI
CCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCHHHH
VQKEMYTFEDKGGRALTLRPEGTAPVVRAFVEHKLYGSPNQPVKLYYAGPMFRYERPEAG
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCEEECCCCCHH
RFRQFVQFGVEAIGSSDPAIDAEVMALAMHIYKALGLKHIRLVINSLGDVDSRRAHREAL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VRHFSDRIHELCPDCQARLETNPLRILDCKKDRDHELMASAPSILDYLNDESSAYFEKVK
HHHHHHHHHHHCCHHHHHCCCCCEEEEECCCCCCCHHHHCCHHHHHHHCCCHHHHHHHHH
QYLTMLDIPFVIDSRLVRGLDYYNHTTFEIMSEAEGFGAAATLCGGGRYNGLVQEIGGPE
HHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHCCCCC
TPGIGFALSIERLLAALEAEGIELPIHRGIDCYVVAVGERAKDETVRLVYELRRAGLRVE
CCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCC
QDYLGRKMKAQLKAADRLGASFVAIIGDEELEKQTAAVKHMASGEQTDVPLGELASFLIE
HHHHCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
RTKREE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA